List of works by Alex John O'Neill

"tet(U)" is not a tetracycline resistance determinant

scientific article

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage. ⬇️

scientific article published on 8 February 2018

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase

scientific article published in 2012

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus ⬇️

scientific article

A fusidic acid-resistant epidemic strain of Staphylococcus aureus carries the fusB determinant, whereas fusA mutations are prevalent in other resistant isolates.

scientific article

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance ⬇️

scientific article published on 19 January 2016

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection ⬇️

scientific article

Acquired Nisin Resistance in Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module ⬇️

scientific article published on 12 December 2018

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase

scientific article published on 14 February 2011

Activity-directed expansion of a series of antibacterial agents

scientific article published on 15 June 2020

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques

scientific article published on 21 April 2009

Anti-staphylococcal activity and mode of action of clofazimine.

scientific article published on 4 February 2004

Antibacterial activity and mode of action of tert-butylhydroquinone (TBHQ) and its oxidation product, tert-butylbenzoquinone (TBBQ).

scientific article published on 5 March 2013

Batumin does not exert its antistaphylococcal effect through inhibition of aminoacyl-tRNA synthetase enzymes ⬇️

scientific article published on 25 October 2016

Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus.

scientific article published on 7 March 2007

Complete nucleotide sequence of pGO1, the prototype conjugative plasmid from the Staphylococci.

scientific article published on 17 March 2009

Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus

scientific article published on 31 July 2008

Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens ⬇️

scientific article published on 2 August 2017

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold

scientific article published on 12 December 2013

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

scientific article

Distribution of fusidic acid resistance determinants in methicillin-resistant Staphylococcus aureus.

scientific article

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa ⬇️

scientific article

Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies.

scientific article published on 7 June 2007

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA ⬇️

scientific article published on 18 July 2018

Evolution of extended-spectrum beta-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator

scientific article published on 10 August 2006

Exploiting current understanding of antibiotic action for discovery of new drugs.

scientific article published in January 2002

Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase

scientific article published on 26 July 2010

Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studies

scientific article published on 31 January 2011

Genetic basis of resistance to fusidic acid in staphylococci.

scientific article published on 26 February 2007

Impact of exposure of methicillin-resistant Staphylococcus aureus to polyhexanide in vitro and in vivo. ⬇️

scientific article

In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance

scientific article published on 7 February 2011

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

scientific article published on 7 November 2005

Increased mutability of Staphylococci in biofilms as a consequence of oxidative stress

scientific article

Loss of function of the gdpP protein leads to joint β-lactam/glycopeptide tolerance in Staphylococcus aureus.

scientific article published on 10 October 2011

Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus.

scientific article published in January 2006

Mutagenesis mapping of the protein-protein interaction underlying FusB-type fusidic acid resistance ⬇️

scientific article

Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus.

scientific article published in May 2001

N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors ⬇️

scientific article published on 18 January 2018

Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence ⬇️

scientific article

Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques

scientific article published in August 2004

Redox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agents ⬇️

scientific article published on 3 November 2014

Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.

scientific article published in June 2002

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide). ⬇️

scientific article published on 30 November 2016

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin ⬇️

scientific article published on 12 December 2017

Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms ⬇️

scientific article

Staphylococcus aureus SH1000 and 8325-4: comparative genome sequences of key laboratory strains in staphylococcal research.

scientific article published on 10 June 2010

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

scientific article published in August 2013

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

scientific article published on 29 July 2011

Target protection as a key antibiotic resistance mechanism

scientific article published on 25 June 2020

Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme ⬇️

scientific article published on 18 July 2016

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

scientific article

Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent ⬇️

scientific article published on 27 April 2016

The antibiotic resistance ABC-F proteins: bringing target protection into the limelight ⬇️

scientific article

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

scientific article

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

scientific article published on 3 March 2009

The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

scientific article published on 25 September 2012

The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens

scientific article published on 31 October 2012

Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure

scientific article published on 29 October 2019

Transposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.

scientific article

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

scientific article published on February 2008

Use of mutator strains for characterization of novel antimicrobial agents

scientific article published on May 2001

Zeocin resistance suppresses mutation in hypermutable Escherichia coli.

scientific article

Paulina is supported by:

About Paulina

Help