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List of works by Alan Fersht

14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

scientific article

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

scientific article published on 22 August 2016

6 Protein engineering in analysis of protein folding pathways and stability

scientific article published on January 1, 1991

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution ⬇️

scientific article published on September 10, 2010

A kinetically significant intermediate in the folding of barnase

scientific article published in December 2000

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

scientific article

A sequential assignment procedure for proteins that have intermediate line widths in MAS NMR spectra: amyloid fibrils of human CA150.WW2.

scientific article published in August 2008

A single-molecule characterization of p53 search on DNA

scientific article

Accuracy of DNA polymerase-alpha in copying natural DNA.

scientific article published on January 1983

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

scientific article

Active barnase variants with completely random hydrophobic cores

scientific article published on May 1996

Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases ⬇️

scientific article published on January 14, 1975

Adaptive evolution of p53 thermodynamic stability

scientific article published on 13 August 2009

Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA.

scientific article published on 30 January 2008

Alpha-helix stability in proteins. II. Factors that influence stability at an internal position

scientific article published on September 20, 1992

Alternative pathways for editing non-cognate amino acids by aminoacyl-tRNA synthetases

scientific article

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

scientific article published on 21 April 2018

An N-terminal fragment of barnase has residual helical structure similar to that in a refolding intermediate

scientific article published on April 5, 1992

An editing mechanism for the methionyl-tRNA synthetase in the selection of amino acids in protein synthesis ⬇️

scientific article published on April 3, 1979

An evaluation of the use of hydrogen exchange at equilibrium to probe intermediates on the protein folding pathway

scientific article

An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein

scientific article published on 08 August 2016

An irregular beta-bulge common to a group of bacterial RNases is an important determinant of stability and function in barnase

scientific article published in March 1999

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents

scientific article published in January 2006

Analyse von Struktur-Aktivitäts-Beziehungen bei Enzymen durch Protein-Engineering

article

Anomalous pH dependence of Kcat/Km in enzyme reactions. Rate constants for the association of chymotrypsin with substrates ⬇️

scientific article published on November 6, 1973

Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein folding

scientific article

Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cycles

scientific article

Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar

scientific article

Awakening guardian angels: drugging the p53 pathway

scientific article

Backbone dynamics of chymotrypsin inhibitor 2: effect of breaking the active site bond and its implications for the mechanism of inhibition of serine proteases

scientific article published on February 1995

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

scientific article

Barnase has subsites that give rise to large rate enhancements ⬇️

scientific article published on July 21, 1992

Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase

article

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

scientific article published on 20 December 2004

Binding of natively unfolded HIF-1alpha ODD domain to p53

scientific journal article

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes

scientific article published in February 2004

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.

scientific article published on 15 September 2009

COSMIC analysis of the major alpha-helix of barnase during folding

scientific article published in May 1991

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

scientific article

Can a simple function for the dielectric response model electrostatic effects in globular proteins?

scientific article

Capping and alpha-helix stability

scientific article

Carboxyl pKa Values and Acid Denaturation of BBL ⬇️

scientific article published on September 15, 2010

Characterization of in vitro oxidized barstar ⬇️

scientific article published on August 21, 1995

Characterization of phosphate binding in the active site of barnase by site-directed mutagenesis and NMR.

scientific article published in November 1991

Characterization of the native and fibrillar conformation of the human Nalpha-acetyltransferase ARD1

scientific article

Characterizing transition states in protein folding: an essential step in the puzzle

scientific article

Climate change and the integrity of science

scientific article

Co-operative interactions during protein folding

scientific article published in April 1992

Combination of Markov state models and kinetic networks for the analysis of molecular dynamics simulations of peptide folding

scientific article published on 9 May 2011

Combining experiment and simulation in protein folding: closing the gap for small model systems

scientific article

Comparative binding of p53 to its promoter and DNA recognition elements

scientific article published in May 2005

Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.

scientific article published on 14 August 2007

Conformational Equilibria and the Salt Bridge in Chymotrypsin ⬇️

scientific article published on January 1, 1972

Conformational entropy of alanine versus glycine in protein denatured states

scholarly article

Conservation of transition state structure in fast folding peripheral subunit-binding domains

scientific article published on 3 July 2008

Contribution of hydrophobic interactions to protein stability

scientific article published in Nature

Cooperative binding of tetrameric p53 to DNA.

scientific article published in August 2004

Core domain interactions in full-length p53 in solution

scholarly article

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro

scientific article published on 22 June 2007

Correlations between kinetic and X-ray analyses of engineered enzymes: crystal structures of mutants Cys----Gly-35 and Tyr----Phe-34 of tyrosyl-tRNA synthetase

scientific article published in May 1991

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

scientific article

Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics

scientific article

Crystallographic analysis of Phe-->Leu substitution in the hydrophobic core of barnase

scientific article

Cysteinyl-tRNA synthetase from Escherichia coli does not need an editing mechanism to reject serine and alanine. High binding energy of small groups in specific molecular interactions ⬇️

scientific article published on April 3, 1979

DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication

scientific article

Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation

scientific article published on 6 May 2015

Deletion mutagenesis using an ‘M13 splint’: the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate ⬇️

scientific article published on January 1, 1983

Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain

scientific article published on 31 January 2008

Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation

scientific article

Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes ⬇️

scientific article published on January 14, 1975

Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique ⬇️

scientific article published on July 29, 1975

Design of highly stable functional GroEL minichaperones.

scientific article

Designing a metal-binding site in the scaffold of Escherichia coli KDO8PS.

scientific article

Detection and characterization of a folding intermediate in barnase by NMR

scientific article published in Nature

Detection of an intermediate in the folding of the (beta alpha)8-barrel N-(5'-phosphoribosyl)anthranilate isomerase from Escherichia coli

scientific article

Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values

scientific article

Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer

scientific article

Direct observation of ultrafast folding and denatured state dynamics in single protein molecules

scientific article published on 19 October 2009

Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold

scientific article

Dissection of the effector-binding site and complementation studies of Escherichia coli phosphofructokinase using site-directed mutagenesis

scientific article

Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis

scientific article published in December 1987

Distinguishing between cooperative and unimodal downhill protein folding

scientific article

Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy

scientific article published on September 12, 2012

Don’t waste good methods on bad buffers and ambiguous data ⬇️

scientific article published on January 17, 2013

Downhill versus barrier-limited folding of BBL 1: energetic and structural perturbation effects upon protonation of a histidine of unusually low pKa.

scientific article published on 30 December 2008

Downhill versus barrier-limited folding of BBL 2: mechanistic insights from kinetics of folding monitored by independent tryptophan probes

scientific article published on 30 December 2008

Downhill versus barrier-limited folding of BBL 3. Heterogeneity of the native state of the BBL peripheral subunit binding domain and its implications for folding mechanisms

scientific article published on 13 February 2009

Early events in protein folding

scientific article

Editing mechanisms in aminoacylation of tRNA:ATP consumption and the binding of aminoacyl-tRNA by elongation factor Tu ⬇️

scientific article published on October 18, 1977

Editing mechanisms in protein synthesis. Rejection of valine by the isoleucyl-tRNA synthetase ⬇️

scientific article published on March 8, 1977

Effect of alanine versus glycine in alpha-helices on protein stability

scientific article published on April 2, 1992

Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2

scientific article

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains

scientific article published on 5 June 2006

Effects of heme on the structure of the denatured state and folding kinetics of cytochrome b562.

scientific article published on 21 December 2004

Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).

scientific article published on 2 August 2006

Effects of stability on the biological function of p53.

scientific article

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA

scientific article

Electrostatic effects on modification of charged groups in the active site cleft of subtilisin by protein engineering

scientific article

Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar

scientific article published in May 1998

Elucidating the mechanism of familial amyloidosis- Finnish type: NMR studies of human gelsolin domain 2.

scientific article published on September 2000

Energetics of complementary side-chain packing in a protein hydrophobic core

scientific article

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles

scientific article published in April 1995

Energy expenditure in the editing mechanism of protein synthesis [proceedings]

scientific article published on January 1977

Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation

scientific article

Engineering a two-helix bundle protein for folding studies

scientific article

Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type

scientific article published on September 1999

Establishing the misacylation/deacylation of the tRNA pathway for the editing mechanism of prokaryotic and eukaryotic valyl-tRNA synthetases ⬇️

scientific article published on April 3, 1979

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

scientific article published on October 1990

Evaluating Drosophila p53 as a model system for studying cancer mutations

scientific article

Evidence for the double-sieve editing mechanism in protein synthesis. Steric exclusion of isoleucine by valyl-tRNA synthetases ⬇️

scientific article published on June 12, 1979

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

scientific article published on 17 September 2015

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

scientific article published on December 2015

Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions

scientific article published on September 1994

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation ⬇️

scientific article published on October 1, 1979

First-order rate-determining aggregation mechanism of p53 and its implications ⬇️

scientific article published on August 6, 2012

Fluorescence properties of a tryptophan residue in an aromatic core of the protein subunit of ribonuclease P from Escherichia coli

scientific article

Fluorescence resonance energy transfer analysis of the folding pathway of Engrailed Homeodomain

scientific article

Fluorescence spectrum of barnase: contributions of three tryptophan residues and a histidine-related pH dependence

scientific article published in July 1991

Folding and binding

scientific article published in February 1996

Folding of Circular and Permuted Chymotrypsin Inhibitor 2: Retention of the Folding Nucleus ⬇️

scientific article published on June 2, 1998

Folding of barstar C40A/C82A/P27A and catalysis of the peptidyl-prolyl cis/trans isomerization by human cytosolic cyclophilin (Cyp18).

scientific article published on July 1999

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

scientific article

Folding of subtilisin BPN': role of the pro-sequence

scientific article

Folding of the Pit1 homeodomain near the speed limit

scientific article

Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates 1 1Edited by J. Karn ⬇️

scientific article published on January 11, 2002

Formation of electrostatic interactions on the protein-folding pathway

scientific article

Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

scientific article

From minichaperone to GroEL 1: information on GroEL-polypeptide interactions from crystal packing of minichaperones

scientific article

From minichaperone to GroEL 2: importance of avidity of the multisite ring structure

scientific article published in December 2000

From minichaperone to GroEL 3: properties of an active single-ring mutant of GroEL.

scientific article published in December 2000

From the first protein structures to our current knowledge of protein folding: delights and scepticisms

scientific article published on 25 June 2008

General structural motifs of amyloid protofilaments

scholarly article

Generation of a family of protein fragments for structure-folding studies. 1. Folding complementation of two fragments of chymotrypsin inhibitor-2 formed by cleavage at its unique methionine residue

scientific article published on June 1994

GroEL recognises sequential and non-sequential linear structural motifs compatible with extended beta-strands and alpha-helices

scientific article

Halogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53

scientific article

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

scientific article

High temperature unfolding simulations of the TRPZ1 peptide

scientific article published on 15 February 2008

Highest paraoxonase turnover rate found in a bacterial phosphotriesterase variant

scientific article

How and why to publish in PNAS

scientific article

Human full-length Securin is a natively unfolded protein

scientific article published in June 2005

Hydrogen bonding and biological specificity analysed by protein engineering

scientific article

Hydrogen bonding in enzymatic catalysis analysed by protein engineering

scientific article published in Nature

Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways? ⬇️

scientific article published on August 1, 1997

Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature ⬇️

scientific article published on July 4, 1997

Identification of the barstar binding site of barnase by NMR spectroscopy and hydrogen-deuterium exchange

scientific article published on September 1993

Importance of two buried salt bridges in the stability and folding pathway of barnase

scientific article published in May 1996

In support of the BMRB.

scientific article published in September 2012

In vivo activities of GroEL minichaperones ⬇️

scientific article published on August 18, 1998

Increased rates of tRNA charging through modification of the enzyme-aminoacyl-adenylate complex of phenylalanyl-tRNA synthetase

scientific article

Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin ⬇️

scientific article published on May 7, 1974

Initiation sites of protein folding by NMR analysis

scientific article published on October 1996

Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics

scientific article published on 12 June 2009

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

scientific article

Involvement of threonine 234 in catalysis of tyrosyl adenylate formation by tyrosyl-tRNA synthetase

scientific article

Is there a unifying mechanism for protein folding?

scientific article

Jubilee Lecture. Pathway and stability of protein folding

scientific article

Kinetic Instability of p53 Core Domain Mutants

scientific article published in Journal of Biological Chemistry

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition ⬇️

scientific article published on August 6, 2012

Kinetic significance of GroEL14.(GroES7)2 complexes in molecular chaperone activity

scientific article

Kinetics of chain motions within a protein-folding intermediate ⬇️

scientific article published on December 6, 2010

Ligand binding and enzymic catalysis coupled through subunits in tyrosyl-tRNA synthetase ⬇️

scientific article published on January 14, 1975

Ligand binding stoichiometries, subunit structure, and slow transitions in aminoacyl-tRNA synthetases ⬇️

scientific article published on September 6, 1977

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

scientific article

Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways

scientific article published on November 1993

Long-Range Modulation of Chain Motions within the Intrinsically Disordered Transactivation Domain of Tumor Suppressor p53 ⬇️

scientific article published on January 12, 2012

Long-range surface charge-charge interactions in proteins. Comparison of experimental results with calculations from a theoretical method

scientific article published in July 1993

Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type

scientific article

MDMX contains an autoinhibitory sequence element

scientific article published on 14 October 2013

Malleability of folding intermediates in the homeodomain superfamily

scientific article

Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.

scientific article

Mapping transition states of protein unfolding by protein engineering of ligand-binding sites ⬇️

scientific article published on October 5, 1991

Max Ferdinand Perutz OM FRS.

scientific article

Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships

scientific article published in March 1973

Mechanism of initiation of aggregation of p53 revealed by Φ-value analysis

scientific article

Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms

scientific article

Members of the S100 family bind p53 in two distinct ways

scientific article published on 11 August 2008

Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction

scientific article published in February 1990

Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity

scientific article (publication date: 13 May 2003)

Minimal and optimal mechanisms for GroE-mediated protein folding

scientific article

Modification of the amino acid specificity of tyrosyl-tRNA synthetase by protein engineering

scientific article

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation

scientific article

Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers

scientific article published on 18 March 2009

Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation

scholarly article

Molecular mechanism of the interaction between MDM2 and p53.

scientific article published in October 2002

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

scientific article

Multisite aggregation of p53 and implications for drug rescue

scientific article published on 14 March 2017

Mutation of asparagine 111 of rubisco from Rhodospirillum rubrum alters the carboxylase/oxygenase specificity ⬇️

scientific article published on June 5, 1992

Mutation of lysine 233 to alanine introduces positive cooperativity into tyrosyl-tRNA synthetase

scientific article

Mutational and kinetic analysis of a mobile loop in tyrosyl-tRNA synthetase

scientific article

Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

scientific article

Natural variation of tyrosyl-tRNA synthetase and comparison with engineered mutants

scientific article published in April 1986

Nature and consequences of GroEL-protein interactions

scientific article

Negative activation enthalpies in the kinetics of protein folding

scientific article

New approach to the study of transient protein conformations: the formation of a semiburied salt link in the folding pathway of barnase

scientific article published in May 1996

Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain ⬇️

scientific article published on May 15, 1998

Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study

scientific article

Nonsequential unfolding of the alpha/beta barrel protein indole-3-glycerol-phosphate synthase

scientific article

On the simulation of protein folding by short time scale molecular dynamics and distributed computing

scientific article

One-state downhill versus conventional protein folding

scientific article published in November 2004

Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications

scientific article

PFD: a database for the investigation of protein folding kinetics and stability

scientific article

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

scientific article published on May 2009

Pathway of protein folding

scientific article published on January 1, 1992

Perturbed pKA-values in the denatured states of proteins

scientific article published on December 1995

Phi value versus psi analysis

scientific article

Phi-analysis at the experimental limits: mechanism of beta-hairpin formation

scientific article

Phi-analysis of the folding of the B domain of protein A using multiple optical probes

scientific article published on 6 June 2006

Phi-value analysis and the nature of protein-folding transition states

scientific article

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters ⬇️

scientific article published on October 30, 2010

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

scientific article published on 09 December 2008

Prediction of electrostatic effects of engineering of protein charges

scientific article published in November 1987

Pro-sequence-assisted protein folding

scientific article published on May 1995

Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli ⬇️

scientific article published on September 25, 1981

Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistry

scientific article

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

scientific article

Protein engineering and the study of structure--function relationships in receptors

scientific article published on July 1990

Protein folding and binding: moving into unchartered territory

scientific article published on 13 February 2009

Protein folding and unfolding at atomic resolution

scientific article

Protein folding: think globally, (inter)act locally

scientific article

Protein stability as a function of denaturant concentration: the thermal stability of barnase in the presence of urea

scientific article published in May 1995

Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

scientific article

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

scientific article

Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships

scientific article published in Nature

Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

scientific article

Rapid amyloid fiber formation from the fast-folding WW domain FBP28.

scientific article published on August 2003

Rapid intramolecular coupling of active sites in the pyruvate dehydrogenase complex of Escherichia coli : Mechanism for rate enhancement in a multimeric structure ⬇️

scientific article published on November 1, 1978

Rational modification of enzyme catalysis by engineering surface charge

scientific article published in Nature

Rationally designing the accumulation of a folding intermediate of barnase by protein engineering

scientific article published in December 1993

Reaction pathway and rate-determining step in the aminoacylation of tRNAArg catalyzed by the arginyl-tRNA synthetase from yeast ⬇️

scientific article published on September 5, 1978

Real-time NMR studies on a transient folding intermediate of barstar

scientific article published on June 1999

Recombinant chymotrypsin inhibitor 2: expression, kinetic analysis of inhibition with alpha-chymotrypsin and wild-type and mutant subtilisin BPN', and protein engineering to investigate inhibitory specificity and mechanism

scientific article

Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism

scientific article

Redesigning enzymes by site-directed mutagenesis

scientific article

Refolding of barnase mutants and pro-barnase in the presence and absence of GroEL.

scientific article

Refolding the Engrailed Homeodomain: Structural Basis for the Accumulation of a Folding Intermediate ⬇️

scientific article published on September 8, 2010

Regulation of DNA binding of p53 by its C-terminal domain

scientific article published in September 2004

Relationship between equilibrium amide proton exchange behavior and the folding pathway of barnase

scientific article published in July 1995

Relationship of Leffler (Bronsted) alpha values and protein folding Phi values to position of transition-state structures on reaction coordinates

scholarly article

Reply to Campos and Muñoz: Why phosphate is a bad buffer for guanidinium chloride titrations ⬇️

scientific article published on April 2, 2013

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

scientific article published on 31 October 2003

Rescue of the p53 tumor suppressor by a rationally designed molecule

scientific article published in February 2004

Rescuing the function of mutant p53.

scientific article

Reversible dissociation of dimeric tyrosyl-tRNA synthetase by mutagenesis at the subunit interface

scientific article

Role of isoleucine-164 at the active site of rubisco from Rhodospirillum rubrum

scientific article

S100 proteins interact with the N-terminal domain of MDM2

scientific article

Searching for multiple folding pathways of a nearly symmetrical protein: temperature dependent phi-value analysis of the B domain of protein A.

scientific article published on 22 June 2007

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

scientific article published on December 1998

Sequence-dependent sliding kinetics of p53

scientific article

Sequential assignment of the 1H nuclear magnetic resonance spectrum of barnase

scientific article

Sequential unfolding of ankyrin repeats in tumor suppressor p16

scientific article (publication date: 2003)

Simulation and experiment at high temperatures: ultrafast folding of a thermophilic protein by nucleation-condensation

scientific article published in April 2005

Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding

scientific article published in July 2005

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53 ⬇️

scientific article published on November 18, 2010

Single-stranded M13 DNA: use as a cloning vector

scientific article published on December 1986

Site-directed mutagenesis in the effector site of Escherichia coli phosphofructokinase

scientific article published on June 1987

Small molecule induced reactivation of mutant p53 in cancer cells

scientific article

Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold

scientific article

Solution structure of a protein denatured state and folding intermediate

scientific article published in October 2005

Solution structure of p53 core domain: structural basis for its instability

scientific article

Solution structure of the C4 zinc finger domain of HDM2.

scientific article published on 29 December 2005

Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns

scientific article

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

scientific article

Stability of p53 homologs

scientific article

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

scientific article published on December 2010

Stabilization of protein structure by interaction of alpha-helix dipole with a charged side chain

scientific article

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

scholarly article

Structural biology of the tumor suppressor p53 and cancer-associated mutants

scientific article published on January 2007

Structural biology of the tumor suppressor p53.

scientific article published on January 2008

Structural biology: analysis of 'downhill' protein folding

scientific article published in February 2007

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

scientific article

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

scientific article

Structural insights in the folding of small single-domain proteins

scientific article published on December 2003

Structure of human MDM4 N-terminal domain bound to a single-domain antibody

scientific article

Structure of the transition state for folding of a protein derived from experiment and simulation

scientific article

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

scientific article published in September 1987

Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations

scientific article published on 9 February 2005

Submillisecond events in protein folding

scientific article

Subunit interactions in the methionyl-tRNA synthetase of Bacillus stearothermophilus ⬇️

scientific article published on January 27, 1976

Surface electrostatic interactions contribute little of stability of barnase

scientific article published in August 1991

Tailoring the pH dependence of enzyme catalysis using protein engineering

scientific article published in Nature

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

scientific article

Testing protein-folding simulations by experiment: B domain of protein A.

scientific article

The binding of bis-ANS to the isolated GroEL apical domain fragment induces the formation of a folding intermediate with increased hydrophobic surface not observed in tetradecameric GroEL.

scientific article published in April 2001

The charge relay system in chymotrypsin and chymotrypsinogen

scientific article

The complete folding pathway of a protein from nanoseconds to microseconds

scientific article published in February 2003

The crystal structure of human CD1b with a bound bacterial glycolipid

scientific article

The crystal structure of human CD1d with and without alpha-galactosylceramide

scientific article published on 10 July 2005

The denatured state of Engrailed Homeodomain under denaturing and native conditions

scientific article published in November 2003

The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death.

scientific article published on January 2004

The folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein family

scientific article

The folding of GroEL-bound barnase as a model for chaperonin-mediated protein folding

scientific article

The helix turn helix motif as an ultrafast independently folding domain: The pathway of folding of Engrailed homeodomain

scientific article

The human peripheral subunit-binding domain folds rapidly while overcoming repulsive Coulomb forces

scientific article published on September 2010

The kinetic pathway of folding of barnase

scientific article

The most influential journals: Impact Factor and Eigenfactor

scholarly article

The novel p53 isoform "delta p53" is a misfolded protein and does not bind the p21 promoter site

scientific article

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

scientific article published on 4 May 2016

The present view of the mechanism of protein folding

scientific article

The rate of isomerisation of peptidyl-proline bonds as a probe for interactions in the physiological denatured state of chymotrypsin inhibitor 2

article published in 1997

The role of the turn in beta-hairpin formation during WW domain folding

scientific article published on 31 August 2007

The sixth Datta Lecture. Protein folding and stability: the pathway of folding of barnase

scientific article

The structure of the major transition state for folding of an FF domain from experiment and simulation

scientific article published in July 2005

The structure of the transition state for the association of two fragments of the barley chymotrypsin inhibitor 2 to generate native-like protein: implications for mechanisms of protein folding

scientific article published in November 1994

The transition state for folding of a peripheral subunit-binding domain contains robust and ionic-strength dependent characteristics

scientific article published on 21 December 2005

The tumor suppressor p53: from structures to drug discovery

scientific article published on 10 February 2010

The valyl-tRNA synthetase from Bacillus stearothermophilus has considerable sequence homology with the isoleucyl-tRNA synthetase from Escherichia coli

scientific article published in May 1987

Time-Resolved Small-Angle X-ray Scattering Study of the Folding Dynamics of Barnase ⬇️

scientific article published on December 10, 2010

Titration properties and thermodynamics of the transition state for folding: comparison of two-state and multi-state folding pathways

scientific article published in November 1996

Toward a mechanism for GroEL.GroES chaperone activity: an ATPase-gated and -pulsed folding and annealing cage

scientific article published on April 1996

Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant

scientific article

Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding

scientific article published in March 2000

Transdisciplinary EU science institute needs funds urgently

scientific article published in February 2010

Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering

scientific article published on December 1985

Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism

scientific article

Tumor suppressor p53 slides on DNA with low friction and high stability

scientific article published on 18 April 2008

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.

scientific article

Tyrosyl-tRNA synthetase from Escherichia coli. Stoichiometry of ligand binding and half-of-the-sites reactivity in aminoacylation ⬇️

scientific article published on July 29, 1975

Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family

scientific article published in October 2005

Ultraslow oligomerization equilibria of p53 and its implications

scientific article published on 10 August 2009

Unifying features in protein-folding mechanisms

scientific article published on 31 October 2003

Use of binding energy in catalysis analyzed by mutagenesis of the tyrosyl-tRNA synthetase

scientific article published in April 1986

pH Dependence of chymotrypsin catalysis. Appendix. Substrate binding to dimeric α-chymotrypsin studied by x-ray diffraction and the equilibrium method ⬇️

scientific article published on March 26, 1974

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