List of works by Emmanuel Mignot

A circadian sleep disorder reveals a complex clock

scientific article

A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy.

scientific article published on 21 December 2017

A harrowing journey through disordered sleep

scientific article published in Nature

A link between short sleep and obesity: building the evidence for causation

scientific article published in October 2005

A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient

scientific article published on August 2013

A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness

scientific article published in November 2006

A year in review--basic science, narcolepsy, and sleep in neurologic diseases.

scientific article

Age estimation from sleep studies using deep learning predicts life expectancy

scientific article published in 2022

An update on the pharmacotherapy of excessive daytime sleepiness and cataplexy

scientific article published in October 2004

Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers

scientific article

Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients.

scientific article published on 26 January 2007

Analysis of onset location, laterality and propagation of cataplexy in canine narcolepsy

scientific article published in June 2002

Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension

scientific article published on 24 September 2004

Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy

scientific article

Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak

scientific article

Article reviewed: Plasma orexin-A is lower in patients with narcolepsy

scientific article published in July 2002

Association of low ferritin with PLM in the Wisconsin Sleep Cohort

scientific article published on 18 June 2015

Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested

scientific article

Association of sleep disordered breathing and cognitive deficit in APOE ε4 carriers

scientific article published on June 2013

Autoimmunity in narcolepsy

scientific article published in November 2017

Behavioural and neurophysiological correlates of human cataplexy: a video-polygraphic study

scientific article published on December 2009

Body mass index-independent metabolic alterations in narcolepsy with cataplexy.

scientific article

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy

scientific article published on December 2013

CSF hypocretin levels are normal in Huntington's disease patients

scientific article published in December 2005

CSF hypocretin-1 assessment in sleep and neurological disorders

scientific article

CSF hypocretin-1 levels in schizophrenics and controls: relationship to sleep architecture

scientific article published in May 2002

CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans

scientific article published on February 2012

CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?

scientific article published in August 2006

Cataplexy features in childhood narcolepsy

scientific article published on April 2008

Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss

scientific article

Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset

scientific article

Challenges in diagnosing narcolepsy without cataplexy: a consensus statement

scientific article

Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants

scientific article

Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system

scientific article

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness ⬇️

scientific article published on April 15, 2003

Circadian and Homeostatic Regulation of Structural Synaptic Plasticity in Hypocretin Neurons ⬇️

scientific article published on October 6, 2010

Clinical and polysomnographic course of childhood narcolepsy with cataplexy

scientific article

Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children

scientific article

Clinical aspects of narcolepsy-cataplexy across ethnic groups

scientific article

Common variants in P2RY11 are associated with narcolepsy

scientific article

Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish

scientific article published on 9 August 2007

Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development.

scientific article

Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies

scientific article published on 18 December 2017

Complex movement disorders at disease onset in childhood narcolepsy with cataplexy

scientific article published on 19 September 2011

Correction: Design and Validation of a Periodic Leg Movement Detector

scientific article published on 10 September 2015

Correction: Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1

Correlates of serum C-reactive protein (CRP)--no association with sleep duration or sleep disordered breathing.

scientific article

Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults

scientific article published on 5 April 2006

DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans

scientific article

DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue ⬇️

scientific article published on October 26, 2010

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status

scientific article

Daytime continuous polysomnography predicts MSLT results in hypersomnias of central origin

scientific article

Decreased Hypocretin-1 (Orexin-A) Levels in the Cerebrospinal Fluid of Patients with Myotonic Dystrophy and Excessive Daytime Sleepiness ⬇️

scientific article published on May 1, 2003

Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic

scientific article

Depression: relationships to sleep paralysis and other sleep disturbances in a community sample

scientific article

Design and validation of a periodic leg movement detector

scientific article

Diagnosis and Management of Narcolepsy

scientific article published on 24 August 2017

Diagnosis, disease course, and management of patients with Kleine-Levin syndrome

scientific article

Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy

scientific article published on 17 February 2017

Different periodicity and time structure of leg movements during sleep in narcolepsy/cataplexy and restless legs syndrome

scientific article

Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area

scientific article published on 29 February 2016

Disrupted nighttime sleep in narcolepsy

scientific article published on September 2013

Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects

scientific article published in July 2003

Dual cases of type 1 narcolepsy with schizophrenia and other psychotic disorders

scientific article

EIF3G is associated with narcolepsy across ethnicities

scientific article

Early IVIg treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency

scientific article published on 20 June 2012

Effect of the prion 129 polymorphism on nocturnal sleep and insomnia complaints: a population-based study

scientific article published in December 2002

Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog.

scientific article published in December 2003

Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset

scientific article published on August 2009

Emerging therapies in narcolepsy-cataplexy.

scientific article

English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary

scientific article

Episodic hypersomnia and unusual behaviors in a 14-year old adolescent

scientific article published in April 2010

Episodic hypersomnia and unusual behaviors in a 14-year old adolescent

scientific article published in December 2007

Erratum: Common variants in P2RY11 are associated with narcolepsy

scholarly article published in Nature Genetics

Erratum: Narcolepsy is strongly associated with the T-cell receptor alpha locus

scholarly article published in Nature Genetics

Excessive daytime sleepiness: population and etiology versus nosology

scientific article published in April 2008

Familial Kleine-Levin Syndrome: A Specific Entity?

scientific article published on 25 May 2016

Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602.

scientific article

Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study

scientific article

Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

scientific article published on 3 January 2018

Future of genetics of mood disorders research

scientific article

Genetic association, seasonal infections and autoimmune basis of narcolepsy

scientific article

Genetic studies in the sleep disorder narcolepsy

scientific article

Genetics of circadian rhythms and sleep in human health and disease

scientific article published in 2022

Genetics of sleep and sleep disorders

scientific article

Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic

scientific journal article

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1

scientific journal article

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia

scientific article published on 16 April 2013

Genomic and functional conservation of sedative-hypnotic targets in the zebrafish.

scientific article published in April 2007

HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency

scientific article

HLA and hypocretin studies in Korean patients with narcolepsy.

scientific article published in June 2002

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy.

scientific article published in May 2015

HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy

scientific article

HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe

scientific article published on January 2015

HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy

scientific article published in Scientific Reports

High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy

scientific article published on February 2013

History of the development of sleep medicine in the United States

scientific article

Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis

scientific article published on 03 February 2022

Hypersomnolence and increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma

scientific article

Hypocretin (orexin) neuropeptide precursor gene, HCRT, polymorphisms in early-onset narcolepsy with cataplexy

scientific article

Hypocretin Deficiency in Human Narcolepsy

Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy

scientific article published on August 2008

IGFBP3 colocalizes with and regulates hypocretin (orexin)

scientific article

ImmunoChip study implicates antigen presentation to T cells in narcolepsy

scientific article

Increase of histaminergic tuberomammillary neurons in narcolepsy

scientific article

Increased EEG Theta Spectral Power in Sleep in Myotonic Dystrophy Type 1.

scientific article published on 30 January 2018

Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity

scientific article published in March 2004

Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

scientific article published in January 2004

Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey

scientific article published on 8 August 2007

Inter-expert and intra-expert reliability in sleep spindle scoring

scientific article published on 10 November 2014

Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy.

scientific article published on 3 September 2008

Kleine-Levin syndrome: a systematic study of 108 patients

scientific article

Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release

scientific article

Letter to the editor regarding our previous publication: "Secondary narcolepsy in children with brain tumors," SLEEP 2002; 25:435-439.

scientific article published in March 2003

Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys

scientific article published on 23 April 2004

Longitudinal associations of hypersomnolence and depression in the Wisconsin Sleep Cohort Study

scientific article

MICA, a gene contributing strong susceptibility to ankylosing spondylitis

scientific article published on June 2013

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

scientific article

Month of birth as a risk factor for narcolepsy.

scientific article

Multiplex family with GAD65-Abs neurologic syndromes

scientific article published on 5 December 2017

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy

scientific article

Narcolepsy and cataplexy

scientific article published on January 1, 2011

Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort

scientific article

Narcolepsy in African Americans

scientific article published on 22 June 2015

Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.

scientific article

Narcolepsy is strongly associated with the T-cell receptor alpha locus

scientific article

Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China

scientific article

Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

Narcolepsy with cataplexy

scientific article published on February 2007

Narcolepsy with cataplexy associated with holoprosencephaly misdiagnosed as epileptic drop attacks

scientific article published on 01 April 2010

Narcolepsy with cataplexy associated with nocturnal compulsive behaviors: a case-control study

scientific article

Narcolepsy with cataplexy mimicry: the strange case of two sisters

scientific article published on 15 June 2013

Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain

scientific article published on 30 September 2011

Narcolepsy: genetic predisposition and neuropharmacological mechanisms. REVIEW ARTICLE.

scientific article

Neurobiology of Narcolepsy and Hypersomnia

Nocturnal Sleep Dynamics Identify Narcolepsy Type 1

scientific article published on 7 March 2015

Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency

scientific article

Normal CSF hypocretin-1 (orexin A) levels in dementia with Lewy bodies associated with excessive daytime sleepiness

scientific article

Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome

scientific article published on 21 March 2007

Normal hypocretin-1 (orexin-A) cerebrospinal fluid level in a previously reported case of severe, life-long insomnia with motor hyperactivity

scientific article published in May 2003

Normal hypocretin-1 levels in the cerebrospinal fluid of patients with fatal familial insomnia

scientific article published in December 2003

On the value of measuring CSF hypocretin-1 in diagnosing narcolepsy

scientific article published on September 1, 2003

Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients

scientific article published in 2022

PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation

scientific article

Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD

scientific article

Physiology. The perfect hypnotic?

scientific article published in April 2013

Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs

scientific article

Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.

scientific article

Post-H1N1 narcolepsy-cataplexy

scientific article published on November 2010

Post-streptococcal antibodies are associated with metabolic syndrome in a population-based cohort

scientific article

Post-streptococcal auto-antibodies inhibit protein disulfide isomerase and are associated with insulin resistance

scientific article

Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy

scientific article

Presentations of primary hypersomnia in Chinese children

scientific article

Primary progressive narcolepsy type 1: the other side of the coin

scientific article

REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy

scientific article published on 13 June 2007

Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain

scientific article

Regulation of hypocretin (orexin) expression in embryonic zebrafish

scientific article

Relationship between CSF hypocretin levels and hypocretin neuronal loss

scientific article published in December 2003

Reply

scientific article published on 30 April 2002

Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy

scientific article

Resting our cortices by going DOWN to sleep

scientific article published in September 2009

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

scientific article published in July 2014

Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec.

scientific article

Serum cytokine levels in Kleine-Levin syndrome

scientific article

Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index

scientific article

Sleep Disorders

Sleep Well and Stay Slim: Dream or Reality? ⬇️

scientific article published on October 5, 2010

Sleep and EEG features in genetic models of Down syndrome

scientific article

Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C.

scientific article published on June 2003

Sleep spindle alterations in patients with Parkinson's disease

scientific article published on May 2015

Sleep, sleep disorders and hypocretin (orexin).

scientific article published in June 2004

Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods

scientific article published on 23 February 2014

Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish

scientific article

Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy

scientific article published on 22 March 2007

Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders

scientific article

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

scientific article published in August 2017

Sodium oxybate for excessive daytime sleepiness in narcolepsy-cataplexy

scientific article published in November 2004

Sodium oxybate is an effective and safe treatment for narcolepsy

scientific article published on 20 October 2009

Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study

scientific article published on 4 December 2015

Sympathetic and cardiovascular activity during cataplexy in narcolepsy

scientific article published on 20 October 2008

T-box 3 is expressed in the adult mouse hypothalamus and medulla

scientific journal article

TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy

scientific article published on 15 December 2011

The Burden of Narcolepsy Disease (BOND) study: health-care utilization and cost findings

scientific article published on 15 February 2014

The Hypocretins and Narcolepsy

The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study

scientific article published on 29 November 2017

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

scientific article

The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension

scientific article published in April 2007

The autoimmune basis of narcolepsy

scientific article

The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients.

scientific article published on 15 September 2015

The diurnal rhythm of hypocretin in young and old F344 rats

scientific article

The genetics of narcolepsy

scientific article

The genetics of sleep disorders

scientific article

The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A).

scientific article published in January 2003

The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions

scientific article published on July 2006

The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias

scientific article

The roles of midbrain and diencephalic dopamine cell groups in the regulation of cataplexy in narcoleptic Dobermans

scientific article

The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse

scientific article

Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey

scientific article published on 13 September 2011

Transcriptional regulation of the hypocretin/orexin gene by NR6A1 ⬇️

scientific article published on November 5, 2010

Transient total sleep loss in cerebral Whipple's disease: a longitudinal study

scientific article

Undetectable CSF hypocretin-1 in "Hashimoto's encephalopathy" associated with coma

scientific article

Urban domestic wastewater: how to reduce individual injection?

scientific article

Validation of minute-to-minute scoring for sleep and wake periods in a consumer wearable device compared to an actigraphy device

Variant between CPT1B and CHKB associated with susceptibility to narcolepsy

scientific article

Why we sleep: the temporal organization of recovery

scientific article published on April 2008

β2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study

scientific article

Paulina is supported by:

About Paulina

Help