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List of works by Jeffrey Lipman

"Not out of the woods"--a wife's perspective: bedside communication

scientific article published on 10 September 2015

"Salvage treatment" for infections by extensively- and pan-drug-resistant pathogens is common and often sub-optimal

scientific article published on 13 April 2017

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts

scientific article

A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis

scientific article published on 22 July 2015

A Population Pharmacokinetic Model-Guided Evaluation of Ceftolozane-Tazobactam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemodiafiltration

scientific article published on 20 December 2019

A Protocol for the Pharmacokinetics of Enteric Coated Mycophenolate Sodium in Lupus Nephritis (POEMSLUN): an open-label, randomised controlled trial

scientific article published on 07 August 2013

A Simulation Study Reveals Lack of Pharmacokinetic/Pharmacodynamic Target Attainment in De-escalated Antibiotic Therapy in Critically Ill Patients

scientific article published on 26 May 2015

A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit

scientific article published on 23 December 2015

A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent

scientific article published on 25 October 2017

A comparison between raw and predicted mortality in a paediatric intensive care unit in South Africa

scientific article published on 26 November 2018

A comparison of CKD-EPI estimated glomerular filtration rate and measured creatinine clearance in recently admitted critically ill patients with normal plasma creatinine concentrations

scientific article

A comparison of epinephrine and norepinephrine in critically ill patients

scientific article published on 25 July 2008

A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance

scientific article published on 8 June 2011

A meta-analysis of ventriculostomy-associated cerebrospinal fluid infections

scientific article published on 8 January 2015

A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

scientific article published on 13 March 2015

A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units

scientific article published on 01 August 2014

A new marker of sepsis post burn injury?*.

scientific article published in September 2014

A new regimen for continuous infusion of vancomycin during continuous renal replacement therapy

scientific article published on 25 June 2013

A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis

scientific article published on 4 December 2007

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration

scientific article published on 19 July 2018

A prospective randomized study comparing once- versus twice-daily amikacin dosing in critically ill adult and paediatric patients

scientific article

A prospective registry of emergency department patients admitted with infection.

scientific article

A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient

scientific article (publication date: June 2004)

A simple LC–MS/MS method using HILIC chromatography for the determination of fosfomycin in plasma and urine: Application to a pilot pharmacokinetic study in humans

scientific article published on 30 November 2014

A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?

scientific article

A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics

scientific article published on June 2009

A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples

scientific article

A validated method for the quantification of fosfomycin on dried plasma spots by HPLC-MS/MS: application to a pilot pharmacokinetic study in humans

scientific article published on 19 July 2015

ARC--augmented renal clearance

scientific article published on December 2011

Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome

scientific article

Acute respiratory distress syndrome precipitated by transjugular intrahepatic porto-systemic shunting for severe hepatic veno-occlusive disease. Is it due to pulmonary leucostasis?

scientific article published on 01 November 1999

Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units

article

Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units

scientific article published on 12 February 2004

Albumin concentration significantly impacts on free teicoplanin plasma concentrations in non-critically ill patients with chronic bone sepsis

scientific article published on 6 March 2015

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

scientific article

Ampicillin/sulbactam: its potential use in treating infections in critically ill patients

scientific article

An LC–MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent

scientific article published on 15 June 2017

An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine

scientific article

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units

scientific article published on 16 January 2014

Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection

scientific article published on 24 May 2010

Antibacterial therapeutic drug monitoring in cerebrospinal fluid: difficulty in achieving adequate drug concentrations

scientific article published on 2 November 2012

Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?

scientific article published on 13 September 2017

Antibiotic Therapy of Pneumonia in Critical Care

scholarly article by Jayesh Dhanani et al published 1 May 2012 in Current Respiratory Medicine Reviews

Antibiotic administration in the critically ill - in need of intensive care!

scientific article published in May 2015

Antibiotic dose optimization in critically ill patients.

scientific article published on 23 September 2015

Antibiotic dosing for multidrug-resistant pathogen pneumonia

scientific article published on 24 December 2016

Antibiotic dosing in multiple organ dysfunction syndrome

scientific article published on May 2011

Antibiotic dosing in obesity: a BIG challenge

scientific article published on 10 August 2016

Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients

scientific article

Antibiotic prescription for respiratory tract infections in ventilated patients: where are we heading? ⬇️

scientific article published on June 28, 2013

Antibiotic resistance--what's dosing got to do with it?

scientific article published on August 2008

Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC)

scientific article published in 2010

Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC).

scientific article published on 24 March 2010

Antimicrobial chemotherapy and lung microdialysis: a review.

scientific article published on 16 October 2010

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

scientific article published on 09 June 2020

Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock

scientific article published on January 2011

Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance.

scientific article published on 29 December 2017

Antimicrobial stewardship of β-lactams in intensive care units

scientific article published on 22 March 2014

Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development

scientific article published on 2 February 2015

Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?

scientific article published on 21 October 2014

Are new gentamicin dosing guidelines suitable for achieving target concentrations in patients with sepsis and septic shock?

scientific article published on 01 October 2016

Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

scientific article

Assays for therapeutic drug monitoring of β-lactam antibiotics: A structured review

scientific article published on 29 July 2015

Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients.

scientific article published on 15 September 2009

Assessment of peripheral arterial catheters as a source of sepsis in the critically ill: a narrative review.

scientific article published on 19 March 2010

Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit

scientific article published on 14 April 2014

Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial

scientific article published on 9 March 2017

Augmented Renal Clearance in Traumatic Brain Injury: A Single-Center Observational Study of Atrial Natriuretic Peptide, Cardiac Output, and Creatinine Clearance

scientific article published on 14 June 2016

Augmented creatinine clearance in traumatic brain injury

scientific article published on 3 November 2010

Augmented renal clearance and therapeutic monitoring of β-lactams

scientific article published on 20 January 2015

Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients

scientific article

Augmented renal clearance in the ICU: results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations*.

scientific article

Augmented renal clearance in the Intensive Care Unit: an illustrative case series

scientific article published on 21 March 2010

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis.

scientific article

Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients?

scientific article published on August 2008

Bugs, genes, and the intensive care unit

scientific article published on August 2016

Burn resuscitation--hourly urine output versus alternative endpoints: a systematic review

scientific article

CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial.

scientific article published on 31 March 2016

Can population pharmacokinetic modelling guide vancomycin dosing during continuous renal replacement therapy in critically ill patients?

scientific article published on 06 March 2013

Can we use an ex vivo continuous hemofiltration model to describe the adsorption and elimination of meropenem and piperacillin?

scientific article published on 4 August 2015

Candida colonization as a risk marker for invasive candidiasis in mixed medical-surgical intensive care units: development and evaluation of a simple, standard protocol

scientific article

Caspofungin Population Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-Venous Haemofiltration or Haemodiafiltration

scientific article published on 29 December 2016

Catheter related infection. A plea for consensus with review and guidelines

scientific article published on January 1988

Cefepime versus ceftazidime: considerations for empirical use in critically ill patients

scientific article published on 8 December 2006

Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain

scientific article published on 19 October 2020

Cerebrospinal fluid penetration of high doses of intravenous ciprofloxacin in meningitis.

scientific article published on 7 November 2000

Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study

scientific article

Characteristics of bloodstream infections in burn patients: An 11-year retrospective study

scientific article published on 18 February 2012

Characteristics, treatment and outcomes for all emergency department patients fulfilling criteria for septic shock: a prospective observational study

scientific article published on 19 August 2016

Characterization of Effects of Renal Replacement Therapy Modalities and Settings on Pharmacokinetics of Meropenem and Vaborbactam

scientific article published on 24 September 2018

Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?

scientific article published on 12 March 2002

Clearance of intravenous 5-fluorocytosine during continuous venovenous haemodiafiltration in a patient with hepatosplenic candidiasis.

scientific article published on 18 June 2009

Clinical implications of antibiotic pharmacokinetic principles in the critically ill.

scientific article

Clinical measures for increased creatinine clearances and suboptimal antibiotic dosing ⬇️

scientific article published on April 20, 2013

Comparative total and unbound pharmacokinetics of cefazolin administered by bolus versus continuous infusion in patients undergoing major surgery: a randomized controlled trial

scientific article published on 15 May 2017

Comparison of disease severity scoring systems in septic shock

scientific article published in September 1991

Comparison of equal doses of continuous venovenous haemofiltration and haemodiafiltration on ciprofloxacin population pharmacokinetics in critically ill patients

scientific article published on 7 March 2016

Comparison of the accuracy and precision of pharmacokinetic equations to predict free meropenem concentrations in critically ill patients

scientific article

Continuous Infusion of Time-dependent Antibiotics

Continuous beta-lactam infusion in critically ill patients: the clinical evidence

scientific article

Continuous infusion ceftazidime in intensive care: a randomized controlled trial

article

Continuous infusion of beta-lactam antibiotics in severe infections: a review of its role

scientific article published on 17 April 2007

Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial

scientific article published on 16 October 2012

Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target?

scientific article published in May 2008

Continuous measurement of cerebral blood flow velocity using transcranial Doppler reveals significant moment-to-moment variability of data in healthy volunteers and in patients with subarachnoid hemorrhage

scientific article

Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials

scientific article

Control of an outbreak of carbapenem-resistant Acinetobacter baumannii in Australia after introduction of environmental cleaning with a commercial oxidizing disinfectant.

scientific article published in April 2010

Coronary embolism causing myocardial infarction

scientific article published in January 1990

Critical care in Africa. North to south and the future with special reference to southern Africa.

scientific article published on April 1997

Critical care research and pre-emptive informed consent: a practical approach used in Chris Hani Baragwanath ICU.

scientific article published on April 1998

DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic

scientific article

Defining Antibiotic Dosing in Lung Infections

Detailed assessment of benefits and risks of retrievable inferior vena cava filters on patients with complicated injuries: the da Vinci multicentre randomised controlled trial study protocol.

scientific article published on 12 July 2017

Determinants of Urinary Output Response to IV Furosemide in Acute Kidney Injury: A Pharmacokinetic/Pharmacodynamic Study.

scientific article published on 13 May 2016

Determination of Cefalothin and Cefazolin in Human Plasma, Urine and Peritoneal Dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans

scientific article published on 23 September 2015

Determining authorship in multicenter trials: a systematic review

scientific article published on 20 June 2011

Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

scientific article

Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis

scientific article published on 20 June 2011

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime

scientific article published on 05 March 2020

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.

scientific article published on 3 January 2018

Difficulty in weaning from respiratory support in a patient with the intermediate syndrome of organophosphate poisoning

scientific article published in October 1989

Do burn patients cost more? The intensive care unit costs of burn patients compared with controls matched for length of stay and acuity

scientific article published in July 2010

Does Appropriate Antibiotic Therapy Mean Only Adequate Spectrum and Timing?

scientific article

Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

scientific article

Does Furosemide Increase Oxidative Stress in Acute Kidney Injury?

scientific article published on 16 August 2016

Does Intensive Care Always Have To Be Expensive Care?

Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study

scientific article

Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study

scientific article published on 27 May 2008

Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration

scientific article published on 30 May 2014

Dose Adjustment and Pharmacodynamic Considerations for Antibiotics in Severe Sepsis and Septic Shock

Dose Adjustment and Pharmacokinetics of Antibiotics in Severe Sepsis and Septic Shock

Dose matters: Dose of antibiotics in the critically ill patient depends on the dose of renal replacement therapy

Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review

scientific article

EPHA4-FC TREATMENT REDUCES ISCHEMIA/REPERFUSION-INDUCED INTESTINAL INJURY BY INHIBITING VASCULAR PERMEABILITY.

scientific article published on February 2016

Editorial Commentary: Closing the Loop--A Colistin Clinical Study to Confirm Dosing Recommendations From PK/PD Modeling

scientific article published on 15 March 2012

Effect of Manual Hyperinflation on Hemodynamics, Gas Exchange, and Respiratory Mechanics in Ventilated Patients

Effect of Obesity on the Population Pharmacokinetics of Fluconazole in Critically Ill Patients

scientific article published on 22 August 2016

Effect of Obesity on the Population Pharmacokinetics of Meropenem in Critically Ill Patients

scientific article published on 16 May 2016

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.

scientific article published on 26 May 2016

Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters.

scientific article published on 18 July 2006

Effect of intravenous GLutamine supplementation IN Trauma patients receiving enteral nutrition study protocol (GLINT Study): a prospective, blinded, randomised, placebo-controlled clinical trial

scientific article

Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

scientific article published on 23 February 2016

Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin

scientific article published on 26 September 2016

Emergency Percutaneous Balloon Mitral Valvotomy in a Patient With Septic Shock ⬇️

scientific article published on August 1, 1995

Erratum to: Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients.

scientific article published in May 2015

Erythropoietin in a patient following multiple trauma.

scientific article

Even high-dose extended infusions may not yield desired concentrations of β-lactams: the value of therapeutic drug monitoring.

scientific article published on 10 March 2015

Factors influencing psychological, social and health outcomes after major burn injuries in adults: cohort study protocol.

scientific article published on 17 June 2017

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

scientific article published on 16 December 2009

Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics

scientific article published on 8 June 2010

Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

scientific article published in July 2005

From the intensive care bed: we need to hear and listen

scientific article published on 23 January 2015

Ganciclovir pharmacokinetics and suggested dosing in continuous venovenous haemodiafiltration

scientific article published on 13 November 2010

Gastric intramucosal pH and blood lactate in severe sepsis.

scientific article published in August 1997

Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey

scientific article

How can we ensure effective antibiotic dosing in critically ill patients receiving different types of renal replacement therapy?

scientific article published on 2 February 2015

How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?

scientific article

How should we dose antibiotics for pneumonia in the ICU?

scientific article published on April 2013

How to optimise antimicrobial prescriptions in the Intensive Care Unit: principles of individualised dosing using pharmacokinetics and pharmacodynamics

scientific article published on 09 January 2012

Hydroxyethyl starch or saline for fluid resuscitation in intensive care

scientific article

Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii

scientific article

Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections.

scientific article

Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients

scientific article published on 06 July 2017

Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy

scientific article published on 21 March 2017

Implications of augmented renal clearance in critically ill patients

scientific article published on 19 July 2011

Importance of High Creatinine Clearance for Antibacterial Treatment in Sepsis

Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation

scientific article published on October 2012

Improving vancomycin prescription in critical illness through a drug use evaluation process: a weight-based dosing intervention study.

scientific article

In 2035, will all bacteria be multidrug-resistant? No.

scientific article

In Vivo Microdialysis To Determine Subcutaneous Interstitial Fluid Penetration and Pharmacokinetics of Fluconazole in Intensive Care Unit Patients with Sepsis

scientific article published on 23 November 2015

Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement

scientific article published on 15 May 2007

Increased fluid resuscitation can lead to adverse outcomes in major-burn injured patients, but low mortality is achievable

scientific article published on 12 May 2008

Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study

scientific article

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

scientific article

Infections and use of antibiotics in patients admitted for severe acute pancreatitis: data from the EPIC II study

scientific article

Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels

scientific article

Influence of Renal Replacement Modalities on Amikacin Population Pharmacokinetics in Critically Ill Patients on Continuous Renal Replacement Therapy

scientific article published on 06 June 2016

Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: Use of microdialysis

scientific article published on 28 March 2015

Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery

scientific article published on 7 July 2016

Inter observer variability of the transcranial Doppler ultrasound technique: impact of lack of practice on the accuracy of measurement

scientific article published in May 1999

Interethnic differences in pharmacokinetics of antibacterials

scientific article

Intermittent bolus dosing of ceftazidime in critically ill patients.

scientific article published in August 1997

International study of the prevalence and outcomes of infection in intensive care units

scientific article

Interpretation of Care Guidelines for Obese Women in Labor: Intergroup Language and Social Identity

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by Gram-negative bacilli: A systematic review

scientific article published on 23 November 2018

Intravascular administration sets are accurate and in appropriate condition after 7 days of continuous use: an in vitro study

scientific article published on 01 February 2002

Intravenous Calcium chloride as an antidote to verapamil-induced hypotension

scientific article published on January 1982

Is a randomized trial of a short course of aminoglycoside added to beta lactam antibiotics for empirical treatment in critically ill patients with sepsis justified?

scientific article published on 5 January 2018

Is augmented renal clearance the Holy Grail of antibiotic therapy failure in ventilator-acquired pneumonia?

scientific article

Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study

scientific article published on 28 November 2006

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patien

scientific article

Is the end-game penetration (of the airway)?

scientific article published in July 2005

Is there a role for microsampling in antibiotic pharmacokinetic studies?

scientific article published on 18 April 2016

Lateral positioning of ventilated intensive care patients: A study of oxygenation, respiratory mechanics, hemodynamics, and adverse events

scientific article published on 01 July 2007

Lessons learnt in the pharmacokinetic analysis of the effect of haemoperfusion for acute overdose with sustained-release diltiazem

scientific article published in July 2008

Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing.

scientific article published in February 2001

Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU.

scientific article published on 20 June 2014

Low mannose-binding lectin function is associated with sepsis in adult patients

scientific article published on 01 November 2006

Making the wrong choice: Consequences for patients with infections due to methicillin-resistant Staphylococcus aureus*

article

Malignant astrocytoma of the cervico-medullary junction masquerading as Guillain-Barré syndrome.

scientific article published on July 1994

Management of meningitis due to antibiotic-resistant Acinetobacter species

scientific article published on April 2009

Manual hyperinflation causes norepinephrine release

scientific article published on 01 July 2006

Maximally effective dosing regimens of meropenem in patients with septic shock.

scientific article published on 12 September 2017

Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?

scientific article

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.

scientific article published on 27 April 2009

Meropenem dosing in critically ill patients with sepsis receiving high-volume continuous venovenous hemofiltration

scientific article

Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial.

scientific article published on 27 January 2015

Midazolam Metabolism: Implications for Individualised Dosing?

article published in 2009

Molecular analysis of the Acinetobacter baumannii biofilm-associated protein

scientific article published on 16 August 2013

Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients.

scientific article

New Regimen for Continuous Infusion of Vancomycin in Critically Ill Patients

scientific article published on 23 May 2016

New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimization rapid microbiological methods

scientific article published on 14 June 2018

Optimal Antibiotic Therapy in the Management of the Lung of the Critically Ill

Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility

scientific article

Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study

scientific article

Optimising meropenem dosing in critically ill Australian Indigenous patients with severe sepsis

scientific article

Optimizing Antibiotic Use in the Intensive Care Unit

Optimizing use of beta-lactam antibiotics in the critically ill.

scientific article published on December 2007

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against <i>Escherichia coli</i> clinical isolates

scientific article published in 2022

Pharmacodynamics of Aerosolized Fosfomycin and Amikacin against Resistant Clinical Isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a Hollow-Fiber Infection Model: Experimental Basis for Combination Therapy

scientific article published on 24 October 2016

Pharmacokinetic evaluation of fluconazole in critically ill patients

scientific article published on 02 September 2011

Pharmacokinetic evaluation of piperacillin-tazobactam

scientific article published on August 2010

Pharmacokinetic issues for antibiotics in the critically ill patient

scientific article published on March 2009

Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

scientific article

Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units.

scientific article

Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill.

scientific article published on October 2015

Pharmacokinetics and pharmacodynamics in critically ill patients

scientific article published on August 2010

Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis

scientific article published on 13 January 2016

Pharmacokinetics of Intravenous Posaconazole in Critically Ill Patients.

scientific article published on 25 May 2018

Pharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis

scientific article published on 10 October 2016

Pharmacokinetics of beta-lactam antibiotics in patients with intra-abdominal disease: a structured review

scientific article published on 08 February 2012

Pharmacokinetics of colistin methanesulfonate and colistin in a critically ill patient receiving continuous venovenous hemodiafiltration

scientific article

Pharmacokinetics of fluconazole in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration

scientific article published on 14 October 2014

Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD study).

scientific article

Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains

scientific article published on 13 April 2013

Pharmacokinetics of meropenem in critically ill patients receiving continuous venovenous haemofiltration: a randomised controlled trial of continuous infusion versus intermittent bolus administration

scientific article published on 18 October 2014

Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration

scientific article published on 10 February 2014

Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: A randomised controlled trial of continuous infusion versus intermittent bolus administration

scientific article published on 28 March 2015

Physiological changes in the critically ill patient with sepsis

scientific article published on December 2011

Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?

scientific article published in March 2009

Pitfalls of using estimations of glomerular filtration rate in an intensive care population

scientific article published on 01 July 2011

Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.

scientific article published on 20 August 2014

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients

scientific article published on 20 January 2015

Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery

scientific article

Point of care measurement of plasma creatinine in critically ill patients with acute kidney injury

scientific article published in April 2009

Population Pharmacokinetics of Doripenem in Critically Ill Patients with Sepsis in a Malaysian Intensive Care Unit.

scientific article

Population Pharmacokinetics of Fosfomycin in Critically Ill Patients.

scientific article

Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

scientific article published on 4 January 2017

Population Pharmacokinetics of Tigecycline in Critically Ill Patients with Severe Infections

scientific article published on 12 June 2017

Population Pharmacokinetics of Unbound Ceftolozane and Tazobactam in Critically Ill Patients without Renal Dysfunction

scientific article published on 23 September 2019

Population pharmacokinetics and dose simulation of vancomycin in critically ill patients during high-volume haemofiltration

scientific article published on 28 April 2014

Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients

scientific article published on 25 June 2013

Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures

scientific article published on 10 June 2014

Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria

scientific article published on 07 March 2007

Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using Monte Carlo simulations to predict doses for specified pharmacodynamic targets

scientific article published on 19 September 2011

Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration

scientific article published on 3 November 2015

Positioning practices for ventilated intensive care patients: current practice, indications and contraindications

scientific article published on 01 November 2006

Prehospital Care

Prescription of Antimicrobial Agents in Patients Undergoing Continuous Renal Replacement Therapy

Preventive Strategies for Ventilator Associated Pneumonia

scholarly article by Robert J. Boots et al published 1 November 2010 in Current Respiratory Medicine Reviews

Principles of antibacterial dosing in continuous renal replacement therapy

scientific article published on July 2009

Principles of antibacterial dosing in continuous renal replacement therapy

scientific article published on 06 October 2010

Prior statin use is not associated with improved outcome in emergency patients admitted with infection: a prospective observational study

scientific article published in February 2011

Problematic Dichotomization of Risk for Intensive Care Unit (ICU)-Acquired Invasive Candidiasis: Results Using a Risk-Predictive Model to Categorize 3 Levels of Risk From a Multicenter Prospective Cohort of Australian ICU Patients

scientific article published on 6 September 2016

Prolonged Versus Intermittent Infusion of β-Lactam Antibiotics: A Systematic Review and Meta-Regression of Bacterial Killing in Preclinical Infection Models

scientific article published on 25 July 2020

Prophylaxis, empirical and preemptive treatment of invasive candidiasis.

scientific article published on October 2010

Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition.

scientific article

Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations?

scientific article published on 30 September 2013

Pyroglutamate (5-oxoproline) measured with hydrophilic interaction chromatography (HILIC) tandem mass spectrometry in acutely ill patients.

scientific article published on 12 January 2017

Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling

scientific article

Remote care by telemedicine in the ICU: many models of care can be effective

scientific article published on December 2011

Reply to Rhodes et al.

scientific article

Reply to Soman et al.

scientific article published in April 2013

Resistance in the intensive care unit: Whose problem is it and how can intensivists help?*

scientific article published on 01 January 2007

Respiratory Burns: A Clinical Review

article

Respiratory Complications in Burns

Returning to the pre-antibiotic era in the critically ill: The XDR problem*

scientific article published on 01 July 2007

Review article: Part one: Goal-directed resuscitation--which goals? Haemodynamic targets

scientific article published on 17 January 2012

Review article: Part two: Goal-directed resuscitation--which goals? Perfusion targets.

scientific article published on 17 January 2012

Right Dose, Right Now: Customized Drug Dosing in the Critically Ill.

scientific article published on February 2017

Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients

scientific article published on 23 July 2014

Routine changing of intravenous administration sets does not reduce colonization or infection in central venous catheters.

scientific article published in August 2004

SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): an observational pharmacokinetic study in critically ill patients

scientific article

Seated and semi-recumbent positioning of the ventilated intensive care patient – Effect on gas exchange, respiratory mechanics and hemodynamics

scientific article published on 01 March 2014

Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy

scientific article published on October 2016

Severity Scores in Emergency Department Patients With Presumed Infection: A Prospective Validation Study.

scientific article

Should β-lactam antibiotics be administered by continuous infusion in critically ill patients? A survey of Australia and New Zealand intensive care unit doctors and pharmacists

scientific article published on 25 April 2016

Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (STAB Study).

scientific article

Subcutaneous oxygen tensions provide similar information to ileal luminal CO 2 tensions in an animal model of haemorrhagic shock

scientific article published on 01 May 2000

Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model

scientific article published on 6 March 2017

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

scientific article published on 01 July 2012

Subtleties in practical application of prolonged infusion of β-lactam antibiotics

scientific article published on 16 February 2015

Successful use of continuous veno-venous haemofiltration to treat profound fluid retention in severe peripartum cardiomyopathy

Sustained low efficiency dialysis allows rational renal replacement therapy, but does it allow rational drug dosing?*

scientific article published on 01 March 2011

Systemic Inflammatory Response Syndrome, Quick Sequential Organ Function Assessment, and Organ Dysfunction: Insights From a Prospective Database of ED Patients With Infection.

scientific article published on 19 November 2016

Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia: an international epidemiological study in four multidisciplinary intensive care units

scientific article published on 22 January 2009

The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs

scientific article published on 13 July 2015

The Durban World Congress Ethics Round Table Conference Report: I. Differences between withholding and withdrawing life-sustaining treatments

scientific article

The Durban World Congress Ethics Round Table Conference Report: II. Withholding or withdrawing of treatment in elderly patients admitted to the intensive care unit

scientific article

The Durban World Congress Ethics Round Table Conference Report: III. Withdrawing Mechanical ventilation--the approach should be individualized

scientific article published on 4 June 2014

The Durban World Congress Ethics Round Table IV: health care professional end-of-life decision making

scientific article published on 22 October 2014

The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial

scientific article

The Impact of Variation in Renal Replacement Therapy Settings on Piperacillin, Meropenem, and Vancomycin Drug Clearance in the Critically Ill

scientific article published on 01 July 2014

The Value of E-Learning for the Prevention of Healthcare-Associated Infections.

scientific article published on 13 May 2016

The authors reply

The authors reply

The authors reply

scientific article published on 01 March 2015

The clinical relevance of plasma protein binding changes

scientific article published in January 2013

The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study

scientific article

The ecology of antibiotic use in the ICU: homogeneous prescribing of cefepime but not tazocin selects for antibiotic resistant infection

scientific article

The effect of pathophysiology on pharmacokinetics in the critically ill patient--concepts appraised by the example of antimicrobial agents

scientific article

The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients

scientific article published on February 2011

The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics

scientific article

The entrapped central venous catheter

scientific article published on 30 October 2006

The impact of hospital and ICU organizational factors on outcome in critically ill patients: results from the Extended Prevalence of Infection in Intensive Care study

scientific article published on March 2015

The influence of acute kidney injury on antimicrobial dosing in critically ill patients: are dose reductions always necessary?

scientific article published on 24 January 2014

The intensive care medicine research agenda on multidrug-resistant bacteria, antibiotics, and stewardship.

scientific article

The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery

scientific article

The role of surveillance cultures in the prediction of susceptibility patterns of Gram-negative bacilli in the intensive care unit.

scientific article

The use and risks of antibiotics in critically ill patients

scientific article published on 9 March 2016

Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Burns Patients—A One-Year Prospective Study

scientific article published on 01 April 2012

Therapeutic drug monitoring of anti-infective agents in critically ill patients

scientific article published on 28 March 2016

Therapeutic drug monitoring of beta-lactams for critically ill patients: unwarranted or essential?

scientific article

Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

scientific article published on 3 August 2010

Therapeutic drug monitoring of the β-lactam antibiotics: what is the evidence and which patients should we be using it for?

scientific article

Therapeutic targets in necrotizing soft tissue infections

scientific article

Tissue Distribution of Beta-Lactam Antibiotics: Continuous versus Bolus Dosing

Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers

scientific article published on 27 October 2008

To increase or decrease dosage of antimicrobials in septic patients during continuous renal replacement therapy: the eternal doubt

scientific article published on 28 October 2015

Total and unbound ceftriaxone pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis.

scientific article published on 4 November 2016

Toward improved surveillance: the impact of ventilator-associated complications on length of stay and antibiotic use in patients in intensive care units.

scientific article

Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury

scientific article published on 14 September 2009

Uncertainty in Antibiotic Dosing in Critically Ill Neonate and Pediatric Patients: Can Microsampling Provide the Answers?

scientific article

Understanding PK/PD

scientific article published on 03 September 2015

Use and Abuse of Antibiotics

Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia

scientific article published on 14 August 2017

Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review

scientific article published on 16 September 2011

Using population pharmacokinetics to determine gentamicin dosing during extended daily diafiltration in critically ill patients with acute kidney injury

scientific article

Vancomycin Serum Concentration after 48 h of Administration: A 3-Years Survey in an Intensive Care Unit

scientific article published on 10 November 2020

Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens

scientific article

Vancomycin pharmacokinetics in critically ill patients receiving continuous venovenous haemodiafiltration

scientific article published in September 2004

Vancomycin-associated nephrotoxicity in the critically ill: a retrospective multivariate regression analysis*.

scientific article published in December 2014

Vancomycin-associated nephrotoxicity: A meta-analysis of administration by continuous versus intermittent infusion

scientific article published on 07 June 2015

Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study

scientific article published on 22 February 2014

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

scientific article

Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?

scientific article published on 04 April 2014

Vitamin B12 levels in the prolonged use of sodium nitroprusside

scientific article published on 01 March 1984

We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how?

scientific article published on 06 June 2016

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review

scientific article published on 01 November 2019

What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

scientific article published on 24 December 2015

What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review

scientific article published on 20 July 2013

What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

scientific article published on 06 April 2012

What's new in pharmacokinetics of antimicrobials in AKI and RRT?

scientific article

β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia

scientific article published on 13 November 2012

β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review

scientific article published on June 2012

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