List of works - Elizabeth Iorns

366 days: Nature's 10.

scientific article

A new mouse model for the study of human breast cancer metastasis

scientific article

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

scientific article published on 03 April 2008

An open investigation of the reproducibility of cancer biology research

scientific article

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy

scientific article

Challenges for assessing replicability in preclinical cancer biology

Dissecting resistance to endocrine therapy in breast cancer

scientific article

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

scientific article

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

scientific article

Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens

scholarly article

Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome

scientific article published on October 2014

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

scientific article

New forms of checks and balances are needed to improve research integrity

scientific article

PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells

scientific article

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

scientific article

Proceedings of the 4th World Conference on Research Integrity

Registered report: androgen receptor splice variants determine taxane sensitivity in prostate cancer

scientific article

Registered report: the androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man

scientific article

Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

scientific article published on 21 April 2020

Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

scientific article published on 17 December 2019

Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

scientific article published on 19 October 2020

Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.

scientific article

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

scientific article published on 08 October 2018

Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells

scientific article

Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

scientific article published on 12 March 2019

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc.

scientific article published on 9 January 2018

Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

scientific article

Replication attempt: "Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival".

scientific article

Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

scientific article published on 11 December 2018

Replication study: androgen receptor splice variants determine taxane sensitivity in prostate cancer.

scientific article published on 16 April 2018

Reproducibility concerns

Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization

scientific article

Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

scientific article published on 24 September 2011

The role of SATB1 in breast cancer pathogenesis.

scientific article

Utilizing RNA interference to enhance cancer drug discovery

scientific article published on July 2007

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

scientific article published on 26 April 2012

Worth the paper it's on?

article

List of works by Elizabeth Iorns

366 days: Nature's 10.

A new mouse model for the study of human breast cancer metastasis

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

An open investigation of the reproducibility of cancer biology research

CRK7 modifies the MAPK pathway and influences the response to endocrine therapy

Challenges for assessing replicability in preclinical cancer biology

Dissecting resistance to endocrine therapy in breast cancer

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

Identifying Modifiers of Tamoxifen Sensitivity Using High-Throughput Genetic and Chemical Screens

Infiltrating S100A8+ myeloid cells promote metastatic spread of human breast cancer and predict poor clinical outcome

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

New forms of checks and balances are needed to improve research integrity

PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

Proceedings of the 4th World Conference on Research Integrity

Registered report: androgen receptor splice variants determine taxane sensitivity in prostate cancer

Registered report: the androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man

Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma.

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells

Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc.

Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Replication attempt: "Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival".

Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Replication study: androgen receptor splice variants determine taxane sensitivity in prostate cancer.

Reproducibility concerns

Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization

Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

The role of SATB1 in breast cancer pathogenesis.

Utilizing RNA interference to enhance cancer drug discovery

Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor

Worth the paper it's on?