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List of works by Eline Slagboom

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

scientific article published on 23 February 2015

A characterization of postzygotic mutations identified in monozygotic twins

article published in 2018

A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study

scientific article published on 14 September 2014

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

scientific article published in March 2003

A data-driven methodology reveals novel myofiber clusters in older human muscles

scientific article published on 05 March 2020

A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis

scientific article

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

scientific article

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study).

scientific article published on June 1998

A genome wide association analysis in the GENDER study.

scientific article published in June 2009

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

scientific article published on 30 August 2011

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genome-wide association study of anorexia nervosa

scientific article

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.

scientific article published on 08 June 2009

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

scientific article published on 16 December 2013

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

scientific article published on 30 December 2016

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels

scientific article

A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p.

scientific article

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

scientific article published on 06 October 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

article

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

scientific article

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A metabolomic profile is associated with the risk of incident coronary heart disease

scientific article published on 4 April 2014

A mixture model with random-effects components for classifying sibling pairs.

scientific article published on 9 September 2011

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

A powerful and rapid approach to human genome scanning using small quantities of genomic DNA

scientific article published on 01 April 2001

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

A whole genome association study of neuroticism using DNA pooling

scientific article published on 31 July 2007

A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep

scientific article

Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation

scientific article published on 10 August 2011

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

scientific article

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population

scientific article published on 8 May 2011

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

scientific article published on 9 May 2017

Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health

scientific article published on 5 June 2006

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study

scientific article

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

scientific article

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

scientific article published on 22 September 2016

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Allele-sharing statistics using information on family history

scientific article published on 12 August 2010

Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study

scientific article published on 29 November 2007

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

scientific article published on 06 February 2013

Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry.

scientific article

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

scientific article published on 27 April 2016

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs

scientific article published on 04 October 2014

An in vivo study on brain microstructure in biological and chronological ageing

scientific article

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

scientific article published on 29 August 2016

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

scientific article published on 01 October 1999

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

scientific article

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

scientific article published on 30 April 2018

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

scientific article

ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article published on 9 May 2006

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

scientific article published on April 2016

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

scientific article

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

scientific article

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

scientific article published on 6 April 2011

Association between several clinical and radiological determinants with long-term clinical progression and good prognosis of lower limb osteoarthritis

scientific article (publication date: 2011)

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

scientific article

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

scientific article published in January 2002

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes

scientific article published on 14 September 2008

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Association of handgrip strength with patient-reported outcome measures after total hip and knee arthroplasty

scientific article published on 18 February 2020

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity

scientific article (publication date: 2014)

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand

scientific article published on 5 January 2006

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites

scientific article published on 01 April 2005

Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis.

scientific article published in March 2009

Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip.

scientific article published in April 2004

Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation

scientific article published on 01 May 2005

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

scientific article published on 01 June 2002

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting.

scientific article published on 22 November 2010

Association study of candidate genes for the progression of hand osteoarthritis.

scientific article published on 26 January 2013

Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: no replication found

scientific article

Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults

scientific article

Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis.

scientific article published on 27 January 2016

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

scientific article published on 10 September 2020

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 31 March 2020

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation

scientific article published on 01 August 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Basal cell carcinoma genetic susceptibility increases the rate of skin ageing: a Mendelian randomization study

scientific article published on 05 September 2019

Blood lipids influence DNA methylation in circulating cells

scientific article published on 27 June 2016

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis

scientific article published on 16 June 2011

Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women.

scientific article published on 9 March 2016

Brain tissue volumes in familial longevity: the Leiden Longevity Study

scientific article published on 4 September 2012

Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity

scientific article published on 30 March 2006

C-reactive protein and glucose regulation in familial longevity

scientific article published on 19 January 2011

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects

scientific article published on 7 October 2011

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

scientific article

CD226(DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis

scientific article published on 23 July 2014

Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults.

scientific article published on 15 March 2016

Cerebral small vessel disease genomics and its implications across the lifespan

scientific article published on 08 December 2020

Characteristics of de novo structural changes in the human genome

scientific article

Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes

scientific article published on 17 April 2013

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

scientific article

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

scientific article published on 10 November 2011

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

scientific article

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

scientific article published on 28 October 2016

Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study

scientific article published on 17 October 2006

Combined association and linkage analysis applied to the APOE locus

scientific article published in May 2004

Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression

scientific article published on 24 December 2005

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

scientific article

Common CFTR gene variants influence body composition and survival in rural Ghana.

scientific article

Common gene variants, mortality and extreme longevity in humans.

scientific article

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

scientific article published on 01 March 2000

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

scientific article (publication date: 2012)

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

scientific article

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

scientific article

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

scientific article published on 13 June 2012

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

scientific article published on 7 July 2015

Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function

scientific article published on 19 December 2014

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

scientific article

DNA Methylation Landscapes of Human Fetal Development

scientific article published on 22 October 2015

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

scientific article published on 30 January 2016

DNA methods for detecting and analyzing mutations in vivo.

scientific article published on December 1987

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

scientific article published on 31 January 2018

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

scientific article published in November 2009

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

scientific article published on February 2011

DNA methylation signatures link prenatal famine exposure to growth and metabolism

scientific article

DNA methylation signatures of educational attainment

scientific article published on 23 March 2018

DNA modification study of major depressive disorder: beyond locus-by-locus comparisons

scientific article

DNA processing, aging, and cancer. The impact of new technology

scientific article published on January 1991

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency

scientific article

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

scientific article

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

scientific article (publication date: November 2011)

Detecting dispersed duplications in high-throughput sequencing data using a database-free approach

scientific article

Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat

scientific article published on 01 November 2000

Developmental determinants in non-communicable chronic diseases and ageing.

scientific article published on 23 January 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

scientific article published in February 2018

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

scientific article

Doyle Index is a valuable additional pain measure in osteoarthritis

scientific article published on 15 May 2010

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

scientific article

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

scientific article published on 05 March 2013

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

scientific article

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

scientific article published on 12 November 2020

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

scientific article

Eating disorders: from twin studies to candidate genes and beyond

scientific article

Effect of calendar age on physical performance: A comparison of standard clinical measures with instrumented measures in middle-aged to older adults

scientific article published on 25 December 2015

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

scientific article

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

scientific article published on April 2006

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

scientific article published on 29 June 2016

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

scientific article

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells

scientific article

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies

scientific article published on 10 May 2018

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

scientific article published in November 2003

Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.

scientific article published on May 2005

Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study.

scientific article published on 30 September 2004

Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly

scientific article published on 6 March 2007

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

scientific article published in January 2006

Exome and whole genome sequencing in aging and longevity.

scientific article published on January 2015

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

scientific article published on 19 November 2012

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.

scientific article published on 19 August 2010

FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians

scientific article

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

scientific article published on 9 August 2012

Facing up to the global challenges of ageing

scientific article published in Nature

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality

scientific article

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

scientific article published on 31 July 2015

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

scientific article

Familial Resemblance for Serum Metabolite Concentrations — Corrigendum

scholarly article published in Twin Research and Human Genetics

Familial longevity is associated with decreased thyroid function

scientific article published on 25 August 2010

Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals.

scientific article

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

scientific article

Familial longevity is marked by enhanced insulin sensitivity

scientific article

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

scientific article

Familial resemblance for serum metabolite concentrations

scientific article published on 28 August 2013

Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers

scientific article published on 14 February 2020

Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression

scientific article published in March 2007

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum

scientific article published on 26 August 2019

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

scientific article

Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients

scientific article published on 04 February 2019

Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire.

scientific article published on 17 November 2017

Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families

article

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

scientific article

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

scientific article

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

scientific article

Genes encoding longevity: from model organisms to humans

scientific article published on 15 January 2008

Genes expressed in blood link osteoarthritis with apoptotic pathways.

scientific article published on 17 July 2013

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

scientific article

Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study

article

Genetic and environmental influences interact with age and sex in shaping the human methylome.

scientific article published on 7 April 2016

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

scientific article

Genetic association analysis of LARS2 with type 2 diabetes

scientific article (publication date: 2010)

Genetic association analysis of RHOB and TXNDC3 in osteoarthritis

scientific article

Genetic determination of telomere size in humans: a twin study of three age groups.

scientific article published on November 1994

Genetic influences on disordered eating behaviour are largely independent of body mass index.

scientific article published on 11 December 2007

Genetic instability and aging: theories, facts, and future perspectives

scientific article published on January 1989

Genetic linkage analysis of 14 candidate gene loci in a family with autosomal dominant osteoarthritis without dysplasia.

scientific article published in December 1997

Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24.

scientific article

Genetic polymorphisms of the renin–angiotensin system and complications of insulin‐dependent diabetes mellitus

scientific article published on 01 July 2000

Genetic predictors of fibrin D-dimer levels in healthy adults

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study.

scientific article published on 27 June 2016

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

scientific article published on 05 May 2006

Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders

scientific article published on 14 December 2012

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis.

scientific article

Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.

scientific article published on 21 October 2009

Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study

scientific article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men.

scientific article published on 16 May 2015

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

scientific article published on 01 June 2020

Genetics and behavioral medicine: risk factors for cardiovascular disease

scientific article published on January 1997

Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).

scientific article published on April 2007

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

scholarly article

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

scientific article published on 26 February 2018

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

scientific article published on 27 February 2020

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

scientific article published on 19 December 2016

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

scientific article published on 30 August 2017

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association scan for five major dimensions of personality

scientific article

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

scientific article

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

scientific article

Genome-wide association study of smoking initiation and current smoking

scientific article published on 05 March 2009

Genome-wide identification of directed gene networks using large-scale population genomics data

scientific article published in Nature Communications

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

scientific article published on 28 August 2020

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands

scientific article published on June 2008

Genome-wide linkage scan in affected sibling pairs identifies novel susceptibility region for venous thromboembolism: Genetics In Familial Thrombosis study.

scientific article published in August 2013

Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairs

scientific article published on 23 December 2005

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

scientific article published on 13 October 2017

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

scientific article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide patterns and properties of de novo mutations in humans

scientific article published on 18 May 2015

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy

scientific article (publication date: 2012)

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

scientific article

Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines

scientific article published on 10 June 2016

Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men

article

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

scientific article published on 19 February 2020

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

scientific article published on 7 September 2016

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk

scientific article published on 11 April 2019

Hallmark features of immunosenescence are absent in familial longevity

scientific article published on 20 September 2010

Handgrip strength at midlife and familial longevity : The Leiden Longevity Study

scientific article

Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis

scientific article (publication date: September 1999)

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

Hematopoietic capacity and exceptional survival: the Leiden Longevity Study

scientific article published on 01 November 2008

Heritabilities of apolipoprotein and lipid levels in three countries

scientific article

Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine

scientific article published on 01 August 1999

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 07 January 2020

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

scientific article published on 05 March 2007

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes.

scientific article

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

scientific article published on 13 September 2017

High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes

scientific article published on 01 August 2006

High serum glucose levels are associated with a higher perceived age.

scientific article published on 20 November 2011

High-yield noninvasive human genomic DNA isolation method for genetic studies in geographically dispersed families and populations

scientific article published on November 1995

Historical demography and longevity genetics: Back to the future

scientific article

Homocysteine and familial longevity: the Leiden Longevity Study

scientific article

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

scientific article published on 9 October 2017

How to deal with the early GWAS data when imputing and combining different arrays is necessary

scientific article

Human Cytokine Response to ex vivo Amyloid-β Stimulation is Mediated by Genetic Factors

article

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health ⬇️

scientific article

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

scientific article

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

article

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human longevity and 11p15.5: a study in 1321 centenarians

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

scientific article published on 19 June 2015

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

scientific article published on 17 November 2011

IL7R gene expression network associates with human healthy ageing

scientific article

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

scientific article published on 06 August 2013

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

scientific article published on 11 March 2008

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study ⬇️

scientific article published on July 3, 2012

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

scientific article published on 19 February 2013

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

Impact of genetic variations in the WRN gene on age related pathologies and mortality

scientific article published on 06 January 2006

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

scientific article published on 26 April 2014

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

scientific article

Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues

scientific article published on 04 April 2012

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

scientific article published on 3 August 2011

Influence of candidate genes on attention problems in children: a longitudinal study

scientific article

Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study

scientific article published on 01 May 2007

Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis

scientific article published on 20 November 2007

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

scientific article

Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study

scientific article published on May 2004

Integrating metabolomics profiling measurements across multiple biobanks.

scientific article published on 16 April 2014

Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis

scientific article published on 16 December 2011

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study

scientific article

Interleukin-1 region meta-analysis with osteoarthritis phenotypes

scientific article published in September 2009

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

scientific article published on 01 April 2020

Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study

scientific article published in October 1997

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.

scientific article published on 26 September 2014

L1 drives IFN in senescent cells and promotes age-associated inflammation

scientific article published on 06 February 2019

LDL cholesterol still a problem in old age? A Mendelian randomization study

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

scientific article published on 30 January 2009

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis

article

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

scientific article published on June 2009

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

scientific article published on 10 December 2010

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

scientific article

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

scientific article

Lifestyle and youthful looks.

scientific article published on 15 April 2015

Lifestyle-intervention-induced Reduction of Abdominal Fat is Reflected by a Decreased Circulating Glycerol Level and An Increased HDL Diameter

scientific article published on 09 April 2020

Linkage analysis of smoking initiation and quantity in Dutch sibling pairs

scientific article published on January 2004

Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype

scientific article

Lipid metabolism in long-lived families: the Leiden Longevity Study

scientific article

Lipoprotein particle profiles mark familial and sporadic human longevity

scientific article

Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

scientific article published on 28 February 2012

Liver Fat Assessed With CT Relates to MRI Markers of Incipient Brain Injury in Middle-Aged to Elderly Overweight Persons

scientific article

Liver X receptor alpha associates with human life span

scientific article published on 01 April 2007

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

scientific article

Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies

scientific article published on 30 April 2020

Longevity around the turn of the 20th century: life-long sustained survival advantage for parents of today's nonagenarians ⬇️

scientific article published on 27 March 2018

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

scientific article published in Nature Communications

Longevity defined as top 10% survivors is transmitted as a quantitative genetic trait: results from large three-generation datasets

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.

scientific article published on 13 March 2015

Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

scientific article

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

scientific article

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

scientific article published on 18 March 2015

Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity

article published in 2013

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

scientific article published on 04 June 2012

Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study

scientific article published on 22 April 2008

MARK-AGE biomarkers of ageing

scientific article

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

scientific article

Markers of health and disease and pigmented spots in a middle-aged population

scientific article published on 03 November 2015

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

scientific article

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

scientific article published on 21 June 2019

Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors

scientific article published on 29 November 2006

Messenger RNA levels and methylation patterns of GAPDH and beta-actin genes in rat liver, spleen and brain in relation to aging

scientific article published in April 1990

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility

scientific article published on 19 August 2010

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

scientific article

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

scientific article published on 23 July 2014

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

scientific article

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

scientific article

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions

scientific article published in October 2005

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

scientific article

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

scientific article

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

scientific article

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study

scientific article published on 25 January 2016

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles

scientific article published on 27 October 2012

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

scientific article published on 21 September 2017

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

article

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

scientific article published on 29 August 2019

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

scientific article published on 02 March 2020

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

MethylAid: visual and interactive quality control of large Illumina 450k datasets.

scientific article published on 21 August 2014

Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis

scientific article published in June 1991

Microstructural brain tissue damage in metabolic syndrome

scientific article published on 2 October 2013

Mobster: accurate detection of mobile element insertions in next generation sequencing data

scientific article

Molecular epidemiology, candidate genes versus genome-wide scans

scientific article published on October 2007

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

scientific article

Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)

scientific article published on 01 February 1999

Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci

scientific article

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.

scientific article

N-glycomic biomarkers of biological aging and longevity: a link with inflammaging

scientific article published on 14 February 2012

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

scientific article

Netherlands twin family study of anxious depression (NETSAD).

scientific article published in December 2000

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New insights into osteoarthritis: early developmental features of an ageing-related disease.

scientific article published on September 2008

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

scientific article

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study

scientific article published on 01 October 2002

No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis

scientific article published on April 2010

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

scientific article

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies

scientific article published on 19 December 2015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Normal prevalence of factor V Leiden gene mutation in patients with severe unstable angina

scientific article published on 01 June 1997

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

scientific article

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

scientific article published on 19 September 2012

Novel loci and pathways significantly associated with longevity

scientific article published on 25 February 2016

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

scientific article published on 06 December 2019

Organisation of the human genome and our tools for identifying disease genes.

scientific article

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis

scientific article published on 01 May 2011

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

scientific article published on 18 August 2015

PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data

scientific article

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

scientific article published on February 2013

Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

scientific article published on 17 July 2015

Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects

scientific article published on 7 April 2011

Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene

scientific article

Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months.

scientific article published in October 2012

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child

scientific article

Persistent epigenetic differences associated with prenatal exposure to famine in humans

scientific article published on 4 November 2008

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

scientific article published on May 2012

Phenome and genome based studies into human ageing and longevity: An overview.

scientific article published on 22 September 2017

Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype

scientific article published on 31 January 2017

Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.

scientific article published on 23 February 2011

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

scientific article

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana.

scientific article

Population haplotype analysis and evolutionary relations of the COL2A1 gene

scientific article published on 01 May 1996

Population-specific genotype imputations using minimac or IMPUTE2.

scientific article published on 30 July 2015

Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

scientific article

Preserved white matter integrity is a marker of familial longevity

scientific article published in December 2013

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

scientific article published on 27 May 2013

Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study

scientific article published on 26 August 2008

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

scientific article published on 03 March 2017

Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

scientific article published on 15 November 2011

QTLs for height: results of a full genome scan in Dutch sibling pairs

scientific article published in October 2004

Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control

scientific article published on December 1989

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

scientific article published on 01 December 2018

RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians

scientific article published on 19 July 2005

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

scientific article published on 6 November 2010

Reduced insulin/IGF-1 signalling and human longevity.

scientific article

Reduced response to activated protein C is associated with increased risk for cerebrovascular disease.

scientific article published in August 1996

Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women

scientific article published on 5 June 2013

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study.

scientific article published on 07 June 2013

Reliability of cluster results for different types of time adjustments in complex disease research

scientific article published in January 2008

Renal function in familial longevity: the Leiden Longevity Study.

scientific article published on 2 January 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

scientific article published on 09 June 2020

Repeat length variations in polyglutamine disease-associated genes affect body mass index

scientific article published on 17 August 2018

Repeat variations in polyglutamine disease-associated genes and cognitive function in old age

scientific article published on 09 August 2019

Replicated linkage for eye color on 15q using comparative ratings of sibling pairs

scientific article published on 9 December 2005

Replication in genetic association studies: Comment on the editorial by Spector et al

scientific article published on 01 September 2006

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

scientific article

Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study

scientific article published in May 1998

Risk factors in familial osteoarthritis: the GARP sibling study

scientific article

SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

scientific article published in September 2007

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population

scientific article

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

scientific article published on 21 October 2019

Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI

scientific article published on 22 September 2020

Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

scientific article

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

scientific article published on 13 April 2014

Sex Differences in Genetic Associations With Longevity

Sex differences in sum scores may be hard to interpret: the importance of measurement invariance

scientific article published on 17 September 2009

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

scientific article

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

scientific article published on 16 February 2020

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

scientific article

Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?

scientific article

Small nucleoli are a cellular hallmark of longevity

scientific article published on 30 August 2016

Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones

scientific article published on 01 March 1991

Stress evokes stronger medial posterior cingulate deactivations during emotional distraction in slower paced aging

scientific article published on 2 March 2018

Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes

scientific article

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 29 May 2018

Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health

scientific article published on 26 September 2017

Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression

scientific article published on April 2009

Systematic discovery of complex insertions and deletions in human cancers.

scientific article published on 14 December 2015

Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study

scientific article

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

scientific article published on 26 September 2016

Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.

scientific article

Telomere length predicts survival independent of genetic influences

scientific article published on 08 October 2007

The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.

scientific article published on 11 September 2007

The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection

scientific article

The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?

article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

scientific article published on 14 May 2013

The Caenorhabditis elegans genome contains monomorphic minisatellites and simple sequences

scientific article published on December 1989

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

scientific article published on 16 March 2013

The Genome of the Netherlands: design, and project goals

scientific article (publication date: February 2014)

The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis

scientific article

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Leiden Family Lab study on Social Anxiety Disorder: A multiplex, multigenerational family study on neurocognitive endophenotypes ⬇️

scientific article published on 26 April 2018

The MC1R Gene and Youthful Looks

scientific article published on 27 April 2016

The Netherlands Twin Register biobank: a resource for genetic epidemiological studies

scientific article published on June 2010

The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture

scientific article published on 29 October 2020

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis.

scientific article

The aging genome: determinant or target? Report of the EURAGE meeting on 'Genomic Instability and Aging', Nerja (Spain)

scientific article published on 01 May 1990

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The continuing value of twin studies in the omics era.

scientific article published on 31 July 2012

The dynamics of genome organization and expression during the aging process

scientific article published on December 1992

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

scientific article published on 30 December 2014

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

scientific article published on 14 December 2016

The epigenome: archive of the prenatal environment.

scientific article

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The influence of clan structure on the genetic variation in a single Ghanaian village.

scientific article published on 27 February 2013

The multifaceted interplay between lipids and epigenetics.

scientific article published on 30 March 2016

The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012

The place of genetics in ageing research.

scientific article published on 10 July 2012

The risk of mortality and the factor V Leiden mutation in a population-based cohort.

scientific article

The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA

scientific article published on 25 October 2008

The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms

scientific article published on December 2010

The transcriptional landscape of age in human peripheral blood

scientific article

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

scientific article

Thyroid status and mortality in nonagenarians from long-lived families and the general population

scientific article published on 25 October 2017

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage

scientific article published on May 2015

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

scientific article published on 25 February 2016

Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21

scientific article published on 01 January 1986

Two-dimensional DNA fingerprinting of human individuals

scientific article

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

scientific article published on 2 April 2014

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

scholarly article published 19 October 2018

Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study

scientific article published on 3 August 2005

VDR gene variants associate with cognitive function and depressive symptoms in old age.

scientific article

Validated inference of smoking habits from blood with a finite DNA methylation marker set

scientific article published on 07 September 2019

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

scientific article published on 01 October 2020

Variants of the IL-10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study

scientific article

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

scientific article published on 01 August 1999

Variation in the CBP gene involved in epigenetic control associates with cognitive function

scientific article

Variation in the SHC1 gene and longevity in humans

scientific article (publication date: February 2004)

Variation in the human TP53 gene affects old age survival and cancer mortality.

scientific article

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

scientific article published on 12 April 2010

Visceral adipose tissue is associated with microstructural brain tissue damage.

scientific article published on May 2015

Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics

scientific article published on 11 January 2018

Vitamin D receptor gene polymorphisms have negligible effect on human height

scientific article published in October 2008

WORLDWIDE GENOME-WIDE ASSOCIATION STUDY OF LONGEVITY

scholarly article in Innovation in Aging, vol. 1, Suppl 1, June 2017

Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study.

scientific article published in January 2009

White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

scientific article

Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines

scientific article published on 23 June 2015

Zygosity diagnosis in young twins by parental report.

scientific article published on September 2000

mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats.

scientific article published in August 1990

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