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List of works by Erik B van den Akker

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

scientific article published on 30 August 2011

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

A transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML

scientific article published in 2024

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Broad phenotype of cysteine altering NOTCH3 variants in UK Biobank: CADASIL to non-penetrance

scientific article published on 30 July 2020

Cerebral small vessel disease genomics and its implications across the lifespan

scientific article published on 08 December 2020

Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing

scientific article published on 03 March 2020

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

scientific article published on 12 November 2020

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

scientific article published on 29 June 2016

Exome and whole genome sequencing in aging and longevity.

scientific article published on January 2015

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice.

scientific article published on 29 July 2016

Gene analysis for longitudinal family data using random-effects models

scientific article

Gene coexpression network analysis for family studies based on a meta-analytic approach

scientific article

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns

scientific article published on 26 February 2018

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

High-throughput data-driven analysis of myofiber composition reveals muscle-specific disease and age-associated patterns

scientific article published on 28 November 2018

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health ⬇️

scientific article

IL7R gene expression network associates with human healthy ageing

scientific article

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

scientific article published on 06 August 2013

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis

scientific article published on 16 December 2011

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Machine Learning Electronic Health Record Identification of Patients with Rheumatoid Arthritis: Algorithm Pipeline Development and Validation Study

scientific article published on 30 November 2020

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

scientific article

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study

scientific article published on 25 January 2016

Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics

scientific article published on 25 April 2016

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile.

scientific article

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

scientific article published on 14 December 2016

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

scientific article published on 2 April 2014

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