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List of works by Elias Arnér

(In)Visible Dialogues

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1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity

scientific article published on 01 February 1995

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification ⬇️

scientific article published on June 3, 2013

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems.

scientific article published on 22 January 2016

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

scientific article published on 24 October 2013

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

scientific article published on 13 April 2017

Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

scientific article published on 12 February 2019

Active sites of thioredoxin reductases: why selenoproteins?

scientific article published on 20 October 2003

Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis.

scientific article published on September 2004

Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 20 November 2019

Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

scientific article published on 13 June 2019

Catabolism of deoxycytidine in human peripheral blood mononuclear cells and its interference with the determination of in situ thymidylate synthase activity

scientific article published on 01 April 1993

Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis

scientific article published on 24 January 2020

Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

scientific article (publication date: 6 June 2016)

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

scientific article

Common modifications of selenocysteine in selenoproteins

scientific article published on 01 February 2020

Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

scientific article published on 11 November 2021

Control of protein function through oxidation and reduction of persulfidated states

scientific article published on 01 January 2020

Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution.

scientific article published on 28 September 2015

Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1

scientific article

Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER.

scientific article published on 16 January 2017

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

scientific article published on 08 July 2019

Deoxycytidine and 2',3'-dideoxycytidine metabolism in human monocyte-derived macrophages. A study of both anabolic and catabolic pathways.

scientific article

Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities

scientific article published on 17 February 2016

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.

scientific article

Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

scientific article published on 22 January 2007

Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

scientific article published on 12 February 2020

Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning

scientific journal article

Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase

scientific article published on 25 May 2018

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

scientific article published on 16 September 2016

Evidence for intriguingly complex transcription of human thioredoxin reductase 1.

scientific article published in March 2004

Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase

scientific article published on 01 January 1991

Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli.

scientific article published in August 2004

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

scientific article published on 11 June 2018

HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule.

scientific article

Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1 ⬇️

scientific article published on December 8, 2011

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.

scientific article published in June 2017

Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1

scientific journal article

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

scientific article (publication date: 28 June 2016)

Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

scientific article published in September 2005

Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

scientific article published in July 2016

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

scientific article published on 20 March 2020

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

scientific article published in February 2018

Mammalian deoxyribonucleoside kinases

scientific article

Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue

scientific article published on 01 May 1998

Maximal flux responses after multiple challenges with vasopressin

scientific article published on 01 July 1984

Measurement of Thioredoxin and Thioredoxin Reductase ⬇️

scientific article published on May 1, 2001

Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates.

scientific article published on 29 April 2008

Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes.

scientific article published on January 1994

Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

scientific article published on 01 June 2021

Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation

scientific article published on 11 March 2013

Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin.

scientific article published on 17 September 2010

On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment.

scientific article published on April 1996

Overexpression of Recombinant Selenoproteins in E. coli

scientific article published in January 2018

Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.

scientific article

Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients

scientific article published on 01 August 1994

Physiological functions of thioredoxin and thioredoxin reductase

scientific article (publication date: October 2000)

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake.

scientific article published on 07 July 2016

Preparation and assay of mammalian thioredoxin and thioredoxin reductase

scientific article published on 01 January 1999

Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice.

scientific article published on 31 January 2009

Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

scientific article published in January 1994

Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase ⬇️

scientific article published on December 29, 2011

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

scientific article published on 10 January 2014

Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

scientific journal article

Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.

scientific article published on April 1998

Redox Pioneer: Professor Arne Holmgren ⬇️

scientific article published on June 6, 2011

Redox active motifs in selenoproteins

scientific article

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.

scientific article

Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.

scientific article published on January 2003

Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events.

scientific article published on February 2004

Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

scientific article published on 7 March 2017

Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.

scientific article

Selective Evaluation of Thioredoxin Reductase Enzymatic Activities

scientific article published in January 2018

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

scientific article published on 30 July 2013

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.

scientific article

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

scientific article published on 16 December 2017

Selenium and selenoproteins in (redox) signaling, diseases, and animal models - 200 year anniversary issue

scientific article published on 01 November 2018

Selenium research in biochemistry and biophysics - 200 year anniversary issue

scientific article published on 24 July 2018

Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation

scientific article

Selenolthiol and dithiol C-terminal tetrapeptide motifs for one-step purification and labeling of recombinant proteins produced in E. coli.

scientific article

Selenoprotein Gene Nomenclature

scientific article published on 19 September 2016

Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

scientific article

Selenoproteins-What unique properties can arise with selenocysteine in place of cysteine?

scientific article published on 03 March 2010

Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

scientific article published on 14 January 2014

Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.

scientific article published on 28 August 2016

Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

scientific article published on 06 March 2014

Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells.

scientific article

Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death.

scientific article published in March 2013

Special issue on selenoprotein expression and function

scientific article published on 01 November 2009

Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme.

scientific article published on 12 May 2006

Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.

scientific article published on 21 December 2010

Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine

scientific article published on 25 October 1993

Superoxide production by dinitrophenyl-derivatized thioredoxin reductase--a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes

scientific article published on 01 January 1999

System-wide identification and prioritization of enzyme substrates by thermal analysis

scientific article published on 26 February 2021

Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C.

scientific article published on 6 July 2006

The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death.

scientific article published on 8 April 2014

The A to Z of modulated cell patterning by mammalian thioredoxin reductases.

scientific article published on 23 December 2017

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

scientific article published on 22 January 2015

The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene.

scientific article published on 24 May 2001

The rare TXNRD1_v3 ("v3") splice variant of human thioredoxin reductase 1 protein is targeted to membrane rafts by N-acylation and induces filopodia independently of its redox active site integrity.

scientific article published on 14 February 2013

The thioredoxin system in cancer-introduction to a thematic volume of Seminars in Cancer Biology

scientific article published on 12 October 2006

Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase.

scientific article

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target

scientific article

Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure

scientific article published on 6 July 2017

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

scientific article published on 27 June 2016

Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.

scientific article

Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways

scientific article published on 06 October 2018

Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways ⬇️

scientific article published on June 5, 1992

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells.

scientific article published on 10 March 2017

Titration and conditional knockdown of the prfB gene in Escherichia coli: effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase.

scientific article published on 3 November 2006

Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma

scientific article published on 01 December 2000

TrxR1 as a potent regulator of the Nrf2-Keap1 response system

scientific article

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

scientific article published on 16 May 2019

Wobble decoding by the Escherichia coli selenocysteine insertion machinery.

scientific article published on 27 August 2013

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