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List of works by Tim Ebbels

1H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice

scientific article

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).

scientific article published on 15 May 2013

A comparison of human serum and plasma metabolites using untargeted 1H NMR spectroscopy and UPLC-MS

scientific article published on 13 February 2018

A statistical framework for biomarker discovery in metabolomic time course data ⬇️

scientific article published on July 15, 2011

A statistically rigorous test for the identification of parent-fragment pairs in LC-MS datasets

scientific article

Analytic properties of statistical total correlation spectroscopy based information recovery in 1H NMR metabolic data sets

scientific article

Analytical reproducibility in (1)H NMR-based metabonomic urinalysis

scientific article

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

scientific article published on 25 September 2017

Automated Annotation of Untargeted All-Ion Fragmentation LC–MS Metabolomics Data with MetaboAnnotatoR

scientific article published in 2022

Bayesian estimation of the number of protonation sites for urinary metabolites from NMR spectroscopic data.

scientific article

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

scientific article

Characterization of data analysis methods for information recovery from metabolic 1H NMR spectra using artificial complex mixtures

Cluster analysis statistical spectroscopy using nuclear magnetic resonance generated metabolic data sets from perturbed biological systems

scientific article

Comparison of Bi- and Tri-Linear PLS Models for Variable Selection in Metabolomic Time-Series Experiments.

scientific article

Computational Metabolomics: From Spectra to Knowledge (Dagstuhl Seminar 22181) ⬇️

proceedings

Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy

scientific article

Data standards can boost metabolomics research, and if there is a will, there is a way

scientific article

Data-Driven Approach for Metabolite Relationship Recovery in Biological 1H NMR Data Sets Using Iterative Statistical Total Correlation Spectroscopy ⬇️

scientific article published on February 16, 2011

Design and analysis of metabolomics studies in epidemiologic research: a primer on -omic technologies

scientific article published on 24 June 2014

Dietary and urinary metabonomic factors possibly accounting for higher blood pressure of black compared with white Americans: results of International Collaborative Study on macro-/micronutrients and blood pressure

scientific article published on 07 October 2013

Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes

scientific article published in January 2010

Embedding standards in metabolomics: the Metabolomics Society data standards task group

Erratum to: COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

scholarly article published in Metabolomics

Extraction and Integration of Genetic Networks from Short-Profile Omic Data Sets

scientific article published on 29 October 2020

Finding Correspondence between Metabolomic Features in Untargeted Liquid Chromatography–Mass Spectrometry Metabolomics Datasets

scientific article published in 2022

Genetic algorithms for simultaneous variable and sample selection in metabonomics

scientific article published on 14 November 2008

Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles

scientific article

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

scientific article published on 13 May 2010

Intra- and Interlaboratory Reproducibility of Ultra Performance Liquid Chromatography–Time-of-Flight Mass Spectrometry for Urinary Metabolic Profiling

article

Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies

scientific article published on 29 November 2010

MetAssimulo:Simulation of Realistic NMR Metabolic Profiles ⬇️

scientific article published on October 6, 2010

Metabolic Signatures of Gestational Weight Gain and Postpartum Weight Loss in a Lifestyle Intervention Study of Overweight and Obese Women

scientific article published on 04 December 2020

Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview.

scientific article

Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies

scientific article published on July 2009

Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification

scientific article

Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts

scientific article

Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study

scientific article

Metabolomics - the stethoscope for the 21st century

scientific article published on 03 December 2020

Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.

scientific article published in December 2009

Modelling short time series in metabolomics: a functional data analysis approach

scientific article

Modelling the acid/base (1)H NMR chemical shift limits of metabolites in human urine

scientific article

NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat.

scientific article published in January 2010

Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology

scientific article published on 08 January 2010

Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS.

scientific article published on September 2010

Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data

scientific article published on 19 February 2018

Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery

article

Optimizing the use of quality control samples for signal drift correction in large-scale urine metabolic profiling studies

scientific article published on 02 March 2012

Orders of magnitude extension of the effective dynamic range of TDC-based TOFMS data through maximum likelihood estimation.

scientific article

Over-representation of correlation analysis (ORCA): a method for identifying associations between variable sets.

scientific article published on 2 September 2014

PathIntegrate: Multivariate modelling approaches for pathway-based multi-omics data integration

scientific article published on 25 March 2024

PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud

scholarly article by Kristian Peters et al published 7 December 2018 in GigaScience

Piecewise multivariate modelling of sequential metabolic profiling data

scientific article

Power Analysis and Sample Size Determination in Metabolic Phenotyping

scientific article

Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach

scientific article

Predictive modelling using pathway scores: robustness and significance of pathway collections

scientific article published on 04 November 2019

Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles

scientific article published in January 2011

Prospects for a statistical theory of LC/TOFMS data.

scientific article

Recent advances in mass spectrometry-based computational metabolomics

Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery

scientific article published in January 2009

Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry.

scientific article published on 18 January 2018

Robust algorithms for automated chemical shift calibration of 1D 1H NMR spectra of blood serum

scientific article published on 15 August 2008

Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease

scientific article published on 01 September 2019

Statistical Correlations between NMR Spectroscopy and Direct Infusion FT-ICR Mass Spectrometry Aid Annotation of Unknowns in Metabolomics

scientific article published on 29 January 2016

Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.

scientific article

Subset Optimization by Reference Matching (STORM): An Optimized Statistical Approach for Recovery of Metabolic Biomarker Structural Information from 1H NMR Spectra of Biofluids

article

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens

scientific article

Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis

scientific article published on 19 August 2008

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

scientific article

The association of fish consumption and its urinary metabolites with cardiovascular risk factors: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP)

scientific article published on 01 February 2020

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

scientific article published on 26 April 2008

The future of metabolomics in ELIXIR

scientific article published in 2017

The future of metabolomics in ELIXIR.

scientific article

Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase

article

Urinary metabolic signatures of human adiposity

scientific article (publication date: 29 April 2015)

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

scientific article published on 10 July 2019

We-P14:381 Metabonomics to assess self-reported data: The international study on macronutrients and blood pressure (INTERMAP)

article by R.L. Loo et al published January 2006 in Atherosclerosis. Supplements

Workflow for Integrated Processing of Multicohort Untargeted 1H NMR Metabolomics Data in Large-Scale Metabolic Epidemiology

scientific article

diXa: a data infrastructure for chemical safety assessment

scientific article

nmrML: a community supported open data standard for the description, storage, and exchange of NMR data

scientific article published on 16 October 2017

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