List of works - Chiara Ruzza

Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze

scientific article published on 29 August 2012

Behavioural phenotypic characterization of CD-1 mice lacking the neuropeptide S receptor

scientific article published on 10 January 2012

Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

scientific article published on 8 February 2016

Biased versus Partial Agonism in the Search for Safer Opioid Analgesics

scientific article published on 25 August 2020

Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice

scientific article published on 28 May 2015

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

scientific article published on July 2009

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

scientific article

In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant

scientific article published on 3 April 2015

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.

scientific article

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.

scientific article

In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S

scientific article

In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1.

scientific article published on 30 July 2013

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

scientific article published on 22 October 2016

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

scientific article

Neuropeptide S receptor ligands: a patent review (2005-2016).

scientific article

Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.

scientific article

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

scientific article published on 02 August 2016

Pharmacological characterization of tachykinin tetrabranched derivatives

scientific article

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

scientific article

Racemic synthesis and solid phase peptide synthesis application of the chimeric valine/leucine derivative 2-amino-3,3,4-trimethyl-pentanoic acid

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

scientific article published on 12 May 2015

Structure-activity study at positions 3 and 4 of human neuropeptide S.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

scientific article

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

scientific article

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

scientific article

[d-Pen(p- t BuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

scholarly article by Chiara Ruzza et al published 11 February 2014 in Medicinal Chemistry Research

[tBu-D-Gly5]NPS, a pure and potent antagonist of the neuropeptide S receptor: in vitro and in vivo studies

scientific article published on 9 February 2012

List of works by Chiara Ruzza

Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze

Behavioural phenotypic characterization of CD-1 mice lacking the neuropeptide S receptor

Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

Biased versus Partial Agonism in the Search for Safer Opioid Analgesics

Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists

Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68.

In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant

In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.

In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.

In vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S

In vitro and in vivo pharmacological characterization of the novel neuropeptide S receptor ligands QA1 and PI1.

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.

Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice

Neuropeptide S receptor ligands: a patent review (2005-2016).

Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor.

Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist

Pharmacological characterization of tachykinin tetrabranched derivatives

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

Racemic synthesis and solid phase peptide synthesis application of the chimeric valine/leucine derivative 2-amino-3,3,4-trimethyl-pentanoic acid

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

Structure-activity study at positions 3 and 4 of human neuropeptide S.

Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonists

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

[d-Pen(p- t BuBzl)5]NPS, a novel ligand for the neuropeptide S receptor: structure activity and pharmacological studies

[tBu-D-Gly5]NPS, a pure and potent antagonist of the neuropeptide S receptor: in vitro and in vivo studies