List of works - Seung Bum Park

9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors ⬇️

scientific article published on June 7, 2011

A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening.

scientific article published on 23 January 2012

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

scientific article published on August 25, 2011

A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics.

scientific article

A nonthiazolidinedione peroxisome proliferator-activated receptor α/γ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice.

scientific article published on 19 August 2010

A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity

scientific article

A pyrazolo[1,5-a]pyridine-fused pyrimidine based novel fluorophore and its bioapplication to probing lipid droplets

scientific article published on 31 May 2016

A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 1: direct binding

scientific article published on 01 May 2000

A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 2: competitive binding

scientific article published on 01 May 2000

A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin

scientific article published on 14 March 2011

Abc amino acids: design, synthesis, and properties of new photoelastic amino acids.

scientific article published in October 2006

An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

scientific article published in November 2009

Anti-inflammatory effects of α-galactosylceramide analogs in activated microglia: involvement of the p38 MAPK signaling pathway

scientific article

Anti-obesity agents: a focused review on the structural classification of therapeutic entities.

scientific article published on January 2009

Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging

scientific article published on 13 September 2013

Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property.

scientific article published on 14 February 2011

Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion

scientific article published on 23 September 2021

Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths.

scientific article

Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one

scientific article published on 23 August 2008

Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

scientific article

Construction of Polyheterocyclic Benzopyran Library with Diverse Core Skeletons through Diversity-Oriented Synthesis Pathway: Part II ⬇️

scientific article published on December 30, 2011

Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway

scientific article

Crystallization and preliminary X-ray diffraction analysis of importin-alpha complexed with NLS peptidomimetics.

scientific article

De novo analysis of protein N-terminal sequence utilizing MALDI signal enhancing derivatization with Br signature ⬇️

scientific article published on December 27, 2011

Development of Azo-Based Turn-On Chemical Array System for Hydrazine Detection with Fluorescence Pattern Analysis

scientific article published on 03 September 2019

Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay

scientific article published on 18 November 2019

Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.

scientific article

Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

scientific article published in July 2015

Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones

scientific article

Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction

scientific article (publication date: 24 October 2016)

Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.

scientific article

Emission wavelength prediction of a full-color-tunable fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one.

scientific article

Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.

scientific article

Ethanol and reactive species increase basal sequence heterogeneity of hepatitis C virus and produce variants with reduced susceptibility to antivirals.

scientific article

Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands

scientific article published on 01 May 2003

Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules.

scientific article

Focus on chemical biology in Asia.

scientific article

Gold-Catalyzed Unexpected Ring Transformation of Pyrimidodiazepine Derivatives.

scientific article published on 10 January 2017

Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1d

scientific article

Host immunomodulatory lipids created by symbionts from dietary amino acids

scientific article published on 10 November 2021

Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ

scientific article published in 2012

Improved Th17 Selectivity of α-Galactosylceramide via Noncovalent Interactions with Diether Moiety

scientific article published on 04 April 2019

Inverse agonist of nuclear receptor ERRγ mediates antidiabetic effect through inhibition of hepatic gluconeogenesis

scientific article published on 17 June 2013

Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent

scientific article published on 19 February 2019

Label-free target identification using in-gel fluorescence difference via thermal stability shift.

scientific article published on 22 September 2016

Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake

scientific article published on 04 May 2012

Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands

scientific article published on 13 May 2016

Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.

scientific article published on 14 December 2017

Near-IR Fluorescent Tracer for Glucose-Uptake Monitoring in Live Cells

scientific article published on 12 September 2018

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis

scientific article

Pharmacophore-based strategy for the development of general and specific scFv biosensors for abused antibiotics.

scientific article

Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR

scientific article published on 21 October 2020

Photochemical generation of a new, highly fluorescent compound from non-fluorescent resveratrol ⬇️

scientific article published on March 9, 2012

Practical solid-phase parallel synthesis of Delta(5)-2-oxopiperazines via N-acyliminium ion cyclization

scientific article

Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces

scientific article

Privileged substructure-based diversity-oriented synthesis pathway for diverse pyrimidine-embedded polyheterocycles

scientific article

Publisher Correction: Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

scientific article published on 29 October 2019

Quantitative evaluation of HiCore resin for the nonspecific binding of proteins by on-bead colorimetric assay.

scientific article

Rational perturbation of the fluorescence quantum yield in emission-tunable and predictable fluorophores (Seoul-Fluors) by a facile synthetic method involving C-H activation.

scientific article

Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage.

scientific article published on 29 July 2016

Regioselective Construction and Screening of 1,3-Disubstituted Tetrahydroindazolones in Enantiomerically Pure Pairs ⬇️

scientific article published on January 9, 2012

Regioselective synthesis of tetrasubstituted pyrroles by 1,3-dipolar cycloaddition and spontaneous decarboxylation.

scientific article

Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein-RNA Interaction

scientific article published on 08 November 2018

Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

scientific article published in November 2002

Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.

scientific article

Solid-phase parallel synthesis of natural product-like diaza-bridged heterocycles through Pictet-Spengler intramolecular cyclization

scientific article published in January 2006

Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ.

scientific article

Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

scientific article published on 01 August 2019

Surface modification for small-molecule microarrays and its application to the discovery of a tyrosinase inhibitor

scientific article published on 16 November 2010

Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.

scientific article

Synthesis and biological evaluation of α-galactosylceramide analogues with heteroaromatic rings and varying positions of a phenyl group in the sphingosine backbone

scientific article published on 26 August 2013

Synthesis and library construction of privileged tetra-substituted Δ5-2-oxopiperazine as β-turn structure mimetics.

scientific article

Synthesis of 3,5-Disubstituted Isoxazoles Containing Privileged Substructures with a Diverse Display of Polar Surface Area

scientific article

Synthesis of molecular frameworks containing two distinct heterocycles connected in a single molecule with enhanced three-dimensional shape diversity.

scientific article published on 28 March 2013

The O‑glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo

scientific article published on 5 September 2013

Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist.

scientific article published in September 2013

Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents

scientific article published on 21 December 2016

Two-Photon and Multicolor Fluorogenic Bioorthogonal Probes Based on Tetrazine-Conjugated Naphthalene Fluorophores

scientific article published on 16 April 2020

β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.

scientific article

List of works by Seung Bum Park

9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors ⬇️

A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening.

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics.

A nonthiazolidinedione peroxisome proliferator-activated receptor α/γ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice.

A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity

A pyrazolo[1,5-a]pyridine-fused pyrimidine based novel fluorophore and its bioapplication to probing lipid droplets

A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 1: direct binding

A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 2: competitive binding

A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin

Abc amino acids: design, synthesis, and properties of new photoelastic amino acids.

An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

Anti-inflammatory effects of α-galactosylceramide analogs in activated microglia: involvement of the p38 MAPK signaling pathway

Anti-obesity agents: a focused review on the structural classification of therapeutic entities.

Bio-inspired, melanin-like nanoparticles as a highly efficient contrast agent for T1-weighted magnetic resonance imaging

Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property.

Callyspongiolide kills cells by inducing mitochondrial dysfunction via cellular iron depletion

Chemistry as a prism: a review of light-emitting materials having tunable emission wavelengths.

Combinatorial discovery of full-color-tunable emissive fluorescent probes using a single core skeleton, 1,2-dihydropyrrolo[3,4-beta]indolizin-3-one

Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

Construction of Polyheterocyclic Benzopyran Library with Diverse Core Skeletons through Diversity-Oriented Synthesis Pathway: Part II ⬇️

Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway

Crystallization and preliminary X-ray diffraction analysis of importin-alpha complexed with NLS peptidomimetics.

De novo analysis of protein N-terminal sequence utilizing MALDI signal enhancing derivatization with Br signature ⬇️

Development of Azo-Based Turn-On Chemical Array System for Hydrazine Detection with Fluorescence Pattern Analysis

Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay

Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.

Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones

Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction

Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.

Emission wavelength prediction of a full-color-tunable fluorescent core skeleton, 9-aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one.

Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.

Ethanol and reactive species increase basal sequence heterogeneity of hepatitis C virus and produce variants with reduced susceptibility to antivirals.

Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands

Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules.

Focus on chemical biology in Asia.

Gold-Catalyzed Unexpected Ring Transformation of Pyrimidodiazepine Derivatives.

Heteroaromatic Moieties in the Sphingosine Backbone of α-Galactosylceramides for Noncovalent Interactions with CD1d

Host immunomodulatory lipids created by symbionts from dietary amino acids

Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ

Improved Th17 Selectivity of α-Galactosylceramide via Noncovalent Interactions with Diether Moiety

Inverse agonist of nuclear receptor ERRγ mediates antidiabetic effect through inhibition of hepatic gluconeogenesis

Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent

Label-free target identification using in-gel fluorescence difference via thermal stability shift.

Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake

Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands

Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton.

Near-IR Fluorescent Tracer for Glucose-Uptake Monitoring in Live Cells

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis

Pharmacophore-based strategy for the development of general and specific scFv biosensors for abused antibiotics.

Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR

Photochemical generation of a new, highly fluorescent compound from non-fluorescent resveratrol ⬇️

Practical solid-phase parallel synthesis of Delta(5)-2-oxopiperazines via N-acyliminium ion cyclization

Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces

Privileged substructure-based diversity-oriented synthesis pathway for diverse pyrimidine-embedded polyheterocycles

Publisher Correction: Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

Quantitative evaluation of HiCore resin for the nonspecific binding of proteins by on-bead colorimetric assay.

Rational perturbation of the fluorescence quantum yield in emission-tunable and predictable fluorophores (Seoul-Fluors) by a facile synthetic method involving C-H activation.

Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage.

Regioselective Construction and Screening of 1,3-Disubstituted Tetrahydroindazolones in Enantiomerically Pure Pairs ⬇️

Regioselective synthesis of tetrasubstituted pyrroles by 1,3-dipolar cycloaddition and spontaneous decarboxylation.

Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein-RNA Interaction

Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons.

Solid-phase parallel synthesis of natural product-like diaza-bridged heterocycles through Pictet-Spengler intramolecular cyclization

Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ.

Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation

Surface modification for small-molecule microarrays and its application to the discovery of a tyrosinase inhibitor

Synthesis and biological evaluation of pyrimidine-based dual inhibitors of human epidermal growth factor receptor 1 (HER-1) and HER-2 tyrosine kinases.

Synthesis and biological evaluation of α-galactosylceramide analogues with heteroaromatic rings and varying positions of a phenyl group in the sphingosine backbone

Synthesis and library construction of privileged tetra-substituted Δ5-2-oxopiperazine as β-turn structure mimetics.

Synthesis of 3,5-Disubstituted Isoxazoles Containing Privileged Substructures with a Diverse Display of Polar Surface Area

Synthesis of molecular frameworks containing two distinct heterocycles connected in a single molecule with enhanced three-dimensional shape diversity.

The O‑glycosylation mutant osteopontin alters lung cancer cell growth and migration in vitro and in vivo

Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist.

Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents

Two-Photon and Multicolor Fluorogenic Bioorthogonal Probes Based on Tetrazine-Conjugated Naphthalene Fluorophores

β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.