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List of works by Richard K Le Leu

6-bromoisatin found in muricid mollusc extracts inhibits colon cancer cell proliferation and induces apoptosis, preventing early stage tumor formation in a colorectal cancer rodent model.

scientific article published on 24 December 2013

A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer

scientific article published on 29 July 2009

Ability of Endogenous Folate from Soy Protein Isolate to Maintain Plasma Homocysteine and Hepatic DNA Methylation during Methyl Group Depletion in Rats ⬇️

scientific article published on 01 June 1998

Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours

scientific article published on 01 July 2005

Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer.

scientific article published in October 2013

Analysis of the Anti-Cancer Effects of Cincau Extract (Premna oblongifolia Merr) and Other Types of Non-Digestible Fibre Using Faecal Fermentation Supernatants and Caco-2 Cells as a Model of the Human Colon.

scientific article

Bowel health in chronic kidney disease: Patient perceptions differ from clinical definitions

scientific article published on 8 January 2018

Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial

scientific article published on 17 June 2015

Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers.

scientific article

Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model

scientific article published on 01 September 2013

Cytokinesis-block micronucleus cytome assays for the determination of genotoxicity and cytotoxicity of cecal water in rats and fecal water in humans.

scientific article published on December 2007

DNA methylation in the rectal mucosa is associated with crypt proliferation and fecal short-chain fatty acids.

scientific article

DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer.

scientific article

Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac

scientific journal article

Denosumab-Induced Severe Hypocalcaemia in Chronic Kidney Disease

scientific article published on 04 November 2018

Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA-mediated real-time PCR clamping and mutant-specific probes

scientific article

Dietary butyrylated high-amylose starch reduces azoxymethane-induced colonic O(6)-methylguanine adducts in rats as measured by immunohistochemistry and high-pressure liquid chromatography.

scientific article published on 7 June 2016

Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial.

scientific article published in August 2014

Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation.

scientific article published on 29 August 2013

Effect of high amylose maize starches on colonic fermentation and apoptotic response to DNA-damage in the colon of rats

scientific article published on 07 March 2009

Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats.

scientific article

Effects of Dietary Fibre from the Traditional Indonesian Food, Green Cincau ( Merr.) on Preneoplastic Lesions and Short Chain Fatty Acid Production in an Azoxymethane Rat Model of Colon Cancer

scientific article published on 31 August 2018

Effects of resistant starch and nonstarch polysaccharides on colonic luminal environment and genotoxin-induced apoptosis in the rat.

scientific article

Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative

scientific article published on 8 March 2010

Fermentation of starch and protein in the colon: implications for genomic instability

scientific article published on 23 February 2007

Gastrointestinal symptoms in patients receiving dialysis: A systematic review

scientific article published on 01 August 2018

Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR‐17‐92 cluster ⬇️

scientific article published on February 5, 2012

Housing experimental rats in solid-based cages with digestible bedding may confound outcomes of nutritional studies

scientific article published on 18 October 2014

Inhibition by resistant starch of red meat-induced promutagenic adducts in mouse colon.

scientific article published in September 2011

Lowering of large bowel butyrate levels in healthy populations is unlikely to be beneficial

scientific article published on 01 May 2015

Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats.

scientific article published on 19 February 2016

Preventing cancer: dietary lifestyle or clinical intervention?

scientific article published in January 2002

R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production.

scientific article published on 25 March 2010

Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis.

scientific article

Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice

scientific article published in January 2014

Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon.

scientific article published on 29 March 2010

Simultaneous Assessment of the Efficacy and Toxicity of Marine Mollusc-Derived Brominated Indoles in an In Vivo Model for Early Stage Colon Cancer.

scientific article published on April 2017

Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans

scientific article

Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch.

scientific article published on 19 July 2007

Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.

scientific article published in June 2008

Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.

scientific article published on 20 August 2009

The colonic response to genotoxic carcinogens in the rat: regulation by dietary fibre.

scientific article

The influence of dietary proteins on colon cancer risk

scientific article published on 01 July 2001

The influence of selenium-enriched milk proteins and selenium yeast on plasma selenium levels and rectal selenoprotein gene expression in human subjects

scientific article published on 30 March 2011

The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice

scientific article published in May 2008

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