List of works - Matthew J Sykes

AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers.

scientific article

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

scientific article published on 9 September 2015

Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome.

scientific article published on 17 March 2016

Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.

scientific article published in March 2007

DNA binding of an organic dppz-based intercalator

scientific article

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

scientific article published on 12 February 2014

Discovery of CDK5 Inhibitors through Structure-Guided Approach

scientific article published on 20 March 2019

Identification of a novel oligomerization disrupting mutation in CRYΑA associated with congenital cataract in a South Australian family.

scientific article published on 17 January 2013

In Search of Novel CDK8 Inhibitors by Virtual Screening

scientific article

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

scientific article published on 14 July 2016

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase

scientific article

Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride.

scientific article published in January 2009

Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.

scientific article

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

scientific article published on 01 January 2018

Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes

scientific article published on 01 November 2006

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

scientific article published on 4 June 2015

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

scientific article published on 16 December 2014

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity ⬇️

scientific article published on June 14, 2012

Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions

scientific article published on 01 March 2003

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

scientific article published on 18 April 2013

Targeting Pim kinases for cancer treatment: opportunities and challenges

scientific article

The Gaussian Generalized Born model: application to small molecules.

scientific article published on 17 July 2007

Tripeptide analogues of MG132 as protease inhibitors

scientific article published on 14 December 2018

List of works by Matthew J Sykes

AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers.

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome.

Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.

DNA binding of an organic dppz-based intercalator

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

Discovery of CDK5 Inhibitors through Structure-Guided Approach

Identification of a novel oligomerization disrupting mutation in CRYΑA associated with congenital cataract in a South Australian family.

In Search of Novel CDK8 Inhibitors by Virtual Screening

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase

Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride.

Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity ⬇️

Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

Targeting Pim kinases for cancer treatment: opportunities and challenges

The Gaussian Generalized Born model: application to small molecules.

Tripeptide analogues of MG132 as protease inhibitors