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List of works by Lukas Chavez

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DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018
The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.

scientific article published on 7 April 2013
Large conserved domains of low DNA methylation maintained by Dnmt3a

scientific article published on 24 November 2013
The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017
MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments

scientific article
Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

scientific article published on 13 January 2014
Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage

scientific article
Active medulloblastoma enhancers reveal subgroup-specific cellular origins

scientific article published on 27 January 2016
Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

scientific article published on 18 April 2016
DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017
Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection.

scientific article published on 5 December 2016
Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

scientific article
A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

scientific article published on 21 May 2010
Acute loss of TET function results in aggressive myeloid cancer in mice

scientific article
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

scientific article published on 27 April 2015
Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation

scientific article published on January 24, 2011
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

scientific article
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017
Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development

scientific article
TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

scientific article published on 21 November 2016
Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

scientific article
In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach

scientific article published on 15 July 2009
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

scientific article
Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway.

scientific article
Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling

scientific article published on 05 December 2016
Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis

scientific article
DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer

scientific article
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018
Evidence of H3 K27M mutations in posterior fossa ependymomas

scientific article
Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data

scientific article published in 2013
H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

scientific article published on 11 April 2017
QSEA-modelling of genome-wide DNA methylation from sequencing enrichment experiments

scientific article
Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

scientific article published on 01 September 2018
Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming.

scientific article published on 9 February 2018
A biobank of patient-derived pediatric brain tumor models

scientific article published on 22 October 2018
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019
Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

scientific article
Integrated molecular characterization of IDH-mutant glioblastomas

scientific article published on 15 November 2018
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

scientific article published on 9 March 2018
Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018
Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea

scientific article
Molecular characterization of cultured adult human liver progenitor cells

scientific article published on October 2010
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

scientific article published on 13 June 2019
DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

scientific article published on 13 October 2017
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

scientific article published on 11 September 2017
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

scientific article published on 27 August 2019
Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

scientific article published on 12 February 2018

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