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List of works by Robert E. W. Hancock

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

scientific article published on 08 October 2019

A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms

scientific article

A facile method of delivery of liposomes by nebulization

scientific article published in November 2002

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

scientific article

A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effects of milling

scientific article published on February 2002

A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation

scientific article published on 14 August 2020

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

scientific article published on 17 June 2009

A polyalanine peptide derived from polar fish with anti-infectious activities

scientific article published on 26 February 2016

A re-evaluation of the role of host defence peptides in mammalian immunity.

scientific article

A systems biology approach to nutritional immunology - focus on innate immunity

scientific article published on 29 October 2011

A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.

scientific article

AMPer: a database and an automated discovery tool for antimicrobial peptides.

scientific article published on 6 March 2007

Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models

scientific article

Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis

scientific article published on 08 November 2012

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

scientific article published on October 2012

Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS

scientific journal article

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

scientific article

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides

scientific article

Alternative mechanisms of action of cationic antimicrobial peptides on bacteria

scientific article published on December 2007

Alternatives to antibiotics—a pipeline portfolio review

scientific article (publication date: February 2016)

Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.

scientific article

An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

scientific article

An anti-infective peptide that selectively modulates the innate immune response

scientific article published on 25 March 2007

An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane

scientific article

An in situ Raman spectroscopy-based microfluidic "lab-on-a-chip" platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms

scientific article published on May 2015

An iron-regulated LysR-type element mediates antimicrobial peptide resistance and virulence in Yersinia pseudotuberculosis

scientific article published on 23 April 2009

Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients

scientific article published in January 2014

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

scientific article

Anti-biofilm peptides as a new weapon in antimicrobial warfare.

scientific article published on 15 June 2016

Anti-endotoxin properties of cationic host defence peptides and proteins

scientific article

Anti-infective peptide IDR-1002 augments monocyte chemotaxis towards CCR5 chemokines

scientific article published on 10 July 2015

Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity

article

Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro

scientific article published on 23 September 2017

Antibiofilm Peptides: Potential as Broad-Spectrum Agents

scientific article published on 9 September 2016

Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens.

scientific article

Antibiotic resistance in Pseudomonas aeruginosa biofilms: towards the development of novel anti-biofilm therapies

scientific article

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment

scientific article

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations

scientific article published on 05 January 2011

Anticancer activities of bovine and human lactoferricin-derived peptides

scientific article

Antimicrobial Peptides: An Introduction

scientific article published in January 2017

Antimicrobial activity and bacterial-membrane interaction of ovine-derived cathelicidins.

scientific article

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum

scientific article published on 03 March 2017

Antimicrobial peptide therapeutics for cystic fibrosis

scientific article

Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections

scientific article published on December 2010

Antimicrobial properties of MX-2401, an expanded-spectrum lipopeptide active in the presence of lung surfactant.

scientific article

Antimicrobial properties of lactoferrin

scientific article

Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.

scientific article published on 9 December 2005

ArrayPipe: a flexible processing pipeline for microarray data

scientific article

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

scientific article

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically

scientific article published on 17 September 2016

Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies.

scientific article published on 20 July 2013

Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets

scientific article published in December 2003

Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies

scientific article

Bioinformatics: Novel Insights from Genomic Information

scientific article published on 14 January 2016

Biomembrane Interactions Reveal the Mechanism of Action of Surface-Immobilized Host Defense IDR-1010 Peptide

article

Bordetella pertussis lipid A glucosamine modification confers resistance to cationic antimicrobial peptides and increases resistance to outer membrane perturbation

scientific article published on 27 May 2014

Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide.

scientific article published on 30 August 2006

Can innate immunity be enhanced to treat microbial infections?

scientific article published on June 2004

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds ⬇️

scientific article published on October 1, 2011

Cathelicidins and functional analogues as antisepsis molecules.

scientific article published on August 2007

Cathelicidins link the endocrine and immune systems

scientific article published in April 2010

Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria

scientific article published on 10 March 2015

Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness

scientific article published in January 2003

Cationic antimicrobial peptides activate a two‐component regulatory system, PmrA‐PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa ⬇️

scientific article published on October 1, 2003

Cationic host defense (antimicrobial) peptides

scientific article

Cationic peptides: distribution and mechanisms of resistance

scientific article

Cellulose-bound peptide arrays: preparation and applications

scientific article published on January 2007

Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation.

scientific article

Characterization of OpdH, a Pseudomonas aeruginosa porin involved in the uptake of tricarboxylates

scientific article published on 17 November 2006

Characterization of a proteolytically stable multifunctional host defense peptidomimetic

scientific article published on 10 October 2013

Characterization of host responses during acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002

article

Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.

scientific article

Characterization of the structure and membrane interaction of the antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs.

scientific article published on 26 January 2007

Ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa

scientific article published on August 2005

Collateral damage

scientific article published on 01 January 2014

Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides

scientific article published on February 2006

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection

scientific article

Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility

scientific article

Complexities of targeting innate immunity to treat infection.

scientific article published on 30 April 2007

Computed tomographic features of suspected traumatic injury to the iliopsoas and pelvic limb musculature of a dog.

scientific article

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

scientific article published on 30 January 2018

Con − Mutants: Class of Mutants in Escherichia coli K-12 Lacking a Major Cell Wall Protein and Defective in Conjugation and Adsorption of a Bacteriophage ⬇️

scientific article published on September 1, 1974

Concerns regarding resistance to self-proteins

scientific article

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life

scientific article (publication date: 2014)

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes

scientific article

Controlling biofilm formation with nitroxide functional surfaces

scientific article published in 2019

Creeping baselines and adaptive resistance to antibiotics ⬇️

scientific article published on February 1, 2011

Curating the innate immunity interactome

scientific article

D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections

scientific article

Delivery of liposomes in dry powder form: aerodynamic dispersion properties

scientific article

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application.

scientific article published on 22 August 2018

Design of host defence peptides for antimicrobial and immunity enhancing activities.

scientific article

Designing antimicrobial peptides: form follows function.

scientific article published on 16 December 2011

Differential expression of porins OmpP2A and OmpP2B of Haemophilus ducreyi

scientific article published on November 2004

Dismantling the bacterial virulence program

article

Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium

scientific article published on 7 May 2012

Effect of divalent cations on the structure of the antibiotic daptomycin.

scientific article published on 30 October 2007

Effect of membrane composition on antimicrobial peptides aurein 2.2 and 2.3 from Australian southern bell frogs

scientific article published on January 2009

Effect of nitroxides on swarming motility and biofilm formation, multicellular behaviors in Pseudomonas aeruginosa.

scientific article published on 22 July 2013

Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria

scientific article published in May 2012

Effects of hydrophobicity on the antifungal activity of alpha-helical antimicrobial peptides

scientific article published on December 2008

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides

scientific article published on January 2008

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides

scientific article

Enabling a systems biology approach to immunology: focus on innate immunity

scientific article published on 08 May 2009

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells

scientific article published on 3 October 2016

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

scientific article published on 16 May 2011

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B

scientific article published on 01 April 2007

Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03.

scientific article published on 3 September 2015

Erratum: Corrigendum: Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

article

Erratum: Designing antimicrobial peptides: form follows function

scholarly article published in Nature Reviews Drug Discovery

Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosa

scientific article

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast

scientific article

Exosomes, your body's answer to immune health

scientific article published on February 2017

Experimental and Theoretical Investigation of Multispecies Oral Biofilm Resistance to Chlorhexidine Treatment

scientific article published on 21 June 2016

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

scientific article published on 25 April 2017

Expression of an engineered heterologous antimicrobial peptide in potato alters plant development and mitigates normal abiotic and biotic responses

scientific article published in 2013

Fatal venous air embolism in a cat with a retropharyngeal diverticulum

scientific article

Fluorescent Probes Alter Miscibility Phase Boundaries in Ternary Vesicles

article

Function and therapeutic potential of host defence peptides.

scientific article

Function of pseudomonas porins in uptake and efflux.

scientific article

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia

scientific article published on 13 March 2013

G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9.

scientific article

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics

scientific journal article

Genome-Wide Identification of Genes Conferring Energy Related Resistance to a Synthetic Antimicrobial Peptide (Bac8c) ⬇️

scientific article published on January 31, 2013

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen

scientific article published on February 2005

Helicobacter pylori Biofilm Formation Is Differentially Affected by Common Culture Conditions, and Proteins Play a Central Role in the Biofilm Matrix

article

High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides

scientific article

High-Performance Liquid Chromatography and Mass Spectrometry-Based Design of Proteolytically Stable Antimicrobial Peptides

scientific article published on January 2017

High-throughput detection of RNA processing in bacteria

scientific article published on 27 March 2018

High-throughput generation of small antibacterial peptides with improved activity

scientific article published on 24 July 2005

Host defence peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-kappaB signaling pathway.

scientific article

Host defence peptides from invertebrates--emerging antimicrobial strategies

scientific article

Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.

scientific article

Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways

scientific article published on 01 December 2007

Host defense peptides: front-line immunomodulators

scientific article

Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs

scientific article published on 7 October 2009

Human host defense peptide LL-37 prevents bacterial biofilm formation

scientific article

INMEX--a web-based tool for integrative meta-analysis of expression data

scientific article

INVEX--a web-based tool for integrative visualization of expression data

scientific article

IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells

scientific article

Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.

scientific article published on 16 February 2016

Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174.

scientific article published on 4 June 2014

Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library

scientific journal article

Identification of novel antibacterial peptides by chemoinformatics and machine learning

scientific article

Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome

scientific article published on November 2008

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

scientific article published on December 2013

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis

scientific article published on 21 July 2011

Immunomodulators as adjuvants for vaccines and antimicrobial therapy ⬇️

scientific article published on 04 October 2010

Immunomodulatory activities of small host defense peptides

scientific article

Immunomodulatory streptococci that inhibit CXCL8 secretion and NFκB activation are common members of the oral microbiota

scientific article published in 2021

Impact of LL-37 on anti-infective immunity.

scientific article

Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung ⬇️

scientific article published on February 1, 2013

Importance of Adaptive and Stepwise Changes in the Rise and Spread of Antimicrobial Resistance

Importance of residue 13 and the C-terminus for the structure and activity of the antimicrobial peptide aurein 2.2.

scientific article

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents

scientific article

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

scientific article published on 16 April 2018

In vitro and in vivo antibiotic capacity of two host defence peptides

scientific article published on 04 May 2020

In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides

scientific article

Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro

scientific article published on 28 April 2014

Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of PsrA in Pseudomonas aeruginosa

scientific article

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

scientific article published on 15 January 2018

Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin.

scientific article

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis ⬇️

scientific article published on October 2, 2012

Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide

scientific article published on 21 February 2012

Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease

scientific article published on 01 June 2008

Innate defense regulator peptide 1018 in wound healing and wound infection

scientific article

Innate defense regulator peptide 1018 protects against perinatal brain injury

scientific article published on 7 March 2014

InnateDB: facilitating systems-level analyses of the mammalian innate immune response.

scientific article

InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation

scientific article

Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells.

scientific article

Interconnection of post-transcriptional regulation: The RNA-binding protein Hfq is a novel target of the Lon protease in Pseudomonas aeruginosa

scientific article published on 27 May 2016

Intracellular receptor for human host defense peptide LL-37 in monocytes

scientific article

Involvement of an ATP-dependent protease, PA0779/AsrA, in inducing heat shock in response to tobramycin in Pseudomonas aeruginosa

scientific journal article

Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.

scientific article published on 27 July 2009

Involvement of the Lon Protease in the SOS Response Triggered by Ciprofloxacin in Pseudomonas aeruginosa PAO1 ⬇️

scientific article published on March 26, 2012

Involvement of two related porins, OprD and OpdP, in the uptake of arginine by Pseudomonas aeruginosa

scientific article published on 01 July 2006

Is synergy the key to treating high-density infections?

scientific article published on 14 November 2018

Killing of trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18

scientific article

LL-37 immunomodulatory activity during Mycobacterium tuberculosis infection in macrophages

scientific article

Linker-insertion mutagenesis of Pseudomonas aeruginosa outer membrane protein OprF.

scientific article

Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes.

scientific article

Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2 ⬇️

scientific article published on June 24, 2011

Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin

Local delivery of antimicrobial peptides using self‐organized TiO2 nanotube arrays for peri‐implant infections ⬇️

scientific article published on November 1, 2011

Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli

scientific article published on 21 May 2009

MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity

scientific article published on 22 August 2020

Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory

scientific article

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

scientific article

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

scientific article published on 9 October 2017

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

scientific article published on 25 April 2020

Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay

scientific article published in November 2003

Metabolic changes associated with adaptive diversification in Escherichia coli

scientific article

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

scientific article published on 20 December 2019

Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides.

scientific article

Modeling the Ion Selectivity of the Phosphate Specific Channel OprP

article

Modulating immunity as a therapy for bacterial infections ⬇️

scientific article published on March 16, 2012

Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts

scientific article published on 11 August 2011

Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37.

scientific article published on February 2006

Mucin promotes rapid surface motility in Pseudomonas aeruginosa

scientific article published in May 2012

Multidrug Adaptive Resistance of Pseudomonas aeruginosa Swarming Cells

scientific article published on 21 February 2020

Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa ⬇️

scientific article published on July 2002

Multifunctional cationic host defence peptides and their clinical applications

scientific article published on 15 May 2011

Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections ⬇️

scientific article published on May 13, 2013

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

scientific article

NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles.

scientific article published on 15 September 2007

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data

scientific article

NetworkAnalyst--integrative approaches for protein-protein interaction network analysis and visual exploration

scientific article published on 26 May 2014

Neutrophil Elastase Mediates Innate Host Protection against Pseudomonas aeruginosa

scientific article published on 01 October 2008

Neutrophil-derived defensins as modulators of innate immune function

scientific article published on January 2008

New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions

scientific article published on 28 February 2017

New Perspectives in Biofilm Eradication

scientific article published on 27 December 2017

New insights into cathelicidin modulation of adaptive immunity ⬇️

scientific article published on 01 October 2011

New strategies and compounds for anti-infective treatment

scientific article published on 30 August 2013

Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa ⬇️

scientific journal article

Notes on facultative predation in Prosimulium larvae (Diptera: Simuliidae) in alpine and subalpine streams in Colorado.

scientific article published in March 2015

Novel anti-infectives: is host defence the answer?

scientific article

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa

scientific article

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

scientific article published on 15 May 2013

On the mechanism of solute uptake in Pseudomonas

scientific article

Optimization of Microbial Specificity in Cyclic Peptides by Modulation of Hydrophobicity within a Defined Structural Framework ⬇️

scientific article published on October 26, 2001

Optimization of antibacterial peptides by genetic algorithms and cheminformatics

scientific article

Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli

scientific article published on 23 September 2019

Overexpression of the Small RNA PA0805.1 in Pseudomonas aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance

scientific article published on 19 May 2020

PSICQUIC and PSISCORE: accessing and scoring molecular interactions

scientific article (publication date: 29 June 2011)

Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2-MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide

scientific article published on 25 November 2016

Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections

scientific article published on 31 October 2014

Peptide antimicrobial agents

scientific article published on July 2006

Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion

scientific article

Peptide design for antimicrobial and immunomodulatory applications

scientific article

Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process

scientific article published on 22 September 2010

Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa

scientific article published on 6 July 2012

Polymyxin: Alternative Mechanisms of Action and Resistance.

scientific article

Potential of immunomodulatory host defense peptides as novel anti-infectives

scientific article published on 14 August 2009

Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide.

scientific article

Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

scientific article published in 2022

ProbeLynx: a tool for updating the association of microarray probes to genes

scientific article published on July 2004

Protein interaction data curation: the International Molecular Exchange (IMEx) consortium

scientific article

Pseudomonas 2007.

scientific article published on 28 December 2007

Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes

scientific article published on 31 October 2008

Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes

scientific article

Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation

scientific article

Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis.

scientific article published on October 2002

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.

scientific article

Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture

scientific article published on September 2002

Pseudomonas aeruginosa: all roads lead to resistance ⬇️

scientific article (publication date: August 2011)

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

scientific article published on 15 March 2013

QSAR modeling and computer-aided design of antimicrobial peptides

scientific article

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

scientific article published on 26 July 2008

Rates and Determinants of Return to Play After Anterior Cruciate Ligament Reconstruction in NCAA Division 1 College Football Athletes: A Study of the ACC, SEC, and PAC-12 Conferences.

scientific article

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

scientific article

Reassessing the Host Defense Peptide Landscape

Recognition of host immune activation by Pseudomonas aeruginosa

scientific article

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa

scientific article published on March 2009

Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model

scientific article published on 30 December 2013

Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells

scientific article

Rethinking the Antibiotic Discovery Paradigm

scientific article

Robert E W Hancock--boosting innate immunity to combat infection: interview by Marilynn Larkin

scientific article published in November 2003

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

scientific article

Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane

scientific article published on August 2003

Role of intracellular proteases in the antibiotic resistance, motility, and biofilm formation of Pseudomonas aeruginosa

scientific journal article

Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin

scientific journal article

Role of membranes in the activities of antimicrobial cationic peptides

scientific article

Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation

scientific article

Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa

scientific article published on January 2006

Salmonella's sensor for host defense molecules.

scientific article

Screening and Characterization of Surface-Tethered Cationic Peptides for Antimicrobial Activity

article

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides

scientific article published on 19 March 2007

Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide

scientific article published on 22 October 2009

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential

scientific article published on 01 May 2019

Short cationic antimicrobial peptides interact with ATP.

scientific article published on 26 July 2010

Signaling Pathways Mediating Chemokine Induction in Keratinocytes by Cathelicidin LL-37 and Flagellin ⬇️

scientific article published on April 17, 2012

Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes

scientific article published on November 2005

Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: role of outer membrane protein OprF.

scientific article

Strategies for the discovery and advancement of novel cationic antimicrobial peptides.

scientific article published on January 2010

Strategies to link innate and adaptive immunity when designing vaccine adjuvants

scientific article

Structural studies of a peptide with immune modulating and direct antimicrobial activity

scientific article published in September 2010

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin

scientific article

Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide

scientific article

Structure, Dynamics, and Antimicrobial and Immune Modulatory Activities of Human LL-23 and Its Single-Residue Variants Mutated on the Basis of Homologous Primate Cathelicidins

scientific article

Structure-activity relationships for the beta-hairpin cationic antimicrobial peptide polyphemusin I.

scientific article published in May 2004

Structure-based design of an indolicidin peptide analogue with increased protease stability

scientific article

Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli

scientific article published on March 2002

Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58

scientific article published on 24 March 2020

Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance

scientific journal article

Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.

scientific article

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens.

scientific article

Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents.

scientific article published on 27 June 2016

Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method

scientific article published on January 2009

Synthetic Immunomodulatory Peptide IDR-1002 Enhances Monocyte Migration and Adhesion on Fibronectin ⬇️

scientific article published on June 19, 2012

Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model

scientific article published on 27 September 2017

Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in mice.

scientific article published on 5 September 2013

Synthetic antibiofilm peptides.

scientific article published on 23 December 2015

Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment

scientific article

Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation

scientific article

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection

scientific article published on 6 November 2017

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

scientific article published on 19 March 2009

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro

scientific article

Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages.

scientific article

The Human Cathelicidin, LL-37, Induces Granzyme-mediated Apoptosis in Regulatory T Cells ⬇️

scientific article published on 01 April 2011

The Lon protease is essential for full virulence in Pseudomonas aeruginosa

scientific journal article

The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility

scientific journal article

The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation

scientific article

The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells

scientific article

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function ⬇️

scientific article published on June 4, 2012

The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa

scientific article published on 04 August 2020

The Structure of a Type 3 Secretion System (T3SS) Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing

scientific article

The Vibrio fischeri sapABCDF locus is required for normal growth, both in culture and in symbiosis

scientific article published on 09 November 2002

The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment

scientific article published in April 2006

The bacterial surface layer provides protection against antimicrobial peptides.

scientific article published on 25 May 2012

The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

scientific article published on 5 March 2011

The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization

scientific article published on 01 January 2004

The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis

scientific article

The complexities of antibiotic action

scientific article published on 16 October 2007

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation ⬇️

scientific article published on December 19, 2011

The extra-cytoplasmic function sigma factor sigX modulates biofilm and virulence-related properties in Pseudomonas aeruginosa

scientific article

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world

scientific article published on 01 March 2009

The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses

scientific article published on October 2002

The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium

scientific article published on 22 January 2010

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

scientific article published on 03 December 2010

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

scientific article published on 22 June 2006

The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes

scientific article published on March 2004

The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity.

scientific article published on 12 May 2009

The human transcriptome during nontyphoid Salmonella and HIV coinfection reveals attenuated NFkappaB-mediated inflammation and persistent cell cycle disruption

scientific article

The immunology of host defence peptides: beyond antimicrobial activity

scientific article

The importance of bacterial membrane composition in the structure and function of aurein 2.2 and selected variants

article

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions ⬇️

scientific article published on April 24, 2013

The intrinsic resistome of Pseudomonas aeruginosa to β-lactams.

scientific article

The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E

scientific article (publication date: 2013)

The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel

scientific journal article

The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility

scientific journal article

The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A.

scientific article

The relationship between peptide structure and antibacterial activity

scientific article published on November 2003

The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells

scientific article

The roles of cathelicidin LL-37 in immune defences and novel clinical applications

scientific article published on January 2009

The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa

scientific journal article

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa

scientific article

The small RNAs PA2952.1 and PrrH as regulators of virulence, motility and iron metabolism in Pseudomonas aeruginosa

scientific article published on 06 November 2020

The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS

scientific journal article

Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections ⬇️

scientific article published on January 1, 2012

Therapeutic potential of HDPs as immunomodulatory agents

scientific article

Toward Infection-Resistant Surfaces: Achieving High Antimicrobial Peptide Potency by Modulating the Functionality of Polymer Brush and Peptide

scientific article

Treatment of Oral Biofilms by a D-Enantiomeric Peptide

scientific article

Treatment of Oral Multispecies Biofilms by an Anti-Biofilm Peptide

scientific article

Tryptic Stability of Synthetic Bactenecin Derivatives Is Determined by the Side Chain Length of Cationic Residues and the Peptide Conformation.

scientific article published on 9 March 2016

Tuning the affinity of anion binding sites in porin channels with negatively charged residues: molecular details for OprP.

scientific article

Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology

scientific article published on 14 November 2016

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs

scientific article

Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose using peptide array technology

scientific article published in January 2007

Use of polymyxin as an endotoxin blocker in the prevention of diffuse lamellar keratitis in an animal model

scientific article published in March 2005

Using Intrinsic X-ray Absorption Spectral Differences To Identify and Map Peptides and Proteins

article

Using anti-biofilm peptides to treat antibiotic-resistant bacterial infections

scientific article published on February 2015

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance

scientific article

X-ray spectromicroscopy study of competitive adsorption of protein and peptide onto polystyrene-poly(methyl methacrylate).

scientific article

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