Search filters

List of works by Roman Jerala

A 3D 1H, 15N, and 13C NOESY Correlating Experiment

A Guide to the design of synthetic gene networks in mammalian cells

scientific article published on 01 December 2020

A bistable genetic switch based on designable DNA-binding domains

scientific article published on 29 September 2014

A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation

scientific article published on 22 June 2008

A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells

scientific article published on 06 January 2020

Accessing the global minimum conformation of stefin A dimer by annealing under partially denaturing conditions

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization

scientific article

Advances in design of protein folds and assemblies

scientific article

Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics

scientific article

Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide

scientific article

Building an international consortium for tracking coronavirus health status

scientific article published on 02 June 2020

Calorimetric measurements of thermal denaturation of stefins A and B. Comparison to predicted thermodynamics of stefin-B unfolding

scientific article published on November 1992

Characterization of quercetin binding site on DNA gyrase

scientific article

Chemistry of lipid A: at the heart of innate immunity.

scientific article

Chimeric flagellin as the self-adjuvanting antigen for the activation of immune response against Helicobacter pylori.

scientific article published on 20 July 2012

Cloning a synthetic gene for human stefin B and its expression in E. coli

scientific article

Coiled coil protein origami: from modular design principles towards biotechnological applications

scientific article

Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines

scientific article

Compactness of the molten globule in comparison to unfolded states as observed by size-exclusion chromatography

scientific article published in November 1994

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides

scientific article

Comparison of backbone dynamics of monomeric and domain-swapped stefin A

scientific article published on 01 February 2004

Conformation and fluctuations of free stefin B: a molecular dynamics study

scientific article published on July 1, 1992

Correlation between Phenotype and Genotype in CTNNB1 Syndrome: A Systematic Review of the Literature

scientific article published in 2022

Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation

scientific article published on 7 November 2007

DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency

scientific article published on 22 October 2011

De novo design of orthogonal peptide pairs forming parallel coiled-coil heterodimers

scientific article published on 28 December 2010

Delivery system for the enhanced efficiency of immunostimulatory nucleic acids

scientific article

Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments

scientific article

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo

scientific article published on 16 October 2017

Design of fast proteolysis-based signaling and logic circuits in mammalian cells

scientific article published on 10 December 2018

Design of split superantigen fusion proteins for cancer immunotherapy

scientific article published on 19 February 2019

Design principles for rapid folding of knotted DNA nanostructures

scientific article published on 18 February 2016

Designable DNA-binding domains enable construction of logic circuits in mammalian cells

scientific article

Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor

scientific article published on 25 April 2013

Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists

scientific article published on 25 September 2014

Differences in the effects of TFE on the folding pathways of human stefins A and B

scientific article published on 01 August 1999

Different functional role of domain boundaries of Toll-like receptor 4.

scientific article published on 11 February 2009

Endotoxin neutralizing peptides

scientific article published in January 2004

Engineered human cells: say no to sepsis

Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain.

scientific article

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

scientific article published on January 2005

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

scientific article published on 24 March 2009

Expression and refolding of functional fragments of the human lipopolysaccharide receptor CD14 in Escherichia coli and Pichia pastoris

scientific article

Expression of soluble versatile peroxidase of Bjerkandera adusta in Escherichia coli.

scientific article

Expression, purification and structural studies of a short antimicrobial peptide

scientific article

Extracellular vesicle-mediated transfer of constitutively active MyD88L265P engages MyD88wt and activates signaling

scientific article published on 22 January 2018

Folding studies of the cysteine proteinase inhibitor--human stefin A.

scientific article

Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation

scientific article published on 27 May 2009

Functional self-assembling polypeptide bionanomaterials

scientific article published on August 2012

Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion

scientific article

Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site

scientific article published in January 2007

Identification of LPS-Binding Peptide Fragment of MD-2, a Toll-Receptor Accessory Protein

scientific article published on 01 April 2002

Improved expression and evaluation of polyethyleneimine precipitation in isolation of recombinant cysteine proteinase inhibitor stefin B.

scientific article

In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B

scientific article published on 03 March 2012

In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors

scientific article published on 3 October 2005

Increased gene translation stringency in mammalian cells by nonsense suppression at multiple permissive sites with a single non-canonical amino acid

scientific article published on 13 May 2020

Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity

scientific article published on 27 March 2006

Interactions of archaeal chromatin proteins Alba1 and Alba2 with nucleic acids

scientific article

MARCKS as a negative regulator of lipopolysaccharide signaling.

scientific article

MD-2 and Der p 2 - a tale of two cousins or distant relatives?

scientific article published in January 2005

MD-2 as the target of curcumin in the inhibition of response to LPS.

scientific article

MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.

scientific article

Major differences in stability and dimerization properties of two chimeric mutants of human stefins

scientific article

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

scientific article published on 11 March 2011

Metabolic enzyme clustering by coiled coils improves the biosynthesis of resveratrol and mevalonate

scientific article published on 24 May 2020

Minimal sequence requirements for oligodeoxyribonucleotides activating human TLR9.

scientific article published on 16 March 2015

Mixed-valence Cu(II)/Cu(I) complex of quinolone ciprofloxacin isolated by a hydrothermal reaction in the presence of L-histidine: comparison of biological activities of various copper-ciprofloxacin compounds

scientific article published in February 2005

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

scientific article

Modulation of Coiled-Coil Dimer Stability through Surface Residues while Preserving Pairing Specificity.

scientific article published on 29 May 2017

Monoclonal antibodies to human stefin B and determination of their epitopes

scientific article published on 01 June 1993

Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue

scientific article

Mutational Analysis of Two Stefin A Epitopes

scientific article published on 01 June 1999

N-acylated peptides derived from human lactoferricin perturb organization of cardiolipin and phosphatidylethanolamine in cell membranes and induce defects in Escherichia coli cell division

scientific article

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

scientific article published in Nature Communications

New designed protein assemblies

scientific article published on 31 October 2013

Noninvasive high-throughput single-cell analysis of HIV protease activity using ratiometric flow cytometry

scientific article

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

scientific article published in Scientific Reports

Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2.

scientific article

On the Origin and Features of an Evolved Boolean Model for Subcellular Signal Transduction Systems

On the mechanism of human stefin B folding: I. Comparison to homologous stefin A. Influence of pH and trifluoroethanol on the fast and slow folding phases

scientific article published on 01 August 1998

On the mechanism of human stefin B folding: II. Folding from GuHCl unfolded, TFE denatured, acid denatured, and acid intermediate states

scientific article published on 01 August 1998

Peptide and protein nanotechnology into the 2020s: beyond biology

scientific article published on 01 May 2018

Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9.

scientific article

Polarized displacement by transcription activator-like effectors for regulatory circuits

scientific article published on 19 November 2018

Postulates for validating TLR4 agonists

scientific article

Prevention of microvesiculation by adhesion of buds to the mother cell membrane — A possible anticoagulant effect of healthy donor plasma

scientific article published on 03 December 2007

Primary structure of a new cysteine proteinase inhibitor from pig leucocytes

scientific article

Production of recombinant antimicrobial peptides in bacteria

scientific article published in January 2010

Production of stable isotope enriched antimicrobial peptides in Escherichia coli: an application to the production of a 15N-enriched fragment of lactoferrin

scientific article published on 01 October 2000

Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide

scientific article (publication date: September 2003)

Publisher Correction: Building an international consortium for tracking coronavirus health status

scientific article published on 26 June 2020

Publisher Correction: Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9

scientific article published on 6 March 2018

Publisher Correction: Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9.

scientific article published on 5 January 2018

Recognition of Nucleic Acids by Toll-Like Receptors and Development of Immunomodulatory Drugs

article

Response to Apostol and Surewicz: Structural Underpinnings of Prion Protein Conversion.

scientific article

Self-assembled bionanostructures: proteins following the lead of DNA nanostructures

scientific article

Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

scientific article published on 11 February 2021

Semiautomatic sequence-specific assignment of proteins based on the tertiary structure--the program st2nmr

scientific article published in February 2002

Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9.

scientific article

Similarities and specificities of fungal keratinolytic proteases: comparison of keratinases of Paecilomyces marquandii and Doratomyces microsporus to some known proteases

scientific article

Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2

scientific article

Structural Characterisation of Human Stefin A in Solution and Implications for Binding to Cysteine Proteinases

scientific article published on 01 November 1994

Structural biology of the LPS recognition

scientific article published on 3 May 2007

Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo

scientific article

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition

scientific article

Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide

scientific article

Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2.

scientific article published on September 2006

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

scientific article published in March 2018

Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides

scientific article

Suppression of TLR signaling by targeting TIR domain-containing proteins

scientific article published on December 2012

Surface with antimicrobial activity obtained through silane coating with covalently bound polymyxin B

scientific article published on 28 July 2010

SwitCCh: Metal-Site Design for Controlling the Assembly of a Coiled-Coil Homodimer

scientific article published on 30 October 2018

Synthetic biology principles for the design of protein with novel structures and functions

scientific article published on 23 April 2020

Synthetic lipopeptides: a novel class of anti-infectives

scientific article published on August 2007

TOPOFOLD, the designed modular biomolecular folds: polypeptide-based molecular origami nanostructures following the footsteps of DNA.

scientific article published on 04 September 2014

Taxanes inhibit human TLR4 signaling by binding to MD-2.

scientific article

Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions

scientific article published on 13 January 2014

Tetracysteine-tagged prion protein allows discrimination between the native and converted forms

scientific journal article

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes

scientific article

The Relevance of Physico-Chemical Properties and Protein Corona for Evaluation of Nanoparticles Immunotoxicity-In Vitro Correlation Analysis on THP-1 Macrophages

scientific article published on 31 May 2022

The acyl group as the central element of the structural organization of antimicrobial lipopeptide

scientific article

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens

scientific article

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition

scientific article

The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2/TLR4 receptor complex

scientific article published on 15 July 2014

The primary structure of inhibitor of cysteine proteinases from potato

scientific article published on 01 October 1993

The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5.

scientific article published on 21 August 2017

The three-dimensional solution structure of human stefin A

scientific article

Three-dimensional domain swapping in the folded and molten-globule states of cystatins, an amyloid-forming structural superfamily

scientific article

Toll-like receptor 4 activation in cancer progression and therapy

scientific article published on 3 November 2011

Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles

scientific article published on 16 June 2015

Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators

scientific article published on 21 October 2014

Vanadate from air pollutant inhibits hrs-dependent endosome fusion and augments responsiveness to toll-like receptors

scientific article (publication date: 2014)

pH-induced Conformational Transitions of the Propeptide of Human Cathepsin L

scientific article published in Journal of Biological Chemistry

Paulina is supported by:

About Paulina

Help