List of works - Russell T. Hepple

A new measurement of tissue capillarity: the capillary-to-fibre perimeter exchange index.

scientific article published on February 1997

Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles

scientific article published on 12 April 2011

Adaptations in capillarization and citrate synthase activity in response to endurance training in older and young men

scientific article published on 29 June 2011

Aerobic power declines with aging in rat skeletal muscles perfused at matched convective O2 delivery.

scientific article published on 4 October 2002

Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles

scientific article published on 01 December 2011

Anatomic capillarization is elevated in the medial gastrocnemius muscle of mighty mini mice.

scientific article published on 12 March 2009

Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle-aged rats

scientific article published on 13 February 2004

Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.

scientific article

Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

scientific article published on 13 August 2008

Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles

scientific article published on 01 January 2006

Cardiac calcium pump inactivation and nitrosylation in senescent rat myocardium are not attenuated by long-term treadmill training

scientific article published on 08 July 2011

Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment

scientific article published on 01 November 2021

Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content

scientific article published on 01 March 2019

Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle

scientific article

Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.

scientific article published on 13 September 2016

Differential sensitivities of cerebral and brachial blood flow to hypercapnia in humans.

scientific article published on 5 October 2006

Dissociation of peak vascular conductance and V(O2) max among highly trained athletes.

scientific article published on October 1999

Editorial: Mitochondria in Skeletal Muscle Health, Aging and Diseases

scientific article published on 6 October 2016

Effects of aging and caloric restriction on bone structure and mechanical properties.

scientific article published in November 2008

Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats

scientific article published on 06 October 2006

Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.

scientific article published on 6 November 2012

Estimating the size of the capillary-to-fiber interface in skeletal muscle: a comparison of methods.

scientific article published in November 2001

Exercise Promotes Healthy Aging of Skeletal Muscle

scientific article published on June 2016

Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function.

scientific article published in July 2009

Exercise training in late middle-aged male Fischer 344 x Brown Norway F1-hybrid rats improves skeletal muscle aerobic function

scientific article published on 20 March 2008

Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats

scientific article published on 23 November 2013

Failed reinnervation in aging skeletal muscle.

scientific article published on September 2016

Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle

scientific article published on 18 February 2016

Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway F1-hybrid rats

scientific article published on 01 February 2004

Fiber typing in aging muscle.

scientific article published on April 2014

Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women

scientific article published on 21 August 2019

High Aerobic Capacity Mitigates Changes in the Plasma Metabolomic Profile Associated with Aging.

scientific article

Higher expression of denervation‐responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA)

scientific article published in June 2024

Impact of aging on mitochondrial function in cardiac and skeletal muscle.

scientific article published on 23 March 2016

Increased capillarity in leg muscle of finches living at altitude ⬇️

scientific article published on November 1, 1998

Initiating exercise training in late middle age minimally protects muscle contractile function and increases myocyte oxidative damage in senescent rats

scientific article published on 17 July 2010

Innervation and neuromuscular control in ageing skeletal muscle

scientific article published on 06 October 2015

Last Word on Viewpoint: Muscle atrophy is not always sarcopenia ⬇️

scientific article published on August 15, 2012

Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function

scientific article published on 14 June 2005

Mitochondria: isolation, structure and function.

scientific article published on 27 June 2011

Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging

scientific article published on 13 January 2020

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

scientific article published on 21 February 2017

Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium.

scientific article

Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

scientific article published on 01 December 2010

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function.

scientific article published on 26 October 2011

Mitochondrial involvement and impact in aging skeletal muscle

scientific article

Mitochondrial protein import in aging muscle: can Tom still do it? Focus on "Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity"

scientific article published on 10 March 2010

Mitochondrial structure and function are disrupted by standard isolation methods

scientific article

Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun?

scientific article published on 24 March 2016

Muscle atrophy is not always sarcopenia ⬇️

scientific article published on April 19, 2012

Nitric oxide synthase inhibition reduces O2 cost of force development and spares high-energy phosphates following contractions in pump-perfused rat hindlimb muscles.

scientific article published on 9 February 2006

Nitric oxide synthase inhibition reduces the O2 cost of force development in rat hindlimb muscles pump perfused at matched convective O2 delivery.

scientific article published on 25 August 2005

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity

scientific journal article

No effect of trans sodium crocetinate on maximal O(2) conductance or V(O(2),max) in moderate hypoxia.

scientific article

Oxidative capacity interacts with oxygen delivery to determine maximal O(2) uptake in rat skeletal muscles in situ.

scientific article

Oxygen uptake kinetics during exercise in chronic heart failure: influence of peripheral vascular reserve

scientific article published on 01 November 1999

Protective role of Parkin in skeletal muscle contractile and mitochondrial function

scientific article published on 22 April 2018

Quantitating the capillary supply and the response to resistance training in older men

scientific article published on 01 January 1997

Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes.

scientific article published on 2 December 2015

Resistance and aerobic training in older men: effects on VO2peak and the capillary supply to skeletal muscle

scientific article published on 01 April 1997

Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses

scientific article published on August 2013

Severe atrophy of slow myofibers in aging muscle is concealed by myosin heavy chain co-expression.

scientific article published on 3 August 2012

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

scientific article published in 2024

Skeletal muscle aging in F344BN F1-hybrid rats: I. Mitochondrial dysfunction contributes to the age-associated reduction in VO2max.

scientific article published in November 2004

Skeletal muscle aging in F344BN F1-hybrid rats: II. Improved contractile economy in senescence helps compensate for reduced ATP-generating capacity.

scientific article published in November 2004

Slow twitch soleus muscle is not protected from sarcopenia in senescent rats.

scientific article published on 14 April 2010

Smoke-induced neuromuscular junction degeneration precedes the fibre type shift and atrophy in COPD.

scientific article

The O2 cost of the tension-time integral in isolated single myocytes during fatigue

scientific article published on 3 February 2010

The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.

scientific article published on 02 September 2016

The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans

scientific article

The role of O2 supply in muscle fatigue.

scientific article

The versatility of the pump-perfused rat hindlimb preparation: examples relating to skeletal muscle function and energy metabolism.

scientific article

Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

scientific article published on 11 April 2022

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

scientific article published on 11 June 2015

V(O2) max is unaffected by altering the temporal pattern of stimulation frequency in rat hindlimb in situ.

scientific article published on 18 April 2003

When motor unit expansion in ageing muscle fails, atrophy ensues.

scientific article published on 13 March 2018

mtDNA Mutation Accumulation in Muscle Is Not a Major Cause of Fiber Loss. Reply to "Comment on: Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197"

scientific article published on 01 August 2020

List of works by Russell T. Hepple

A new measurement of tissue capillarity: the capillary-to-fibre perimeter exchange index.

Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles

Adaptations in capillarization and citrate synthase activity in response to endurance training in older and young men

Aerobic power declines with aging in rat skeletal muscles perfused at matched convective O2 delivery.

Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles

Anatomic capillarization is elevated in the medial gastrocnemius muscle of mighty mini mice.

Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle-aged rats

Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.

Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia

Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles

Cardiac calcium pump inactivation and nitrosylation in senescent rat myocardium are not attenuated by long-term treadmill training

Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment

Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content

Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle

Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.

Differential sensitivities of cerebral and brachial blood flow to hypercapnia in humans.

Dissociation of peak vascular conductance and V(O2) max among highly trained athletes.

Editorial: Mitochondria in Skeletal Muscle Health, Aging and Diseases

Effects of aging and caloric restriction on bone structure and mechanical properties.

Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats

Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.

Estimating the size of the capillary-to-fiber interface in skeletal muscle: a comparison of methods.

Exercise Promotes Healthy Aging of Skeletal Muscle

Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function.

Exercise training in late middle-aged male Fischer 344 x Brown Norway F1-hybrid rats improves skeletal muscle aerobic function

Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats

Failed reinnervation in aging skeletal muscle.

Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle

Fiber atrophy and hypertrophy in skeletal muscles of late middle-aged Fischer 344 x Brown Norway F1-hybrid rats

Fiber typing in aging muscle.

Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women

High Aerobic Capacity Mitigates Changes in the Plasma Metabolomic Profile Associated with Aging.

Higher expression of denervation‐responsive genes is negatively associated with muscle volume and performance traits in the study of muscle, mobility, and aging (SOMMA)

Impact of aging on mitochondrial function in cardiac and skeletal muscle.

Increased capillarity in leg muscle of finches living at altitude ⬇️

Initiating exercise training in late middle age minimally protects muscle contractile function and increases myocyte oxidative damage in senescent rats

Innervation and neuromuscular control in ageing skeletal muscle

Last Word on Viewpoint: Muscle atrophy is not always sarcopenia ⬇️

Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function

Mitochondria: isolation, structure and function.

Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging

Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium.

Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function.

Mitochondrial involvement and impact in aging skeletal muscle

Mitochondrial protein import in aging muscle: can Tom still do it? Focus on "Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity"

Mitochondrial structure and function are disrupted by standard isolation methods

Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun?

Muscle atrophy is not always sarcopenia ⬇️

Nitric oxide synthase inhibition reduces O2 cost of force development and spares high-energy phosphates following contractions in pump-perfused rat hindlimb muscles.

Nitric oxide synthase inhibition reduces the O2 cost of force development in rat hindlimb muscles pump perfused at matched convective O2 delivery.

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity

No effect of trans sodium crocetinate on maximal O(2) conductance or V(O(2),max) in moderate hypoxia.

Oxidative capacity interacts with oxygen delivery to determine maximal O(2) uptake in rat skeletal muscles in situ.

Oxygen uptake kinetics during exercise in chronic heart failure: influence of peripheral vascular reserve

Protective role of Parkin in skeletal muscle contractile and mitochondrial function

Quantitating the capillary supply and the response to resistance training in older men

Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes.

Resistance and aerobic training in older men: effects on VO2peak and the capillary supply to skeletal muscle

Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses

Severe atrophy of slow myofibers in aging muscle is concealed by myosin heavy chain co-expression.

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

Skeletal muscle aging in F344BN F1-hybrid rats: I. Mitochondrial dysfunction contributes to the age-associated reduction in VO2max.

Skeletal muscle aging in F344BN F1-hybrid rats: II. Improved contractile economy in senescence helps compensate for reduced ATP-generating capacity.

Slow twitch soleus muscle is not protected from sarcopenia in senescent rats.

Smoke-induced neuromuscular junction degeneration precedes the fibre type shift and atrophy in COPD.

The O2 cost of the tension-time integral in isolated single myocytes during fatigue

The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.

The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans

The role of O2 supply in muscle fatigue.

The versatility of the pump-perfused rat hindlimb preparation: examples relating to skeletal muscle function and energy metabolism.

Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

V(O2) max is unaffected by altering the temporal pattern of stimulation frequency in rat hindlimb in situ.

When motor unit expansion in ageing muscle fails, atrophy ensues.

mtDNA Mutation Accumulation in Muscle Is Not a Major Cause of Fiber Loss. Reply to "Comment on: Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197"