List of works - Federico Focher

"Programmed death" in Schopenhauer's World?

scientific article published in June 2002

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations

scientific article

9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice

scientific article published on May 1996

A double-loop model for the replication of eukaryotic DNA

scientific article published on 01 May 1989

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development

scientific article

An enzymatic method for microdetermination of aphidicolin: a promising anticancer drug

scientific article published on 01 February 1981

An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia

scientific article published on April 1985

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

scientific article

Anti-(herpes simplex virus) activity of 4′-thio-2′-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

article

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

scientific article

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ

scientific article published on 24 February 2016

Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds

scientific article

DNA repair mechanisms in neurological diseases: facts and hypotheses

scientific article published on October 1992

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

scientific article published on July 2003

Detection of the effects of intercalating and non-intercalating drugs on DNA structure

scientific article published on May 1988

Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?

scientific article published on 01 February 1988

Effect of combinations of antiviral drugs on herpes simplex encephalitis.

scientific article

Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.

scientific article published in January 1990

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

article

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

scientific article

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

scientific article published on 9 June 2017

Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-(p-n-Octylanilino)Uracil ⬇️

scientific article published on August 1, 1995

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

scientific article

In vivo distribution and activity of aphidicolin on dividing and quiescent cells

scientific article published in April 1985

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo

scientific article

Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon

scientific article published on 01 March 1994

L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?

scientific article published on February 1999

Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

scientific article published on December 2003

Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes

scientific article published in April 1980

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

scientific article published on January 1995

Maupertuis: the 'old synthesis'.

scientific article published in August 2014

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase

scientific article published in December 2004

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides

scientific article published in August 1998

N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases

scientific article published on January 2012

N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase

scientific article published in May 1988

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

scientific article published on 14 February 2011

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis

scientific article published on 01 June 2000

Prodrugs of herpes simplex thymidine kinase inhibitors.

scientific article published on 13 October 2015

Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta

scientific article published on 01 December 1988

Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.

scientific article published on February 2003

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides

scientific article published on 16 April 2007

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

scientific article published on October 2006

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

scientific article

Super-telomeres in transformed human fibroblasts

scientific article published on 6 April 2013

Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives

scientific article published in April 2001

The control of cultural evolution has been tried, what's next?

scientific article

The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.

scientific article

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

scientific article published on October 2006

Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

scientific article published on 16 April 2009

Two-step genetic screening of thrombophilia by pyrosequencing.

scientific article published in July 2005

Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?

scientific article published in January 1992

List of works by Federico Focher

"Programmed death" in Schopenhauer's World?

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations

9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice

A double-loop model for the replication of eukaryotic DNA

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development

An enzymatic method for microdetermination of aphidicolin: a promising anticancer drug

An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Anti-(herpes simplex virus) activity of 4′-thio-2′-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ

Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds

DNA repair mechanisms in neurological diseases: facts and hypotheses

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

Detection of the effects of intercalating and non-intercalating drugs on DNA structure

Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?

Effect of combinations of antiviral drugs on herpes simplex encephalitis.

Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-(p-n-Octylanilino)Uracil ⬇️

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

In vivo distribution and activity of aphidicolin on dividing and quiescent cells

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo

Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon

L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?

Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

Maupertuis: the 'old synthesis'.

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides

N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases

N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis

Prodrugs of herpes simplex thymidine kinase inhibitors.

Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta

Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

Super-telomeres in transformed human fibroblasts

Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives

The control of cultural evolution has been tried, what's next?

The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

Two-step genetic screening of thrombophilia by pyrosequencing.

Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?