List of works - Stefania Butini

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation

scientific article published on 16 February 2018

1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators

scientific article published on 24 September 2008

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles

scientific article published on 29 November 2019

A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs

scientific article published on 18 July 2012

A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin

scientific article published on 13 February 2008

A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring

A stereoselective approach to peptidomimetic BACE1 inhibitors.

scientific article published on 6 October 2013

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides

Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.

scientific article published on 13 November 2017

Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders

scientific article published on 23 January 2019

An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds

scientific article

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

scientific article published on 21 September 2015

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity

scientific article published in Scientific Reports

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.

scientific article published on 12 March 2018

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

scientific article published on 19 November 2019

Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies

scientific article published on 16 February 2008

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials

scientific article

Computational Tool for Fast in silico Evaluation of hERG K+ Channel Affinity

scientific article published on 23 February 2017

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore

scientific article published on 31 January 2007

Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents

scientific article published on 16 February 2008

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

scientific article

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

article

Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors

article

Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs

Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

scientific article

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors

scientific article

Development of novel cyclic peptides as pro-apoptotic agents

scientific article published on 5 April 2016

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

scientific article published on 29 April 2007

Discovery of Huperzine A−Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Midgorge Recognition Sites

scientific article published on 01 June 2006

Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

scientific article published in January 2009

Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors

scientific article published in June 2010

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases

scientific article published on 26 July 2012

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

scientific article published on 6 September 2010

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

scientific article

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

scientific article published on 9 October 2015

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases

scientific article

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

article

Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats

scientific article published on 11 September 2015

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors

scientific article published on 15 May 2008

Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents

scientific article published on 5 September 2015

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

scientific article published on 9 June 2017

From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum

scholarly article in RSC Advances, vol. 4 no. 9, 2014

HCV-targeted antivirals: current status and future challenges

scientific article published on January 2014

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

scholarly article in RSC Advances, vol. 6 no. 69, 2016

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties

scientific article published on 22 November 2012

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

scientific article published on November 2016

In Silico Analysis of Peptide-Based Derivatives Containing Bifunctional Warheads Engaging Prime and Non-Prime Subsites to Covalent Binding SARS-CoV-2 Main Protease (Mpro)

scientific article published in 2022

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

scientific article published on 19 January 2016

Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines

scientific article published on 25 May 2015

Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells

scientific article published on 22 June 2016

Malaria chemotherapy: recent advances in drug development

scientific article

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

scholarly article by Sandra Gemma et al published March 2008 in Tetrahedron Letters

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

scientific article

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

scientific article

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

scientific article

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

scientific article

Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases

scientific article

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

scientific article published on 14 February 2011

Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia

Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies

scientific article

Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies

scientific article published on 14 November 2012

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization

scientific article published in November 2009

Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

scientific article published on 27 August 2019

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling

scientific article

PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

scientific article published on 16 July 2013

PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells

scientific article

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

scientific article published on 24 August 2016

Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors

scholarly article in RSC Advances, vol. 5 no. 29, 2015

Polycondensed heterocycles. Part 12: An approach to the synthesis of 2-acetyl-1′-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4′-pyrrolidine]-2′-one

Polypharmacology of dopamine receptor ligands.

scientific article published on 24 May 2016

Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines

scientific article

Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies

scientific article

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents

scientific article published in January 2004

Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target

scientific article published on June 2005

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils

scientific article published on 01 June 2011

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

scientific article

Rational design of the first difluorostatone-based PfSUB1 inhibitors

scientific article published on 23 May 2014

Retraction notice to “PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines” [Eur. J. Pharmacol. 714(1–3) (2013) 379–387]

scientific article published on 01 April 2014

Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

scientific article

Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants

scientific article

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

scientific article

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity

scientific article published in November 2005

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

scientific article published in July 2005

Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations

scientific article published in February 2009

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

scientific article published in June 2009

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

scientific article published on 24 April 2017

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

scientific article published on 7 May 2015

Synthesis and Antiplasmodial Activity of Bicyclic Dioxanes as Simplified Dihydroplakortin Analogues

scientific article published on 29 July 2011

Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors

scientific article published in August 2003

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds

scientific article published on 8 February 2013

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

scientific article published on 4 August 2006

Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues

scientific article published in April 2010

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

Tacrine based human cholinesterase inhibitors: Synthesis of peptidic-tethered derivatives and their effect on potency and selectivity

scientific article published on 26 August 2008

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors

scientific article

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies

scientific article published on 7 November 2014

The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional

scientific article published on 13 September 2011

The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity

scientific article published on 11 September 2017

The Structural Evolution of &#946;-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors ⬇️

scientific article published on January 1, 2013

The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium

scientific article published on January 2010

The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.

scientific article published on 17 February 2016

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.

scientific article

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.

scientific article published on 6 January 2014

The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia

scientific article published on 13 October 2009

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells

scientific article published on 12 May 2016

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents.

scientific article published on 8 August 2015

List of works by Stefania Butini

(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation

1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators

A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents

A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles

A Straightforward Approach for Engineering Efficacy and Selectivity at GPCRs

A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin

A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring

A stereoselective approach to peptidomimetic BACE1 inhibitors.

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides

Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation.

Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders

An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity

Author Correction: The FAAH inhibitor URB597 suppresses hippocampal maximal dentate afterdischarges and restores seizure-induced impairment of short and long-term synaptic plasticity.

Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas

Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials

Computational Tool for Fast in silico Evaluation of hERG K+ Channel Affinity

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore

Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors

Development of a practical and scalable route for the preparation of the deacetoxytubuvaline (dTuv) fragment of pretubulysin and analogs

Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors

Development of novel cyclic peptides as pro-apoptotic agents

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

Discovery of Huperzine A−Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Midgorge Recognition Sites

Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior

Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation

Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats

Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors

Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum

HCV-targeted antivirals: current status and future challenges

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties

Identification of novel fluorescent probes preventing PrPSc replication in prion diseases

In Silico Analysis of Peptide-Based Derivatives Containing Bifunctional Warheads Engaging Prime and Non-Prime Subsites to Covalent Binding SARS-CoV-2 Main Protease (Mpro)

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines

Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells

Malaria chemotherapy: recent advances in drug development

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia

Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies

Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization

Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling

PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines.

PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors

Polycondensed heterocycles. Part 12: An approach to the synthesis of 2-acetyl-1′-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4′-pyrrolidine]-2′-one

Polypharmacology of dopamine receptor ligands.

Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines

Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents

Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Rational design of the first difluorostatone-based PfSUB1 inhibitors

The Structural Evolution of β-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors ⬇️