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List of works by Giuseppe Saglio

5'UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

scientific article published on 18 January 2017

7q-and loss of a polymorphism for the met oncogene in a patient with myelofibrosis

scientific article published on 01 October 1987

A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocation

scientific article

A Clinically Applicable Approach to the Classification of B-Cell Non-Hodgkin Lymphomas with Flow Cytometry and Machine Learning

scientific article published on 24 June 2020

A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics

scientific article

A Retrospective Analysis about Frequency of Monitoring in Italian Chronic Myeloid Leukemia Patients after Discontinuation

scientific article published on 17 November 2020

A comparative study of myocardial molecular phenotypes of two tfr2β null mice: role in ischemia/reperfusion

article

A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): analysis of the GIMEMA 0496 protocol

scientific article published on 13 January 2005

A fourth case of BCR-FGFR1 positive CML-like disease with t(8;22) translocation showing an extensive deletion on the derivative chromosome 8p

scientific article published on 01 January 2002

A frequent A gamma-hereditary persistence of fetal hemoglobin in northern Sardinia: its molecular basis and hematologic phenotype in heterozygotes and compound heterozygotes with beta-thalassemia.

scientific article published in May 1988

A large-scale study of bone marrow involvement in patients with Hodgkin's lymphoma

scientific article published on 01 June 2004

A new BCR-ABL1 Drosophila model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia

article

A new HPLC-UV validated method for therapeutic drug monitoring of tyrosine kinase inhibitors in leukemic patients.

scientific article

A newly-characterized alpha-thalassaemia-1 deletion removes the entire alpha-like globin gene cluster in an Italian family

scientific article published on 01 August 1991

A novel assay to detect calreticulin mutations in myeloproliferative neoplasms.

scientific article published on 23 December 2016

A novel type of c-myc translocation in a T lymphoma cell line

scientific article published on 01 January 1987

A randomized study of interferon-alpha versus interferon-alpha and low-dose arabinosyl cytosine in chronic myeloid leukemia

scientific article published in March 2002

A young man with persistent eosinophilia

scientific article published on 01 June 2007

ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party o

article by Simona Soverini et al published 20 June 2005 in Journal of Clinical Oncology

AIDS-related Burkitt's lymphoma. Morphologic and immunophenotypic study of biopsy specimens.

scientific article published in May 1995

AIDS-related non-Hodgkin's lymphomas: molecular genetics, viral infection and cytokine deregulation.

scientific article published on January 1996

Aberrant activation of ROS1 represents a new molecular defect in chronic myelomonocytic leukemia

scientific article

Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia.

scientific article published in February 2004

Achieving a major molecular response at the time of a complete cytogenetic response (CCgR) predicts a better duration of CCgR in imatinib-treated chronic myeloid leukemia patients.

scientific article

Acute myeloid leukemia induced by mitoxantrone treatment for aggressive multiple sclerosis.

scientific article published in June 2008

Additional chromosomal abnormalities in Philadelphia-positive clone: adverse prognostic influence on frontline imatinib therapy: a GIMEMA Working Party on CML analysis.

scientific article

Adherence to BCR-ABL inhibitors: issues for CML therapy

scientific article published on 24 May 2012

Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol

scientific article published on 22 September 2005

Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop

scientific article published on 10 December 2012

Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias

scientific article published on 16 September 2011

Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis

scientific article

Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches

scientific article published on 01 June 2007

Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues.

scientific article published in January 1991

Analysis of human herpesvirus type 8 infection in AIDS-related and AIDS-unrelated primary central nervous system lymphoma

scientific article published on 01 May 1997

Analysis of microsatellite instability in chronic lymphoproliferative disorders

scientific article published on 01 February 1996

Analysis of the gamma chains in a homozygote for HPFH Negro type and in three related heterozygotes

scientific article published on 01 January 1980

Assessment of minimal residual disease (MRD) in CBFbeta/MYH11-positive acute myeloid leukemias by qualitative and quantitative RT-PCR amplification of fusion transcripts

scientific article published on 01 June 2002

Association between imatinib transporters and metabolizing enzymes genotype and response in newly diagnosed chronic myeloid leukemia patients receiving imatinib therapy

scientific article published on 8 August 2012

Association of the hOCT1/ABCB1 genotype with efficacy and tolerability of imatinib in patients affected by chronic myeloid leukemia.

scientific article

BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP.

scientific article

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.

scientific article published on January 2015

BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet

scientific article published on 11 May 2011

BCR-ABL nuclear entrapment kills human CML cells: ex vivo study on 35 patients with the combination of imatinib mesylate and leptomycin B.

scientific article published on 25 October 2005

BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia.

scientific article

BCR-ABL1 mutation development during first-line treatment with dasatinib or imatinib for chronic myeloid leukemia in chronic phase

scientific article

BCR-ABL1 mutation ≠ ponatinib resistance

scientific article published in February 2016

BCR/ABL rearrangement and leukemia phenotype

scientific article published on 01 April 1999

BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias.

scientific article published on June 2012

Bcl-6 p53 mutations in lymphomas carrying the bcl-2/Jh rearrangement.

scientific article published in September 2002

Bcl-xL represents a therapeutic target in Philadelphia negative myeloproliferative neoplasms

scientific article published on 13 August 2020

Beyond the comfort zone of deep molecular response: discontinuation in major molecular response chronic myeloid leukemia

scientific article published on 04 June 2019

Biological determinants of long-term survival in chronic myelogenous leukemia patients treated with conventional chemotherapy

scientific article published on 01 January 1997

Bone marrow microenvironment: The guardian of leukemia stem cells

scientific article published on 01 August 2019

CALR-positive myeloproliferative disorder in a patient with Ph-positive chronic myeloid leukemia in durable treatment-free remission: a case report

scientific article

CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536

scientific article published on 22 March 2007

CML: a model for targeted therapy.

scientific article published on September 2009

Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience

scientific article

Can we and should we improve on frontline imatinib therapy for chronic myeloid leukemia?

scientific article published on October 2010

Cardiovascular and pulmonary adverse events in patients treated with BCR-ABL inhibitors: Data from the FDA Adverse Event Reporting System

scientific article

Characterization of a monoclonal antibody specific for novel Bcr/Abl out-of-frame fusion proteins.

scientific article published on June 2011

Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements.

scientific article published on 3 May 2007

Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control

scientific article

Children and Adolescents with Chronic Myeloproliferative Neoplasms: Still an Unmet Biological and Clinical Need?

scientific article published on 01 August 2019

Chromosome abnormalities involving heterochromatic regions in monocytic leukemia

scientific article published on 01 May 1990

Chronic Myeloproliferative Neoplasms: Some Remaining Challenges

scientific article published on 02 October 2018

Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders

scientific article

Chronic myeloid leukemia in blast crisis treated with imatinib 600 mg: outcome of the patients alive after a 6-year follow-up

scientific article published on 06 October 2008

Chronic myeloid leukemia management at the time of the COVID-19 pandemic in Italy. A campus CML survey

scientific article published on 18 June 2020

Chronic myeloid leukemia stem cells

scientific article published on 24 May 2019

Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet

scientific article

Chronic myeloid leukemia: reminiscences and dreams

scientific article

Chronic myeloid leukemia: room for improvement?

scientific article published on July 2017

Chronic myeloid leukemia: state of the art in 2012.

scientific article published on October 2012

Chronic neutrophilic leukaemia associated with polycythemia vera: pathogenetic implications and therapeutic approach

scientific article published on 01 June 1991

Chronic phase chronic myeloid leukemia patients with low OCT-1 activity randomized to high-dose imatinib achieve better responses and have lower failure rates than those randomized to standard-dose imatinib

scientific article

Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial

scientific article published on 29 March 2014

Clinical and haematological data in 254 cases of beta-thalassaemia trait in Italy

scientific article published on May 1, 1976

Clinical significance of TFR2 and EPOR expression in bone marrow cells in myelodysplastic syndromes

scientific article published on 23 February 2016

Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4 and of the BCR/ABL fusion genes correlates with a significantly better clinical outcome

scientific article

Clone wars: co-occurrence of IDH2 R140Q and R172K in myelodysplastic syndromes

scientific article published on 04 February 2020

Common-variable immunodeficiency-related lymphomas associate with mutations and rearrangements of BCL-6: Pathogenetic and histogenetic implications

scientific article published in July 2000

Comparison between patients with Philadelphia-positive chronic phase chronic myeloid leukemia who obtained a complete cytogenetic response within 1 year of imatinib therapy and those who achieved such a response after 12 months of treatment

scientific article published in January 2006

Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

scientific article published on 23 February 2010

Comparison of imatinib 400 mg and 800 mg daily in the front-line treatment of high-risk, Philadelphia-positive chronic myeloid leukemia: a European LeukemiaNet Study

scientific article

Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia

scientific article published on 24 May 2012

Considerations for Treatment-free Remission in Patients With Chronic Myeloid Leukemia: A Joint Patient-Physician Perspective.

scientific article

Contemporary insights into the pathogenesis and treatment of chronic myeloproliferative neoplasms

scientific article published on 31 May 2016

Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia

article by Simona Soverini et al published 15 December 2006 in Clinical Cancer Research

Conventional and novel tools for defining the risk of the individual patient with chronic myeloid leukemia and for monitoring treatment

scientific article published on 01 January 2004

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

scientific article published on 29 January 2019

Correction: A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics

scientific article published on 16 February 2017

Current management of CML patients: Summary of the Italian Consensus Meeting held in Rome, April 11-12, 2013.

scientific article published on 17 December 2013

Current pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms

scientific article published on May 2014

Cytogenetic and molecular analyses in Philadelphia chromosome positive acute lymphoblastic leukaemia

scientific article published on 01 July 1988

Cytogenetic and molecular studies in patients with chronic myeloid leukemia and variant Philadelphia translocations

scientific article published on 01 October 1989

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

scientific article

Dasatinib dose management for the treatment of chronic myeloid leukemia

scientific article published on 25 January 2018

Dasatinib first-line: Multicentric Italian experience outside clinical trials

scientific article

Dasatinib in imatinib-resistant or -intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034.

scientific article published on 19 May 2016

Dasatinib in imatinib-resistant or imatinib-intolerant chronic myeloid leukemia in blast phase after 2 years of follow-up in a phase 3 study: efficacy and tolerability of 140 milligrams once daily and 70 milligrams twice daily

scientific article published on August 2010

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis

scientific article published on 21 December 2006

Dasatinib vs. imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) who have not achieved an optimal response to 3 months of imatinib therapy: the DASCERN randomized study

scientific article published on 07 April 2020

De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways

scientific article published on 28 February 2019

Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

scientific article

Deferasirox treatment improved the hemoglobin level and decreased transfusion requirements in four patients with the myelodysplastic syndrome and primary myelofibrosis.

scientific article published on October 2008

Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

scientific article published on 16 October 2020

Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet

scientific article published on 16 April 2012

Deletions of the derivative chromosome 9 do not influence the response and the outcome of chronic myeloid leukemia in early chronic phase treated with imatinib mesylate: GIMEMA CML Working Party analysis

scientific article published on 3 May 2010

Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib

scientific article published on 23 April 2004

Design and application of a novel PNA probe for the detection at single cell level of JAK2V617F mutation in Myeloproliferative Neoplasms.

scientific article

Desirable performance characteristics for BCR-ABL measurement on an international reporting scale to allow consistent interpretation of individual patient response and comparison of response rates between clinical trials.

scientific article published on 6 August 2008

Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

scientific article published on 3 July 2015

Detection of Humoral Immune Responses against WT1 Antigen in Patients Affected by Different Hematological Malignancies

scientific article published in 2008

Detection of Ph1-positive acute lymphoblastic leukaemia by PCR. GIMEMA Cooperative Study Group

scientific article published on 01 October 1991

Detection of minimal residual disease in peripheral blood stem cells from two acute myeloid leukemia patients with trisomy 8 predicts early relapse after autologous bone marrow transplantation

scientific article published on 01 February 2002

Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale

scientific article published on 25 April 2016

Development of cellular and humoral response against WT1 protein vaccination in mice

scientific article published on 19 June 2015

Differences among young adults, adults and elderly chronic myeloid leukemia patients.

scientific article published on 30 October 2014

Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.

scientific article published on 17 September 2009

Digital PCR in Myeloid Malignancies: Ready to Replace Quantitative PCR? ⬇️

scientific article published on 07 May 2019

Distribution of Ha-RAS-1 proto-oncogene alleles in breast cancer patients and in a control population

scientific article published on 01 May 1988

Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain

article

Distribution of TP53 mutations among acute leukemias with MLL rearrangements

scientific article published on 01 January 1996

Down-modulation of the C/EBPalpha transcription factor in core binding factor acute myeloid leukemias

scientific article published on 01 October 2003

Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case.

scientific article

Durable treatment-free remission in patients with chronic myeloid leukemia in chronic phase following frontline nilotinib: 96-week update of the ENESTfreedom study

scientific article published on 22 February 2018

E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features

scientific article published on 01 February 2003

Early BCR-ABL1 Reduction Is Predictive of Better Event-free Survival in Patients With Newly Diagnosed Chronic Myeloid Leukemia Treated With Any Tyrosine Kinase Inhibitor

scientific article published on April 2016

Early molecular response predicts outcomes in patients with chronic myeloid leukemia in chronic phase treated with frontline nilotinib or imatinib

scientific article

Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy

scientific article

Early response does not predict outcome in children and adolescents with chronic myeloid leukaemia treated with high-dose imatinib.

scientific article

Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION).

scientific article

Effect of IFN alpha therapy on secondary Ph1-positive clones

scientific article published on 01 July 1992

Effect of recombinant human IL-3 on the mitotic index and karyotype of hemopoietic cells

scientific article published on 01 September 1991

Effects of erythropoiesis-stimulating agents on overall survival of IPSS low/INT-1 risk, transfusion independent myelodysplastic syndrome patients: a cohort study

scholarly article by Emanuela Messa et al published 3 August 2018 in Haematologica

Electrophoretic separation of A gamma and G gamma human globin chains in Nonidet P-40

scientific article published on 01 November 1979

Emerging drugs for chronic myeloid leukemia

scientific article

Emerging targets for hematological malignancies

scientific article published on September 1, 2010

Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms

scientific article published on 20 June 2019

Epha3 acts as proangiogenic factor in multiple myeloma

scientific article published on 10 March 2017

Erratum: Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up

scholarly article published in Leukemia

Erythroid response and decrease of WT1 expression after proteasome inhibition by bortezomib in myelodysplastic syndromes

scientific article

Erythroid response during iron chelation therapy in a cohort of patients affected by hematologic malignancies and aplastic anemia with transfusion requirement and iron overload: a FISM Italian multicenter retrospective study.

scientific article published on 9 May 2017

Establishment of the first World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA.

scientific article published on 18 August 2010

European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.

scientific article published on 26 June 2013

Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program.

scientific article

Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios.

scientific article

Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

scientific article

Expert opinion-management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors

scientific article published on 04 May 2020

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance

scientific article

Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells

scientific article published on 15 March 2018

Extranodal Hodgkin lymphoma with renal, splenic and uterine involvement. A case report

scientific article published on 01 January 2002

FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells

scientific article published in December 2009

False-positive results with PCR to detect leukaemia-specific transcript.

scientific article published in April 1990

Fetal diagnosis of beta-thalassaemia by DNA analysis in Italy

scientific article published on 01 February 1986

Fetal haemoglobin synthesis following fetal liver transplantation in man

scientific article published on 01 December 1983

Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial

scientific article published on 23 May 2016

First-line imatinib vs second- and third-generation TKIs for chronic-phase CML: a systematic review and meta-analysis

scientific article published on 01 June 2020

First-line therapy for chronic myeloid leukemia: new horizons and an update

scientific article published on June 2010

First-line therapy for chronic phase CML: selecting the optimal BCR-ABL1-targeted TKI.

scientific article published on 3 October 2017

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

scientific article (publication date: 7 December 2006)

Frequency and distribution of trisomy 11 in multiple myeloma patients: relation with overexpression of CCND1 and t(11;14).

scientific article published in February 2007

From genes to therapy: the case of Philadelphia chromosome-positive leukemias.

scientific article

Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5-year outcome

scientific article published on 26 March 2008

Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party

article by Gabriele Gugliotta et al published 26 May 2011 in Blood

Frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the European ENEST1st study.

scientific article

G gamma and a gamma globin chain synthesis in bone marrow and peripheral blood of beta-thalassaemia homozygotes

scientific article published on 01 October 1982

Genetic abnormalities as targets for molecular therapies in myelodysplastic syndromes

scientific article

Genetic analysis of chromosome 13 deletions in BCR/ABL negative chronic myeloproliferative disorders

scientific article published on 01 October 1995

Genetic analysis of p53 and RB1 tumor-suppressor genes in blast crisis of chronic myeloid leukemia

scientific article published on 01 January 1994

Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations ofBCL6: Implications for disease pathogenesis and histogenesis

scientific article published in January 1999

Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia

Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia

scientific article published in August 1997

Gγ and Aγ globin chains separation and quantitation by isoelectric focusing ⬇️

scientific article published on March 15, 1979

HAUSP compartmentalization in chronic myeloid leukemia.

scientific article

HHV8-positive, HIV-negative multicentric Castleman's disease: early and sustained complete remission with rituximab therapy without reactivation of Kaposi sarcoma.

scientific article

HPLC-MS method for the simultaneous quantification of the antileukemia drugs imatinib, dasatinib and nilotinib in human peripheral blood mononuclear cell (PBMC)

scientific article published on 14 October 2011

Haplotype distribution and molecular defects at the phenylalanine hydroxylase locus in Italy.

scientific article

Haplotype distribution and molecular defects of PKU in Italy

scientific article published on 01 January 1990

Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories

scientific article published on 18 October 2007

Harmonization of molecular monitoring of CML therapy in Europe

scientific article published on 27 August 2009

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

scientific article published in February 2002

Hematopoietic growth factors in autologous transplantation

scientific article published on 01 January 1998

Herpetic leg paralysis and abdominal ileus in a patient with idiopathic myelofibrosis

scientific article published on 16 July 2008

Heterogeneity of delta, beta-thalassemia and hereditary persistence of Hb F in the Mediterranean area

scientific article published on 01 January 1985

Highly Sensitive Detection of IDH2 Mutations in Acute Myeloid Leukemia

scientific article published on 19 January 2020

Human T gamma globin chain is a variant of A gamma chain (A gamma Sardinia) ⬇️

scientific article published on July 1, 1979

IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report

scientific article

Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute

scientific article

Identification of a novel mutation in the L ferritin iron-responsive element causing hereditary hyperferritinemia-cataract syndrome

scientific article published on 29 October 2009

Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method

article published in 2008

Identifying and addressing unmet clinical needs in Ph-neg classical myeloproliferative neoplasms: a consensus-based SIE, SIES, GITMO position paper

scientific article published on 19 September 2013

Identifying the time to change BCR-ABL inhibitor therapy in patients with chronic myeloid leukemia.

scientific article published on 15 August 2013

Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies

scientific article published on 27 June 2020

Imatinib and pegylated human recombinant interferon-alpha2b in early chronic-phase chronic myeloid leukemia

scientific article

Imatinib and polypharmacy in very old patients with chronic myeloid leukemia: effects on response rate, toxicity and outcome

scientific article published on 27 August 2016

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

scientific article

Imatinib mesylate in the treatment of c-kit-positive acute myeloid leukemia: is this the real target?

scientific article published in January 2005

Imatinib mesylate in the treatment of newly diagnosed or refractory/resistant c-KIT positive acute myeloid leukemia. Results of an Italian Multicentric Phase II Study

scientific article published in December 2007

Immunoglobulin DNA Analysis as a Marker of Clonality in the Follow-up of Patients with Hairy Cell Leukemia Treated with Alpha-Interferon

scientific article published on 01 January 1990

Immunoglobulin gene rearrangements in human multiple myeloma

scientific article published on 01 November 1989

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

scientific article published on 23 May 2006

Immunologic evaluation of peptides derived from BCR/ABL-out-of-frame fusion protein in HLA A2.1 transgenic mice

scientific article

Impact of age on the outcome of patients with chronic myeloid leukemia in late chronic phase: results of a phase II study of the GIMEMA CML Working Party

scientific article published on 01 January 2007

Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase

scientific article published on 03 August 2009

In chronic myeloid leukemia patients on second-line tyrosine kinase inhibitor therapy, deep sequencing of BCR-ABL1 at the time of warning may allow sensitive detection of emerging drug-resistant mutants

scientific article

Incidence and significance of cryptic chromosome aberrations detected by fluorescence in situ hybridization in acute myeloid leukemia with normal karyotype.

scientific article published in September 2002

Incidence of second primary malignancies and related mortality in patients with imatinib-treated chronic myeloid leukemia

scientific article

Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid

scientific article published in July 2005

Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations

scientific article

Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome.

scientific article

Influence of additional cytogenetic abnormalities on the response and survival in late chronic phase chronic myeloid leukemia patients treated with imatinib: long-term results

scientific article published in January 2009

Inhibition of bromodomain and extra-terminal proteins increases sensitivity to venetoclax in chronic lymphocytic leukaemia

scientific article published on 10 December 2019

Inhibition of c-myc expression induced by 4-hydroxynonenal, a product of lipid peroxidation, in the HL-60 human leukemic cell line.

scientific article published on August 1994

Inhibition of stromal cell-derived factor-1/CXCR4 axis for the cure of BCR-ABL positive chronic myeloid leukemia.

scientific article published on October 2009

Initial molecular response at 3 months may predict both response and event-free survival at 24 months in imatinib-resistant or -intolerant patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase treated with nilotini

scientific article published on 29 October 2012

Insertions generating the 5'RUNX1/3'CBFA2T1 gene in acute myeloid leukemia cases show variable breakpoints

scientific article published in September 2004

Interferon-alpha plus low-dose cytosine arabinoside in advanced phase chronic myelogenous leukaemia patients

scientific article published on 01 September 1995

Interstitial deletions at the long arm of chromosome 13 may be as common as monosomies in multiple myeloma. A genotypic study

scientific article published in August 2002

Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia.

scientific article

Iron chelation therapy in myelodysplastic syndromes.

scientific article

Iron overload alters the energy metabolism in patients with myelodysplastic syndromes: results from the multicenter FISM BIOFER study

scientific article published on 08 June 2020

Isochromosome 6p and deletion of 6q characterize two related cytogenetic clones in a patient with immunoblastic lymphoma.

scientific article published on June 1995

Isolated molecular relapse in FIP1L1-PDGFRalpha hypereosinophilic syndrome after discontinuation and single weekly dose of imatinib: need of quantitative molecular procedures to modulate imatinib dose

scientific article

IκB-α: At the crossroad between oncogenic and tumor-suppressive signals.

scientific article published on 6 December 2016

JAK2 V617F mutation in leukaemic transformation of philadelphia-negative chronic myeloproliferative disorders

scientific article published on 4 September 2006

Kaposi's sarcoma-associated herpesvirus DNA sequences in AIDS-related and AIDS-unrelated lymphomatous effusions

scientific article published on 01 September 1996

Karyotypic analysis of gastric carcinoma cell lines carrying an amplified c-met oncogene.

scientific article published on December 1992

Kinase-inhibitor-insensitive cancer stem cells in chronic myeloid leukemia

scientific article published on 03 January 2014

Laboratory recommendations for scoring deep molecular responses following treatment for chronic myeloid leukemia.

scientific article published on 5 February 2015

Lenalidomide, melphalan, and prednisone association is an effective salvage therapy in relapsed plasma cell leukaemia

scientific article published on January 2009

Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial

scientific article published on 3 February 2016

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

scholarly article by Oliver Ottmann et al published 3 September 2018 in Blood Cancer Journal

Long-term outcome of a phase 2 trial with nilotinib 400 mg twice daily in first-line treatment of chronic myeloid leukemia

scientific article published on 25 June 2015

Long-term outcome of chronic myeloid leukemia patients treated frontline with imatinib.

scientific article published on 19 June 2015

Long-term outcome of complete cytogenetic responders after imatinib 400 mg in late chronic phase, philadelphia-positive chronic myeloid leukemia: the GIMEMA Working Party on CML.

scientific article published in January 2008

Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study

scientific article published on 25 February 2014

Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis

scientific article published on 07 January 2021

Long-term results of high-dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: the Italian experience

scientific article

Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia

scientific article published on 13 February 2007

Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity

scientific article published on 21 March 2016

MLL-AF6 fusion resulting from a new three-way translocation t(6;11;7) in a patient with acute myeloid leukemia

scientific article published on 01 October 2001

Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP

scientific article published on 01 December 2019

Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex

scientific article published on 29 November 2016

Microsatellite instability in KSHV/HHV-8 positive body-cavity-based lymphoma

scientific article published on 01 June 1997

Milestones and monitoring

scientific article published on June 2015

Mimicking the Acute Myeloid Leukemia Niche for Molecular Study and Drug Screening

scientific article published on 22 December 2016

Minimal residual disease in B-lymphoproliferative disorders by PCR detection of immunoglobulin heavy chain gene recombination

scientific article published on 01 October 1997

Modeling myeloproliferative neoplasms: From mutations to mouse models and back again

scientific article published on 24 November 2016

Molecular and cytogenetic studies of a patient with Philadelphia-negative, BCR-positive chronic myeloid leukemia and t(12;12)(q13;p12)

scientific article published on 01 March 1990

Molecular characterization of Ph' + hybrid acute leukemia

scientific article published on 01 January 1989

Molecular defects associated with the acute phase CML.

scientific article

Molecular evidence of transient complete remission after autografting in Ph-/bcr rearranged chronic myelogenous leukaemia

scientific article published on 01 June 1989

Molecular heterogeneity of B-lineage diffuse large cell lymphoma

scientific article published on 01 May 1996

Molecular monitoring in patients with chronic myelogenous leukemia

scientific article published in April 2008

Molecular pathways: BCR-ABL.

scientific article published on 08 December 2011

Molecular response to imatinib in late chronic-phase chronic myeloid leukemia

scientific article

Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results

scientific article published on 7 March 2006

Monitoring minimal residual disease and controlling drug resistance in chronic myeloid leukaemia patients in treatment with imatinib as a guide to clinical management

scientific article published on December 2006

Monitoring treatment of chronic myeloid leukemia

scientific article

Morgana acts as an oncosuppressor in chronic myeloid leukemia.

scientific article published on 12 February 2015

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

scholarly article by Robert J Kreitman et al published August 2018 in Leukemia

Myelodysplastic Syndromes

scientific article published in December 2004

NF-kB inhibition as a strategy to enhance etoposide-induced apoptosis in K562 cell line.

scientific article published on December 2006

NPM1 deletion is associated with gross chromosomal rearrangements in leukemia

scientific article (publication date: 21 September 2010)

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

scientific article

Nanocarriers as Magic Bullets in the Treatment of Leukemia

scientific article published on 06 February 2020

Neutrophilic-chronic myeloid leukemia

Neutrophilic-chronic myeloid leukemia: low levels of p230 BCR/ABL mRNA and undetectable BCR/ABL protein may predict an indolent course

scientific article

New HPLC-MS method for the simultaneous quantification of the antileukemia drugs imatinib, dasatinib, and nilotinib in human plasma.

scientific article published on 24 April 2009

New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia.

scientific article published on 11 November 2015

New therapeutic approaches and prognostic factors in chronic myeloid leukemia.

scientific article published on April 2008

Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper

scientific article published on 05 December 2019

Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia

scientific article

Nilotinib 300 mg twice daily: an academic single-arm study of newly diagnosed chronic phase chronic myeloid leukemia patients

scientific article published on 28 July 2016

Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemia

scientific article published on 12 October 2009

Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.

scientific article

Nilotinib in the treatment of chronic myeloid leukemia

scientific article published on 14 December 2018

Nilotinib is associated with a reduced incidence of BCR-ABL mutations vs imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase

scientific article published on 15 March 2013

Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results

scientific article published on 22 November 2010

Nilotinib is superior to imatinib as first-line therapy of chronic myeloid leukemia: the ENESTnd study.

scientific article published on 9 November 2010

Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia

scientific article

Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial

scientific article published on 17 August 2011

Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up.

scientific article

Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion

scientific article

Novel Multiplex Droplet Digital PCR Assays to Monitor Minimal Residual Disease in Chronic Myeloid Leukemia Patients Showing Atypical BCR-ABL1 Transcripts

scientific article published on 13 May 2020

Novel insights into the biology and treatment of chronic myeloproliferative neoplasms

scientific article

Novel types of bcr-abl transcript with breakpoints in BCR exon 8 found in Philadelphia positive patients with typical chronic myeloid leukemia retain the sequence encoding for the DBL- and CDC24 homology domains but not the pleckstrin homology one

scientific article published on 01 July 2002

Nuclear factor kB as a target for new drug development in myeloid malignancies

scientific article

Observational study of chronic myeloid leukemia Italian patients who discontinued tyrosine kinase inhibitors in clinical practice

scientific article published on 28 February 2019

Occurrence of the same chromosome abnormalities in Ph+ and Ph- cells in chronic myeloid leukaemia. Evidence of a secondary origin of the Ph chromosome?

scientific article published on 04 September 2006

Off-target effects of BCR-ABL1 inhibitors and their potential long-term implications in patients with chronic myeloid leukemia

scientific article

Out of frame peptides from BCR/ABL alternative splicing are immunogenic in HLA A2.1 transgenic mice.

scientific article

P230 BCR/ABL protein may be associated with an acute leukaemia phenotype

scientific article published on 01 December 1998

PML targeting eradicates quiescent leukaemia-initiating cells

scientific article

Patterns of cytokine expression in AIDS-related non-Hodgkin's lymphoma

article

Persistence of E2A/PBX1 transcripts in t(1;19) childhood acute lymphoblastic leukemia: correlation with chemotherapy intensity and clinical outcome.

scientific article published in May 1996

Phase 3 study of nilotinib vs imatinib in Chinese patients with newly diagnosed chronic myeloid leukemia in chronic phase: ENESTchina

scientific article published on 12 March 2015

Philadelphia-positive acute lymphoblastic leukemia with multiple subclones including duplication of the Philadelphia chromosome and Abelson oncogene

scientific article published on 01 January 2002

Plasma and intracellular imatinib concentrations in patients with chronic myeloid leukemia.

scientific article published on June 2014

Pleural effusion and molecular response in dasatinib-treated chronic myeloid leukemia patients in a real-life Italian multicenter series

scientific article published on 2 October 2017

Point mutations of the BCL-6 gene in Burkitt's lymphoma.

scientific article published on October 1997

Point: Is there a best duration of deep molecular response to achieve therapy-free remission in chronic myeloid leukaemia?

scientific article published on 10 November 2020

Polyclonal haemopoieses associated with long-term persistence of the AML1-ETO transcript in patients with FAB M2 acute myeloid leukaemia in continous clinical remission

scientific article published on 01 June 1995

Polymorphism of human fetal haemoglobin studied by isoelectric focusing

scientific article published on 01 June 1980

Polymorphism of human gamma-globin genes in Mediterranean populations

scientific article published on 01 November 1979

Ponatinib for chronic myeloid leukaemia: future perspectives

scientific article published on 12 April 2016

Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase

scientific article published on 30 December 2011

Practical advice for determining the role of BCR-ABL mutations in guiding tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia

scientific article

Practical monitoring of chronic myelogenous leukemia: when to change treatment

scientific article published on January 2012

Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms

scientific article published on 03 August 2018

Precision tyrosine kinase inhibitor dosing in chronic myeloid leukemia?

scholarly article by Giuseppe Saglio et al published May 2019 in Haematologica

Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance.

scientific article

Prediction of response to imatinib by prospective quantitation of BCR-ABL transcript in late chronic phase chronic myeloid leukemia patients

scientific article published on 10 January 2006

Preferential clustering of chromosomal breakpoints in Burkitt's lymphomas and L3 type acute lymphoblastic leukemias with a t(8;14) translocation

scientific article published on 01 September 1993

Preferential induction of fetal versus embryonic globin chains in human leukemic cell lines ⬇️

scientific article published on January 1, 1982

Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia

scientific article published on 01 November 2006

Present results and future perspectives in optimizing chronic myeloid leukemia therapy

scientific article published on 01 June 2018

Previous thalidomide therapy may not affect lenalidomide response and outcome in relapse or refractory multiple myeloma patients

scientific article published on 18 February 2011

Primitive hematopoietic stem cells shows a polyclonal pattern in myelodysplastic syndromes

scientific article published on 01 January 2004

Proceedings of the Third Global Workshop on Chronic Myeloid Leukemia

scientific article published on December 2010

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

scientific article published on 27 May 2008

Prognostic relevance of cytometric quantitative assessment in patients with myelodysplastic syndromes

scientific article published on 11 August 2011

Prognostic significance of The Wilms' Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia

scientific article

Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study

scientific article published on 01 February 2020

Prospects for achieving treatment-free remission in chronic myeloid leukaemia

scientific article published on 14 February 2020

Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias

scientific article

Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients

scientific article published on 01 October 2002

Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid leukemia

scientific article published on 17 September 2008

Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.

scientific article

RBC-transfusion guidelines update

scientific article published on 14 February 2012

Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia

scientific article

Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis.

scientific article published on 5 March 2013

Rational approaches to the design of therapeutics targeting molecular markers: the case of chronic myelogenous leukemia

scientific article

Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.

scientific article

Rearrangements of bcl-6, bcl-2, c-myc and 6q deletion in B-diffuse large-cell lymphoma: Clinical relevance in 71 patients

scientific article published in January 1998

Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.

scientific article published on 14 February 2018

Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.

scientific article published on 24 October 2014

Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells

scientific article published on 04 July 2019

Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study

scientific article

Renal Hodgkin's disease.

scientific article published in March 2002

Repeated PCR in CML during IFN-alpha therapy

scientific article published on 01 March 1994

Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain

scientific article published on 01 March 2007

Results and outcome of intermittent imatinib (ON/OFF schedule) in children and adolescents with chronic myeloid leukaemia

scientific article published on 22 February 2020

Results of high-dose imatinib mesylate in intermediate Sokal risk chronic myeloid leukemia patients in early chronic phase: a phase 2 trial of the GIMEMA CML Working Party

scientific article published on 11 February 2009

Retrospective comparison of qualitative and quantitative reverse transcriptase polymerase chain reaction in diagnosing and monitoring the ALL1-AF4 fusion transcript in patients with acute lymphoblastic leukaemia

scientific article published on 01 November 2004

Risk and early cytogenetic response to imatinib and interferon in chronic myeloid leukemia

scientific article published in March 2003

Rotation of nilotinib and imatinib for first-line treatment of chronic phase chronic myeloid leukemia

scientific article published on 11 March 2016

SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia

scientific article

Safety and efficacy of switching to nilotinib 400 mg twice daily for patients with chronic myeloid leukemia in chronic phase with suboptimal response or failure on front-line imatinib or nilotinib 300 mg twice daily

scientific article published on 14 February 2014

Second-generation tyrosine kinase inhibitors can induce complete molecular response in Ph-positive acute lymphoblastic leukemia after allogeneic stem cell transplant.

scientific article

Second-generation tyrosine kinase inhibitors: the future of frontline CML therapy

scientific article published on 09 February 2011

Selective strong synergism of Ruxolitinib and second generation tyrosine kinase inhibitors to overcome bone marrow stroma related drug resistance in chronic myelogenous leukemia

scientific article published on 15 November 2013

Sensitive Replicate Real-Time Quantitative PCR of BCR-ABL Shows Deep Molecular Responses in Long-Term Post-Allogeneic Stem Cell Transplantation Chronic Myeloid Leukemia Patients.

scientific article published on 4 July 2015

Sensitive quantitation of minimal residual disease in chronic myeloid leukemia using nanofluidic digital polymerase chain reaction assay.

scientific article published on 21 February 2011

Sensitivity to imatinib therapy may be predicted by testing Wilms tumor gene expression and colony growth after a short in vitro incubation.

scientific article published in September 2004

Significance of a new type of human fetal hemoglobin carrying a replacement isoleucine replaced by threonine at position 75 )E 19) of the gamma chain

scientific article published on 01 June 1976

Significance of the Philadelphia chromosome in acute leukemias: variable correlation with rearrangements involving the c-abl and bcr genes

scientific article published on 01 January 1987

Significant correlation between the degree of WT1 expression and the International Prognostic Scoring System Score in patients with myelodysplastic syndromes

scientific article published in May 2003

Significant reduction of the hybrid BCR/ABL transcripts after induction and consolidation therapy is a powerful predictor of treatment response in adult Philadelphia-positive acute lymphoblastic leukemia.

scientific article published in April 2005

Soluble factor(s) released by the PF-382 T-cell line enhances the stimulatory effect of monocytes on the BFU-E growth

scientific article published on 01 April 1988

Specific Monoclonal Antibody Against Bcr/Abl Out-of-Frame Alternative Proteins as Diagnostic Tool in Chronic Myelogenous Leukemia Patients

scientific article published on 13 July 2017

Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

scientific article published on December 2003

Standardization of BCR-ABL1 p210 Monitoring: From Nested to Digital PCR

scientific article published on 06 November 2020

Standardized definitions of molecular response in chronic myeloid leukemia.

scientific article published on 16 April 2012

Suboptimal responses in chronic myeloid leukemia: implications and management strategies

scientific article

Synergistic effect of eltrombopag and deferasirox in aplastic anemia: a clinical case and review of the literature

scientific article published on 10 September 2019

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

scientific article published on 09 July 2018

Thalidomide after lenalidomide: a possible treatment regimen in relapse refractory multiple myeloma patients

scientific article published on 18 November 2010

Thalidomide-induced partial stable remission in a case of refractory progressive B Cell Chronic Lymphoid Leukemia

scientific article published on 04 June 2007

The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias

scientific article

The BCR-ABL1 transcript type influences response and outcome in Philadelphia chromosome-positive chronic myeloid leukemia patients treated frontline with imatinib

scientific article published on 2 May 2017

The Role of PTEN in Myeloid Malignancies

scientific article

The Wilms' tumor (WT1) gene expression correlates with the International Prognostic Scoring System (IPSS) score in patients with myelofibrosis and it is a marker of response to therapy

scientific article

The best frontline therapy for CML: imatinib?

scientific article published in April 2010

The biology of CML supports second-generation TKIs as frontline treatment

The choice of first-line chronic myelogenous leukemia treatment

scientific article

The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines

scientific article published on 01 May 2006

The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study

scientific article published on 01 August 2007

The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.

scientific article published on 21 March 2014

The hOCT1 and ABCB1 polymorphisms do not influence the pharmacodynamics of nilotinib in chronic myeloid leukemia.

scientific article

The homozygous state for the -87 C----G beta + thalassaemia

scientific article published on 01 May 1990

The long-term durability of cytogenetic responses in patients with accelerated phase chronic myeloid leukemia treated with imatinib 600 mg: the GIMEMA CML Working Party experience after a 7-year follow-up

scientific article published on 14 January 2009

The molecular anatomy of the FIP1L1-PDGFRA fusion gene

scientific article published on 6 November 2008

The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase

scientific article

The response to imatinib and interferon-alpha is more rapid than the response to imatinib alone: a retrospective analysis of 495 Philadelphia-positive chronic myeloid leukemia patients in early chronic phase

scientific article

The role of BCR/ABL isoforms in the presentation and outcome of patients with Philadelphia-positive acute lymphoblastic leukemia: a seven-year update of the GIMEMA 0496 trial.

scientific article

The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia.

scientific article published on September 2016

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones

scientific article

Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse

scientific article

Transplantation Induces Profound Changes in the Transcriptional Asset of Hematopoietic Stem Cells: Identification of Specific Signatures Using Machine Learning Techniques

scientific article published on 01 June 2020

Treatment of Philadelphia-positive chronic myeloid leukemia with imatinib: importance of a stable molecular response

scientific article published in February 2009

Treatment-free remission after imatinib discontinuation is possible in paediatric patients with chronic myeloid leukaemia

scientific article published on 27 August 2014

Treatment-free remission following frontline nilotinib in patients with chronic myeloid leukemia in chronic phase: results from the ENESTfreedom study

scientific article

Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes

scientific article published on 01 February 2005

Tumorigenic activity of a rearranged c-myc gene from a human T-cell leukemia line

scientific article published on May 1, 1992

Two new translocations involving the 11q23 region map outside the MLL locus in myeloid leukemias

scientific article published on 01 October 2002

Two novel mutations in the tmprss6 gene associated with iron-refractory iron-deficiency anaemia (irida) and partial expression in the heterozygous form

article

Unleashing the Guardian: The Targetable BCR-ABL/HAUSP/PML/PTEN Network in Chronic Myeloid Leukemia

scientific article

Up-regulated MSI2 is associated with more aggressive chronic myeloid leukemia.

scientific article

Update on emerging treatments for chronic myeloid leukemia.

scientific article published on 31 March 2015

Usefulness of quantitative assessment of Wilms tumor suppressor gene expression in chronic myeloid leukemia patients undergoing imatinib therapy

scientific article

Usefulness of quantitative assessment of the WT1 gene transcript as a marker for minimal residual disease detection.

scientific article

Usefulness of the quantitative assessment of PRV-1 gene expression for the diagnosis of polycythemia vera and essential thrombocythemia patients.

scientific article published in March 2004

Valproate enhances imatinib-induced growth arrest and apoptosis in chronic myeloid leukemia cells

scientific article published in March 2006

Variable but consistent pattern of Meningioma 1 gene (MN1) expression in different genetic subsets of acute myelogenous leukaemia and its potential use as a marker for minimal residual disease detection

scientific article

Variant Philadelphia translocations: molecular-cytogenetic characterization and prognostic influence on frontline imatinib therapy, a GIMEMA Working Party on CML analysis.

scientific article

Very low doses of thalidomide as single agent in relapsed/refractory multiple myeloma

scientific article published on 01 January 2006

WT1 as a universal marker for minimal residual disease detection and quantification in myeloid leukemias and in myelodysplastic syndrome.

scientific article published on January 2004

WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes.

scientific article

WT1 overexpression: a clinically useful marker in acute and chronic myeloid leukemias

scientific article

WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia.

scientific article

What are RBC-transfusion-dependence and -independence?

scientific article published on 07 August 2010

What challenges remain in chronic myeloid leukemia research?

scientific article published on August 2013

c-erbB-2 andras expression levels in breast cancer are correlated and show a co-operative association with unfavorable clinical outcome

scientific article published on 01 April 1991

gamma chain composition in five Italian newborns heterozygous for Hb F Malta G gamma-117 His leads to Arg

scientific article published on 01 January 1980

mTOR pathway activation in multiple myeloma cell lines and primary tumour cells: pomalidomide enhances cytoplasmic-nuclear shuttling of mTOR protein

scientific article published on 6 April 2015

p53 mutation in a case of blastic transformation of follicular lymphoma with double bcl-2 rearrangement (MBR and VCR).

scientific article published in May 1998

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