List of works - Maria O'Connell

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

scientific article published on 25 September 2017

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential.

scientific article published on 15 January 2018

A small molecule that induces assembly of a four way DNA junction at low temperature.

scientific article

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

scientific article published on 4 July 2017

Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.

scientific article published on 25 August 2005

Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells

scientific article published on 13 April 2018

Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78.

scientific article published on March 1995

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

scientific article published on 3 February 2016

Curcumin: potential for hepatic fibrosis therapy?

scientific article published on 26 November 2007

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

scientific article published on 01 November 2018

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

scientific article

Design and synthesis of threading intercalators to target DNA.

scientific article published on 7 October 2010

Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles.

scientific article published in November 2015

Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women

scientific article published on 01 August 2004

Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2.

scientific article

Ethnic differences in the relationship between fasting leptin and BMI in children

scientific article published on 01 January 2004

Ferracyclic carbonyl complexes as anti-inflammatory agents

scientific article published on 18 March 2020

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

scientific article published on 03 May 2015

Formal Total Synthesis of (+)-C9-Deoxyomuralide from l-Leucine Using a Double Sacrificial Chirality Transfer Approach.

scientific article published on 7 November 2017

Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts.

scientific article

Glycaemic impact of patient-led use of sensor-guided pump therapy in type 1 diabetes: a randomised controlled trial

scientific article published on 25 April 2009

Haem oxygenase-1 in inflammation

scientific article published on 01 December 2004

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

scientific article published in April 2014

Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).

scientific article published on 30 November 2015

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

scientific article published on 14 June 2015

Identification of selective protein-protein interaction inhibitors using efficient peptide-directed ligand design

scientific article published on 22 March 2019

Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort.

scientific article published on 27 May 2008

Interferon-gamma and tumour necrosis factor production in patients with Helicobacter pylori infection

scientific article published on 01 October 1993

Leptin and undernutrition.

scientific article

Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.

scientific article published on October 2005

Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis.

scientific article published on 29 May 2007

Microalbuminuria in inflammatory bowel disease

scientific article

Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms.

scientific article published on August 2006

Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.

scientific article published on 2 July 2017

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.

scientific article published on 3 March 2018

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

scientific article published on 25 January 2006

Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype

scientific article

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

scientific article published on 29 April 2017

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

scientific article published on 30 September 2015

Soluble adhesion molecules in inflammatory bowel disease

scientific article published on 01 April 2001

Synthesis of small molecules targeting multiple DNA structures using click chemistry

scientific article

Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.

scientific article

TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.

scientific article published on February 1997

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.

scientific article published on 3 August 2015

The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype

scientific article published on 01 January 2007

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children

scientific article published on 20 August 2008

Tumour necrosis factor-alpha and microalbuminuria in patients with inflammatory bowel disease.

scientific article published in March 1995

List of works by Maria O'Connell

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential.

A small molecule that induces assembly of a four way DNA junction at low temperature.

A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.

Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells

Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78.

Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.

Curcumin: potential for hepatic fibrosis therapy?

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

Design and synthesis of threading intercalators to target DNA.

Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles.

Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women

Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2.

Ethnic differences in the relationship between fasting leptin and BMI in children

Ferracyclic carbonyl complexes as anti-inflammatory agents

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

Formal Total Synthesis of (+)-C9-Deoxyomuralide from l-Leucine Using a Double Sacrificial Chirality Transfer Approach.

Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts.

Glycaemic impact of patient-led use of sensor-guided pump therapy in type 1 diabetes: a randomised controlled trial

Haem oxygenase-1 in inflammation

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

Identification of selective protein-protein interaction inhibitors using efficient peptide-directed ligand design

Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort.

Interferon-gamma and tumour necrosis factor production in patients with Helicobacter pylori infection

Leptin and undernutrition.

Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.

Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis.

Microalbuminuria in inflammatory bowel disease

Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms.

Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.

Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype

Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells.

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

Soluble adhesion molecules in inflammatory bowel disease

Synthesis of small molecules targeting multiple DNA structures using click chemistry

Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.

TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic.

The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children

Tumour necrosis factor-alpha and microalbuminuria in patients with inflammatory bowel disease.