List of works - Makoto Oba

A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery

scientific article published on 27 January 2016

A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool

scientific article published on 03 December 2015

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

scientific article published on 21 April 2015

Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.

scientific article published on 13 March 2014

An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids

scientific article published on 01 July 2003

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

scientific article

Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

scientific article

Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation.

scientific article

Cell-Penetrating Peptide Foldamers: Drug-Delivery Tools

scientific article published on 09 July 2019

Cell-Penetrating Peptides Using Cyclic α,α-Disubstituted α-Amino Acids with Basic Functional Groups

scientific article published on 14 March 2018

Cell-penetrating helical peptides having l-arginines and five-membered ring α,α-disubstituted α-amino acids

scientific article published on 19 September 2014

Conformational studies on peptides having dipropylglycine (Dpg) or 1-aminocycloheptanecarboxylic acid (Ac7 c) within the sequence of l-leucine (Leu) residues

scientific article published on 01 March 2016

Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle.

scientific article published on 26 November 2007

Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins

scientific article

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

scientific article published on 01 July 2019

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

scientific article published on 9 September 2016

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.

scientific article published in February 2017

Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography ⬇️

scientific article published on October 21, 2010

Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging.

scientific article published on 6 August 2011

Effects of five-membered ring amino acid incorporation into peptides for coiled coil formation.

scientific article published on 9 February 2018

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling.

scientific article

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

scientific article

Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo

scientific article

Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups

scientific article published on 16 September 2014

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

scientific article

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions.

scientific article published on 9 June 2011

In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy ⬇️

scientific article published on March 3, 2011

Intracellular internalization mechanism of protein transfection reagents.

scientific article

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown.

scientific article published on 30 March 2010

Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H···Ethereal O-Type Hydrogen Bond

scientific article published on 30 November 2018

Low pH-triggering changes in peptide secondary structures

scientific article published in August 2017

Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection.

scientific article

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.

scientific article published on 8 April 2014

PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.

scientific article published on 9 April 2008

Plasmid DNA Delivery Using Cell-Penetrating Peptide Foldamers Composed of Arg-Arg-Aib Repeating Sequences

scientific article published on 22 April 2019

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids

scientific article published on 19 April 2016

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.

scientific article published on 21 May 2015

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.

scientific article published on 7 August 2010

Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting

scientific article

Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue

scientific article published on 10 September 2008

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

scientific article published on 6 October 2010

Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking

scientific article

Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity

scientific article

Protein transfection study using multicellular tumor spheroids of human hepatoma Huh-7 cells

scientific article

Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers

scientific article published in Scientific Reports

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues.

scientific article published on 26 April 2011

Spontaneous formation of nanosized unilamellar polyion complex vesicles with tunable size and properties.

scientific article published in February 2010

Study on development of polymeric micellar gene carrier and evaluation of its functionality.

scientific article published on January 2013

Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptides

scientific article published on 01 November 2016

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

scientific article published on 15 January 2014

The side-chain hydroxy groups of a cyclic α,α-disubstituted α-amino acid promote oligopeptide 310 -helix packing in the crystalline state.

scientific article

Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer

scientific article published on 2 April 2014

Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of l-Leu and d-Leu

scientific article published on 22 August 2015

Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies.

scientific article

pDNA/poly(L‐lysine) Polyplexes Functionalized with a pH‐Sensitive Charge‐Conversional Poly(aspartamide) Derivative for Controlled Gene Delivery to Human Umbilical Vein Endothelial Cells ⬇️

scientific article published on May 20, 2010

List of works by Makoto Oba

A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery

A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability.

An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles.

Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-1.

Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation.

Cell-Penetrating Peptide Foldamers: Drug-Delivery Tools

Cell-Penetrating Peptides Using Cyclic α,α-Disubstituted α-Amino Acids with Basic Functional Groups

Cell-penetrating helical peptides having l-arginines and five-membered ring α,α-disubstituted α-amino acids

Conformational studies on peptides having dipropylglycine (Dpg) or 1-aminocycloheptanecarboxylic acid (Ac7 c) within the sequence of l-leucine (Leu) residues

Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle.

Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment.

Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.

Direct and instantaneous observation of intravenously injected substances using intravital confocal micro-videography ⬇️

Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging.

Effects of five-membered ring amino acid incorporation into peptides for coiled coil formation.

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling.

Enhanced percolation and gene expression in tumor hypoxia by PEGylated polyplex micelles.

Gene transfer using micellar nanovectors inhibits choroidal neovascularization in vivo

Helical peptide-foldamers having a chiral five-membered ring amino acid with two azido functional groups

Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors.

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions.

In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy ⬇️

Intracellular internalization mechanism of protein transfection reagents.

Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown.

Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H···Ethereal O-Type Hydrogen Bond

Low pH-triggering changes in peptide secondary structures

Modulated protonation of side chain aminoethylene repeats in N-substituted polyaspartamides promotes mRNA transfection.

Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors.

PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors.

Plasmid DNA Delivery Using Cell-Penetrating Peptide Foldamers Composed of Arg-Arg-Aib Repeating Sequences

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids

Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.

Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system.

Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting

Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomal escaping, and DNA-condensing functions for systemic gene delivery to pancreatic tumor tissue

Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery.

Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking

Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity

Protein transfection study using multicellular tumor spheroids of human hepatoma Huh-7 cells

Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues.

Spontaneous formation of nanosized unilamellar polyion complex vesicles with tunable size and properties.

Study on development of polymeric micellar gene carrier and evaluation of its functionality.

Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptides

Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors

The side-chain hydroxy groups of a cyclic α,α-disubstituted α-amino acid promote oligopeptide 310 -helix packing in the crystalline state.

Three-layered polyplex micelle as a multifunctional nanocarrier platform for light-induced systemic gene transfer

Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of l-Leu and d-Leu

Transfection study using multicellular tumor spheroids for screening non-viral polymeric gene vectors with low cytotoxicity and high transfection efficiencies.

pDNA/poly(L‐lysine) Polyplexes Functionalized with a pH‐Sensitive Charge‐Conversional Poly(aspartamide) Derivative for Controlled Gene Delivery to Human Umbilical Vein Endothelial Cells ⬇️