List of works - Isabel Santos

(99m)Tc-tricarbonyl complexes functionalized with anthracenyl fragments: synthesis, characterization, and evaluation of their radiotoxic effects in murine melanoma cells

scientific article published in October 2009

13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: chemical and biological evaluation of their (153)Sm and (166)Ho complexes as potential agents for therapy or bone pain palliation

scientific article published on 4 January 2006

153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms

scientific article published on 28 August 2004

99mTc(CO)3-labeled pamidronate and alendronate for bone imaging

scientific article published on 7 February 2011

99mTc(I) scorpionate complexes for brain imaging: synthesis, characterization and biological evaluation

scientific article published in April 2012

99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation

scientific article

99mTcI/ReI Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides.

scientific article published on 9 April 2009

A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies

scientific article

Biological assessment of novel bisphosphonate-containing 99mTc/Re-organometallic complexes

Biological evaluation of 153Sm and 166Ho complexes with tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms

Bisphosphonates as radionuclide carriers for imaging or systemic therapy.

scientific article published on 30 August 2011

Cationic Re(V) Oxo Complexes with Poly(pyrazolyl)borates: Synthesis, Characterization, and Stability

scientific article published on 01 December 2000

Cellular uptake mechanisms of an antitumor ruthenium compound: the endosomal/lysosomal system as a target for anticancer metal-based drugs

scientific article published on 24 June 2013

Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4 dotp OEt).

scientific article published on 12 February 2008

Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/phosphinic acid pendant arm

Copper(II) complexes with tridentate pyrazole-based ligands: synthesis, characterization, DNA cleavage activity and cytotoxicity

scientific article published on 26 January 2011

Coupling of a sheep anti-T3 IgG to a solid phase for a triiodothyronine radioimmunoassay

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1.

scientific article published on 31 January 2012

Disruption of Unprecedented B-H…M Agostic Interactions: An Alternative Approach for Labeling Bioactive Molecules

Dramatic effect of the tridentate ligand on the stability of 99mTC "3 + 1" oxo complexes bearing arylpiperazine derivatives.

scientific article published in May 2005

Estrogen receptor ligands for targeting breast tumours: a brief outlook on radioiodination strategies

scientific article published on April 2012

Evaluation of Novel Radioiodinated C7-substituted Δ6,7 – estradiol Derivatives for Molecular Recognition of ER-Positive Breast Tumours

article published in 2009

Evaluation of novel 99mTc(I)-labeled homobivalent α-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting

scientific article published on 01 April 2012

Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands.

scientific article published on 31 July 2013

In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys).

scientific article published on March 2007

Influence of the bifunctional chelator on the pharmacokinetic properties of 99mTc(CO)3-labeled cyclic α-melanocyte stimulating hormone analog.

scientific article

Influence of the ligand donor atoms on the in vitro stability of rhenium(I) and technetium (I)-99m complexes with pyrazole-containing chelators: Experimental and DFT studies

scholarly article by Carolina Moura et al published March 2009 in Journal of Organometallic Chemistry

Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms

scientific article published on 21 December 2012

Iodo bis bistrimethylsilylamido lanthanides

Lanthanide(III) complexes of 4,10-bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in solution and in the solid state: structural studies along the series

scientific article

Mannosylated dextran derivatives labeled with fac-[M(CO)₃]+ (M = (99m)Tc, Re) for specific targeting of sentinel lymph node

scientific article published on 23 February 2011

Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: effect of cyclization on tumor-seeking properties.

scientific article published on 8 January 2008

Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA ⬇️

scientific article published on March 3, 2011

Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging

scientific article published on 07 March 2011

Mixed-Ligand Rhenium Tricarbonyl Complexes Anchored on a (κ2-H,S) Trihydro(mercaptoimidazolyl)borate: A Missing Binding Motif for Soft Scorpionates

scholarly article by Margarida Videira et al published March 2008 in Organometallics

Mono- and dicationic Re(I)/(99m)Tc(I) tricarbonyl complexes for the targeting of energized mitochondria

scientific article published on 26 February 2013

New (99m)Tc(CO)(3) mannosylated dextran bearing S-derivatized cysteine chelator for sentinel lymph node detection.

scientific article

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

scientific article published on 16 March 2013

New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins

New water-soluble ruthenium(II) cytotoxic complex: biological activity and cellular distribution

scientific article published on 7 October 2013

Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands

scientific article published on 01 January 2004

Novel 7α-alkoxy-17α-(4'-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: synthesis and binding affinity evaluation.

scientific article published on 24 May 2012

Novel estradiol based metal complexes of Tc-99m for breast cancer imaging

scholarly article by Carina Neto et al published August 2010 in Nuclear Medicine and Biology

Novel estradiol based metal complexes of Tc-99m.

scientific article

Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, (99m)Tc) complexes: synthesis, characterization, and cell studies

scientific article published on 25 June 2011

Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting

scientific article

Pt(II) complexes with bidentate and tridentate pyrazolyl-containing chelators: synthesis, structural characterization and biological studies.

scientific article published on 21 April 2011

Pyrazolyl conjugates of bombesin: a new tridentate ligand framework for the stabilization of fac-[M(CO)3]+ moiety

scientific article published on 02 May 2006

Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M(CO)3]+ moiety (M = 99mTc, Re): synthesis, characterization, and biological behavior.

scientific article

Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: synthesis, characterisation and DNA-binding properties

scientific article published on January 2008

Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle

Radiochemical and biological evaluation of novel153Sm/166Ho-amino acid-chitosan complexes

Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents

scientific article

Radioiodinated ligands for the estrogen receptor: effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols

scientific article

Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis-radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib.

scientific article

Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer

scientific article published on 10 April 2007

Radiometallated peptides for molecular imaging and targeted therapy.

scientific article published on 25 February 2011

Radiopharmaceuticals for targeted radiotherapy

scientific article published on 01 January 2005

Radiosynthesis and in vivo evaluation of a ¹⁸F-labelled styryl-benzoxazole derivative for β-amyloid targeting

scientific article published on 13 July 2013

Rapid hepatic clearance of 99mTc-TMEOP: a new candidate for myocardial perfusion imaging.

scientific article published on 29 December 2010

Re and Tc tricarbonyl complexes: from the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase.

scientific article published on 2 November 2010

Reactivity of [Re[kappa(3)-H(mu-H)B(tim(Me))(2)](CO)(3)] (tim(Me) = 2-mercapto-1-methylimidazolyl) toward neutral substrates.

scientific article published in May 2002

Rhenium oxocomplexes with the heteroscorpionate phenyltris(pyrazolyl)borate: synthesis and structural studies

scholarly article by Raquel Garcia et al published January 2003 in Inorganica Chimica Acta

Rhenium(I) organometallic complexes with novel bis(mercaptoimidazolyl)borates and with hydrotris(mercaptoimidazolyl)borate: chemical and structural studies

scholarly article by Raquel Garcia et al published August 2001 in Journal of Organometallic Chemistry

Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism

scientific article published on May 2013

Silylated mixed-ligand rhenium complexes with the [PNS/S] donor atom set

scholarly article by Torsten Kniess et al published May 2003 in Inorganica Chimica Acta

Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent ⬇️

scientific article published on November 12, 2011

Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors

scientific article published on 6 July 2006

Synthesis and biological studies of pyrazolyl-diamine Pt(II) complexes containing polyaromatic DNA-binding groups

scientific article

Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging.

scientific article

Synthesis and structural characterization of novel Re(i) tricarbonyl complexes anchored on a phosphinoarylbenzylamine and a phosphinoaryloxazoline generated in situ.

scientific article published in September 2003

Synthesis and structural characterization of unprecedented bis-asymmetric heteroscorpionate U(III) complexes: [U(kappa3-H2B(pztBu,Me)(pzMe,tBu))2I] and [U(kappa3-H2B(pztBu,Me)(pzMe2))2I].

scientific article published in May 2003

Synthesis and structural studies of rhenium(I) tricarbonyl complexes with thione containing chelators

scholarly article by Leonor Maria et al published November 2006 in Journal of Organometallic Chemistry

Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines

scientific article

Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety

scientific article published on July 2010

Synthesis, characterization and biological evaluation of tricarbonyl M(i) (M = Re, 99mTc) complexes functionalized with melanin-binding pharmacophores

Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands

scientific article

Synthesis, characterization, and evaluation of a novel 99mTc(CO)3 pyrazolyl conjugate of a peptide nucleic acid sequence

scientific article published on 6 September 2008

Synthesis, structure and solution behaviour of U(III) poly(3,5-diisopropylpyrazoly)borate complexes

TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes.

scientific article published on 17 September 2010

Target-specific Tc(CO)3-complexes for in vivo imaging

article published in 2013

The [(Cp)M(CO)(3)] (M=Re, (99m)Tc) building block for imaging agents and bioinorganic probes: perspectives and limitations.

scientific article published on September 2012

The role of neutral coligands on the stabilization of mono-Tp(i)Pr2 U(III) complexes

scientific article published in October 2004

Theoretical studies on the binding of rhenium(I) complexes to inducible nitric oxide synthase

scientific article published on 11 August 2013

Towards 99mTc-based imaging agents with effective doxorubicin mimetics: a molecular and cellular study

scientific article published on 01 August 2016

Tricarbonyl M(I) (M = Re, (99m)Tc) complexes bearing acridine fluorophores: synthesis, characterization, DNA interaction studies and nuclear targeting

scientific article published on 20 July 2010

Tris(pyrazolyl)methane 99mtc tricarbonyl complexes for myocardial imaging

scientific article published in January 2009

Unique Uranium(III) Cations Anchored by Polydentate Sulfur-Based Ligands: Synthesis and Structure of [U{H(R)B(timMe)2}2(THF)3][BPh4] (R = H, Ph)

scientific article published on 01 December 2001

Uranium iodides as catalysts for Diels–Alder reactions

scholarly article by Jacqueline Collin et al published October 2000 in Journal of Molecular Catalysis A

[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX

scientific article

[RuII(η⁵-C₅H₅)(bipy)(PPh₃)]⁺, a promising large spectrum antitumor agent: cytotoxic activity and interaction with human serum albumin.

scientific article

List of works by Isabel Santos

(99m)Tc-tricarbonyl complexes functionalized with anthracenyl fragments: synthesis, characterization, and evaluation of their radiotoxic effects in murine melanoma cells

13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: chemical and biological evaluation of their (153)Sm and (166)Ho complexes as potential agents for therapy or bone pain palliation

153Sm and 166Ho complexes with tetraaza macrocycles containing pyridine and methylcarboxylate or methylphosphonate pendant arms

99mTc(CO)3-labeled pamidronate and alendronate for bone imaging

99mTc(I) scorpionate complexes for brain imaging: synthesis, characterization and biological evaluation

99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation

99mTcI/ReI Tricarbonyl Complexes with Tridentate Cysteamine Based Ligands: Synthesis, Characterization and in vitro/in vivo Evaluation

A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides.

A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies

Biological assessment of novel bisphosphonate-containing 99mTc/Re-organometallic complexes

Biological evaluation of 153Sm and 166Ho complexes with tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms

Bisphosphonates as radionuclide carriers for imaging or systemic therapy.

Cationic Re(V) Oxo Complexes with Poly(pyrazolyl)borates: Synthesis, Characterization, and Stability

Cellular uptake mechanisms of an antitumor ruthenium compound: the endosomal/lysosomal system as a target for anticancer metal-based drugs

Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4 dotp OEt).

Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/phosphinic acid pendant arm

Copper(II) complexes with tridentate pyrazole-based ligands: synthesis, characterization, DNA cleavage activity and cytotoxicity

Coupling of a sheep anti-T3 IgG to a solid phase for a triiodothyronine radioimmunoassay

Cytotoxic gold compounds: synthesis, biological characterization and investigation of their inhibition properties of the zinc finger protein PARP-1.

Disruption of Unprecedented B-H…M Agostic Interactions: An Alternative Approach for Labeling Bioactive Molecules

Dramatic effect of the tridentate ligand on the stability of 99mTC "3 + 1" oxo complexes bearing arylpiperazine derivatives.

Estrogen receptor ligands for targeting breast tumours: a brief outlook on radioiodination strategies

Evaluation of Novel Radioiodinated C7-substituted Δ6,7 – estradiol Derivatives for Molecular Recognition of ER-Positive Breast Tumours

Evaluation of novel 99mTc(I)-labeled homobivalent α-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting

Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands.

In vitro and in vivo evaluation of a novel 99mTc(CO)3-pyrazolyl conjugate of cyclo-(Arg-Gly-Asp-d-Tyr-Lys).

Influence of the bifunctional chelator on the pharmacokinetic properties of 99mTc(CO)3-labeled cyclic α-melanocyte stimulating hormone analog.

Influence of the ligand donor atoms on the in vitro stability of rhenium(I) and technetium (I)-99m complexes with pyrazole-containing chelators: Experimental and DFT studies

Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms

Iodo bis bistrimethylsilylamido lanthanides

Lanthanide(III) complexes of 4,10-bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in solution and in the solid state: structural studies along the series

Mannosylated dextran derivatives labeled with fac-[M(CO)₃]+ (M = (99m)Tc, Re) for specific targeting of sentinel lymph node

Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: effect of cyclization on tumor-seeking properties.

Metal-Based Inhibition of Poly(ADP-ribose) Polymerase − The Guardian Angel of DNA ⬇️

Metalloprobes for functional monitoring of tumour multidrug resistance by nuclear imaging

Mixed-Ligand Rhenium Tricarbonyl Complexes Anchored on a (κ2-H,S) Trihydro(mercaptoimidazolyl)borate: A Missing Binding Motif for Soft Scorpionates

Mono- and dicationic Re(I)/(99m)Tc(I) tricarbonyl complexes for the targeting of energized mitochondria

New (99m)Tc(CO)(3) mannosylated dextran bearing S-derivatized cysteine chelator for sentinel lymph node detection.

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy

New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins

New water-soluble ruthenium(II) cytotoxic complex: biological activity and cellular distribution

Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands

Novel 7α-alkoxy-17α-(4'-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: synthesis and binding affinity evaluation.

Novel estradiol based metal complexes of Tc-99m for breast cancer imaging

Novel estradiol based metal complexes of Tc-99m.

Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, (99m)Tc) complexes: synthesis, characterization, and cell studies

Preparation and biological evaluation of cyclopentadienyl-based 99mTc-complexes [(Cp-R)99mTc(CO)3] mimicking benzamides for malignant melanoma targeting

Pt(II) complexes with bidentate and tridentate pyrazolyl-containing chelators: synthesis, structural characterization and biological studies.

Pyrazolyl conjugates of bombesin: a new tridentate ligand framework for the stabilization of fac-[M(CO)3]+ moiety

Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M(CO)3]+ moiety (M = 99mTc, Re): synthesis, characterization, and biological behavior.

Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: synthesis, characterisation and DNA-binding properties

Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle

Radiochemical and biological evaluation of novel153Sm/166Ho-amino acid-chitosan complexes

Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents

Radioiodinated ligands for the estrogen receptor: effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols

Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis-radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib.

Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer

Radiometallated peptides for molecular imaging and targeted therapy.

Radiopharmaceuticals for targeted radiotherapy

Radiosynthesis and in vivo evaluation of a ¹⁸F-labelled styryl-benzoxazole derivative for β-amyloid targeting

Rapid hepatic clearance of 99mTc-TMEOP: a new candidate for myocardial perfusion imaging.

Re and Tc tricarbonyl complexes: from the suppression of NO biosynthesis in macrophages to in vivo targeting of inducible nitric oxide synthase.

Reactivity of [Re[kappa(3)-H(mu-H)B(tim(Me))(2)](CO)(3)] (tim(Me) = 2-mercapto-1-methylimidazolyl) toward neutral substrates.

Rhenium oxocomplexes with the heteroscorpionate phenyltris(pyrazolyl)borate: synthesis and structural studies

Rhenium(I) organometallic complexes with novel bis(mercaptoimidazolyl)borates and with hydrotris(mercaptoimidazolyl)borate: chemical and structural studies

Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism

Silylated mixed-ligand rhenium complexes with the [PNS/S] donor atom set

Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent ⬇️

Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors

Synthesis and biological studies of pyrazolyl-diamine Pt(II) complexes containing polyaromatic DNA-binding groups

Synthesis and characterization of rhenium and technetium-99m tricarbonyl complexes bearing the 4-[3-bromophenyl]quinazoline moiety as a biomarker for EGFR-TK imaging.

Synthesis and structural characterization of novel Re(i) tricarbonyl complexes anchored on a phosphinoarylbenzylamine and a phosphinoaryloxazoline generated in situ.

Synthesis and structural characterization of unprecedented bis-asymmetric heteroscorpionate U(III) complexes: [U(kappa3-H2B(pztBu,Me)(pzMe,tBu))2I] and [U(kappa3-H2B(pztBu,Me)(pzMe2))2I].

Synthesis and structural studies of rhenium(I) tricarbonyl complexes with thione containing chelators

Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines

Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety

Synthesis, characterization and biological evaluation of tricarbonyl M(i) (M = Re, 99mTc) complexes functionalized with melanin-binding pharmacophores

Synthesis, characterization and cytotoxic activity of gallium(III) complexes anchored by tridentate pyrazole-based ligands

Synthesis, characterization, and evaluation of a novel 99mTc(CO)3 pyrazolyl conjugate of a peptide nucleic acid sequence