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List of works by Paul Freemont

20S human proteasomes bind with a specific orientation to lipid monolayers in vitro

scientific article published on 01 May 1996

A Cell-Free Biosensor for Detecting Quorum Sensing Molecules in P. aeruginosa-Infected Respiratory Samples.

scientific article published on 5 October 2017

A GenoChemetic strategy for derivatization of the violacein natural product scaffold

A domain of the Klenow fragment of Escherichia coli DNA polymerase I has polymerase but no exonuclease activity.

scientific article published on September 1986

A low-cost biological agglutination assay for medical diagnostic applications

A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis

scientific article

A new labeling method for methyl transverse relaxation-optimized spectroscopy NMR spectra of alanine residues

scientific article published on 28 November 2007

A new role for Biofoundries in rapid prototyping, development, and validation of automated clinical diagnostic tests for SARS-CoV-2

scientific article published on 06 May 2020

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

scientific article

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

scientific article

A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics

scientific article published on 08 September 2020

AAA proteins and the life process

scientific article published on 01 February 2008

AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis

scientific article

Analysis of spatial point patterns in nuclear biology

scientific article

Author Correction: A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics

scientific article published on 17 September 2020

Author Correction: Building a global alliance of biofoundries

scientific article published on 11 July 2019

Automated assignment in selectively methyl-labeled proteins.

scientific article

Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases

scientific article

Building a global alliance of biofoundries

scientific article published on 09 May 2019

Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins

scientific article published on 28 September 2007

Cell-Free Protein Synthesis as a Prototyping Platform for Mammalian Synthetic Biology

scientific article published on 03 January 2020

Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer

scientific article published in December 2002

Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer

scientific article

Characterisation of a novel cysteine/histidine-rich metal binding domain from Xenopus nuclear factor XNF7

scientific article published on 01 December 1993

Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers

scientific article published on 01 January 1995

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia ⬇️

scientific article published on November 29, 1991

Co-culture systems and technologies: taking synthetic biology to the next level

scientific article

Cocrystal structure of an editing complex of Klenow fragment with DNA

scientific article

Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes.

scientific article published on 10 October 2014

Computational design approaches and tools for synthetic biology ⬇️

scientific article published on January 24, 2011

Conformational analysis of the first observed non-proline cis-peptide bond occurring within the complementarity determining region (CDR) of an antibody

scientific article published on 01 December 1998

Conformational changes in the AAA ATPase p97-p47 adaptor complex

scientific article published on 3 May 2006

Correction to EcoFlex: A Multifunctional MoClo Kit for E. coli Synthetic Biology

scientific article published on 17 April 2020

Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding

scientific article published on 22 November 2019

Crystallization and preliminary X-ray diffraction studies of pancreatic spasmolytic polypeptide

scientific article published on 01 December 1992

Crystallization and preliminary X-ray studies of T4 phage beta-glucosyltransferase

scientific article published on 01 September 1988

Crystallization of an antitumour antibody SM3 complexed with a peptide epitope

scientific article published on 01 November 1997

Crystallization of an intact GST-estrogen receptor hormone binding domain fusion protein

scientific article published on 01 May 1998

Crystallization of the Fab fragment of the tumour-specific antibody PR1A3.

scientific article published in July 1997

Design of a prototype flow microreactor for synthetic biology in vitro

scientific article published on 10 July 2013

Detailed structural insights into the p97-Npl4-Ufd1 interface

scientific article

Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity

scientific article

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

scientific article published on 9 January 2012

Fold recognition study of alpha3-galactosyltransferase and molecular modeling of the nucleotide sugar-binding domain

scientific article published on 01 July 1999

Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.

scientific article

Going through the motions: The ATPase cycle of p97

scientific article published in October 2006

How synthetic biology will reconsider natural bioluminescence and its applications.

scientific article published on January 2014

Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9

scientific article published on 6 June 2003

Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments

scientific journal article

Identification and preliminary characterization of a protein motif related to the zinc finger

scientific article

In vivo and in vitro characterization of σ70 constitutive promoters by real-time PCR and fluorescent measurements

scientific article

Insights into adaptor binding to the AAA protein p97.

scientific article published on February 2008

Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy.

scientific article published on 05 March 2014

Interaction between nucleosome assembly protein 1-like family members.

scientific article published on 17 February 2011

Ionomycin-regulated phosphorylation of the myeloid calcium-binding protein p14

scientific article (publication date: 9 November 1989)

Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.

scientific article

Janus-faced proteins.

scientific article published in February 1992

Letter to the Editor: Complete Backbone Resonance Assignments of p47: The 41kDa Adaptor Protein of the AAA ATPase p97

scientific article published in March 2004

Machinery of protein folding and unfolding

scientific article

Max in a complex affair

scientific article published in Nature

Motions and negative cooperativity between p97 domains revealed by cryo-electron microscopy and quantised elastic deformational model

scientific article (publication date: 28 March 2003)

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders

scientific article

New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts.

scientific article

One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy.

scientific article

Opportunities for microfluidic technologies in synthetic biology

scientific article published on 27 May 2009

PML nuclear bodies and their spatial relationships in the mammalian cell nucleus

scientific article published on January 2009

PML protein isoforms and the RBCC/TRIM motif ⬇️

scientific article (publication date: 29 October 2001)

Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions

scientific article

Protein regulation: tag wrestling with relatives of ubiquitin

scientific article published on 01 October 1998

Purification and crystallization of thymidine kinase from herpes simplex virus type 1.

scientific article published on August 1988

Quantitative analysis of cell nucleus organisation.

scientific article

R2oDNA designer: computational design of biologically neutral synthetic DNA sequences

scientific article

Rapid acquisition and model-based analysis of cell-free transcription-translation reactions from nonmodel bacteria.

scientific article published on 17 April 2018

Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.

scientific article published on 22 September 2011

Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

scientific article published in June 2001

SSX and the synovial-sarcoma-specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex

scientific article published on 01 April 1999

SUMO

scientific article published on 01 April 2003

Segmentation of fluorescence microscopy images for quantitative analysis of cell nuclear architecture.

scientific article

Sequence identity

scientific article published in Nature

Solution structure and interaction surface of the C-terminal domain from p47: a major p97-cofactor involved in SNARE disassembly

scientific article

Specialization of an Exonuclease III family enzyme in the repair of 3' DNA lesions during base excision repair in the human pathogen Neisseria meningitidis.

scientific article

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.

scholarly article

SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling

scientific journal article

Structural and functional implications of phosphorylation and acetylation in the regulation of the AAA+ protein p97.

scientific article published on February 2010

Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system.

scientific article

Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis

scientific article

Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

scientific journal article

Structural insights into the p97-Ufd1-Npl4 complex.

scholarly article

Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97.

scientific article

Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.

scientific article published on August 1998

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS

scientific article

Structure-function analysis of HsiF, a gp25-like component of the type VI secretion system, in Pseudomonas aeruginosa

scientific article published on 26 August 2011

Substance P-related antagonists inhibit vasopressin and bombesin but not 5'-3-O-(thio)triphosphate-stimulated inositol phosphate production in Swiss 3T3 cells.

scientific article published on April 1995

Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding.

scientific article published in June 2000

Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro

scientific article (publication date: 6 March 1998)

Synthetic biology – the state of play ⬇️

scientific article published on June 13, 2012

The BRCA1 C-terminal domain: structure and function.

scientific article

The HsiB1C1 (TssB-TssC) complex of the Pseudomonas aeruginosa type VI secretion system forms a bacteriophage tail sheathlike structure

scientific article published on 22 January 2013

The Human Polycomb Group Complex Associates with Pericentromeric Heterochromatin to Form a Novel Nuclear Domain ⬇️

scientific article published on August 24, 1998

The RING finger domain: a recent example of a sequence-structure family

scientific article

The RING finger. A novel protein sequence motif related to the zinc finger.

scientific article published on June 1993

The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton

scientific article

The archetype Pseudomonas aeruginosa proteins TssB and TagJ form a novel subcomplex in the bacterial type VI secretion system

scientific article published on 29 August 2012

The crystal structure of murine p97/VCP at 3.6A

scientific article

The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution

scientific article published on 01 December 1990

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites ⬇️

scientific article published on November 3, 1997

The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger

scientific article published on 01 May 1994

The p97-FAF1 protein complex reveals a common mode of p97 adaptor binding

scientific article published on 11 March 2014

The role of the N-domain in the ATPase activity of the mammalian AAA ATPase p97/VCP.

scientific article published on 23 January 2012

The transcriptional regulator CBP has defined spatial associations within interphase nuclei.

scientific article published on 8 September 2006

The ubiquitin-homology gene PIC1: characterization of mouse (Pic1) and human (UBL1) genes and pseudogenes

scientific article

Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)

scientific journal article

VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo

scientific article

Validating a Coarse-Grained Potential Energy Function through Protein Loop Modelling

scientific article

Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology

scientific article

Whole-Cell Biosensor with Tunable Limit of Detection Enables Low-Cost Agglutination Assays for Medical Diagnostic Applications

scientific article published on 25 January 2019

p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis

scientific article published in December 2006

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