Search filters

List of works by Roger Chung

A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.

scientific article published on 15 September 2016

A versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system

scientific article published on 6 September 2017

Acute reactive and regenerative changes in mature cortical axons following injury.

scientific article published in February 2007

Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging

scientific article published on 26 November 2018

Alterations in erythrocyte fatty acid composition in preclinical Alzheimer's disease

scientific article published on 6 April 2017

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

scientific article published on 22 May 2018

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse

scientific article published on 28 April 2016

Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants.

scientific article published on 4 April 2018

Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish.

scientific article published on 21 February 2018

Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

scientific article published on 10 April 2018

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

scientific article published on 15 April 2016

Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission.

scientific article published on 16 March 2018

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.

scientific article

Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems.

scientific article

Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons

scientific article published on 16 May 2014

Characterisation of the expression of NMDA receptors in human astrocytes

scientific article (publication date: 2010)

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

scientific article published on 07 February 2020

Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos

scientific article published on 23 May 2019

Corrigendum to: "Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy" [Biomaterials 229 (2020) 119576]

scientific article published on 20 January 2020

Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer.

scientific article published on 23 June 2017

Cyclosporin-A treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury.

scientific article

DNA nanoclew templated spherical nucleic acids for siRNA delivery

scientific article published on 23 March 2018

Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism

scientific article

Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

scientific article published in May 2009

Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice.

scientific article published in November 2012

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.

scientific article published on 13 December 2017

Editorial: The molecular pathology of cognitive decline: focus on metals

scientific article published on 17 June 2015

Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine

scientific article published on 16 October 2018

Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load.

scientific article published on 11 July 2017

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

scientific article published on October 2007

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

scientific article published on 21 April 2017

Extracellular Interactions of Alpha-Synuclein in Multiple System Atrophy ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2018

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin.

scientific article published on 21 August 2017

Identification and characterization of a population of motile neurons in long-term cortical culture.

scientific article

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

scientific article published on 30 August 2017

In vitro neuronal depolarization and increased synaptic activity induced by infrared neural stimulation

scientific article

In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS)

scientific article published on 07 January 2021

In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord

scientific article

Isotope metallomics approaches for medical research

scientific article published on 04 March 2020

Label-Free Fluorescent Poly(amidoamine) Dendrimer for Traceable and Controlled Drug Delivery

scientific article published on 24 April 2019

Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity.

scientific article published in September 2006

Longitudinal biometal accumulation and Ca isotope composition of the Göttingen minipig brain

scientific article published on 01 October 2020

Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.

scientific article

Metallothionein biology in the ageing and neurodegenerative brain.

scientific article

Metallothionein expression by NG2 glial cells following CNS injury

scientific article published on 01 October 2007

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.

scientific article published on 04 April 2017

Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury.

scientific article published in April 2003

Metallothionein-IIA promotes neurite growth via the megalin receptor.

scientific article

Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting

scientific journal article

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

scientific article published on 23 March 2014

Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy

scientific article published in October 2005

Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons

scientific article published on 31 March 2017

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation

scientific article

Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain.

scientific article published on 15 June 2010

Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins.

scientific article published on 21 July 2011

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

scientific article published on 25 June 2018

Observation and characterisation of macrophages in zebrafish liver

scientific article published on 13 February 2020

Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes

scientific article published on 16 September 2010

Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord.

scientific article published in January 2004

Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors

scientific article published on 01 May 2004

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina.

scientific article published on 22 June 2016

One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell.

scientific article published on 23 February 2016

PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells.

scientific article published on 22 September 2017

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

scientific article published on 29 August 2017

Potential Modes of Intercellular α-Synuclein Transmission

scientific article published on 22 February 2017

Prolonged Abeta treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca2+ homeostasis.

scientific article

Protective role of metallothioneins in the injured mammalian brain.

scientific article published in January 2004

Pulsatile stretch as a novel modulator of amyloid precursor protein processing and associated inflammatory markers in human cerebral endothelial cells

scientific article published on 26 January 2018

Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo

scientific article published on 23 August 2018

Recent rodent models for Alzheimer's disease: clinical implications and basic research

scientific article

Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury

scientific article published on 11 March 2008

Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer's disease.

scientific article published on March 2017

SERS-based nanostrategy for rapid anemia diagnosis

scientific article published on 01 January 2020

Selective spatio-temporal vulnerability of central nervous system neurons to pathological TAR DNA-binding protein 43 in aged transgenic mice

scientific article published on 22 March 2018

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

scientific article published on 06 May 2020

Spinal cord tissue affects ensheathing cell proliferation and apoptosis

scientific article published on 01 May 2005

Stable Upconversion Nanohybrid Particles for Specific Prostate Cancer Cell Immunodetection.

scientific article

Switching on Endogenous Metal Binding Proteins in Parkinson's Disease

scientific article published on 19 February 2019

Tg2576 cortical neurons that express human Ab are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration

scientific article

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

scientific article published on 27 February 2015

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

scientific article published on 27 October 2015

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration.

scientific article published on 22 February 2018

The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1G93A amyotrophic lateral sclerosis mice

scientific article published on 18 January 2020

The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.

scientific article

The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival.

scientific article published on April 2010

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro

scientific article published on April 2012

Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy

scientific article

Ultrastructural Mapping of the Zebrafish Gastrointestinal System as a Basis for Experimental Drug Studies

scientific article

Upconversion Nanoparticle-Based Strategy for Crossing the Blood-Brain Barrier to Treat the Central Nervous System Disease

scientific article published on 01 January 2019

Using proteomics to identify ubiquitin ligase-substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases

scientific article published on 27 March 2019

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators.

scientific article published on 8 July 2009

Paulina is supported by:

About Paulina

Help