List of works - Francesco Silvestris

A peculiar molecular profile of umbilical cord-mesenchymal stromal cells drives their inhibitory effects on multiple myeloma cell growth and tumor progression

scientific article published on 11 March 2015

ALK gene alterations in cancer: biological aspects and therapeutic implications

scientific article published on 23 January 2017

Abdominal obesity is characterized by higher pulse pressure: possible role of free triiodothyronine.

scientific article

Adverse drug reactions after intravenous rituximab infusion are more common in hematologic malignancies than in autoimmune disorders and can be predicted by the combination of few clinical and laboratory parameters: results from a retrospective, mul

scientific article published on 3 April 2017

Affinity columns containing anti-DNA Id+ human myeloma proteins adsorb human epibodies from intravenous gamma globulin

scientific article published on 01 April 1997

An imbalance between Beclin-1 and p62 expression promotes the proliferation of myeloma cells through autophagy regulation

scientific article

Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules.

scientific article

Arterial hypertension in obesity: relationships with hormone and anthropometric parameters.

scientific article published on 11 February 2011

Avβ3 integrin: Pathogenetic role in osteotropic tumors.

scientific article published on 23 June 2015

Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe.

scientific article published on 4 February 2013

Bone metastases in hepatocellular carcinoma: an emerging issue

scientific article published on March 2014

CD8+/CD57+cells and apoptosis suppress T-cell functions in multiple myeloma

scientific article published in March 1998

Cancer treatment-induced bone loss (CTIBL): pathogenesis and clinical implications.

scientific article published on 15 September 2015

Cell fusion and hyperactive osteoclastogenesis in multiple myeloma.

scientific article published on January 2011

Cell fusion in myeloma marrow microenvironment: role in tumor progression.

scientific article published on January 2013

Cilengitide restrains the osteoclast-like bone resorbing activity of myeloma plasma cells

scientific article published on 5 January 2016

Circulating dendritic cell levels identify high-risk stage II-III melanoma patients: a potential role as additional prognostic marker

scientific article published on 15 January 2015

Constitutive down-regulation of Osterix in osteoblasts from myeloma patients: in vitro effect of Bortezomib and Lenalidomide.

scientific article published on 4 August 2009

Cross-reactivity of human IgG anti-F(ab')2 antibody with DNA and other nuclear antigens.

scientific article published in January 1997

Cytokine Overproduction, T-Cell Activation, and Defective T-Regulatory Functions Promote Nephritis in Systemic Lupus Erythematosus ⬇️

scientific article published on June 29, 2010

Cytotherapies in multiple myeloma: a complementary approach to current treatments? ⬇️

scientific article published on May 24, 2013

Dendritic cell-derived exosomes (Dex) are potential biomarkers of response to Ipilimumab in metastatic melanoma

Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?

scientific article published on 9 June 2011

Deregulated expression of monocyte chemoattractant protein-1 (MCP-1) in arterial hypertension: role in endothelial inflammation and atheromasia.

scientific article

Differential isotype expression and binding properties of T cell-reactive antibodies in human immunodeficiency virus (HIV) infection.

scientific article published on March 1992

Discrepancy in the expression of autoantibodies in healthy aged individuals

scientific article published on 01 May 1985

Distribution and antigenic analysis of circulating F(ab')2-reactive IgG in patients with HIV-1 infection

scientific article published on 01 November 1994

Distribution of anti-F(ab')2 antibodies and the 16/6 idiotype in systemic lupus erythematosus (SLE) probands and kindreds

scientific article published on 01 November 1989

Does cilengitide deserve another chance?

scientific article published on 24 November 2014

Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-I) in active lupus

scientific article published in January 2003

Erdheim-Chester disease: a systematic review

scientific article

Everolimus restrains the IL-17A-dependent osteoclast-like transdifferentiation of dendritic cells in multiple myeloma.

scientific article published on 17 October 2016

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells.

scientific article published on 14 October 2015

Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro

scientific article published in April 2008

Expression of F4, 8.12, 3I, and 16/6 anti-DNA idiotype-related antigens on cationic human IgG myeloma proteins

scientific article published on 01 November 1994

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression.

scientific article

Functional Fas-ligand expression on T cells from HIV-1-infected patients is unrelated to CD4+ lymphopenia

scientific article published in December 1998

Functional expression of the calcitonin receptor by human T and B cells.

scientific article published on 13 May 2009

Functional osteoclast-like transformation of cultured human myeloma cell lines.

scientific article

Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18

scientific article published on 01 January 2008

Human anti-F(ab')2 antibodies show preferential reactivity for F(ab')2 molecules bearing lambda light chains.

scientific article

IgG anti-F(ab')2 antibodies from SLE patients react with immunodominant residues in kappa CDRs, but show reduced C kappa region reactivity

scientific article published on 01 December 1995

IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

scientific article published on 01 December 1985

Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitro.

scientific article published on 25 April 2011

Immune Profile of Obese People and In Vitro Effects of Red Grape Polyphenols on Peripheral Blood Mononuclear Cells

scientific article published on 24 January 2017

Immunomodulation of T and B cell functions in multiple myeloma patients treated with combined erythropoietin and alpha-interferon therapy.

scientific article

Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells

scientific article published in August 2004

In vitro anti-myeloma activity of TRAIL-expressing adipose-derived mesenchymal stem cells.

scientific article

In vitro inhibition of anti-DNA producing cells from systemic lupus erythematosus patients by autologous anti-F(ab')2 antibodies

scientific article published on 01 January 1987

In vitro modulation of cell-mediated immunity by prostaglandin E2. I. Enhancing-inhibitory effects on antibody-dependent cellular cytotoxicity

scientific article published on 01 September 1982

Independent Relationship of Osteocalcin Circulating Levels with Obesity, Type 2 Diabetes, Hypertension, and HDL Cholesterol

scientific article

Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies

scientific article published on 01 October 2006

Lenalidomide in multiple myeloma: current experimental and clinical data.

scientific article

Long-term therapy with recombinant human erythropoietin (rHu-EPO) in progressing multiple myeloma.

scientific article published in June 1995

Mediterranean Diet and cancer risk: an open issue

scientific article published on 2 June 2016

Molecular localization of human IgG anti-F(ab')2 reactivity with variable- and constant-region lambda light-chain epitopes

scientific article published on 01 November 1995

Molecular specificities of CD4+ T cell-reactive IgM in human immunodeficiency virus (HIV-1) infection.

scientific article

Molecular target therapy for bone metastasis: starting a new era with denosumab, a RANKL inhibitor

scientific article published on 28 October 2013

Monoclonal antibodies against human anti-F(ab')2 antibodies react with light chain epitopes

scientific article published on 01 April 1991

Myeloma bone disease: pathogenetic mechanisms and clinical assessment.

scientific article published on 9 June 2006

NETs: organ-related epigenetic derangements and potential clinical applications

scientific article published on 13 July 2016

Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.

scientific article published in February 2002

Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells.

scientific article

New clinical and immunological trends in cryoglobulinemia

scientific article published on 01 January 1980

New insights into the molecular pathogenesis of langerhans cell histiocytosis

scientific article published on 16 January 2014

Novel lenalidomide-based combinations for treatment of multiple myeloma.

scientific article published on 17 July 2012

Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications.

scientific article published on 10 February 2016

Obesity and heart failure.

scientific article published in March 2013

Obesity as a major risk factor for cancer.

scientific article published on 29 August 2013

Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro.

scientific article published on 6 February 2017

Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis

scientific article published on 15 September 2008

PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression.

scientific article published on January 2014

Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and obese subjects

scientific article published on 30 September 2015

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations

scientific article published in January 2015

Parallelism of serum anti-F(ab')2 and anti-cationic IgG reactivities in patients with systemic lupus erythematosus

scientific article published on 01 May 1991

Paraneoplastic focal segmental glomerulosclerosis in sarcomatoid renal cell cancer.

scientific article published on 24 March 2014

Pharmacogenetics and pharmacogenomics: role of mutational analysis in anti-cancer targeted therapy.

scientific article published on 03 July 2012

Possible direct influence of complement 3 in decreasing insulin sensitvity in a cohort of overweight and obese subjects

scientific article published in December 2013

Possible role of hyperinsulinemia and insulin resistance in lower vitamin D levels in overweight and obese patients

scientific article published on 14 January 2013

Relationship between C3 levels and common carotid intima-media thickness in overweight and obese patients.

scientific article published on 15 April 2011

Reviewing the Osteotropism in Neuroendocrine Tumors: The Role of Epithelial-Mesenchymal Transition

scientific article published on 28 July 2015

Role of active drug transporters in refractory multiple myeloma.

scientific article published on January 2009

Shared V-region antigens and cross-reacting specificities of human IgG anti-F(ab')2 and anti-DNA antibodies

scientific article published on 01 August 1996

Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition

scientific article

Studies of anti-F(ab')2 antibodies and VH region distribution among SLE kindreds

scientific article published on 01 August 1989

Th1 cytokines in the pathogenesis of lupus nephritis: the role of IL-18.

scientific article

The effectiveness and tolerability of epoetin alfa in patients with multiple myeloma refractory to chemotherapy ⬇️

scientific article published on January 1, 1998

The immune escape in melanoma: role of the impaired dendritic cell function.

scientific article published on 02 September 2014

The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis.

scientific article

Umbilical cord mesenchymal stem cells: role of regulatory genes in their differentiation to osteoblasts

scientific article published on 01 October 2009

Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis

scientific article published on 01 October 2004

Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease

scientific article published in July 2003

Urokinase receptor (uPAR) ligand based recombinant toxins for human cancer therapy.

scientific article published on January 2011

[Bone health in the oncologic patient]

scientific article published on 01 October 2012

[Cell-based strategies: novel perspectives for cancer therapy]

scientific article published on 01 February 2012

miRNAs in melanoma: a defined role in tumor progression and metastasis

scientific article

List of works by Francesco Silvestris

A peculiar molecular profile of umbilical cord-mesenchymal stromal cells drives their inhibitory effects on multiple myeloma cell growth and tumor progression

ALK gene alterations in cancer: biological aspects and therapeutic implications

Abdominal obesity is characterized by higher pulse pressure: possible role of free triiodothyronine.

Adverse drug reactions after intravenous rituximab infusion are more common in hematologic malignancies than in autoimmune disorders and can be predicted by the combination of few clinical and laboratory parameters: results from a retrospective, mul

Affinity columns containing anti-DNA Id+ human myeloma proteins adsorb human epibodies from intravenous gamma globulin

An imbalance between Beclin-1 and p62 expression promotes the proliferation of myeloma cells through autophagy regulation

Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules.

Arterial hypertension in obesity: relationships with hormone and anthropometric parameters.

Avβ3 integrin: Pathogenetic role in osteotropic tumors.

Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe.

Bone metastases in hepatocellular carcinoma: an emerging issue

CD8+/CD57+cells and apoptosis suppress T-cell functions in multiple myeloma

Cancer treatment-induced bone loss (CTIBL): pathogenesis and clinical implications.

Cell fusion and hyperactive osteoclastogenesis in multiple myeloma.

Cell fusion in myeloma marrow microenvironment: role in tumor progression.

Cilengitide restrains the osteoclast-like bone resorbing activity of myeloma plasma cells

Circulating dendritic cell levels identify high-risk stage II-III melanoma patients: a potential role as additional prognostic marker

Constitutive down-regulation of Osterix in osteoblasts from myeloma patients: in vitro effect of Bortezomib and Lenalidomide.

Cross-reactivity of human IgG anti-F(ab')2 antibody with DNA and other nuclear antigens.

Cytokine Overproduction, T-Cell Activation, and Defective T-Regulatory Functions Promote Nephritis in Systemic Lupus Erythematosus ⬇️

Cytotherapies in multiple myeloma: a complementary approach to current treatments? ⬇️

Dendritic cell-derived exosomes (Dex) are potential biomarkers of response to Ipilimumab in metastatic melanoma

Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?

Deregulated expression of monocyte chemoattractant protein-1 (MCP-1) in arterial hypertension: role in endothelial inflammation and atheromasia.

Differential isotype expression and binding properties of T cell-reactive antibodies in human immunodeficiency virus (HIV) infection.

Discrepancy in the expression of autoantibodies in healthy aged individuals

Distribution and antigenic analysis of circulating F(ab')2-reactive IgG in patients with HIV-1 infection

Distribution of anti-F(ab')2 antibodies and the 16/6 idiotype in systemic lupus erythematosus (SLE) probands and kindreds

Does cilengitide deserve another chance?

Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-I) in active lupus

Erdheim-Chester disease: a systematic review

Everolimus restrains the IL-17A-dependent osteoclast-like transdifferentiation of dendritic cells in multiple myeloma.

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells.

Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro

Expression of F4, 8.12, 3I, and 16/6 anti-DNA idiotype-related antigens on cationic human IgG myeloma proteins

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression.

Functional Fas-ligand expression on T cells from HIV-1-infected patients is unrelated to CD4+ lymphopenia

Functional expression of the calcitonin receptor by human T and B cells.

Functional osteoclast-like transformation of cultured human myeloma cell lines.

Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18

Human anti-F(ab')2 antibodies show preferential reactivity for F(ab')2 molecules bearing lambda light chains.

IgG anti-F(ab')2 antibodies from SLE patients react with immunodominant residues in kappa CDRs, but show reduced C kappa region reactivity

IgM, IgA and IgG rheumatoid factors in patients with rheumatoid arthritis and normal donors

Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitro.

Immune Profile of Obese People and In Vitro Effects of Red Grape Polyphenols on Peripheral Blood Mononuclear Cells

Immunomodulation of T and B cell functions in multiple myeloma patients treated with combined erythropoietin and alpha-interferon therapy.

Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells

In vitro anti-myeloma activity of TRAIL-expressing adipose-derived mesenchymal stem cells.

In vitro inhibition of anti-DNA producing cells from systemic lupus erythematosus patients by autologous anti-F(ab')2 antibodies

In vitro modulation of cell-mediated immunity by prostaglandin E2. I. Enhancing-inhibitory effects on antibody-dependent cellular cytotoxicity

Independent Relationship of Osteocalcin Circulating Levels with Obesity, Type 2 Diabetes, Hypertension, and HDL Cholesterol

Interleukin-18 overexpression as a hallmark of the activity of autoimmune inflammatory myopathies

Lenalidomide in multiple myeloma: current experimental and clinical data.

Long-term therapy with recombinant human erythropoietin (rHu-EPO) in progressing multiple myeloma.

Mediterranean Diet and cancer risk: an open issue

Molecular localization of human IgG anti-F(ab')2 reactivity with variable- and constant-region lambda light-chain epitopes

Molecular specificities of CD4+ T cell-reactive IgM in human immunodeficiency virus (HIV-1) infection.

Molecular target therapy for bone metastasis: starting a new era with denosumab, a RANKL inhibitor

Monoclonal antibodies against human anti-F(ab')2 antibodies react with light chain epitopes

Myeloma bone disease: pathogenetic mechanisms and clinical assessment.

NETs: organ-related epigenetic derangements and potential clinical applications

Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.

Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells.

New clinical and immunological trends in cryoglobulinemia

New insights into the molecular pathogenesis of langerhans cell histiocytosis

Novel lenalidomide-based combinations for treatment of multiple myeloma.

Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications.

Obesity and heart failure.

Obesity as a major risk factor for cancer.

Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro.

Overexpression of interleukin-12 and T helper 1 predominance in lupus nephritis

PTHrP produced by myeloma plasma cells regulates their survival and pro-osteoclast activity for bone disease progression.

Para- and perirenal ultrasonographic fat thickness is associated with 24-hours mean diastolic blood pressure levels in overweight and obese subjects

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations

Parallelism of serum anti-F(ab')2 and anti-cationic IgG reactivities in patients with systemic lupus erythematosus

Paraneoplastic focal segmental glomerulosclerosis in sarcomatoid renal cell cancer.

Pharmacogenetics and pharmacogenomics: role of mutational analysis in anti-cancer targeted therapy.

Possible direct influence of complement 3 in decreasing insulin sensitvity in a cohort of overweight and obese subjects

Possible role of hyperinsulinemia and insulin resistance in lower vitamin D levels in overweight and obese patients