List of works - Thomas Valerius

A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

scientific article published on 16 October 2015

Activated neutrophils as effector cells for bispecific antibodies ⬇️

scientific article published on 01 November 1997

An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo.

scientific article published on 3 December 2015

Antibody-dependent cellular cytotoxicity in patients on chronic hemodialysis.

scientific article published on 23 October 2013

Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions ⬇️

scientific article published on July 9, 2013

CA 125 Elevations in Patients with Malignant Lymphomas

scientific article published on January 1, 1998

Clinical evaluation of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (Filgrastim) for treatment of advanced breast cancer ⬇️

scientific article published on 01 November 1997

Complement in antibody-based tumor therapy.

scientific article

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

scientific article published on 01 January 2021

EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies ⬇️

scientific article published on May 1, 2013

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2m(1) antibody.

scientific article published on November 2013

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30.

scientific article published on 05 June 2015

Epidermal growth factor receptor targeting IgG3 triggers complement-mediated lysis of decay-accelerating factor expressing tumor cells through the alternative pathway amplification loop.

scientific article

Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization.

scientific article published in January 2014

HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity

scientific article published on 15 September 2015

HLA Class II Antibodies Recruit G-CSF Activated Neutrophils for Treatment of B Cell Malignancies ⬇️

scientific article published on July 1, 1997

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47-SIRPα Checkpoint Inhibition

scientific article published on 05 November 2019

Impact of Epidermal Growth Factor Receptor (EGFR) Cell Surface Expression Levels on Effector Mechanisms of EGFR Antibodies ⬇️

scientific article published on October 24, 2012

Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting

scientific article published on 14 October 2015

Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity.

scientific article published on 11 December 2013

Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells.

scientific article published on 6 January 2017

Nanobody Targeting of Epidermal Growth Factor Receptor (EGFR) Ectodomain Variants Overcomes Resistance to Therapeutic EGFR Antibodies

scientific article published on 01 March 2019

Renal Dysfunction in a Human Immunodeficiency Virus–Infected Patient Who Was Treated with Indinavir ⬇️

scientific article published on November 1, 1997

Response to Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells".

scientific article published in April 2018

Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing

scientific article published on 25 September 2015

Targeting FcαRI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy ⬇️

scientific article published on June 8, 2011

The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development.

scientific article published on 18 February 2015

Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells.

scientific article published on 2 November 2016

List of works by Thomas Valerius