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List of works by Thomas von Zglinicki

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

scientific article

25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study

scientific article published on 20 June 2014

A DNA damage checkpoint response in telomere-initiated senescence

scientific article (publication date: 13 November 2003)

A continuous correlation between oxidative stress and telomere shortening in fibroblasts

scientific article

A senescent cell bystander effect: senescence-induced senescence

scientific article published on 9 February 2012

A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations

scientific article

Accelerated Aging in Bone Marrow Transplant Survivors

scientific article published on 2 June 2016

Accelerated telomere shortening in fibroblasts after extended periods of confluency.

scientific article published on April 1998

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

scientific article published in January 2000

Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study.

scientific article

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

scientific article published on September 2010

Age-related frailty and its association with biological markers of ageing

scientific article published on 13 July 2015

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells

scientific article

Architectural changes in the thymus of aging mice.

scientific article

Are the ends of chromosomes the beginning of tumor genesis? On the role of telomeres in cancer development

scientific article published in November 1996

Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

scientific article published on 16 August 2011

Assessment of sleep and circadian rhythm disorders in the very old: the Newcastle 85+ Cohort Study

scientific article published on 11 October 2013

Association between mitochondria and rough endoplasmic reticulum (rer) in rat hepatocytes.

scientific article

Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations

article

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism.

scientific article published on 4 August 2014

BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

scientific article

Binding of ions to nuclear chromatin.

scientific article published in December 1989

Bioengineering the microanatomy of human skin

scientific article published on 10 February 2019

Biomarkers of healthy ageing: expectations and validation

scientific article published on 09 May 2014

CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study

scientific article published on 22 December 2015

Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs

scientific article

Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays

scientific article

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

scientific article published on 03 December 2006

Cell Sorting of Young and Senescent Cells

scientific article published on 01 January 2013

Cellular Senescence: Defining a Path Forward

scientific article published on 01 October 2019

Cellular senescence drives age-dependent hepatic steatosis.

scientific article

Cellular senescence: unravelling complexity

scientific article published on December 2009

Changes of ion and water content of mouse intestinal cells after pilocarpine and isoproterenol stimulation.

scientific article published in January 1994

Childhood growth, IQ and education as predictors of white blood cell telomere length at age 49-51 years: the Newcastle Thousand Families Study

scientific article

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

scientific article

Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts

scientific article

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

scientific article

Correction of radiolabel pulse-chase data by a mathematical model: application to mitochondrial turnover studies

scientific article

Correlated ultrastructural and morphometric studies on the liver during prenatal development of rats

article

DNA damage foci in mitosis are devoid of 53BP1.

scientific article published on 19 October 2009

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

scientific article

DNA damage response and cellular senescence in tissues of aging mice

scientific article published on 09 April 2009

Data from molecular dynamics simulations in support of the role of human CES1 in the hydrolysis of Amplex Red

scientific article

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

scientific article

Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey.

scientific article published in January 2018

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

scientific article published on 29 November 2007

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions

scientific article

Electron microscopic preparation of DNA on uncharged carbon films (author's transl)

scientific article published on July 1, 1979

Element concentrations in the intestinal mucosa of the mouse as measured by X-ray microanalysis.

scientific article

Elemental concentrations in air-exposed and vacuum-stored cryosections of rat liver cells.

scientific article published in June 1989

Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length.

scientific article published on 2 May 2008

Estimation of organelle water fractions from frozen-dried cryosections

scientific article published on 01 April 1987

Experimentelle Untersuchungen zum Einfluß der Ovarialhormone auf die Entwicklung der Rattenmandibula

scientific article published on 01 December 1984

Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients.

scientific article published in February 2006

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

scientific article

Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.

scientific article

Fat tissue, aging, and cellular senescence

scientific article

Feedback between p21 and reactive oxygen production is necessary for cell senescence

scientific article

Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old.

scientific article published on 30 April 2013

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study.

scientific article

Frailty in mouse ageing: A conceptual approach

scientific article

Gender and telomere length: systematic review and meta-analysis

scientific article published on 21 December 2013

Grip strength and inflammatory biomarker profiles in very old adults.

scientific article published on 25 May 2017

Gross energy metabolism in mice under late onset, short term caloric restriction

scientific article published on 9 April 2011

Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study

scientific article

High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction.

scientific article

Human cell senescence as a DNA damage response.

scientific article

Human fibroblasts in vitro senesce with a donor-specific telomere length.

scientific article published in April 2002

Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen

scientific article published on 01 August 2003

Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents.

scientific article published on 7 June 2012

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

scientific article

Inflammation, telomere length, and grip strength: a 10-year longitudinal study

scientific article

Intracellular water and ionic shifts during growth and ageing of rats

scientific article published on 01 April 1987

Iron overload of spleen, liver and kidney as a consequence of hemolytic anaemia

scientific article published on 01 January 1983

Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements

scientific article published on 24 September 2015

Lipofuscin accumulation and ageing of fibroblasts.

scientific article

Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress.

scientific article published on March 2001

Localization artefacts in ultracytochemical ion precipitation reactions

scientific article published on 01 January 1986

Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921.

scientific article published on 10 February 2016

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

scientific article

Lymphocyte telomere dynamics and telomerase activity in inflammatory bowel disease: effect of drugs and smoking.

scientific article published in January 2005

Lysosomal redox-active iron is important for oxidative stress-induced DNA damage

scientific article published on June 2004

Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction

scientific article published on 03 September 2012

Measuring DNA repair incision activity of mouse tissue extracts towards singlet oxygen-induced DNA damage: a comet-based in vitro repair assay

scientific article published on 25 February 2011

Measuring reactive oxygen species in senescent cells.

scientific article

Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue

article

Methods for cell sorting of young and senescent cells.

scientific article published on January 2007

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

scientific article published on 01 September 1995

MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress

scientific article published on 01 April 2003

Mitochondria and ageing: winning and losing in the numbers game.

scientific article published in September 2007

Mitochondria are required for pro-ageing features of the senescent phenotype.

scientific article

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

scientific article

Mitochondria, telomeres and cell senescence

scientific article

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

scientific article

Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging ⬇️

scientific article published on February 1, 2012

Mitochondrial dysfunction and cell senescence: cause or consequence?

scientific article

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.

scientific article

Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose.

scientific article

Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model

scientific article

Monitoring DNA damage during cell senescence

scientific article published in January 2013

Morphological changes of isolated rat liver mitochondria during Fe2+/ascorbate-induced peroxidation and the effect of thioctacid

scientific article published on 01 March 1991

Morphometric study on the absolute volume of differentiating hepatocytes in rats

scientific article published on 01 January 1984

Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients

scientific article

No association between socio-economic status and white blood cell telomere length.

scientific article published on 5 December 2006

Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts

scientific article

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

scientific article published on 03 January 2019

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

scientific article published on 01 May 2019

Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage.

scientific article

Oxidative stress shortens telomeres

scientific article (publication date: July 2002)

Oxygen free radicals in cell senescence: are they signal transducers?

scientific article published on December 2006

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.

scientific article

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

scientific article published on 12 September 2012

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts ⬇️

scientific article published on February 25, 1998

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage

scientific article published on 20 August 2007

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells

scientific article published on 01 December 2000

Quantitative assessment of markers for cell senescence.

scientific article

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort

scientific article

Reactive oxygen species production and mitochondrial dysfunction in white blood cells are not valid biomarkers of ageing in the very old

scientific article

Reliability of intracellular water and ion distributions as measured by X-ray microanalysis--a review

scientific article published on January 1, 1991

Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage

scientific article

Replicative aging, telomeres, and oxidative stress

scientific article

Replicative senescence and the art of counting

scientific article published on November 2003

Replikative Seneszenz als Alternsmodell: Die Rolle von oxidativem Streß und Telomerenverkürzung - eine übersicht

scientific article published on 01 April 1999

Reproducibility of Telomere Length Assessment--An International Collaborative Study

scientific article published on 24 September 2015

Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic

scientific article published on 24 September 2015

Reproducibility of telomere length assessment: an international collaborative study

scientific article published on 19 September 2014

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

scientific article

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

scientific article

Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson's Disease: The ICICLE-PD Study

scientific article published on 01 January 2020

Senolytics and senostatics as adjuvant tumour therapy

scientific article published on 06 February 2019

Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study

scientific article

Shared Ageing Research Models (ShARM): a new facility to support ageing research.

scientific article published on 02 October 2013

Shifting focus

scientific article published on 01 February 2010

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

scientific article

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

scientific article published in November 2000

Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts

scientific article published on 05 June 2019

Standardization and quality controls for the methylated DNA immunoprecipitation technique

scientific article published on 01 June 2012

Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span

scientific article published on 12 February 2004

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

scientific article

Sublethal whole-body irradiation causes progressive premature frailty in mice

scientific article published on 04 April 2019

Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response.

scientific article published on 16 December 2008

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver.

scientific article

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts

scientific article

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

scientific article published on 25 March 2019

Telomerase as a promising target for human cancer gene therapy.

scientific article

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

scientific article published on 11 March 2008

Telomerase inhibition by induced expression of antisense RNA.

scientific article published on January 1998

Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936.

scientific article

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.

scientific article

Telomere length and physical performance at older ages: an individual participant meta-analysis

scientific article

Telomere length as a marker of oxidative stress in primary human fibroblast cultures

article

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.

scientific article

Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study

scientific article published on 10 January 2007

Telomere length predicts cardiovascular disease

scientific article published in the British Medical Journal

Telomere length predicts poststroke mortality, dementia, and cognitive decline.

scientific article published in August 2006

Telomere shortening and haemodialysis

scientific article published on 22 December 2005

Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3'-overhang

scientific article published in June 2004

Telomere shortening reduces regenerative capacity after acute kidney injury

scientific article

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments.

scientific article published on September 1999

Telomere-driven replicative senescence is a stress response

scientific article published on 01 March 2003

Telomeres as biomarkers for ageing and age-related diseases.

scientific article

Telomeres, telomerase and the cancer cell: an introduction

scientific article published on 01 May 2003

The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult

scientific article

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice

scientific article published on 17 February 2017

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

scientific article published on 18 April 2017

The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol.

scientific article

The bystander effect contributes to the accumulation of senescent cells in vivo

scientific article published on 21 November 2018

The epigenetic clock and telomere length are independently associated with chronological age and mortality

scientific article published on 13 April 2016

The epigenetic clock and telomere length are independently associated with chronological age and mortality

scientific article published on 27 November 2017

The intracellular distribution of ions and water in rat liver and heart muscle

scientific article published on 01 April 1987

The mTORC1-autophagy pathway is a target for senescent cell elimination.

scientific article published on 23 February 2019

The relationship between the aging- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts

scientific article

The role of telomeres in Etoposide induced tumor cell death.

scientific article published on 13 September 2004

The senescent bystander effect is caused by ROS-activated NF-κB signalling

scientific article

Tissue differences in BER-related incision activity and non-specific nuclease activity as measured by the comet assay.

scientific article published on 4 October 2013

Tumour-cell apoptosis after cisplatin treatment is not telomere dependent

scientific article published on June 2006

Very low cadmium concentrations stimulate DNA synthesis and cell growth

scientific article published on December 1, 1992

Vulnerability to oxidative stress and different patterns of senescence in human peritoneal mesothelial cell strains

scientific article

Water and ion distribution profiles in human skin.

scientific article

Water and ion distributions in myocytes cultured under oxidative stress mimic changes found in the process of aging

scientific article published on 01 April 1991

Water and ion shifts in mouse intestinal cells following VIP stimulation.

scientific article

Will your telomeres tell your future? ⬇️

scientific article published on March 13, 2012

X-ray microanalysis of intracellular elemental distribution

scientific article published on 01 January 1984

[Experimental diabetic neuropathy. Morphometric studies of spinal ganglia cells in short-term streptozotocin-induced diabetes]

scientific article published on 01 January 1987

[Ions and chromatin structure--morphologic and x-ray microanalytic findings]

scientific article published in January 1990

[Molecular mechanisms of senescence in cell culture].

scientific article

[Quantitative roentgen microanalysis of biological ultrathin sections with aluminum-carbon vapor films as standards]

scientific article

[X-ray microanalysis--possibilities and methods]

scientific article published in January 1990

hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines

article

ssDNA fragments induce cell senescence by telomere uncapping

scientific article

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