Search filters

List of works by Douglas Kell

'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries

scientific article

A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs

scientific article published on 19 September 2014

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

scientific article (publication date: 8 August 2016)

A Dormant Microbial Component in the Development of Preeclampsia

scientific article

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

scientific article published in April 2008

A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery

scientific article published on 13 August 2020

A bacterial cytokine

scientific article

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

scientific article published on 24 July 2019

A community-driven global reconstruction of human metabolism. ⬇️

scientific article

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

scientific article

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

scientific article (publication date: 2001)

A general model of error-prone PCR

article

A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text

scientific article (publication date: July 2013)

A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units

scientific article

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

scientific article published on 04 July 2013

A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans

scientific article published in April 1982

A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

scientific article published on 19 April 2013

A proposed framework for the description of plant metabolomics experiments and their results

article

A systematic approach to modeling, capturing, and disseminating proteomics experimental data

scientific article

A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation.

scientific article

A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating Dictyostelium discoideum amoebae

scientific article published in February 1999

Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach

scientific article

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

scientific article published on September 2016

Adam (robot scientist)

laboratory robot that can discover scientific knowledge independently of its creators

Adoption of the transiently non-culturable state--a bacterial survival strategy?

scientific article published on January 2003

Alignment by numbers: sequence assembly using compressed numerical representations

An adenine nucleotide translocase in the procaryote Methanobacterium thermoautotrophicum

scientific article published on 01 August 1980

An analysis of a 'community-driven' reconstruction of the human metabolic network

scientific article

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

scientific article published on 08 June 2018

Anaesthetic function

Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries

scientific article published on 23 November 2017

Analysis of a complete DNA-protein affinity landscape

scientific article

Analysis of aptamer sequence activity relationships

scientific article

Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures

scientific article published on 9 March 2017

Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers

scientific article published on 24 June 2008

Aptamer evolution for array-based diagnostics

scientific article

Arcadia: a visualization tool for metabolic pathways

scientific article published on 7 May 2010

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

scientific article

Author Correction: Hitchhiking into the cell

scientific article published on 08 April 2020

Automated manipulation of systems biology models using libSBML within Taverna workflows

scientific article

Automated tracking of gene expression in individual cells and cell compartments.

scientific article

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

scientific article

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

scientific article published in 2011

Automatic tracking of biological cells and compartments using particle filters and active contours

article published in 2006

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

article published in 2019

Bacterial dormancy and culturability: the role of autocrine growth factors

scientific article

Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo

scientific article published on 20 March 2008

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains

scientific article published in February 2018

Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration ⬇️

scientific article (publication date: September 2011)

Butyricin 7423 and the membrane H+-ATPase of Clostridium pasteurianum

scientific article published on 01 February 1982

Calling International Rescue: knowledge lost in literature and data landslide!

scientific article

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

scientific article published on March 2008

Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.

scientific article published on 22 September 2009

Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies

scientific article published on 13 August 2010

Channelling can decrease pool size

scientific article published in February 1992

Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations.

scientific article

Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics

scientific article published in January 2007

Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks".

scientific article published on 26 January 2017

Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs

scientific article

Comprehensive Natural Products Chemistry, Volume 4: Amino Acids, Peptides, Porphyrins and Alkaloids

Computational cluster validation in post-genomic data analysis

scientific article

Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA.

scientific article

Concussion's impact

Confirmation by using mutant strains that the membrane-bound H(+)-ATPase is the major source of non-linear dielectricity in Saccharomyces cerevisiae

scientific article published in November 1991

Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites [...]

scientific article

Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important natural drug transporter substra

Continuous monitoring of the electrical potential across energy-transducing membranes using ion-selective electrodes. Application to submitochondrial particles and chromatophores

scientific article published on February 1978

Controlled vocabularies and semantics in systems biology

scientific article (publication date: 25 October 2011)

Convergent evolution to an aptamer observed in small populations on DNA microarrays

scientific article published on September 2010

Correction of mass spectral drift using artificial neural networks

scientific article published on January 1996

Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra

scientific article published in February 2000

Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus

scientific article published in Scientific Reports

Corrigendum to "Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery" [Drug Discov. Today 19 (2014), 171-182.

scientific article published on 31 March 2014

Coupling factor B and the bovine mitochondrial H+-ATP synthase

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

scientific article published on 21 July 2020

Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery

scientific article published on 01 December 2000

DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

scientific article published on 04 September 2020

Defrosting the digital library: bibliographic tools for the next generation web.

scientific article

Detection and identification of novel metabolomic biomarkers in preeclampsia

scientific article published on 20 May 2008

Detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier transform infrared spectroscopy

scientific article published in January 2000

Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae

scientific article published in 2009

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

article

Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum

scientific article

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

scientific article published on May 2014

Dielectric spectroscopy as a tool for the measurement of the formation of biofilms and of their removal by electrolytic cleaning pulses and biocides

article

Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique

scientific article published on November 2004

Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry.

scientific article published on January 2002

Diffusion of protein complexes in prokaryotic membranes: fast, free, random or directed?

Discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks.

scientific article published in January 1998

Discrimination of Aerobic Endospore-forming Bacteria via Electrospray-Ionization Mass Spectrometry of Whole Cell Suspensions

scientific article published on 01 September 2001

Discrimination of modes of action of antifungal substances by use of metabolic footprinting.

scientific article

Do bacteria need to communicate with each other for growth?

scientific article published on June 1996

Dormant microbes: time to revive some old ideas

scientific article published in Nature

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

scientific article

Efficient improvement of silage additives by using genetic algorithms

scientific article

Energetic evolution of cellular Transportomes.

scientific article

Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

scientific article

Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine

scientific article

Enzyme kinetics informatics: from instrument to browser

scientific article

Erratum: The Systems Biology Graphical Notation

scholarly article published in Nature Biotechnology

Eryptosis as a marker of Parkinson's disease

scientific article

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19

scientific article published on 03 November 2020

Estimation of Microbial Viability Using Flow Cytometry

scientific article published on 01 September 2004

Event extraction for systems biology by text mining the literature

scientific article

Event-based text mining for biology and functional genomics

scientific article

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

scientific article

Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin

scientific article published on 29 March 2017

Explanatory Optimization of Protein Mass Spectrometry via Genetic Search

scientific article published on 01 December 2003

Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing

scientific article (publication date: 2012)

Extracting semantically enriched events from biomedical literature

scientific article

Facilitating the development of controlled vocabularies for metabolomics technologies with text mining

scientific article

Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels

scientific article published on 28 April 2004

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

scientific article

Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly

scientific article

Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification

scientific article

Fluorescent brighteners: novel stains for the flow cytometric analysis of microorganisms.

scientific article published in August 1997

Formulation and some biological uses of a buffer mixture whose buffering capacity is relatively independent of pH in the range pH 4–9

scientific article published on 01 September 1980

From code to mode for orphan genes

article

Functional genomic hypothesis generation and experimentation by a robot scientist

scientific article (publication date: 15 January 2004)

Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry

scientific article

Further developments towards a genome-scale metabolic model of yeast

scientific article (publication date: 28 October 2010)

GeneGenie: optimized oligomer design for directed evolution

scientific article

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

scientific article published on 07 June 2019

Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry

scholarly article by David I Broadhurst et al published August 1997 in Analytica Chimica Acta

Genetic programming as an analytical tool for non-linear dielectric spectroscopy

scientific article published in May 1999

Genetic programming:  a novel method for the quantitative analysis of pyrolysis mass spectral data

scientific article

Genetics and iron in the systems biology of Parkinson's disease and some related disorders

scientific article published on 07 December 2012

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability

article

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

scientific article

Genomic computing. Explanatory analysis of plant expression profiling data using machine learning

scientific article

Genotype-phenotype mapping: genes as computer programs

scientific article

Going places: forced and natural molecular evolution.

scientific article published in September 1996

Growth control of the eukaryote cell: a systems biology study in yeast ⬇️

scientific article (publication date: 2007)

Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era

scientific article (publication date: 2003)

Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops

scientific article

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.

scientific article published on 06 December 2013

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

scientific article

High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics

scientific article published on March 2004

Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging

scientific article published on 01 November 2001

Hitchhiking into the cell

scientific article published on 01 April 2020

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

scientific article

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

scientific article published on 7 February 2006

Hydrodynamic deposition: A novel method of cell immobilization

scientific article published on 01 June 1990

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.

scientific article published on 23 December 2007

If you've got it, flaunt it--rapid screening for microbial biocatalysts

scientific article published in April 1997

Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father

scientific article published in January 2017

Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness

scientific article published on 01 February 2016

Implications of the dominant role of transporters in drug uptake by cells

scientific article

Improving metabolic flux predictions using absolute gene expression data

scientific article

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

scientific article published on 17 November 2008

Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology

scientific article

Information management for high content live cell imaging

scientific article

Information-theoretic sensitivity analysis: a general method for credit assignment in complex networks

scientific article published on February 2008

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway

scientific article published on 23 October 2006

Intelligent host engineering for metabolic flux optimisation in biotechnology

scientific article published in 2021

Interactions among oscillatory pathways in NF-kappa B signaling

scientific article

Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli

scientific article published on 22 August 2019

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia

scholarly article by Lesha Pretorius et al published 2018 in Frontiers in Neuroscience

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease

scientific article published on 29 December 2020

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

scientific article

Journal club. A systems biologist ponders how disparate ideas can sometimes come together beautifully

scientific article

KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways

scientific article published on 31 March 2009

Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how ⬇️

scientific article published on June 5, 2012

Lipopolysaccharide-Binding Protein (LBP) Can Reverse The Amyloid State Of Fibrin Seen Or Induced In Parkinson's Disease: Implications For Its Aetiology

scholarly article published 4 April 2017

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease

scientific article published in March 2018

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities.

scientific article published on 29 August 2017

Localized energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22

scientific article published on 01 October 1982

Macromolecular interactions: tracing the roots

scientific article published on 01 February 2001

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

scientific article

Making cells work — metabolic engineering for everyone

scientific article published on 01 January 1997

Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model

scientific article

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

scientific article

MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules from Their Mass Spectra

scientific article published in 2021

Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes

scientific article published in July 1987

MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics

scientific article

Measurement by a flow dialysis technique of the steady-state proton-motive force in chromatophores from Rhodospirillum rubrum. Comparison with phosphorylation potential

scientific article published on April 1978

Mechanisms for the interaction between nonstationary electric fields and biological systems I. Linear dielectric theory and its limitations

article

Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction

article

Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli

scientific article published in 2021

Membrane tension

scientific article published on 01 May 1996

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

scientific article

Mental health: Drug search on risky path

scientific article published in April 2014

MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites

scientific article

Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway

scientific article

Metabolic control theory: its role in microbiology and biotechnology

scholarly article by Douglas Kell published in October 1986

Metabolic footprinting and systems biology: the medium is the message

scientific article

Metabolic footprinting as a tool for discriminating between brewing yeasts

article

Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

scientific article

Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy

scientific article

Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils

scientific article published on 01 November 2002

Metabolites do social networking ⬇️

scientific article published on January 1, 2011

Metabolomic biomarkers: search, discovery and validation

Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules

scientific article

Metabolomics and systems biology: making sense of the soup

scientific article

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

scientific article

Metabolomics by numbers: acquiring and understanding global metabolite data

scientific article

Metabolomics, machine learning and modelling: towards an understanding of the language of cells.

scientific article

Microbes and Alzheimer's Disease

scientific article

Mining metabolites: extracting the yeast metabolome from the literature

scientific article

Molecular phenotyping of a UK population: defining the human serum metabolome

scientific article

Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production

scientific article

Mosaic protonic coupling hypothesis for free energy transduction.

scientific article published on January 1984

Multiobjective optimization in bioinformatics and computational biology

scientific article

Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation

scientific article published in January 2006

New materials and technology for cell immobilization

scientific article

New materials and technology for cell immobilization

scientific article published on 01 April 1992

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.

scientific article

Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating

Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation

scientific article

Non-linear systems: Coherent excitation in biology

scientific article published in Nature

On harmonic generation in nonlinear biological systems

article

On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins

scholarly article by Douglas Kell published in May 1981

On resuscitation from the dormant state of Micrococcus luteus.

scientific article

On the Mode of Action of the Bacteriocin Butyricin 7423. Effects on Membrane Potential and Potassium-Ion Accumulation in Clostridium pasteurianum

scientific article published on 01 September 1982

On the analysis of the inverse problem of metabolic pathways using artificial neural networks

scientific article published in January 1996

On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 1. Theory and overview

scientific article published in January 1985

On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 2. Experiments with microbial cells, protoplasts and membrane vesicles

scientific article published in January 1985

On the effects of thiocyanate and venturicidin on respiration-driven proton translocation in Paracoccus denitrificans

scientific article published on 01 July 1984

On the functional proton current pathway of electron transport phosphorylation ⬇️

scientific article published on July 3, 1979

On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning.

scientific article

On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridiumpasteurianum

scientific article published on 01 March 1981

On the physiological significance of metabolite channelling: If, how, and where, but not why

scientific article published on 01 September 1991

On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool

scientific article published in June 1993

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

scientific article published on 8 September 2015

Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning.

scientific article

Oscillations in NF-kappaB signaling control the dynamics of gene expression

scientific article

Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically controlled yeast cultures

scientific article published in January 1996

Oxidation-reduction properties of coenzyme M (2-mercaptoethane sulphonate) at the mercury electrode

scientific article published on December 1979

Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens

scholarly article published 24 May 2019

PartsGenie: an integrated tool for optimising and sharing synthetic biology parts

scholarly article published 15 September 2017

PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts

scholarly article by Neil Swainston published in February 2018

Path2Models: large-scale generation of computational models from biochemical pathway maps

scientific article

Performing statistical analyses on quantitative data in Taverna workflows: an example using R and maxdBrowse to identify differentially-expressed genes from microarray data

scientific article

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

scientific article

Pheromones, social behaviour and the functions of secondary metabolism in bacteria

scientific article published on 01 March 1995

Physical Aspects of Protein Interactions

scholarly article by Douglas Kell published in November 1979

Physiological studies on the solid-state quinoa tempe fermentation, using on-line measurements of fungal biomass production

article

Plant seed classification using pyrolysis mass spectrometry with unsupervised learning: The application of auto-associative and Kohonen artificial neural networks

article

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

scientific article

Predicting the points of interaction of small molecules in the NF-κB pathway

scientific article

Predictive models for population performance on real biological fitness landscapes

scientific article

Prevalence of readily detected amyloid blood clots in 'unclotted' Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report

scientific article published on 17 November 2020

Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor

scientific article

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

article

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.

scientific article published on 09 January 2014

Progress being made on standards for use in data sharing

scientific article published on November 2008

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

scientific article

Proton-coupled energy transduction by biological membranes. Principles, pathways and praxis

article

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

scientific article published on 9 October 2007

Publishing: Reviews turn facts into understanding

scientific article published in Nature

Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

scientific article

Pyrolysis mass spectrometry and its applications in biotechnology.

scientific article published in February 1996

Quantification of microbial productivity via multi-angle light scattering and supervised learning

scientific article

Quantifying heterogeneity: flow cytometry of bacterial cultures

scientific article published on October 1991

Quantitative Problems in Biochemistry (Sixth Edition)

scholarly article by Douglas Kell published in December 1981

Quantitative approaches to the analysis of the control and regulation of microbial metabolism

scientific article published on October 1991

Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to alpha 2-interferon production.

scientific article published in July 1999

Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b5 in Escherichia coli

scientific article published in May 1994

Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning

scientific article

Rapid authentication of animal cell lines using pyrolysis mass spectrometry and auto-associative artificial neural networks

scientific article

Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks

scientific article published in July 1996

Rapid identification using pyrolysis mass spectrometry and artificial neural networks of Propionibacterium acnes isolated from dogs

scientific article published in February 1994

Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks.

scientific article

Real-time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation

scientific article published on 01 March 1991

Recon 2.2: from reconstruction to model of human metabolism ⬇️

scientific article

Response to 'The Need for Speed', by Matsson et al.

scientific article

Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers

scientific article published in October 2010

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

scientific article

Sample preparation in matrix-assisted laser desorption/ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins

scientific article

Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

scientific article published in August 2002

Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments?

scientific article published on 18 January 2012

Screen idols: faster, smaller, cheaper and smarter

scientific article published on 01 May 2000

Screensavers: trends in high-throughput analysis

article

Secretion of an antibacterial factor during resuscitation of dormant cells in Micrococcus luteus cultures held in an extended stationary phase

article

Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics

scientific article

Selenzyme: Enzyme selection tool for pathway design

scientific article published on 7 February 2018

Selenzyme: Enzyme selection tool for pathway design

Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha

scientific article

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation

scientific article published on 28 February 2019

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

scientific article published on 01 April 2014

Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment

scientific article

Single-nucleotide polymorphism detection using nanomolar nucleotides and single-molecule fluorescence

scientific article published in April 2004

Solvent selection for whole cell biotransformations in organic media.

scientific article published on January 1995

Something from nothing: bridging the gap between constraint-based and kinetic modelling

scientific article published on 8 October 2007

SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution

scientific article

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation

scientific article

Stimulation by potassium ions of the growth of Rhizopus oligosporus during liquid-and solid-substrate fermentations

scientific article published on 01 March 1991

Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor

scientific article published on 01 July 1999

Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products

scientific article published on 23 November 2020

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains

scientific article published on 2 November 2017

Synergistic control of oscillations in the NF-kappaB signalling pathway

scientific article

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

scientific article

Systematic functional analysis of the yeast genome

scientific article

Systematic integration of experimental data and models in systems biology ⬇️

scientific article (publication date: 29 November 2010)

Systems biology, metabolic modelling and metabolomics in drug discovery and development

scientific article published on 19 October 2006

Text mining and its potential applications in systems biology

scientific article published on 12 October 2006

The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia

scientific article published on 22 August 2018

The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks

scientific article

The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities

scientific article published on 17 November 2015

The biology of ergothioneine, an antioxidant nutraceutical

scientific article published on 13 February 2020

The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).

scientific article

The dielectric permittivity at radio frequencies and the bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures

article

The dogs that did not bark.

scientific article published in November 1994

The dormant blood microbiome in chronic, inflammatory diseases

scientific article

The dynamics of electrostatic interactions between membrane proteins

article

The effect of heteroscedastic noise on the chemometric modelling of frequency domain data

The estimation of microbial biomass

scientific article

The genetic control of growth rate: a systems biology study in yeast.

scientific article

The growth and nutrition of Clostridium sporogenes NCIB 8053 in defined media

scientific article published on 01 January 1987

The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements:

The inhibition by CO2 of the growth and metabolism of micro-organisms

scientific article published on August 1989

The markup is the model: reasoning about systems biology models in the Semantic Web era

scientific article

The metabolome 18 years on: a concept comes of age

scientific article

The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology

scientific article

The physiology of Clostridium sporogenes NCIB 8053 growing in defined media

scientific article published on 01 January 1987

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so.

scientific article

The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data

scientific article published on 29 November 2019

The rpf gene of Micrococcus luteus encodes an essential secreted growth factor

scientific article published in November 2002

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).

scientific article

The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture

scientific article published in January 1995

The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time

scientific article published on 01 January 2000

The virtual human: towards a global systems biology of multiscale, distributed biochemical network models

scientific article

The virtue of innovation: innovation through the lenses of biological evolution

scientific article

Theodor Bücher Lecture. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and the 9th IUBMB conference in Budapest.

scientific article

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

scientific article

Towards a rational approach to the optimization of flux in microbial biotransformations

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples ⬇️

scientific article published on August 17, 2010

Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting

scientific article published on 01 September 2018

Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

scientific article published on 13 May 2015

Utopia documents: linking scholarly literature with research data

scientific article

VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder

scientific article published on 29 July 2020

Vacuum packing: a model system for laboratory-scale silage fermentations.

scientific article published in January 2005

Variable selection and multivariate methods for the identification of microorganisms by flow cytometry

scientific article published on 01 February 1999

Variable selection in discriminant partial least-squares analysis

scientific article published in October 1998

Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth

scientific article published on 11 February 2019

Viability and activity in readily culturable bacteria: a review and discussion of the practical issues

scientific article published on 01 February 1998

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

scientific article published on 10 October 2015

Visualising biological data: a semantic approach to tool and database integration

scientific article

What bio technologists knew all along...?

scientific article published in October 1996

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

scientific article

Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel

scientific article published in March 1996

Yeast cells with impaired drug resistance accumulate glycerol and glucose.

scientific article published in January 2014

[40] Localized protonic coupling: Overview and critical evaluation of techniques

scientific article published on 01 January 1986

biochem4j: Integrated and extensible biochemical knowledge through graph databases.

scientific article published on 14 July 2017

maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination

scientific article

Paulina is supported by:

About Paulina

Help