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List of works by Doug Hilton

A convenient method for preparation of an engineered mouse interleukin-3 analog with high solubility and wild-type bioactivity

scientific article

A family of cytokine-inducible inhibitors of signalling

scientific article

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency

scientific article published in February 2009

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

scientific article published on 25 July 2014

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

scientific article

A preliminary molecular phylogeny of shield-bearer moths (Lepidoptera: Adeloidea: Heliozelidae) highlights rich undescribed diversity.

scientific article published on 8 December 2017

A somatic cell genetic system for dissecting hemopoietic cytokine signal transduction

scientific article

Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest

scientific article (publication date: November 2000)

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

scientific journal article

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

scientific article

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.

scientific article

An Interleukin (IL)-13 Receptor Lacking the Cytoplasmic Domain Fails to Transduce IL-13-Induced Signals and Inhibits Responses to IL-4 ⬇️

scientific article published on September 5, 1997

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

scientific article

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

scientific article

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene

scientific article published on 21 January 2005

Antennal scales improve signal detection efficiency in moths

scientific article published on 01 March 2018

Australian science needs more female fellows ⬇️

scientific article published on May 2, 2013

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

scientific article

Cellular Processing of Murine Colony-Stimulating Factor (Multi-CSF, GM-CSF, G-CSF) Receptors by Normal Hemopoietic Cells and Cell Lines

scientific article published on 01 January 1988

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

scientific article

Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice

scientific article published on 01 September 1991

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

scientific article

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4

scientific article

Complex Binding of Leukemia Inhibitory Factor to Its Membrane-Expressed and Soluble Receptors

scientific article published on 01 July 1994

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

scientific article published on 8 May 2015

Critical roles for c-Myb in lymphoid priming and early B-cell development

scientific article

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes

scientific article

DAN is a secreted glycoprotein related to Xenopus cerberus.

scientific article published in October 1998

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

scientific article

Defining Control

scientific article published on 01 September 2003

Development of hydrocephalus in mice lacking SOCS7.

scholarly article

Differential regulation of SOCS genes in normal and transformed erythroid cells

scientific article published on May 2003

Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction

scientific article (publication date: 8 August 1997)

Donald Metcalf (1929-2014).

scientific article

Donald Metcalf (1929–2014)

scientific article published on 01 January 2015

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

scientific article

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

scientific article

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model

scientific article published on 14 May 2015

Epigenetic regulator Smchd1 functions as a tumor suppressor

scientific article published on 26 December 2012

Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions.

scientific article

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

scientific article published on 14 June 2011

Estimating the proportion of microarray probes expressed in an RNA sample

scientific article

Function of PRC2 accessory factors in haematopoietic stem cells

Functional analysis of Asb-1 using genetic modification in mice

scientific article

Generating mouse models of retinal disease using ENU mutagenesis.

scientific article published in February 2002

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

scientific article published on 19 June 2015

Gigantism in mice lacking suppressor of cytokine signalling-2

scientific article (publication date: 29 June 2000)

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

scientific article (publication date: June 2002)

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

scientific article published on 3 August 2016

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

scientific article published on 24 December 2008

Identification of a Siglec-F+ granulocyte-macrophage progenitor.

scientific article published on 12 April 2018

Identification of diploid platelet-forming cells prior to the emergence of polyploidy megakaryocyte in the mouse embryo

Ihstone H3 lysine 9 methylation is involved not only in maintaining epigenetic silencing, but is essential for setting up gene silencing

article

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology

scientific article published in June 2015

Inhibition of differentiation in a murine F9 embryonal carcinoma cell subline by leukemia inhibitory factor (LIF).

scientific article published on January 1992

Inhibitors of cytokine signal transduction

scientific article

LIF: a molecule with divergent actions on myeloid leukaemic cells and embryonic stem cells

scientific article published on January 1989

LIF: lots of interesting functions

scientific article

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

scientific article published on December 1996

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

scientific article published on 01 March 1990

Leukemia inhibitory factor and its receptor

Leukemia inhibitory factor: a biological perspective.

scientific article published on May 1991

Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.

scientific article

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

scientific article published on November 1998

Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα

scientific article published on 01 October 2007

Membrane budding is a major mechanism of in vivo platelet biogenesis

scientific article published on 01 September 2020

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Rα)

scientific article published on 01 October 2019

MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets

scientific article published on 4 May 2017

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.

scientific article

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

scientific article published on 07 April 2014

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule

scientific journal article

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia

scientific article

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

scientific article

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

scientific article

Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1

scientific article published on 08 September 2002

Negative Regulation of the JAK/STAT Signaling Pathway

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

scientific article published on 28 January 2009

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

scientific article published on 5 May 2010

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

scientific article

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

scientific journal article

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

scientific article

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

scientific article

Probabilistic analysis of recessive mutagenesis screen strategies

scientific article published on 23 January 2007

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1

scientific article

Proximal genomic localization of STAT1 binding and regulated transcriptional activity

scientific article published on 11 October 2006

Purification of a murine leukemia inhibitory factor from Krebs ascites cells

scientific article published on 01 September 1988

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

scientific article published on 21 November 2011

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

scientific article

Regulation of hematopoietic stem cells by their mature progeny

scientific article

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.

scientific article

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

scientific article

SOCS-3 is an insulin-induced negative regulator of insulin signaling

scientific article published on May 2000

SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling.

scientific article published in March 2003

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

scientific article

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

scientific article published in September 1999

SOCS2 negatively regulates growth hormone action in vitro and in vivo

scientific journal article

SOCS2 negatively regulates growth hormone action in vitro and in vivo

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

scientific article published in February 2004

SOCS3 negatively regulates IL-6 signaling in vivo

scientific article

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

scientific article published on July 2004

SOCS: suppressors of cytokine signalling

scientific article

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

scientific article published on 01 December 1999

Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor.

scientific article

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

scientific article published on 18 May 2016

Signaling by type I and II cytokine receptors: ten years after

scientific article

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

scientific journal article

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

scientific article published on 8 April 2008

Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus.

scientific article

Structural characterization of a murine myeloid leukaemia inhibitory factor

scientific article published on 01 August 1988

Suckling defect in mice lacking the soluble haemopoietin receptor NR6.

scientific article published in June 1999

Suppression of cytokine signaling: the SOCS perspective

scientific article published on 30 March 2013

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transductionin Vitroandin Vivo

scientific article published on 16 April 2001

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

scientific article published on 28 March 2003

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

scientific journal article

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

scientific article published on 15 January 2006

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

scientific article published on 27 November 2005

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

scientific article

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

scientific article published in April 2003

Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.

scientific article

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

scientific article published on June 2000

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

scientific article

Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease

scientific article

Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors

scientific article

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

scientific article published on 25 April 2013

The Negative Regulation of JAK/STAT Signaling

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

scientific article

The SOCS box: a tale of destruction and degradation

scientific article (publication date: May 2002)

The art and design of genetic screens: mouse

scientific article

The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.

scientific article published on December 1998

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling

scientific article published on 10 February 2006

The erythropoietin receptor: dimerization, activation, and tumorigenesis

scientific article published on January 1992

The gene for the human interleukin-11 receptor alpha chain locus is highly homologous to the murine gene and contains alternatively spliced first exons.

scientific article published on May 1997

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

scientific article

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

scientific article published on January 2004

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

scientific article published on April 2006

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

scientific article

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

scientific article

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

scientific article

Tissue-specific induction of SOCS gene expression by PRL

scientific article published on 01 November 2001

Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice.

scientific article

Tribute to Donald Metcalf

scientific article published in December 2015

Twenty proteins containing a C-terminal SOCS box form five structural classes

scientific article published in January 1998

Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells.

scientific article published on October 1996

Understanding the molecular regulation of eosinophil production: a basis for intervention in inflammatory disease

Why Australia needs a Medical Research Future Fund

scientific article published on February 2015

c-Myb is required for progenitor cell homeostasis in colonic crypts.

scholarly article

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