List of works - Sarah Richardson

A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

scientific article published on 8 January 2018

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

scientific article published on 20 September 2018

Activity of thalidomide and lenalidomide in mantle cell lymphoma.

scientific article

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

scientific article published on 7 December 2015

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

scientific article published on 22 May 2020

Analysis of islet inflammation in human type 1 diabetes.

scientific article

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes

scientific article

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

scientific article

Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

scientific article published on 01 August 2019

Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice.

scientific article published on 20 September 2016

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

scientific article published on 29 January 2017

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes

scientific article

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

scientific article published on 16 January 2014

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

scientific article published on 8 February 2016

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

scientific article published on 10 June 2015

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

scientific article published on 29 July 2018

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

scientific article published on 28 August 2014

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845

scientific article published on September 2015

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

scientific article published on 5 November 2013

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes.

scientific article published on 9 June 2010

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

scientific article published on 14 October 2012

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

scholarly article by Noel G Morgan et al published 1 December 2018 in Diabetologia

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes

scientific article

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

scientific article published on 04 March 2019

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

scientific journal article

Identifying the 'Achilles Heel' of type 1 diabetes

scientific article published on 24 December 2020

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

scientific article published on 20 May 2011

Immunopathology of the human pancreas in type-I diabetes

scientific article published on 28 April 2010

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets

scientific article published on May 2013

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

scientific article published on 19 November 2013

Is type 1 diabetes "going viral"?

scientific article published on July 2014

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

scientific article

Islet inflammation in human type 1 diabetes mellitus

scientific article

Islet-associated macrophages in type 2 diabetes.

scientific article published on 6 June 2009

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

scientific article published on 23 April 2019

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

scientific article published on 17 January 2018

Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

article

Pancreas Pathology During the Natural History of Type 1 Diabetes

scholarly article by Teresa Rodriguez-Calvo et al published 6 October 2018 in Current diabetes report

Pancreatic pathology in type 1 diabetes mellitus

scientific article published on March 2014

Physiological doses of cannabinoids do not adversely affect MCL viability

scientific article published on 01 September 2007

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

scientific article published on 21 October 2020

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes

scientific article published on 23 January 2019

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

scientific article published on 9 January 2017

Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

scientific article published in 2024

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

scientific article

Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences.

scientific article published on 9 August 2012

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

scientific article

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

scientific article

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

scientific article published on 15 March 2020

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

scientific article published on 26 September 2018

The diagnosis of insulitis in human type 1 diabetes.

scientific article

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

scientific article

The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells

scientific article

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor

scientific article published on 9 June 2015

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

scientific article published on 18 October 2018

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

scientific article published on 15 September 2020

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

scientific article published on 03 August 2018

Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue

scientific article published on 21 August 2010

What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes

scientific article published on 09 December 2019

Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1.

scientific article published on 26 September 2016

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

scientific article published on 06 December 2005

miR, miR in the Cell, Does the Virus Control Them All?

scientific article published on April 2016

List of works by Sarah Richardson

A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Activity of thalidomide and lenalidomide in mantle cell lymphoma.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

Analysis of islet inflammation in human type 1 diabetes.

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase.

Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

Central nervous system infection following vertical transmission of Coxsackievirus B4 in mice.

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845

Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes.

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

Identifying the 'Achilles Heel' of type 1 diabetes

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

Immunopathology of the human pancreas in type-I diabetes

Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets

Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

Is type 1 diabetes "going viral"?

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

Islet inflammation in human type 1 diabetes mellitus

Islet-associated macrophages in type 2 diabetes.

Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

Pancreas Pathology During the Natural History of Type 1 Diabetes

Pancreatic pathology in type 1 diabetes mellitus

Physiological doses of cannabinoids do not adversely affect MCL viability

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

Single-agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences.

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms

The diagnosis of insulitis in human type 1 diabetes.

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue

What the HLA-I!-Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes

Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1.

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

miR, miR in the Cell, Does the Virus Control Them All?