List of works by Thomas E Willnow

A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction

scientific article published on 05 March 2008

Animal models for disorders of hepatic lipoprotein metabolism ⬇️

scientific article published on May 1, 1995

Apolipoprotein E receptor pathways in Alzheimer disease

scientific article published on 06 March 2014

Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

scientific article published on 24 April 2020

Author Correction: Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity

scientific article published on 05 May 2020

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

scientific article published in December 2009

Cadm2 regulates body weight and energy homeostasis in mice.

scientific article published on 22 November 2017

Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter

scientific article

Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein

scientific article published on 01 October 1997

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

scientific article

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

scientific article

Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria

scientific article published on 10 November 2017

Differential binding of ligands to the apolipoprotein E receptor 2.

scientific article

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

scientific article published on 10 August 2017

Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain.

scientific article published on September 2015

Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation.

scientific article published on 20 December 2013

Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros

scientific article published on 25 April 2006

Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.

scientific article

Essential role of the apolipoprotein E receptor-2 in sperm development.

scientific article published on 14 April 2003

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.

scientific article

Evidence for the Role of Megalin in Renal Uptake of Transthyretin

scientific article published in Journal of Biological Chemistry

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

scientific article published in November 2002

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

scientific article

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

scientific article

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule

scientific article

Functions of the LDL receptor gene family

scientific article published on 01 September 1994

Homologous recombination for gene replacement in mouse cell lines.

scientific article published on January 1994

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.

scientific article published on 3 December 2002

Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.

scientific article published in March 2012

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

scientific article

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist

scientific article

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

scientific article

Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).

scientific article published in April 2004

LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.

scientific article published on 29 September 2015

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche

scientific article published on 11 May 2010

LRP2 mediates folate uptake in the developing neural tube

scientific article published on 17 March 2014

LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease

scientific article published on 13 February 2016

Lipoprotein and receptor interactions in vivo.

scientific article published on April 1995

Lipoprotein receptors: new roles for ancient proteins.

scientific article

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease

scientific journal article

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.

scientific article

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

scientific article published in Journal of Biological Chemistry

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation

scientific article

Mechanisms of Hepatic Chylomicron Remnant Clearance ⬇️

scientific article published on August 1, 1997

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

scientific article published in Journal of Biological Chemistry

Megalin antagonizes activation of the parathyroid hormone receptor.

scientific article

Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria

scientific article

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).

scientific article published in March 2002

Megalin knockout mice as an animal model of low molecular weight proteinuria.

scientific article published on October 1999

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

scientific article

Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis

scientific article

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

scientific article published in February 2006

Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease

scientific article

Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.

scientific article

Nanotubes, the fast track to treatment of Dent disease?

scientific article published in April 2017

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

scientific article

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

scientific journal article

PET imaging of leptin biodistribution and metabolism in rodents and primates.

scientific article

Pin-pointing APP processing.

scientific article published in June 2006

Protein sorting gone wrong--VPS10P domain receptors in cardiovascular and metabolic diseases

scientific article

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

scientific article

Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors

scientific article published on 01 August 1998

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.

scientific article

Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin ⬇️

scientific article published on April 29, 2003

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.

scientific article published in January 2012

Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease

scientific article

Role of Sortilin in Models of Autoimmune Neuroinflammation

scientific article published on 13 November 2015

Role of endocytosis in cellular uptake of sex steroids.

scientific article

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

scientific article published on 14 October 2007

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein.

scientific article published on July 2016

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

scientific article published on 12 February 2018

SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration

scientific article published on 7 November 2017

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity

scientific article published on 20 June 2016

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

scientific article

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

scientific article

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

scientific article

SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease.

scientific article published on January 2010

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

scientific article published on 26 July 2016

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia

scientific journal article

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1

scientific article

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

scientific article

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

scientific article

Sortilin is essential for proNGF-induced neuronal cell death

scientific article

Sortilin: a receptor to regulate neuronal viability and function

scientific article

Sorting receptor SORLA: cellular mechanisms and implications for disease

scientific article published on 10 November 2016

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

scientific article published on 18 May 2014

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

scientific article published in November 1996

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.

scientific article published on 10 February 2010

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

scientific article published in April 2005

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

scientific article published on January 1996

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit

scientific article published on 01 August 1996

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

scientific article

The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.

scientific article published on 9 June 2010

The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

scientific article published on 16 October 2012

VPS10P-domain receptors - regulators of neuronal viability and function.

scientific article

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