List of works - Evan W Newell

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

scientific article

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

scientific article published on 27 March 2019

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

scientific article published on November 2014

Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma.

scientific article published on 12 March 2018

Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.

scientific article published on 11 November 2015

Author Correction: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8 T cells

scientific article published in Nature Communications

Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

scientific article

Bystander CD4<sup>+</sup> T cells infiltrate human tumors and are phenotypically distinct

scientific article published in 2022

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

scientific article published in Nature

CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung

scientific article published on 9 September 2015

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

scientific article published on 23 October 2014

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

scientific article

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy

scientific article published on December 2013

Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding

scientific article

Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.

scientific article published in December 2017

Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants

scientific article published on 3 January 2018

Characterization of influenza vaccine immunogenicity using influenza antigen microarrays.

scientific article

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

scientific article published on 15 September 2017

Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells

scientific article published on 01 January 2020

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes

scientific article published on May 2015

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

article

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

scientific article published on 22 June 2020

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization.

scientific article

Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline

scientific article

Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

scientific article

Deep Profiling Human T Cell Heterogeneity by Mass Cytometry.

scientific article published on 8 April 2016

Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes

scientific article

Determining T-cell specificity to understand and treat disease

scientific article

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

scientific article published in February 2018

Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease

scientific article published on 22 July 2013

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

scientific article published on 26 December 2018

Dimensionality reduction for visualizing single-cell data using UMAP

scientific article published on 03 December 2018

Dissecting human ILC heterogeneity: more than just three subsets.

scientific article

Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation ⬇️

scientific article published on August 25, 2011

Dynamics of helper CD4 T cells during acute and stable allergic asthma

scientific article published on 07 August 2018

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

scientific article published on 01 May 2018

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients

scientific article published on 16 December 2016

Evaluation of UMAP as an alternative to t-SNE for single-cell data

scholarly article published 10 April 2018

Evidence for a functional sidedness to the alphabetaTCR.

scientific article

Gamma delta T cells recognize haptens and mount a hapten-specific response.

scientific article

Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.

scientific article published on 8 January 2018

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

article

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

scientific article published on 01 November 2018

High-Dimensional Profiling of Tumor-Specific Immune Responses: Asking T Cells about What They "See" in Cancer.

scientific article published in January 2018

High-dimensional analysis of human CD8(+) T cell phenotype, function, and antigen specificity.

scientific article published on January 2014

High-dimensional analysis of the murine myeloid cell system.

scientific article published on 12 October 2014

High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry

scientific article

Higher throughput methods of identifying T cell epitopes for studying outcomes of altered antigen processing and presentation

scientific article published on 05 December 2013

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

scientific article

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

scientific article published on 6 December 2016

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

scientific article published on 01 May 2018

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

scientific article published on 14 June 2017

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

scientific article

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

scientific article

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

scientific article published on 01 February 2020

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

scientific article published on July 2017

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.

scientific article published on February 2016

Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis

scientific article published on 15 July 2011

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

scientific article published on 5 May 2017

Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates

scientific article published on 19 November 2019

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

scientific article published on 12 September 2019

Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

scientific article published on 06 December 2019

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

scientific article published on 18 September 2019

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

scientific article published on 17 January 2018

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence

scientific article published on 07 December 2018

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

scientific article published on 11 June 2015

Mapping the human DC lineage through the integration of high-dimensional techniques.

scientific article published on 4 May 2017

Mass Cytometry Analysis of Human T Cell Phenotype and Function

article

Mass cytometry: a powerful tool for dissecting the immune landscape

scientific article published on 11 April 2018

Mass cytometry: blessed with the curse of dimensionality.

scientific article

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

scientific article published on 01 June 2019

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

scientific article published on 16 October 2020

Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection

scientific article published on 01 February 2019

Multiparameter Phenotyping of Human PBMCs Using Mass Cytometry

scientific article published on January 2015

Multiplex MHC Class I Tetramer Combined with Intranuclear Staining by Mass Cytometry

scientific article published on 01 January 2019

Multiplex peptide-MHC tetramer staining using mass cytometry for deep analysis of the influenza-specific T-cell response in mice

scientific article published on 30 September 2017

Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry

scientific article published in January 2015

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

scientific article published in June 2019

Novel therapeutic targets on the horizon for lung cancer.

scientific article

OpenCyto: an open source infrastructure for scalable, robust, reproducible, and automated, end-to-end flow cytometry data analysis

scientific article

Optimization of mass cytometry sample cryopreservation after staining.

scientific article published on 31 October 2016

Organ-Specific Fate, Recruitment, and Refilling Dynamics of Tissue-Resident Macrophages during Blood-Stage Malaria

scientific article published on 01 December 2018

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

article

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.

scientific article published on 15 May 2014

Partial absence of PD-1 expression by tumor-infiltrating EBV-specific CD8+ T cells in EBV-driven lymphoepithelioma-like carcinoma

scientific article published on 09 September 2020

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.

scientific article

Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage

scientific article published on 18 June 2019

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer

article

Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8<sup>+</sup> T Cells during Convalescence

scientific article published on 13 August 2021

Publisher Correction: Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

article

Regulation of a TRPM7-like current in rat brain microglia

scientific journal article

Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain

scientific article

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

scientific article published in July 2014

Reverse-engineering flow-cytometry gating strategies for phenotypic labelling and high-performance cell sorting

scientific article published on 01 January 2019

Simultaneous detection of many T-cell specificities using combinatorial tetramer staining.

scientific article published on 21 June 2009

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

scientific article published on 29 August 2019

Small-conductance Cl- channels contribute to volume regulation and phagocytosis in microglia.

scientific article published in October 2007

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-E

scientific article

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions

scientific article

T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.

scientific article published on 11 January 2017

T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis

scientific article published on 05 December 2019

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

scientific article published on February 2010

Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease.

scientific article

The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells.

scientific article published on 6 March 2018

The promised land of human immunology

scientific article published on January 2013

Toward Meaningful Definitions of Innate-Lymphoid-Cell Subsets

scientific article published on 01 May 2017

Transplantation of cells and tissues expressing Fas ligand

scientific article published on 01 May 1999

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

scientific article published on 12 October 2020

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

scientific article published on 13 September 2016

[Identification of tumor-specific CD8 T cells with a surface marker]

scientific article published on 01 December 2018

mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function

scientific article published on 10 July 2015

γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.

scientific article

List of works by Evan W Newell

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

Activation of the receptor tyrosine kinase AXL regulates the immune microenvironment in glioblastoma.

Adenoviral Vector Vaccination Induces a Conserved Program of CD8(+) T Cell Memory Differentiation in Mouse and Man.

Author Correction: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8 T cells

Beyond model antigens: high-dimensional methods for the analysis of antigen-specific T cells

Bystander CD4<sup>+</sup> T cells infiltrate human tumors and are phenotypically distinct

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy

Categorical Analysis of Human T Cell Heterogeneity with One-Dimensional Soli-Expression by Nonlinear Stochastic Embedding

Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.

Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants

Characterization of influenza vaccine immunogenicity using influenza antigen microarrays.

Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells

Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization.

Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline

Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

Deep Profiling Human T Cell Heterogeneity by Mass Cytometry.

Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes

Determining T-cell specificity to understand and treat disease

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti-CTLA-4 antibody

Dimensionality reduction for visualizing single-cell data using UMAP

Dissecting human ILC heterogeneity: more than just three subsets.

Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation ⬇️

Dynamics of helper CD4 T cells during acute and stable allergic asthma

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Establishing High Dimensional Immune Signatures from Peripheral Blood via Mass Cytometry in a Discovery Cohort of Stage IV Melanoma Patients

Evaluation of UMAP as an alternative to t-SNE for single-cell data

Evidence for a functional sidedness to the alphabetaTCR.

Gamma delta T cells recognize haptens and mount a hapten-specific response.

Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

High-Dimensional Profiling of Tumor-Specific Immune Responses: Asking T Cells about What They "See" in Cancer.

High-dimensional analysis of human CD8(+) T cell phenotype, function, and antigen specificity.

High-dimensional analysis of the murine myeloid cell system.

High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry

Higher throughput methods of identifying T cell epitopes for studying outcomes of altered antigen processing and presentation

Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.

Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment

Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence

Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis

Mapping the human DC lineage through the integration of high-dimensional techniques.

Mass Cytometry Analysis of Human T Cell Phenotype and Function

Mass cytometry: a powerful tool for dissecting the immune landscape

Mass cytometry: blessed with the curse of dimensionality.

Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection

Multiparameter Phenotyping of Human PBMCs Using Mass Cytometry

Multiplex MHC Class I Tetramer Combined with Intranuclear Staining by Mass Cytometry

Multiplex peptide-MHC tetramer staining using mass cytometry for deep analysis of the influenza-specific T-cell response in mice

Multiplexed Peptide-MHC Tetramer Staining with Mass Cytometry

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

Novel therapeutic targets on the horizon for lung cancer.