List of works - Tim Nicolai Siegel

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.

scientific article

Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay

scientific article published on 16 September 2021

Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging.

scientific article published on 12 April 2008

Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination

scientific article published on 29 April 2016

Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages.

scientific article published on 17 January 2014

Distinct roles for H4 and H2A.Z acetylation in RNA transcription in African trypanosomes

scientific article published on 20 March 2020

Efficient and specific oligo-based depletion of rRNA

scientific article published on 22 August 2019

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

scientific article (publication date: 18 September 2014)

Exploiting CRISPR-Cas9 technology to investigate individual histone modifications

scientific article published on 01 October 2018

Fragment ion patchwork quantification for measuring site-specific acetylation degrees.

scientific article published on 3 September 2015

GT‐rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomes

scientific article

Genome organization and DNA accessibility control antigenic variation in trypanosomes

scientific article published in Nature

Genome-wide analysis of chromatin structures in Trypanosoma brucei using high-resolution MNase-ChIP-seq

scientific article

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites

scientific article

Genome-wide chromatin immunoprecipitation-sequencing in Plasmodium.

scientific article published in January 2013

H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasion

scientific article published on 18 February 2022

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

scientific article published on 21 January 2016

Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression.

scientific article

PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites

scientific article (publication date: April 2012)

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.

scientific article published on 17 December 2013

Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei

scientific article

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in

scientific article published on 20 November 2018

Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum

scientific article

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

scientific article published on 9 July 2008

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.

scientific article

List of works by Tim Nicolai Siegel

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.

Allele-specific assembly of a eukaryotic genome corrects apparent frameshifts and reveals a lack of nonsense-mediated mRNA decay

Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging.

Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination

Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages.

Distinct roles for H4 and H2A.Z acetylation in RNA transcription in African trypanosomes

Efficient and specific oligo-based depletion of rRNA

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

Exploiting CRISPR-Cas9 technology to investigate individual histone modifications

Fragment ion patchwork quantification for measuring site-specific acetylation degrees.

GT‐rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomes

Genome organization and DNA accessibility control antigenic variation in trypanosomes

Genome-wide analysis of chromatin structures in Trypanosoma brucei using high-resolution MNase-ChIP-seq

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites

Genome-wide chromatin immunoprecipitation-sequencing in Plasmodium.

H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host cell invasion

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression.

PfAlbas constitute a new eukaryotic DNA/RNA-binding protein family in malaria parasites

Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.

Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in

Strand-specific RNA-Seq reveals widespread and developmentally regulated transcription of natural antisense transcripts in Plasmodium falciparum

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.