Search filters

List of works by Charlotte K Y Ng

A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)

scientific article published in September 2018

A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations

scientific article

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer

scientific article

Alterations in homologous recombination repair genes in prostate cancer brain metastases

scientific article published on 03 May 2022

Are acinic cell carcinomas of the breast and salivary glands distinct diseases?

scientific article published on 16 February 2015

Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations

scientific article published on 28 October 2014

Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.

scientific article published on 15 March 2017

Breast cancer intratumor genetic heterogeneity: causes and implications ⬇️

scientific article published on August 1, 2012

Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations.

scientific article published on 9 May 2018

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

scientific article published on 09 July 2014

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

scientific article

Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast

scientific article

Chromosomal instability determines taxane response

scholarly article

Circulating Cell-Free DNA in Hepatocellular Carcinoma: Current Insights and Outlook.

scientific article published on 26 March 2018

Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast.

scientific article

Contralateral breast cancers: Independent cancers or metastases?

scientific article

Corrigendum: metastatic breast carcinomas display genomic and transcriptomic heterogeneity

scientific article published on 01 April 2015

DNA Copy Number Aberrations, and Human Papillomavirus Status in Penile Carcinoma. Clinico-Pathological Correlations and Potential Driver Genes

scientific article

Diagnostic Targeted Sequencing Panel for Hepatocellular Carcinoma Genomic Screening

scientific article published on 22 August 2018

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer.

scientific article

ESR1 and endocrine therapy resistance: more than just mutations.

scientific article published on 7 March 2018

Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

scientific article published on 29 December 2021

Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing

scientific article published on 31 October 2013

Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

scientific article published on 08 January 2019

Fibroepithelial Breast Lesion: When Sequencing Can Help to Make a Clinical Decision. A Case Report

scientific article published on 01 November 2018

Genetic Alterations in Benign Breast Biopsies of Subsequent Breast Cancer Patients

scientific article published on 24 July 2019

Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer

scientific article published on 05 August 2016

Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

scientific article

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study.

scientific article published on 2 March 2018

Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma.

scientific article published on 2 February 2018

Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.

scientific article

Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast

scientific article published in December 2017

Genomic characterization of metastatic breast cancers

scientific article published on 22 May 2019

Genomic landscape of adenoid cystic carcinoma of the breast

scientific article

Genomic profiling of histological special types of breast cancer.

scientific article published on 27 October 2013

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

scientific article

HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models

scientific article

Hepatocellular Carcinoma Xenografts Established From Needle Biopsies Preserve the Characteristics of the Originating Tumors

scientific article published on 06 May 2019

High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models

scientific article

High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations.

scientific article published on 28 February 2018

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.

scientific article

IDH2 Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

scientific article published on 20 October 2016

Infiltrating epitheliosis of the breast: characterization of histological features, immunophenotype and genomic profile

scientific article published on 24 October 2015

Infiltration by interleukin-22 producing T cells promotes neutrophil recruitment and predicts favorable clinical outcome in human colorectal cancer

scientific article published on 24 August 2020

Infiltration by myeloperoxidase-positive neutrophils is an independent prognostic factor in breast cancer

scientific article published on 02 July 2019

Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages

scientific article published on 04 May 2022

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

scientific article published on 12 August 2021

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification

scientific article published on 22 May 2015

Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.

scientific article

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

scientific article published on 17 December 2019

Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland

scientific article published on October 2015

Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma

scientific article published on 05 September 2018

Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases.

scientific article published on 7 September 2010

Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein

scientific article published on 11 May 2015

Metaplastic breast carcinoma: more than a special type.

scientific article

Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected]. .

scientific article published on 21 November 2014

Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations

scientific article published on 25 January 2016

Molecular classification of hepatocellular carcinoma: The view from metabolic zonation

scientific article published on 29 September 2017

Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases

scientific article published on 03 April 2018

NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis.

scientific article published on 28 August 2017

Nectin-4 Expression Is an Independent Prognostic Biomarker and Associated With Better Survival in Triple-Negative Breast Cancer

scientific article published on 13 September 2019

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

scientific article published on 01 July 2018

PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma

scientific article

Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.

scientific article published on 26 October 2017

Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways

scientific article published on 12 October 2017

PipeIT: A Singularity Container for Molecular Diagnostic Somatic Variant Calling on the Ion Torrent Next-Generation Sequencing Platform

scientific article published on 21 June 2019

Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance

scientific article

Pregnancy at early age is associated with a reduction of progesterone-responsive cells and epithelial Wnt signaling in human breast tissue

scientific article

Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification

scientific article published on 16 December 2019

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.

scientific article published on 8 May 2018

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

scientific article published on 01 November 2018

Resolving quandaries: basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing.

scientific article

Response to dual HER2 blockade in a patient with HER3-mutant metastatic breast cancer

scientific article published on 7 May 2015

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis

scientific article

Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures

scientific article published on 15 December 2020

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

scientific article

Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships

scientific article

The Dilemma of HER2 Double-equivocal Breast Carcinomas: Genomic Profiling and Implications for Treatment

scientific article published on 01 September 2018

The Genomic Landscape of Male Breast Cancers

scientific article published on 9 March 2016

The Genomic Landscape of Mucinous Breast Cancer

scientific article published on 11 January 2019

The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas

scientific article published on 2 February 2017

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

scientific article published on 28 February 2018

The protein histidine phosphatase LHPP is a tumour suppressor.

scientific article published on 21 March 2018

The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement

scientific article published on 01 April 2019

The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study

scientific article published on 23 May 2015

The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer

scientific article

Therapeutic Targeting of CD146/MCAM Reduces Bone Metastasis in Prostate Cancer

scientific article published on 11 February 2019

Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members

scientific article published on 20 January 2021

Uterine adenosarcomas are mesenchymal neoplasms.

scientific article published on 23 November 2015

Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes

scientific article

Paulina is supported by:

About Paulina

Help