List of works - Toyoaki Natsume

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast

scientific article

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

scientific article published on 9 May 2017

Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression

scientific article published on 25 January 2019

Conditional Degrons for Controlling Protein Expression at the Protein Level

scientific article published in November 2017

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

scientific article published on 31 May 2018

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

scientific article published on 24 April 2019

Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.

scientific article published on 25 May 2005

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates

scientific article published on 20 June 2019

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

scientific article published on 01 April 2020

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

scientific article published on 14 February 2019

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms.

scientific article published on 27 February 2018

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment

scientific article

MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome"

scientific article published on 09 December 2021

Perichromosomal protein Ki67 supports mitotic chromosome architecture.

scientific article published on 9 September 2016

Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.

scientific article published on 22 March 2016

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

scientific article

Spatial regulation and organization of DNA replication within the nucleus.

scientific article published on January 2010

Stochastic association of neighboring replicons creates replication factories in budding yeast.

scientific article published on 23 September 2013

The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

scientific article published on 03 November 2020

Three wise centromere functions: see no error, hear no break, speak no delay

scientific article

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

scientific article published on 8 February 2018

List of works by Toyoaki Natsume

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression

Conditional Degrons for Controlling Protein Expression at the Protein Level

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms.

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment

MYC assembles and stimulates topoisomerases 1 and 2 in a "topoisome"

Perichromosomal protein Ki67 supports mitotic chromosome architecture.

Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors.

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

Spatial regulation and organization of DNA replication within the nucleus.

Stochastic association of neighboring replicons creates replication factories in budding yeast.

The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Three wise centromere functions: see no error, hear no break, speak no delay

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity