List of works - Yuan-Xiang Pan

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model.

scientific article

A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications

scientific article published on 09 December 2011

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

scientific article published on 27 October 2010

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

scientific journal article

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.

scientific article published on January 2007

An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.

scientific article

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

scientific article

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

scientific article published on 9 September 2016

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

scientific article published on February 2008

Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

scientific article published on 5 March 2015

Developmental regulation of a turkey intestinal peptide transporter (PepT1).

scientific article

Early-Life Nutritional Programming of Cognition-The Fundamental Role of Epigenetic Mechanisms in Mediating the Relation between Early-Life Environment and Learning and Memory Process

scientific article published on 15 March 2017

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

scientific article published on 22 November 2014

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

scientific article published on 28 December 2017

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

scientific article

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

scientific article published on 01 May 2019

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

scientific article published on 31 December 2018

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

scientific article published on 21 December 2013

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.

scientific article published on 12 January 2016

Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors

scientific article published on 31 May 2022

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats ⬇️

scientific article published on March 28, 2011

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation.

scientific article published on October 2010

Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.

scientific article published on 18 July 2011

Hepatic Cystathionine β-Synthase Activity Is Increased by Greater Postruminal Supply of Met during the Periparturient Period in Dairy Cows

scientific article published on 07 November 2019

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model.

scientific article

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

scientific article published on 21 July 2015

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats.

scientific article published on 14 March 2018

Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet

scientific journal article

Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats ⬇️

scientific article published on October 12, 2010

In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge.

scientific article

In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases.

scientific article published on 11 January 2012

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to m

scientific article published on 22 July 2015

Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.

scientific article published on 17 August 2005

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

scientific article

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

scientific article published on 20 February 2008

Maternal Low-Fat Diet Programs the Hepatic Epigenome despite Exposure to an Obesogenic Postnatal Diet

scientific article published on 03 September 2019

Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle.

scientific article published in February 2011

Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

scientific article published on 01 January 2019

Methods and novel technology for microRNA quantification in colorectal cancer screening.

scientific article published on 24 October 2017

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation ⬇️

scientific article published on 14 December 2018

Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation

scientific article

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

scientific article published on 21 December 2018

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

scientific article published on 04 December 2018

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.

scientific article

Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight.

scientific article

Poly(A)+ RNA from sheep omasal epithelium induces expression of a peptide transport protein(s) in Xenopus laevis oocytes.

scientific article published in December 1997

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet.

scientific article published on 8 September 2017

Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring.

scientific article published on 12 November 2011

Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats

scientific article published on 15 January 2020

The Efficacy of miR-20a as a Diagnostic and Prognostic Biomarker for Colorectal Cancer: A Systematic Review and Meta-Analysis

scientific article published on 03 August 2019

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

scientific article published on 6 November 2013

The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model.

scientific article published on 21 February 2012

Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure.

scientific article

List of works by Yuan-Xiang Pan

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model.

A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.

An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

Developmental regulation of a turkey intestinal peptide transporter (PepT1).

Early-Life Nutritional Programming of Cognition-The Fundamental Role of Epigenetic Mechanisms in Mediating the Relation between Early-Life Environment and Learning and Memory Process

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles.

Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats ⬇️

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation.

Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.

Hepatic Cystathionine β-Synthase Activity Is Increased by Greater Postruminal Supply of Met during the Periparturient Period in Dairy Cows

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model.

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats.

Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet

Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats ⬇️

In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge.

In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases.

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to m

Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

Maternal Low-Fat Diet Programs the Hepatic Epigenome despite Exposure to an Obesogenic Postnatal Diet

Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle.

Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

Methods and novel technology for microRNA quantification in colorectal cancer screening.

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation ⬇️

Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.

Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight.

Poly(A)+ RNA from sheep omasal epithelium induces expression of a peptide transport protein(s) in Xenopus laevis oocytes.

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet.

Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring.

Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats

The Efficacy of miR-20a as a Diagnostic and Prognostic Biomarker for Colorectal Cancer: A Systematic Review and Meta-Analysis

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model.

Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure.