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List of works by Oliver Wirths

A microRNA signature that correlates with cognition and is a target against cognitive decline

scientific article published on 11 October 2021

A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer's disease

scientific article published on 08 December 2018

Age-dependent axonal degeneration in an Alzheimer mouse model.

scientific article published on 11 September 2006

Altered cholesterol metabolism in APP695-transfected neuroblastoma cells

scientific article published on 15 March 2007

Altered neurogenesis in mouse models of Alzheimer disease

scientific article published on 9 May 2017

Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells

scientific article published in February 2012

An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form

scientific article published on 31 March 2022

Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates

scientific article published in January 2012

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation

scientific article

Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease

scientific article published on 7 March 2006

AβPP accumulation and/or intraneuronal amyloid-β accumulation? The 3xTg-AD mouse model revisited

scientific article published in January 2012

Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer's Disease

scientific article published on 10 September 2020

Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice.

scientific article published on 25 March 2010

Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing

scientific article published on 16 April 2014

Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease

scientific article published on 22 November 2005

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models

scientific article published on 8 March 2016

Development and Technical Validation of an Immunoassay for the Detection of APP669-711 (Aβ-3-40) in Biological Samples

scientific article published on 08 September 2020

Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial

scientific article

Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice.

scientific article

Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer's disease

scientific article published on 12 December 2019

Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease

scientific article published on 7 January 2016

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease

scientific article

Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease.

scientific article published in January 2015

Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease

scientific article published on 30 November 2015

Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients

scientific article published in March 2010

Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia

scientific article published on 19 October 2018

I716F AβPP mutation associates with the deposition of oligomeric pyroglutamate amyloid-β and α-synucleinopathy with Lewy bodies

scientific article published in January 2015

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

scientific article published on 11 November 2021

Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.

scientific article published on 3 September 2008

Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.

scientific article published in July 2002

Intraneuronal Aβ accumulation and neurodegeneration: lessons from transgenic models.

scientific article published on 26 February 2012

Intraneuronal Aβ as a trigger for neuron loss: can this be translated into human pathology? ⬇️

scientific article published on August 1, 2011

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

scientific article

Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques

scientific article published in November 2000

Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice.

scientific article published on 12 October 2016

Loss of Hippocampal Calretinin and Parvalbumin Interneurons in the 5XFAD Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2020

Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.

scientific article published on February 2008

N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo

scientific article published on 01 January 2019

N-Terminally Truncated Aβ Peptide Variants in Alzheimer’s Disease

article published in 2020

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer's disease

scientific article published on 04 June 2020

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

scientific article published on 06 September 2013

N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models

scientific article published in September 2015

N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models

scientific article published on 4 October 2017

Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease.

scientific article published in January 2015

Neuron Loss in Alzheimer's Disease: Translation in Transgenic Mouse Models

scientific article published on 30 October 2020

Neuron loss in transgenic mouse models of Alzheimer's disease

scientific article

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease ⬇️

scientific article published on September 22, 2011

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

scientific article published on February 2006

Oligomeric Pyroglutamate Amyloid-β is Present in Microglia and a Subfraction of Vessels in Patients with Alzheimer's Disease: Implications for Immunotherapy ⬇️

scientific article published on January 1, 2013

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice ⬇️

scientific article published on December 10, 2010

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

scientific article published on 22 February 2016

Physical Activity Ameliorates Impaired Hippocampal Neurogenesis in the Tg4-42 Mouse Model of Alzheimer's Disease

scientific article published on 01 January 2019

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model

scientific article published on 03 May 2016

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease ⬇️

scientific article published on September 29, 2011

Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease

scientific article

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

scientific article published on 24 September 2009

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4-42 and Pyroglutamate Aβ3-42 in a Mouse Model of Alzheimer's Disease.

scientific article published on 8 March 2018

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

scientific article

The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease

scientific article published on 13 November 2018

The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease

scientific article published on 20 July 2018

Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

scientific article published on 01 November 2003

Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies

scientific article

[Alzheimer's disease. Molecular pathology, animal models, and current treatment].

scientific article published in November 2008

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