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List of works by Nicholas Veldhuis

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

scientific article published on 28 January 2021

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

scientific article published on 04 November 2019

Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk

scientific article

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

scientific article published on 12 August 2014

Cellular Interactions of Liposomes and PISA Nanoparticles during Human Blood Flow in a Microvascular Network

scientific article published on 25 June 2020

Conservation of copper-transporting P(IB)-type ATPase function

scientific article published on 7 April 2010

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

scientific journal article

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

scientific article published on 24 August 2015

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

scientific article published on 16 June 2020

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

scientific article published on 30 October 2017

G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch.

scientific article

Inflammation-associated changes in DOR expression and function in the mouse colon

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

scientific article published on 2 July 2015

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon.

scientific article

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

scientific article

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

scientific article published on 15 December 2020

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

scientific article

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase.

scientific article published on 2 July 2009

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

scientific article published on 3 January 2013

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.

scientific article published on March 2003

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

scientific article published on 22 April 2015

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.

scientific article published on 24 April 2017

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

scientific article published on 03 February 2022

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

scientific article published on January 2015

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

scientific article published on 27 April 2020

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

scientific article

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

scientific article

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