List of works - Jian Zhao

A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.

scientific article published on 12 January 2010

A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation.

scientific article

A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets.

scientific article

Activation of aryl hydrocarbon receptor (ahr) by tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming.

scientific article published on 2 July 2013

An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity

scientific article

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors

scientific article

Attenuation of delta opioid receptor-mediated signaling by kainic acid in neural cells: involvement of protein kinase C and intracellular Ca2+.

scientific article published in July 1999

Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.

scientific article published in March 1998

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules ⬇️

scientific article published in Nature Communications

Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma)

scientific article

Beta-arrestin-1 protein represses diet-induced obesity

scientific article

Carboxyl Terminus of Delta Opioid Receptor Is Required for Agonist-Dependent Receptor Phosphorylation ⬇️

scientific article published on September 8, 1997

Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin.

scientific article published on December 1998

Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization ⬇️

scientific article published on October 1, 1998

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

scientific article

Derivation of induced pluripotent stem cells TUSMi006 from an 87-year old Chinese Han Alzheimer's disease patient carrying GRINB and SORL1 mutations

scientific article published on 25 July 2018

Differential neurotoxicity of etorphine-like opiates: lack of correlation with their ability to activate opiate receptors.

scientific article published on May 1998

Direct conversion of astrocytes into neuronal cells by drug cocktail

scientific article published on 2 October 2015

ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

scientific article

Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization

scientific article published in May 1997

Establishment of TUSMi003-A, an induced pluripotent stem cell (iPSC) line from a 62-year old Chinese Han patient with Alzheimer's disease with ApoE3/4 genetic background

scientific article published on 4 January 2018

Establishment of TUSMi004-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Obsessive-Compulsive Disorder (OCD)

scientific article published on 24 August 2018

Establishment of TUSMi005-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Bipolar Disorder (BD)

article

Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD)

scientific article published on 28 November 2018

Evoking plasmin for beta-amyloid clearance.

scientific article published on August 2008

Expression, Purification and Characterization of Regulatory Subunit of Type I cAMP-dependent Protein Kinase in E.coli.

scientific article

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors

scientific article

Functional expression of opioid receptor-like receptor and its endogenous specific agonist nociceptin/orphanin FQ during mouse embryogenesis.

scientific article published in December 1997

Generation of a human control PBMC derived iPS cell line TUSMi001-A from a healthy male donor of Han Chinese genetic background

scientific article published on 6 October 2017

Generation of a human induced pluripotent stem cell line from a 65-year old healthy female donor with Chinese Han genetic background.

scientific article

Generation of neural progenitor cells by chemical cocktails and hypoxia

scientific article

Generation of neural progenitor cells by chemical cocktails and hypoxia.

scientific article published in May 2015

Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.

scientific article

Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice.

scientific article published on 6 May 2013

Molecular characterization and functional expression of opioid receptor-like1 receptor.

scientific article published on June 1997

Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter

scientific article

N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.

scientific article published in April 1998

NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death

scientific article published on 27 February 2018

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

scientific article published on 22 September 2009

Nuclear actin and myosin I are required for RNA polymerase I transcription.

scientific article

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

scientific article

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

scientific article

Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits

scientific article

Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation

scientific article published on 16 October 2017

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis

scientific article (publication date: 2015)

The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.

scientific article

Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

scientific article

Transdifferentiation: a new promise for neurodegenerative diseases

scientific article published on 06 August 2018

Why cell reprogramming is functionally linked to aging?

scientific article published on August 2011

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

scientific article

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

scientific article

β-Arrestin-1 directly interacts with Gαs and regulates its function

scientific article

β-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo.

scientific article published on 10 September 2015

β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.

scientific article published on 15 June 2016

β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

scientific article published on 4 December 2012

γ-Secretase Modulators and Inhibitors Induce Different Conformational Changes of Presenilin 1 Revealed by FLIM and FRET.

scientific article published on August 2015

List of works by Jian Zhao

A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.

A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation.

A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets.

Activation of aryl hydrocarbon receptor (ahr) by tranilast, an anti-allergy drug, promotes miR-302 expression and cell reprogramming.

An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors

Attenuation of delta opioid receptor-mediated signaling by kainic acid in neural cells: involvement of protein kinase C and intracellular Ca2+.

Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules ⬇️

Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma)

Beta-arrestin-1 protein represses diet-induced obesity

Carboxyl Terminus of Delta Opioid Receptor Is Required for Agonist-Dependent Receptor Phosphorylation ⬇️

Carboxyl terminal of rhodopsin kinase is required for the phosphorylation of photo-activated rhodopsin.

Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization ⬇️

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

Derivation of induced pluripotent stem cells TUSMi006 from an 87-year old Chinese Han Alzheimer's disease patient carrying GRINB and SORL1 mutations

Differential neurotoxicity of etorphine-like opiates: lack of correlation with their ability to activate opiate receptors.

Direct conversion of astrocytes into neuronal cells by drug cocktail

ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

Endogenous opioid receptor-like receptor in human neuroblastoma SK-N-SH cells: activation of inhibitory G protein and homologous desensitization

Establishment of TUSMi003-A, an induced pluripotent stem cell (iPSC) line from a 62-year old Chinese Han patient with Alzheimer's disease with ApoE3/4 genetic background

Establishment of TUSMi004-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Obsessive-Compulsive Disorder (OCD)

Establishment of TUSMi005-A, an induced pluripotent stem cell (iPSC) line from a 32-year old Chinese Han patient with Bipolar Disorder (BD)

Establishment of TUSMi007-A, an induced pluripotent stem cell (iPSC) line from an 83-year old Chinese Han patient with Alzheimer's disease (AD)

Evoking plasmin for beta-amyloid clearance.

Expression, Purification and Characterization of Regulatory Subunit of Type I cAMP-dependent Protein Kinase in E.coli.

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors

Functional expression of opioid receptor-like receptor and its endogenous specific agonist nociceptin/orphanin FQ during mouse embryogenesis.

Generation of a human control PBMC derived iPS cell line TUSMi001-A from a healthy male donor of Han Chinese genetic background

Generation of a human induced pluripotent stem cell line from a 65-year old healthy female donor with Chinese Han genetic background.

Generation of neural progenitor cells by chemical cocktails and hypoxia

Generation of neural progenitor cells by chemical cocktails and hypoxia.

Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.

Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice.

Molecular characterization and functional expression of opioid receptor-like1 receptor.

Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter

N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.

NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

Nuclear actin and myosin I are required for RNA polymerase I transcription.

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells.

Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits

Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis

The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.

Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

Transdifferentiation: a new promise for neurodegenerative diseases

Why cell reprogramming is functionally linked to aging?

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

β-Arrestin-1 directly interacts with Gαs and regulates its function

β-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo.

β-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.

β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

γ-Secretase Modulators and Inhibitors Induce Different Conformational Changes of Presenilin 1 Revealed by FLIM and FRET.