List of works - Jonathan S Wall

A Peptide-Fc Opsonin with Pan-Amyloid Reactivity

scientific article published on 4 September 2017

A Routine PET/CT Protocol with Streamlined Calculations for Assessing Cardiac Amyloidosis Using (18)F-Florbetapir.

scientific article published on 8 May 2015

A bifunctional peptide, "peptope", for pre-targeting antibody 7D8 to systemic amyloid deposits.

scientific article

A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo

scientific article

A functional assay to identify amyloidogenic light chains

scientific article published on 23 March 2018

A novel method for quantifying peripheral tissue amyloid load by using the radiolabeled amyloidophilic peptide, p5 ⬇️

scientific article published on January 17, 2013

A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid

scientific article published on 01 March 2017

AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils.

scientific article

Antibody-mediated resolution of light chain-associated amyloid deposits.

scientific article published on October 2000

Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of Screenings

scientific article published on 13 February 2019

Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy

article published in the Proceedings of the National Academy of Sciences of the United States of America

Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake.

scientific article

Cell Damage in Light Chain Amyloidosis: FIBRIL INTERNALIZATION, TOXICITY AND CELL-MEDIATED SEEDING.

scientific article published on 26 July 2016

Cerebral Blastomyces dermatitidis infection in a cat.

scientific article published in October 2007

Characterization of X-ray Dose in Murine Animals Using microCT, a New Low-Dose Detector and nanoDot Dosimeters

scientific article

Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens.

scientific article

Comparative Analysis of Peptide p5 and Serum Amyloid P Component for Imaging AA Amyloid in Mice Using Dual-Isotope SPECT ⬇️

scientific article published on August 1, 2012

Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis.

scientific article published on 3 March 2016

Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera

scientific article published on 01 June 2006

Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity

scientific article

Diffuse intestinal T-cell lymphosarcoma in a yellow-naped Amazon parrot (Amazona ochrocephala auropalliata).

scientific article

Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.

scientific article published in May 2008

Distribution of 2-deoxy-2-fluoro-d-glucose in the coelom of healthy bald eagles (Haliaeetus leucocephalus).

scientific article published on March 2013

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

scientific article

Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: a positive role for peptide dehalogenation.

scientific article

Effect of lysine modification on the stability and cellular binding of human amyloidogenic light chains.

scientific article published on 6 August 2010

Enhanced capture of small histidine-containing polypeptides on membranes in the presence of ZnCl2.

scientific article published in June 2001

Evaluation of CT-based lean-body SUV.

scientific article

Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides

scientific article published on 11 December 2017

Flow cytometric characterization of amyloid fibrils

scientific article published on 01 January 1999

Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects

scientific journal article

GAIM fusions are therapeutic candidates for peripheral amyloidosis

scientific article published on 01 January 2019

GATE validation of standard dual energy corrections in small animal SPECT-CT

scientific article

Generation and characterization of anti-AA amyloid-specific monoclonal antibodies.

scientific article published on 8 August 2011

Gold coated lanthanide phosphate nanoparticles for targeted alpha generator radiotherapy

scientific article

Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies

scientific article published on 01 November 2008

Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies

scientific article

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

scientific article published on 27 February 2017

Immunotherapy in systemic primary (AL) amyloidosis using amyloid-reactive monoclonal antibodies.

scientific article published on December 2003

In vitro immunoglobulin light chain fibrillogenesis

scientific article published on 01 January 1999

In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.

scientific article

Interim analysis of the phase 1a/b study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis

article

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients.

scientific article

Kinetics of vascular targeted monoclonal antibody

scientific article published on 01 December 2010

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

scientific article published on 22 September 2015

Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells

scientific article published on 03 December 2019

Light chain-associated amyloid deposits comprised of a novel κ constant domain ⬇️

scientific article published on August 4, 1998

LnPO4 nanoparticles doped with Ac-225 and sequestered daughters for targeted alpha therapy

scientific article published on 08 October 2013

Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains.

scientific article published on February 2007

Macrophage-Mediated Phagocytosis and Dissolution of Amyloid-Like Fibrils in Mice, Monitored by Optical Imaging

scientific article published on 06 February 2019

Mechanistic insights into the pH-dependent membrane peptide ATRAM

scientific article published on 11 February 2019

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage.

scientific article published on 13 October 2017

Micro-imaging of amyloid in mice.

scientific article published on January 2006

Novel heparan sulfate-binding peptides for blocking herpesvirus entry.

scientific article published on 18 May 2015

ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.

scientific article

One year follow up analysis of the phase 1a/b study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis

scientific article published on 01 January 2019

Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts ⬇️

scientific article published on May 23, 2013

Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope

scientific article

Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice

scientific article

Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis

scientific article published on 27 April 2015

Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits.

scientific article

Preliminary evaluation of serial (18) FDG-PET/CT to assess response to toceranib phosphate therapy in canine cancer.

scientific article published on 24 February 2012

Pretargeting immunotherapy: a novel treatment approach for systemic amyloidosis

scientific article published on 21 August 2017

Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity

scientific article published in March 2017

Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis.

scientific article published in September 2005

Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice

scientific article published on December 2008

Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody

scientific article published on December 2006

Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity

scientific article published in March 2017

Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[ F]fluorothymidine

article

SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.

scientific article published on 29 September 2011

Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization

scientific article published on 11 August 2016

Serendipitous inhibition of Aβ and rVλ6Wil amyloid fibril growth by bi-functional peptides.

scientific article published in March 2017

Specific Amyloid Binding of Polybasic Peptides In Vivo Is Retained by β-Sheet Conformers but Lost in the Disrupted Coil and All D-Amino Acid Variants

scientific article published on 22 February 2017

Static and dynamic (18) FDG-PET in normal hispaniolan Amazon parrots (Amazona ventralis).

scientific article

Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins.

scientific article

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice ⬇️

scientific article published on August 22, 2012

Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis

scientific article published on 16 November 2015

The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro.

scientific article published on 24 September 2016

The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.

scientific article published on 7 December 2013

The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo.

scientific article published on 3 April 2008

The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.

scientific article

The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice

scientific article published on 24 December 2015

The use of fluoresceinphosphatidylethanolamine (FPE) as a real-time probe for peptide-membrane interactions

scientific article published on 01 April 1995

Therapeutic potential of chimeric amyloid-reactive monoclonal antibody 11-1F4.

scientific article published in September 2003

Thermodynamic instability of human lambda 6 light chains: correlation with fibrillogenicity

scientific article published on 01 October 1999

Thermodynamic modulation of light chain amyloid fibril formation

scientific article published on 01 January 2000

Whole-body biodistribution of 3'-deoxy-3'-[(18) f]fluorothymidine ((18) FLT) in healthy adult cats ⬇️

scientific article published on March 7, 2013

List of works by Jonathan S Wall

A Peptide-Fc Opsonin with Pan-Amyloid Reactivity

A Routine PET/CT Protocol with Streamlined Calculations for Assessing Cardiac Amyloidosis Using (18)F-Florbetapir.

A bifunctional peptide, "peptope", for pre-targeting antibody 7D8 to systemic amyloid deposits.

A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo

A functional assay to identify amyloidogenic light chains

A novel method for quantifying peripheral tissue amyloid load by using the radiolabeled amyloidophilic peptide, p5 ⬇️

A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid

AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils.

Antibody-mediated resolution of light chain-associated amyloid deposits.

Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of Screenings

Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy

Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake.

Cell Damage in Light Chain Amyloidosis: FIBRIL INTERNALIZATION, TOXICITY AND CELL-MEDIATED SEEDING.

Cerebral Blastomyces dermatitidis infection in a cat.

Characterization of X-ray Dose in Murine Animals Using microCT, a New Low-Dose Detector and nanoDot Dosimeters

Chemical typing of amyloid protein contained in formalin-fixed paraffin-embedded biopsy specimens.

Comparative Analysis of Peptide p5 and Serum Amyloid P Component for Imaging AA Amyloid in Mice Using Dual-Isotope SPECT ⬇️

Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis.

Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera

Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity

Diffuse intestinal T-cell lymphosarcoma in a yellow-naped Amazon parrot (Amazona ochrocephala auropalliata).

Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.

Distribution of 2-deoxy-2-fluoro-d-glucose in the coelom of healthy bald eagles (Haliaeetus leucocephalus).

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: a positive role for peptide dehalogenation.

Effect of lysine modification on the stability and cellular binding of human amyloidogenic light chains.

Enhanced capture of small histidine-containing polypeptides on membranes in the presence of ZnCl2.

Evaluation of CT-based lean-body SUV.

Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides

Flow cytometric characterization of amyloid fibrils

Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects

GAIM fusions are therapeutic candidates for peripheral amyloidosis

GATE validation of standard dual energy corrections in small animal SPECT-CT

Generation and characterization of anti-AA amyloid-specific monoclonal antibodies.

Gold coated lanthanide phosphate nanoparticles for targeted alpha generator radiotherapy

Human plasma contains cross-reactive Abeta conformer-specific IgG antibodies

Immunodiagnostic capabilities of anti-free immunoglobulin light chain monoclonal antibodies

Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

Immunotherapy in systemic primary (AL) amyloidosis using amyloid-reactive monoclonal antibodies.

In vitro immunoglobulin light chain fibrillogenesis

In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.

Interim analysis of the phase 1a/b study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis

Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients.

Kinetics of vascular targeted monoclonal antibody

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

Light chain amyloidosis induced inflammatory changes in cardiomyocytes and adipose-derived mesenchymal stromal cells

Light chain-associated amyloid deposits comprised of a novel κ constant domain ⬇️

LnPO4 nanoparticles doped with Ac-225 and sequestered daughters for targeted alpha therapy

Localization of a conformational epitope common to non-native and fibrillar immunoglobulin light chains.

Macrophage-Mediated Phagocytosis and Dissolution of Amyloid-Like Fibrils in Mice, Monitored by Optical Imaging

Mechanistic insights into the pH-dependent membrane peptide ATRAM

Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage.

Micro-imaging of amyloid in mice.

Novel heparan sulfate-binding peptides for blocking herpesvirus entry.

ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.

One year follow up analysis of the phase 1a/b study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis

Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts ⬇️

Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope

Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice

Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis

Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits.

Preliminary evaluation of serial (18) FDG-PET/CT to assess response to toceranib phosphate therapy in canine cancer.

Pretargeting immunotherapy: a novel treatment approach for systemic amyloidosis

Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity

Quantitative high-resolution microradiographic imaging of amyloid deposits in a novel murine model of AA amyloidosis.

Quantitative tomography of early-onset spontaneous AA amyloidosis in interleukin 6 transgenic mice

Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody

Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity

Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[ F]fluorothymidine

SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.

Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization

Serendipitous inhibition of Aβ and rVλ6Wil amyloid fibril growth by bi-functional peptides.

Specific Amyloid Binding of Polybasic Peptides In Vivo Is Retained by β-Sheet Conformers but Lost in the Disrupted Coil and All D-Amino Acid Variants

Static and dynamic (18) FDG-PET in normal hispaniolan Amazon parrots (Amazona ventralis).

Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins.

Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice ⬇️

Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis

The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro.

The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.