List of works - Hollis D Showalter

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

scientific article

A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing

scientific article published on 12 September 2011

Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens

scientific article

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

scientific article

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK and Reveal Mechanisms for Selective Inhibition

scholarly article by Tyler S Beyett et al published October 2018 in Molecular Pharmacology

Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses

scientific article (publication date: 2014)

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

scientific article

Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality

scientific article published in January 2014

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.

scientific article published on 04 September 2016

Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition

scientific article published on 21 August 2017

Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors

scientific article published on 14 August 2017

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity

scholarly article by Tyler S Beyett published in September 2018

Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

scientific article published on 11 May 2017

Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

scientific article

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

scientific article published on 13 March 2012

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia ⬇️

scientific article published on January 29, 2012

New generation tamoxifen analogs as potential treatments for amphetamine abuse

scholarly article by Colleen A. Carpenter et al published February 2017 in Drug and Alcohol Dependence

RecO and RecR are necessary for RecA loading in response to DNA damage and replication fork stress

scientific article

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

scientific article published on 10 September 2020

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

scientific article published on 19 October 2018

Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity

scientific article

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

scientific article published on 14 March 2018

Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes

scientific article published on 03 April 2019

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies

scientific article

Use of enterally delivered angiotensin II type Ia receptor antagonists to reduce the severity of colitis

scientific article

Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs

scientific article

List of works by Hollis D Showalter

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing

Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK and Reveal Mechanisms for Selective Inhibition

Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.

Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition

Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity

Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia ⬇️

New generation tamoxifen analogs as potential treatments for amphetamine abuse

RecO and RecR are necessary for RecA loading in response to DNA damage and replication fork stress

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies

Use of enterally delivered angiotensin II type Ia receptor antagonists to reduce the severity of colitis

Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs