Search filters

List of works by Derek van der Kooy

A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation

scientific article published on 14 May 2015

A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans

scientific article published on 01 July 2019

A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation

scientific article published on 21 May 2021

A diacetyl-induced quiescence in young Caenorhabditis elegans

scientific article

A genetic dissociation of learning and recall in Caenorhabditis elegans

scientific article published in December 2004

A hydrogel-based stem cell delivery system to treat retinal degenerative diseases

scientific article published on 6 January 2010

A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse.

scientific article

A proposed resolution to the paradox of drug reward: Dopamine's evolution from an aversive signal to a facilitator of drug reward via negative reinforcement

scientific article published on 24 June 2015

A safer stem cell: inducing pluripotency

scientific article

A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents.

scientific article published on 4 April 2017

A test of the opponent-process theory of motivation using lesions that selectively block morphine reward

scientific article

Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects

scientific article

Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency

scientific article published on 01 May 2007

Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors.

scientific article published in March 2002

Analysis of Mutants Suggests Kamin Blocking in C. elegans is Due to Interference with Memory Recall Rather than Storage

scientific article published on 20 February 2019

BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions

scientific article

Biology and therapeutic potential of adult retinal stem cells

scientific article published on August 2010

Bone morphogenetic proteins and secreted frizzled related protein 2 maintain the quiescence of adult mammalian retinal stem cells ⬇️

scientific article published on October 1, 2013

Cell competition during reprogramming gives rise to dominant clones

scientific article published on 21 March 2019

Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling

scientific article published on 16 May 2007

Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

scientific article

Clonal neural stem cells from human embryonic stem cell colonies.

scientific article published in June 2012

Contextual taste cues modulate olfactory learning in C. elegans by an occasion-setting mechanism

scientific article published in July 2004

Correction

Corrigendum to "EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function" [Behav. Brain Res. 300 (2016) 85-96].

scientific article published on 28 April 2016

Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum

scientific article published in May 2008

Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective

scientific article

DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine

scientific article

DREAM is a critical transcriptional repressor for pain modulation

scientific article (publication date: 11 January 2002)

Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism.

scientific article published on 12 May 2017

Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries.

scientific article

Diabetes enhances the proliferation of adult pancreatic multipotent progenitor cells and biases their differentiation to more β-cell production

scientific article published on 12 November 2014

Different neural systems mediate morphine reward and its spontaneous withdrawal aversion.

scientific article

Disguising adult neural stem cells

scientific article published on February 2004

Don't look: growing clonal versus nonclonal neural stem cell colonies

scientific article

Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner

scientific article published on 26 March 2013

Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.

scientific article

Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.

scientific article published in June 2005

Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine

scientific article published on 23 December 2009

Dual embryonic origin of the mammalian enteric nervous system

scientific article published on 22 November 2018

E-Cadherin regulates neural stem cell self-renewal

scientific article published in March 2009

Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells.

scientific article

Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences

scientific article

Enrichment of Oligodendrocyte Progenitors from Differentiated Neural Precursors by Clonal Sphere Preparations

scientific article published on 14 March 2016

Entwined engrams: The evolution of associative and non-associative learning

scientific article published on April 2013

EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function

scientific article published on 22 September 2015

Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats ⬇️

scientific article published on November 1, 2003

Exogenous Neural Precursor Cell Transplantation Results in Structural and Functional Recovery in a Hypoxic-Ischemic Hemiplegic Mouse Model

scientific article published on 01 September 2018

Expansion of retinal stem cells and their progeny using cell microcarriers in a bioreactor

scientific article published on 28 March 2019

Facile isolation and the characterization of human retinal stem cells

scholarly article

Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice.

scientific article

Functional coordination of alternative splicing in the mammalian central nervous system

scientific article published on January 2007

GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol

scientific article published in March 2009

GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state

scientific article published in October 2004

Generation and clonal isolation of retinal stem cells from human embryonic stem cells ⬇️

scientific article published on May 16, 2012

Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization

scientific article published on 5 July 2011

Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse

scientific article published on 13 April 2015

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.

scientific article published on 6 January 2011

Global survey of genomic imprinting by transcriptome sequencing

scientific article

Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations

scientific article published in March 2002

Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration

scientific article published on 30 July 2020

In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord

scientific article published in September 2002

Induction of Rod and Cone Photoreceptor-Specific Progenitors from Stem Cells

scientific article published on 01 January 2019

Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells

scientific article published on 13 November 2018

Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation.

scientific article published on 21 December 2012

Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval

scientific article published in June 2010

Intrinsic differences distinguish transiently neurogenic progenitors from neural stem cells in the early postnatal brain

scientific article published in February 2005

Isolation of Retinal Stem Cells from the Mouse Eye ⬇️

scientific article published on September 11, 2010

It is ethical to transplant human stem cells into nonhuman embryos

scientific article published on 01 April 2004

Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area.

scientific article published in October 2002

Lineage tracing reveals the hierarchical relationship between neural stem cell populations in the mouse forebrain

scientific article published on 27 November 2019

Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye.

scientific article

Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo

scientific article published in January 2006

Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways

scientific article published on August 2009

Maximizing functional photoreceptor differentiation from adult human retinal stem cells

scientific article published on March 2010

Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes

scientific article published in February 2002

Mutations in the Guanylate Cyclase gcy-28 Neuronally Dissociate Naïve Attraction and Memory Retrieval

scientific article published on 19 November 2018

Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain ⬇️

scientific article published on 01 January 2002

Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

scientific article published on 07 March 2011

Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1.

scientific article published on June 2008

Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.

scientific article published on 25 January 2013

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

scientific article

Notch signaling induces retinal stem-like properties in perinatal neural retina progenitors and promotes symmetric divisions in adult retinal stem cells

scientific article published on 4 November 2013

Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche

scientific article published in January 2006

Oct4 is required ~E7.5 for proliferation in the primitive streak

scientific article

Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area

scientific article

P-Cadherin is necessary for retinal stem cell behavior in vitro, but not in vivo

scientific article published on 03 May 2017

Parental Bias Has Benefits

scientific article published on 01 September 2020

Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal ⬇️

scientific article published on January 20, 2012

Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling

scientific article published on August 2004

Primitive neural stem cells in the adult mammalian brain give rise to GFAP-expressing neural stem cells.

scientific article

Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain

scientific article published on 21 July 2017

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein

scientific journal article

Segregation of caffeine reward and aversion in the rat nucleus accumbens shell versus core

scientific article published on 09 March 2020

Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans

scientific article

Single-Cell Tumbling Enables High-Resolution Size Profiling of Retinal Stem Cells

Social defeat stress switches the neural system mediating benzodiazepine conditioned motivation ⬇️

scientific article published on June 3, 2013

Stem and progenitor cells: the premature desertion of rigorous definitions

scientific article (publication date: March 2003)

Stem cells in 2009.

scientific article published in November 2009

Subretinal gene delivery using helper-dependent adenoviral vectors.

scientific article

Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro

scientific article

Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.

scientific article published in February 2009

Surfaceome profiling reveals regulators of neural stem cell function

scientific article published on January 2014

Targeted activation of primitive neural stem cells in the mouse brain

scientific article published on 5 March 2016

Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward

scientific article published in February 2009

The Adult Mammalian Pancreas Contains Separate Precursors of Pancreatic and Neural Crest Developmental Origins ⬇️

scientific article published on April 23, 2013

The Neurobiology of Opiate Motivation ⬇️

scientific article published on October 1, 2012

The adult mouse and human pancreas contain rare multipotent stem cells that express insulin

scientific article

The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells

scientific article published in September 2011

The aggregation and inheritance of damaged proteins determines cell fate during mitosis

scientific article

The asymmetric segregation of damaged proteins is stem cell–type dependent ⬇️

scientific article published on May 6, 2013

The functional landscape of mouse gene expression

scientific article

The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway

scientific article

The germline stem cells of Drosophila melanogaster partition DNA non-randomly

scientific article published on 22 April 2009

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

scientific article published on 21 July 2020

The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor

scientific article

The neural stem cell lineage reveals novel relationships among spermatogonial germ stem cells and other pluripotent stem cells

scientific article published on 11 December 2013

The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour

scientific article published on January 2004

The proliferation and expansion of retinal stem cells require functional Pax6.

scientific article published on 19 January 2007

Two Forms of Learning following Training to a Single Odorant in Caenorhabditis elegans AWC Neurons ⬇️

scientific article published on June 27, 2012

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.

scientific article

Vascular Endothelial Growth Factor Directly Inhibits Primitive Neural Stem Cell Survival But Promotes Definitive Neural Stem Cell Survival

scientific article published on 01 June 2006

Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats

scientific article

Ventral tegmental area GABA neurons and opiate motivation

scientific article published on 8 February 2013

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

scientific article published on March 2005

β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship

scientific article published on 16 June 2011

β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward

scientific article published on 27 November 2019

Paulina is supported by:

About Paulina

Help