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List of works by Derek LeRoith

14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation

scientific article published on 8 June 2004

A MESSAGE FROM THE EDITOR-IN-CHIEF.

scientific article

A Message from the Editor-in-Chief

scientific article published in January 2017

A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization

scientific article

A novel Drosophila insulin receptor: fly in the ointment or evolutionary conservation?

scientific article published in June 1995

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS

scientific article published on 01 June 2016

Activating Transcription Factor-5 Knockdown Reduces Aggressiveness of Mammary Tumor Cells and Attenuates Mammary Tumor Growth

scientific article

Adrenal cortical neoplasia

scientific article published in June 2015

Aging and endocrinology. Foreword

scientific article published on 27 March 2013

Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats

scientific article published in January 1992

Alternative leader sequences in insulin-like growth factor I mRNAs modulate translational efficiency and encode multiple signal peptides

scientific article published on October 1995

American association of clinical endocrinologists and american college of endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015

scientific article

Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications

scientific article

Bacillus subtilis contains multiple forms of somatostatin-like material

scientific article

Basic aspects and clinical applicability in the field of lipidology. Foreword

scientific article published in March 2009

Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities

scientific article

Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum

scientific article published on September 2014

Bidirectional impact of endocrine disorders

scientific article published on 4 July 2013

Building Momentum: Taking on the Real “Issues” of Diabetes Care!

scientific article published on January 2016

CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy

scientific article published on 14 May 2016

CD24(+) cells fuel rapid tumor growth and display high metastatic capacity

scientific article published on 4 June 2015

Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models

scientific article published on 12 October 2010

Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression

scientific article published in September 1990

Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.

scientific article published in January 1992

Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain

scientific article published on March 1987

Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells ⬇️

scientific article published on March 8, 1988

Characterization of the chicken muscle insulin receptor

scientific article

Characterization of the mouse sulfonylurea receptor 1 promoter and its regulation

scientific article published on June 1999

Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.

scientific article

Circulating levels of IGF-1 directly regulate bone growth and density

scientific article

Clinical relevance of systemic and local IGF-I.

scientific article

Clinical relevance of systemic and local IGF-I: lessons from animal models.

scientific article published on February 2008

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene

scientific article published in June 1990

Comparison of the counterregulatory hormone response to semisynthetic human insulin and purified porcine insulin in normal subjects and patients with type I diabetes mellitus

scientific article published on 01 September 1991

Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system

scientific article

Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus

scientific article

Cytokines and growth factors modulate cell growth and insulin‐like growth factor binding protein secretion by the human salivary cell line (HSG) ⬇️

scientific article published on November 1, 1995

Decreased IGF Type 1 Receptor Signaling in Mammary Epithelium during Pregnancy Leads to Reduced Proliferation, Alveolar Differentiation, and Expression of Insulin Receptor Substrate (IRS)-1 and IRS-2 ⬇️

scientific article published on May 31, 2011

Determining Mammosphere-Forming Potential: Application of the Limiting Dilution Analysis ⬇️

scientific article published on June 8, 2012

Development of brain insulin receptors

scientific article published on January 1988

Development of brain insulin receptors: structural and functional studies of insulin receptors from whole brain and primary cell cultures

scientific article published in July 1986

Developmental expression of rat insulin-like growth factor-II/mannose 6-phosphate receptor messenger ribonucleic acid

scientific article published in June 1992

Developmental regulation of insulin-like growth factor-I-stimulated glucose transporter in rat brain astrocytes

scientific article published on May 1991

Developmental regulation of rat brain/Hep G2 glucose transporter gene expression

scientific article published in February 1989

Developmental regulation of somatostatin gene expression in the brain is region specific

scientific article published in February 1987

Developmental regulation of the rat insulin-like growth factor I receptor gene

scientific article

Dexamethasone reduces steady state insulin-like growth factor I messenger ribonucleic acid levels in rat neuronal and glial cells in primary culture

scientific article

Diabetes Care: "Lagniappe" and "Seeing Is Believing"!

scientific article published on 9 June 2016

Diabetes Care: "Taking It to the Limit One More Time".

scientific article published in January 2017

Diabetes cure--is the glass half full?

scientific article published in September 2006

Diabetes in the aging male

Diabetes mellitus: associated conditions. Foreword

scientific article published on 2 December 2013

Diabetes, antihyperglycemic medications and cancer risk: smoke or fire?

scientific article published on October 2013

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

scientific article published on December 2011

Diabetes, glucose control, glucose lowering medications, and cancer risk: a 10-year population-based historical cohort

scientific article

Diabetes, obesity and breast cancer

scientific article published on 01 November 2018

Diabetic nephropathy in a nonobese mouse model of type 2 diabetes mellitus

scientific article

Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo

scientific article

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

scientific article

Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: role for the C-terminal domain of the beta-subunit

scientific article published on June 1997

Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor

scientific article published on February 1997

Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

scientific article published on May 1995

Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells

scientific article published in February 1993

Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling

scientific article

Does a Single Nucleotide Polymorphism in the FGFR Explain the Connection between Diabetes and Cancer? ⬇️

scientific article published on June 4, 2013

Dyslipidemia and glucose dysregulation in overweight and obese patients

scientific article published on January 2007

Dysregulation of IGF-I signaling in uterine leiomyoma ⬇️

scientific article published on January 1, 2002

EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice

scientific article published on 19 July 2016

Editorial: A blast from the past--insulin does it again!

scientific article published in July 2004

Effect of Case-Based Training for Medical Residents on Confidence, Knowledge, and Management of Inpatient Glycemia ⬇️

scientific article published on July 1, 2011

Effect of altered nutritional states on insulin receptors

scientific article published on January 1988

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice

scientific article

Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats

scientific article published on March 1994

Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia

scientific article

Endocrine hypertension. Forward.

scientific article published in June 2011

Endocrinology and Metabolism Clinics of North America. Acute and chronic complications of diabetes. Foreword

scientific article published in August 2013

Endocrinology and Metabolism Clinics of North America. HIV and endocrine disorders. Foreword

scientific article published in September 2014

Endocrinology and Metabolism Clinics of North America. Neuroendocrine control of metabolism. Foreword

scientific article published on 28 December 2012

Endocrinology: Endogenous plasma growth hormone and the occurrence of pregnancies in patients undergoing in-vitro fertilization and embryo transfer with ovarian stimulation ⬇️

scientific article published on May 1, 1995

Epidemiology and Molecular Mechanisms Tying Obesity, Diabetes, and the Metabolic Syndrome With Cancer ⬇️

scientific article published on August 1, 2013

Erratum to: Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes

scientific article published in April 2017

Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action

scientific article published on January 1994

Evidence for an insulin-like growth factor autocrine-paracrine system in the retinal photoreceptor-pigment epithelial cell complex

scientific article

Evolutionary aspects of the endocrine and nervous systems

scientific article published on January 1986

Evolutionary origins of intercellular communication systems: implications for mammalian biology

scientific article

Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary

scientific article published in November 1993

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells

scientific article published on September 1989

Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries

scientific article

Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary

scientific article

Expression of the insulin-like growth factor (IGF)-I and -II and the IGF-I and -II receptor genes during postnatal development of the rat ovary

scientific article published on September 1992

Expression, action, and steroidal regulation of insulin-like growth factor-I (IGF-I) and IGF-I receptor in the rat corpus luteum: their differential role in the two cell populations forming the corpus luteum

scientific article published in December 1991

Extracellular Regulated Kinase, but Not Protein Kinase C, Is an Antiapoptotic Signal of Insulin-like Growth Factor-1 on Cultured Cardiac Myocytes

scientific article published in 2000

Extracts of protozoa contain materials that react specifically in the immunoassay for guinea pig insulin

scientific article published in February 1986

Failure of metoclopramide to influence LH, FSH and TSH secretion or their responses to releasing hormones ⬇️

scientific article published on December 1, 1979

Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene ⬇️

scientific article published on August 25, 1993

Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors.

scientific article

Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors

scientific article

Functional insulin-like growth factor I receptors are expressed by neural-derived continuous cell lines.

scientific article published in January 1988

Getting to the "Heart" of the Matter on Diabetic Cardiovascular Disease: "Thanks for the Memory".

scientific article published on May 2016

Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes

scientific article published on 20 February 2015

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment of the GH-deficient dwarf rat: differential effects on IGF-I transcription start site expression in hepatic and extrahepatic tissues and lack of effect on type I IGF receptor mRN

scientific article published in May 1994

Growth hormone (GH) status regulates GH receptor and GH binding protein mRNA in a tissue- and transcript-specific manner but has no effect on insulin-like growth factor-I receptor mRNA in the rat.

scientific article published in February 1996

Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

scientific article

Growth hormone receptor signaling is dispensable for HSC function and aging

scientific article

Growth hormone treatment induces mammary gland hyperplasia in aging primates ⬇️

scientific article published on October 1, 1997

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice

scientific article

Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice

scientific article published in October 2017

High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model

scientific article published on 19 January 2016

High-efficient FLPo deleter mice in C57BL/6J background

scientific article

Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes

scientific article published on 29 August 2020

Highly specific role of the insulin receptor in breast cancer progression

scientific article

Hodgkin lymphoma in temporal association with growth hormone replacement

scientific article

Hormonal regulation of rat hypothalamic neuropeptide mRNAs: effect of hypophysectomy and hormone replacement on growth-hormone-releasing factor, somatostatin and the insulin-like growth factors

scientific article published in March 1991

How distinct are the insulin and insulin-like growth factor I signalling systems?

scientific article published on January 1, 1992

How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?

scientific article published on January 1994

Hyperinsulinemia and type 2 diabetes: impact on cancer

scientific article published on 15 April 2010

Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer

scientific article

IGF1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors

scientific article published on 4 August 2014

Identification of multiple transcription start sites in the human insulin-like growth factor-I gene

scientific article published in June 1991

Impaired muscle regeneration and myoblast differentiation in mice with a muscle-specific KO of IGF-IR.

scientific article published in October 2010

In vivo regulation of CrkII and CrkL proto-oncogenes in the uterus by insulin-like growth factor-I. Differential effects on tyrosine phosphorylation and association with paxillin

scientific article published on October 1997

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

scientific article

Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones

scientific article published on 7 September 2006

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

scientific article

Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia

scientific article published on 31 October 2011

Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression

scientific article published on July 1995

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice

scientific article

Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis

scientific article published on November 2001

Insulin and IGFs in obesity-related breast cancer

scientific article published on 24 October 2013

Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction ⬇️

scientific article published on January 1, 2001

Insulin and Insulin‐like Growth Factor‐I Induced Phosphorylation in Neurally Derived Cells ⬇️

scientific article published on August 27, 1993

Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects

scientific article published on 31 January 2014

Insulin and insulin-like growth factor receptors in the nervous system

scientific article published on March 1989

Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation

scientific article published on July 1994

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells

scientific article published in November 1987

Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor ⬇️

scientific article published on 08 July 2013

Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting

scientific article

Insulin receptors from guinea pig liver and brain: structural and functional studies

scientific article published in April 1986

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell

scientific article

Insulin resistance as the underlying cause for the metabolic syndrome

scientific article published on November 2007

Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance

scientific article published in October 2003

Insulin resistance syndrome, pre-diabetes, and the prevention of type 2 diabetes mellitus

scientific article

Insulin stimulates PKCζ -mediated phosphorylation of insulin receptor substrate-1 (IRS-1): A self-attenuated mechanism to negatively regulate the function of IRS proteins.

scientific article

Insulin's Role in Diabetes Management: After 90 Years, Still Considered the Essential "Black Dress".

scientific article published in December 2015

Insulin, insulin resistance, obesity, and cancer

scientific article published on April 2010

Insulin-Like Growth Factor-I Affects Perinatal Lethality and Postnatal Development in a Gene Dosage-Dependent Manner: Manipulation Using the Cre/loxP System in Transgenic Mice ⬇️

scientific article published on September 1, 1998

Insulin-Like Growth Factors ⬇️

scientific article published on July 1, 1992

Insulin-Like growth factors in health and disease. Foreword.

scientific article

Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways

scientific article

Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim ⬇️

scientific article published on March 19, 2012

Insulin-like growth factor I (IGF-I) receptors and IGF-I action in oligodendrocytes from rat brains

scientific article published in April 1991

Insulin-like growth factor I (IGF-I): a molecular basis for endocrine versus local action?

scientific article published on May 1991

Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage

scientific article published on 27 February 2002

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

scientific article

Insulin-like growth factor I messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat.

scientific article published in June 1989

Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy

scientific article published on 18 September 2008

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture

scientific article

Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.

scientific article

Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment

Insulin-like growth factor receptors and binding proteins

scientific article

Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line

scientific article published on October 1992

Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

scientific article published on 12 March 2001

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

scientific article

Insulin-like growth factor-I: compartmentalization within the somatotropic axis?

scientific article

Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line

scientific article published on January 1994

Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner

scientific article published on 3 January 2008

Insulin-like growth factors and the brain

scientific article published on December 2008

Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes

scientific article

Insulin-related materials in the nervous system of vertebrates and non-vertebrates: possible extrapancreatic production

scientific article published on July 1988

Insulin-sensitive tyrosine kinase is increased in livers of adult obese Zucker rats: correction with prolonged fasting

scientific article published in July 1988

Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression

scientific article

Insulin‐like Growth Factor Receptors: Implications for Nervous System Function ⬇️

scientific article published on August 27, 1993

Interaction between the insulin receptor and its downstream effectors. Use of individually expressed receptor domains for structure/function analysis

scientific article

Intracerebroventricular Leptin Infusion Improves Glucose Homeostasis in Lean Type 2 Diabetic MKR Mice via Hepatic Vagal and Non-Vagal Mechanisms ⬇️

scientific article published on February 17, 2011

Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model

scientific article published on 20 March 2013

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

scientific article published on May 1996

Is Growth Hormone Resistance/IGF-1 Reduction Good for You? ⬇️

scientific article published on April 6, 2011

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes

scientific article published on 9 June 2005

Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance

scientific article published in June 2003

Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice

scientific article published on 13 September 2017

Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes

scientific article

Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon

scientific article

Luteinizing hormone-releasing hormone antagonists interfere with autocrine and paracrine growth stimulation of MCF-7 mammary cancer cells by insulin-like growth factors

scientific article

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

scientific article

Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model ⬇️

scientific article published on April 2, 2012

Mechanism of insulin resistance induced by sustained levels of cytosolic free calcium in rat adipocytes

scientific article

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

scientific article published on March 2007

Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells

scientific article published on June 1997

Metabolic Clearance and Plasma Half Disappearance Time of Exogenous Gonadotropin Releasing Hormone in Normal Subjects and in Patients with Liver Disease and Chronic Renal Failure ⬇️

scientific article published on February 1, 1977

Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms

scientific article published on 23 April 2015

Metabolic memory in diabetes--focus on insulin

scientific article

Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways

scientific article published on 19 February 2016

Microarray analysis and identification of novel molecules involved in insulin-like growth factor-1 receptor signaling and gene expression

scientific article

Minireview: IGF, Insulin, and Cancer ⬇️

scientific article published on 03 May 2011

Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology

scientific article

Mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis

scientific article published on June 1997

Molecular and Cellular Aspects of Insulin-like Growth Factor Action

scientific article published on January 1, 1994

Molecular and cellular aspects of the insulin-like growth factor I receptor

scientific article

Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues

scientific article

Molecules of intercellular communication in vertebrates, invertebrates and microbes: do they share common origins?

scientific article published in January 1986

Monitoring glycemic control: the cornerstone of diabetes care

scientific article

Mouse models created to study the pathophysiology of Type 2 diabetes

scientific article

Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice

scientific article

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

scientific article

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice

scientific article

Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function

scientific article published on February 1995

NIH conference. Insulin-like growth factors in health and disease

scientific article published on May 15, 1992

New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut.

scientific article published on 13 November 2017

Non-metabolisable insulin glargine does not promote breast cancer growth in a mouse model of type 2 diabetes

scientific article published on 30 May 2016

Normal growth and development in the absence of hepatic insulin-like growth factor I ⬇️

scientific article

Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens

scientific article published in June 1996

Nutritional regulation of insulin-sensitive glucose transporter gene expression in rat cardiac muscle

scientific article published in June 1993

OP449 inhibits breast cancer growth without adverse metabolic effects

scientific article published in October 2017

Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

scientific article published in July 2015

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

scientific article published on 05 September 2008

Obesity, type 2 diabetes, and cancer: the insulin and IGF connection ⬇️

scientific article published on 05 September 2012

Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice

scientific article

Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE.

scientific article

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

scientific article

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

scientific article

Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes

scientific article published in December 2004

Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in Chinese hamster ovary cells

scientific article published on July 1993

Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies

scientific article published on 11 December 2003

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes

scientific article published in November 2004

Phylogeny of the insulin-like growth factors (IGFs) and receptors: a molecular approach

scientific article published on August 1993

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

scientific article

Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene

scientific article published on April 1994

Polyol accumulation in muscle and liver in a mouse model of type 2 diabetes

scientific article published on 27 April 2016

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis ⬇️

scientific article published on January 23, 2013

Prediabetes and diabetes among HIV-infected adults in Cameroon

scientific article

Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain

scientific article published in April 2004

Rat IGF-I cDNA's contain multiple 5'-untranslated regions

scientific article published in August 1987

Rationale and strategies for early detection and management of diabetic kidney disease

scientific article

Receptors for intercellular messenger molecules in microbes: similarities to vertebrate receptors and possible implications for diseases in man.

scientific article

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus

scientific article published on 2 March 2006

Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors.

scientific article published in August 2003

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding

scientific article

Regulation of Start Site Usage in the Leader Exons of the Rat Insulin-Like Growth Factor-I Gene by Development, Fasting, and Diabetes ⬇️

scientific article published on November 1, 1991

Regulation of endometrial cancer cell growth by insulin-like growth factors and the luteinizing hormone-releasing hormone antagonist SB-75.

scientific article published on October 1993

Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid

scientific article published on November 1993

Regulation of insulin-like growth factor I receptor gene expression by Sp1: physical and functional interactions of Sp1 at GC boxes and at a CT element

scientific article published on September 1995

Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

scientific article published in January 1996

Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.

scientific article

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells

scientific article published on January 1995

Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells

scientific article published on June 1993

Regulation of rat brain/HepG2 glucose transporter gene expression by phorbol esters in primary cultures of neuronal and astrocytic glial cells

scientific article published on January 1990

Renal IGF-1 mRNA levels are enhanced following unilateral nephrectomy in immature but not adult rats

scientific article published in May 1991

Renal tubulointerstitial injury from ureteral obstruction in the neonatal rat is attenuated by IGF-1.

scientific article

Replacement of Tyrosine 1251 in the Carboxyl Terminus of the Insulin-like Growth Factor-I Receptor Disrupts the Actin Cytoskeleton and Inhibits Proliferation and Anchorage-independent Growth ⬇️

scientific article published on July 17, 1998

Retinal insulin receptors. 1. Structural heterogeneity and functional characterization

scientific article

Retinal insulin receptors. 2. Characterization and insulin-induced tyrosine kinase activity in bovine retinal rod outer segments

scientific article

Retinal insulin receptors: localization using a polyclonal anti-insulin receptor antibody

scientific article

Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells

scientific article

Retinoic acid inhibits growth of breast cancer cell lines: the role of insulin-like growth factor binding proteins

scientific article published on 01 March 1993

Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation

scientific article published on February 1991

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

scientific article

Role of growth hormone (GH) in liver regeneration

scientific article published on 8 July 2004

Role of the IGF-I receptor in mutagenesis and tumor promotion

scientific article published on March 1997

Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function.

scientific article published on May 1994

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

scientific article published on 24 October 2008

Serum insulin-like growth factor I regulates brain amyloid-beta levels

scientific article published on 4 November 2002

Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression

scientific article published on 29 August 2016

Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis

scientific article published on November 1995

Skeletal muscle

scientific article

Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation

scientific article

Somatostatin-Like Immunoactivity and Biological Activity Is Present in Tetrahymena pyriformis, a Ciliated Protozoan* ⬇️

scientific article published on June 1, 1982

Somatostatin-like material is present in flowering plants

scientific article published on November 1985

Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins

scientific article published on April 1997

Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.

scientific article published on June 1997

Statin Use and Breast Cancer Prognosis in Black and White Women

scientific article

Status of Diabetes Care: "It just doesn't get any better . . . or does it?".

scientific article published on July 2014

Status of Diabetes Care: New Challenges, New Concepts, New Measures--Focusing on the Future!

scientific article published on July 2015

Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins

scientific article

Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression ⬇️

scientific article published on July 15, 1998

Structural and functional analysis of the insulin-like growth factor I receptor gene promoter

scientific article published on October 1, 1992

Structure, expression, and regulation of the IGF-I gene.

scientific article published on January 1993

Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models.

scientific article

Survival of patients with stage IV lung cancer with diabetes treated with metformin

scientific article

T cell receptor-induced activation and apoptosis in cycling human T cells occur throughout the cell cycle

scientific article published on December 1999

TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival

scientific article

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression

scientific article

Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration

scientific article published on January 2012

The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor ⬇️

scientific article published on November 21, 1997

The Epidemiology and Molecular Mechanisms Linking Obesity, Diabetes, and Cancer

scientific article published on January 1, 2013

The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein

scientific article published on August 1996

The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration ⬇️

scientific article published on January 1, 1992

The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts ⬇️

scientific article published on December 5, 1997

The Link between the Metabolic Syndrome and Cancer ⬇️

scientific article published on August 16, 2011

The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

scientific article published in Journal of Biological Chemistry

The WT1 Wilms' tumor suppressor gene: a novel target for insulin-like growth factor-I action

scientific article published on 17 July 2003

The beneficial effect of growth hormone treatment on islet mass in streptozotocin-treated mice

scientific article published on 6 February 2015

The benefits of tight glycemic control in type 2 diabetes mellitus

scientific article published on January 2007

The carboxyl‐terminal domain of insulin‐like growth factor‐I receptor interacts with the insulin receptor and activates its protein tyrosine kinase ⬇️

scientific article published on January 2, 1998

The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells

scientific article published on 15 July 2003

The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes

scientific article

The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology

scientific article published on March 1982

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor

scientific article published on November 1992

The insulin-like growth factor I (IGF-I) gene is expressed in chick embryos during early organogenesis

scientific article published in September 1990

The insulin-like growth factor system and cancer

scientific article

The interaction of brain insulin receptors with wheat germ agglutinin

scientific article published in January 1987

The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt.

scientific article published on 24 September 2004

The metabolic syndrome--from insulin resistance to obesity and diabetes

scientific article published on September 2008

The new kid on the block(ade) of the IGF-1 receptor

scientific article published on March 2004

The pathway from diabetes and obesity to cancer, on the route to targeted therapy

scientific article published on September 2010

The proliferating role of insulin and insulin-like growth factors in cancer ⬇️

scientific article published on July 19, 2010

The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors

scientific article published on January 1993

The role of endocrine insulin-like growth factor-I and insulin in breast cancer

scientific article

The role of growth hormone, insulin-like growth factors (IGFs), and IGF-binding proteins in experimental diabetic kidney disease

scientific article published on October 1995

The role of insulin receptor signaling in zebrafish embryogenesis

scientific article published on 07 August 2008

The role of insulin-like growth factors in diabetic kidney disease

scientific article

The role of the IGF system in cancer growth and metastasis: overview and recent insights

scientific article published on 24 August 2006

The role of the insulin-like growth factor system in human cancer

scientific article published on January 1996

The role of the insulin-like growth factor-I receptor in cancer

scientific article published on September 1995

The tyrosine kinase activity of the chicken insulin receptor is similar to that of the human insulin receptor

scientific article published on April 2000

The worldwide diabetes epidemic ⬇️

scientific article published on April 1, 2012

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes

scientific article published on 15 December 2004

Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat.

scientific article

Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: evidence for differential regulation in the developing kidney

scientific article

Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site

scientific article published on April 1994

Treatment of diabetes: a clinical update on insulin trials

scientific article published on January 2007

Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor

scientific article published on February 1996

Two insulin genes are present in the salmon genome

scientific article published in March 1993

Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy

scientific article

Type 2 diabetes and cancer: what is the connection?

scientific article published on March 2010

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis

scientific article

Tyrosine kinase activity of brain insulin and IGF-1 receptors

scientific article published in January 1986

Tyrosine residues in the C-terminal domain of the insulin-like growth factor-I receptor mediate mitogenic and tumorigenic signals

scientific article published on July 1997

Xenopus laevis contains two nonallelic preproinsulin genes. cDNA cloning and evolutionary perspective

scientific article published in June 1989

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.

scientific article

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