List of works - Lee B Smith

Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes

scientific article

An essential role for katanin p80 and microtubule severing in male gamete production

scientific article

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics

scientific article

Androgen action via testicular peritubular myoid cells is essential for male fertility

scientific article

Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit

scientific article published on 22 December 2010

Androgen receptor roles in spermatogenesis and infertility

scientific article (publication date: August 2015)

Androgen receptor signalling in Vascular Endothelial cells is dispensable for spermatogenesis and male fertility ⬇️

scientific article published on January 9, 2012

Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells

scientific article published on 09 June 2011

Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action

scientific article

Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein

scientific journal article

Cell-specific ablation in the testis: what have we learned?

scientific article

Characterisation of a mural cell network in the murine pituitary gland

scientific article published on 31 August 2020

Characterisation of a novel Fc conjugate of macrophage colony-stimulating factor

scientific article published on 25 June 2014

Contrasting genome organisation: two regions of theBrassica oleraceagenome compared with collinear regions of theArabidopsisthalianagenome ⬇️

scientific article published on October 1, 2001

Critical androgen-sensitive periods of rat penis and clitoris development

scientific article

DNA microarrays and development

scientific article

Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol

scientific article

Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.

scientific article published on 13 March 2012

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts

scientific article

Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression.

scientific article published on 12 April 2009

Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia

scientific article

Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells

scientific article

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract

scientific article published on 24 January 2009

Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility

scientific article

Good planning and serendipity: exploiting the Cre/Lox system in the testis ⬇️

scientific article published on November 17, 2010

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome

scientific journal article

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

scientific article

Influence of Testosterone on Inflammatory Response in Testicular Cells and Expression of Transcription Factor Foxp3 in T Cells.

scientific article

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

scientific article

KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility

scientific article

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis

scientific article (publication date: 2011)

Modulation of neointimal lesion formation by endogenous androgens is independent of vascular androgen receptor

scientific article

New insights into the role of androgens in wolffian duct stabilization in male and female rodents.

scientific article published on 8 January 2009

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

scientific article

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

scientific article

Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse

scientific article

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

scientific article

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

scientific article

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents

scientific article (publication date: 2012)

Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development

scientific article published on 9 June 2015

Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis

scientific article

Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis

scientific article

Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development.

scientific article published in June 2000

Single primer amplification (SPA) of cDNA for microarray expression analysis.

scientific article

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

scientific article published on 5 July 2011

Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men

scientific article published on 01 March 2021

Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice

scientific article published on 03 January 2014

The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice

scientific article

The Skeleton: The New Controller of Male Fertility? ⬇️

scientific article published on 01 March 2011

The regulation of spermatogenesis by androgens

scientific article

List of works by Lee B Smith

Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes

An essential role for katanin p80 and microtubule severing in male gamete production

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics

Androgen action via testicular peritubular myoid cells is essential for male fertility

Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit

Androgen receptor roles in spermatogenesis and infertility

Androgen receptor signalling in Vascular Endothelial cells is dispensable for spermatogenesis and male fertility ⬇️

Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells

Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action

Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein

Cell-specific ablation in the testis: what have we learned?

Characterisation of a mural cell network in the murine pituitary gland

Characterisation of a novel Fc conjugate of macrophage colony-stimulating factor

Contrasting genome organisation: two regions of theBrassica oleraceagenome compared with collinear regions of theArabidopsisthalianagenome ⬇️

Critical androgen-sensitive periods of rat penis and clitoris development

DNA microarrays and development

Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol

Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts

Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression.

Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia

Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells

Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract

Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility

Good planning and serendipity: exploiting the Cre/Lox system in the testis ⬇️

Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

Influence of Testosterone on Inflammatory Response in Testicular Cells and Expression of Transcription Factor Foxp3 in T Cells.

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility

LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis

Modulation of neointimal lesion formation by endogenous androgens is independent of vascular androgen receptor

New insights into the role of androgens in wolffian duct stabilization in male and female rodents.

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.

Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents

Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development

Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis

Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis

Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development.

Single primer amplification (SPA) of cDNA for microarray expression analysis.

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men

Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice

The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice

The Skeleton: The New Controller of Male Fertility? ⬇️

The regulation of spermatogenesis by androgens