List of works by Phillip D. Zamore

A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation.

scientific article

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals

scientific article published on 01 September 2018

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

scientific article (publication date: 3 August 2001)

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

scientific article published on 01 January 1988

A microRNA in a multiple-turnover RNAi enzyme complex

scientific article (publication date: 20 September 2002)

A protein sensor for siRNA asymmetry

scientific article

A role for microRNAs in the Drosophila circadian clock

scientific article

A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe

scientific article

A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis

scientific article published on 30 April 2014

Adaptation to P element transposon invasion in Drosophila melanogaster ⬇️

scientific article published on December 2011

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes

scientific article published on 21 March 2013

An automated Bayesian pipeline for rapid analysis of single-molecule binding data

scientific article published in Nature Communications

Analysis of Small RNAs by Northern Hybridization

scientific article published on 01 August 2018

Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin

scientific article published on March 2014

Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties

scientific article published on November 2012

Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies.

scientific article

Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.

scientific article

Argonaute proteins

scientific article published on 01 June 2011

Assessing long-distance RNA sequence connectivity via RNA-templated DNA-DNA ligation

scientific article published on 13 April 2015

Asymmetry in the assembly of the RNAi enzyme complex

scientific article (publication date: 17 October 2003)

Beginning to understand microRNA function

scientific article published on August 2007

Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice

scientific article published on 13 August 2018

Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit ⬇️

scientific article published on September 15, 1992

Cnidarian microRNAs frequently regulate targets by cleavage

scientific article (publication date: April 2014)

Competitive endogenous RNAs cannot alter microRNA function in vivo

scientific article published on 01 June 2014

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence

scientific article

Defining piRNA primary transcripts.

scientific article

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells.

scientific article published on January 2008

Designing siRNA that distinguish between genes that differ by a single nucleotide

scientific article

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

scientific article published on 08 November 2012

Dicer partner proteins tune the length of mature miRNAs in flies and mammals

scientific article published on 11 October 2012

Diversifying microRNA sequence and function

scientific article published on 26 June 2013

Drosophila development: homeodomains and translational control.

scientific article published on July 1996

Effective and Accurate Gene Silencing by a Recombinant AAV-Compatible MicroRNA Scaffold

scientific article published on 27 November 2019

Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers.

scientific article published on 13 July 2018

Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells

scientific article

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

scientific article published in September 2002

Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans

scientific article published on 23 December 2019

Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients

scientific article published on 9 April 2009

High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

scientific article published on 16 July 2019

High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody

scientific article

Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study.

scientific article published on 28 January 2013

Huntington's disease: silencing a brutal killer

scientific article

In vitro analysis of RNA interference in Drosophila melanogaster.

scientific article published in August 2003

Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain

scientific article published in January 2013

Inhibiting miRNA Function by Antisense Oligonucleotides in Cultured Mammalian Cells

scientific article published in February 2018

Inhibiting miRNA Function by Antisense Oligonucleotides in Drosophila S2 Cells.

scientific article published in February 2018

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain

scientific article published on 31 January 2014

Isolation of Drosophila melanogaster testes

scientific article

Kinetic analysis of the RNAi enzyme complex

scientific article

Linking SNPs to CAG repeat length in Huntington's disease patients.

scientific article published on 19 October 2008

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

scientific article

Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster

scientific article published on 06 December 2018

MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region

scientific article (publication date: 18 August 2004)

MicroRNA therapeutics.

scientific article published on 28 April 2011

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

scientific article

MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

scientific article

MicroRNAs tame CRISPR-Cas9

scientific article published on 01 April 2019

MicroRNAs: regulating a change of heart.

scientific article published on April 2009

Molecular biology. RNA interference

scientific article published on 01 March 2000

Molecular biology: Rhino gives voice to silent chromatin.

scientific article

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

scientific article published on 18 April 2016

Nucleus and gene expression

scientific article published on 14 May 2009

PIWI-interacting RNAs: small RNAs with big functions

scientific article published on 01 February 2019

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

article

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

scientific journal article

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals

scientific article

Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease

scientific article

Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.

scientific article

Plant RNA interference in vitro

scientific article published on 01 January 2004

Plant RNAi: How a viral silencing suppressor inactivates siRNA.

scientific article published on March 2004

Preparation of Antisense Oligonucleotides to Inhibit miRNA Function

scientific article published in February 2018

Preparation of dsRNAs for RNAi by In Vitro Transcription

scientific article published on 01 March 2019

Preparation of siRNA Duplexes

scientific article published on 01 April 2019

RISC assembly defects in the Drosophila RNAi mutant armitage.

scientific article

RNA Interference and Small RNA Analysis

scientific article published on 01 April 2019

RNA binding: βS and basics

scientific article published in Nature

RNA silencing: genomic defence with a slice of pi.

scientific article published in April 2007

RNA: methods and protocols - a new series.

scientific article published on 7 June 2012

RNAi in Drosophila S2 Cells by dsRNA Soaking

scientific article published on 01 March 2019

RNAi in Drosophila S2 Cells by siRNA Duplex or dsRNA Transfection

scientific article published on 01 April 2019

RNAi in Mammalian Cells by siRNA Duplex Transfection

scientific article published on 01 April 2019

Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion.

scientific article published on 19 August 2016

Rapid and specific purification of Argonaute-small RNA complexes from crude cell lysates

scientific article published on 18 December 2012

Ribo-gnome: the big world of small RNAs

scientific article (publication date: 2 September 2005)

Sequence-specific inhibition of small RNA function

scientific article

Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides

scientific article

Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides

scientific article published on 14 July 2016

Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms

scientific article

Small RNA-directed silencing: the fly finds its inner fission yeast?

scientific article published in April 2013

Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine

scientific article

Small silencing RNAs

scientific article published on 01 September 2007

Small silencing RNAs: an expanding universe

scientific article

SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle.

scientific article

Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway

scientific article

Startups on the menu: Alnylam

scientific article published in September 2014

Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection.

scientific article

Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles.

scientific article published on 17 January 2012

Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs

scientific article

Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins

scientific article

Target RNA-directed trimming and tailing of small silencing RNAs

scientific article

The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1.

scientific article published on 3 November 2011

The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.

scientific article published on 03 September 2009

The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.

scientific article

The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing

scientific article

The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence

scientific article published on 01 January 1999

The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

scientific article published on 07 May 2019

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

scientific article

The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility

scientific article published on 29 June 2020

The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology

scientific article

The initial uridine of primary piRNAs does not create the tenth adenine that Is the hallmark of secondary piRNAs.

scientific article

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.

scientific article published in March 1993

Thirty-three years later, a glimpse at the ribonuclease III active site.

scientific article published in December 2001

Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs.

scientific article published on 30 December 2017

Translational regulation in development.

scientific article published on April 1995

UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery

scientific article

Welcome to silence

scientific article published on 12 January 2010

Why do miRNAs live in the miRNP?

scientific article published in May 2002

microPrimer: the biogenesis and function of microRNA.

scientific article

piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing

scientific article

piRNAs

scientific article published on 01 August 2014

siRNAs knock down hepatitis

scientific article published on 01 March 2003

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