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List of works by Fiona Gribble

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium

scientific article

A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line

scientific article published on May 2003

A tag to track short chain fatty acid sensors

scientific article published on 01 October 2013

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

scientific article

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

scientific article

Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets

scientific article published on 17 May 2021

Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system

scientific article

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

scientific article published on 04 March 2019

Alpha2A-adrenergic receptors and type 2 diabetes

scientific article published on 01 January 2010

An SCN9A channelopathy causes congenital inability to experience pain

scientific article

An absorbing sense of sweetness

scientific article published on 01 February 2015

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides

scientific article

Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans

scientific article published on 22 July 2016

Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome

scientific article published on 01 October 2018

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

scientific article

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors

scientific article

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

scientific article published on 17 March 2018

CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs

scientific article

Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line.

scientific article

Chylomicrons stimulate incretin secretion in mouse and human cells

scientific article

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells.

scientific article published on 22 March 2013

Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

scientific article published on 30 July 2018

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

scientific article published on 07 February 2019

Correlating structure and function in ATP-sensitive K+ channels.

scientific article published on July 1998

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

scientific article published on 9 November 2017

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

scientific article

Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions

scientific article

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

scientific article

Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults

scientific article published on 5 June 2015

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

scientific article published on 06 October 2015

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

scientific article published on 23 July 2018

Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

scientific article

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

scientific article

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.

scientific article published on 13 February 2014

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

scientific article published on 01 April 2019

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.

scientific article

G protein-coupled receptors as new therapeutic targets for type 2 diabetes

scientific article published on 12 December 2015

G-protein-coupled receptors in intestinal chemosensation

scientific article

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

scientific article published on 10 January 2019

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

scientific article published in June 2010

GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence

scientific article

GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness

scientific article published on 19 October 2015

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

scientific article published on 25 October 2016

Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells

scientific article published on 12 December 2015

Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery

scientific article published on 03 February 2018

Generation of L cells in mouse and human small intestine organoids

scientific article

Genetic cause of hyperglycaemia and response to treatment in diabetes

scientific article (publication date: 18 October 2003)

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the <i>GIPR</i> Region

scientific article published on 23 August 2021

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

scientific article

Glucose sensing in L cells: a primary cell study

scientific article

Glucose-sensing in glucagon-like peptide-1-secreting cells

scientific article published on September 2002

Glutamine Reduces Postprandial Glycemia and Augments the Glucagon-Like Peptide-1 Response in Type 2 Diabetes Patients

article

Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

scientific article published on 9 September 2004

Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP.

scientific article published on 5 January 2011

Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study

scientific article

Gut Hormone Regulation and Secretion via FFA1 and FFA4.

scientific article published on 22 November 2016

Gut chemosensing mechanisms

scientific article

Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides

scientific article

Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.

scientific article published in July 1996

Hierarchical neural architecture underlying thirst regulation

scientific article

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

scientific article published on 3 July 2015

Human α-endosulfine, a possible regulator of sulfonylurea-sensitive K ATP channel: Molecular cloning, expression and biological properties

scientific article published on July 7, 1998

Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

scientific article

Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model

scientific article published on 2 December 2013

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

scientific article published on 04 December 2018

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

scientific article published on 06 February 2020

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis

scientific article

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

scientific article published on 28 January 2021

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

scientific article

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

scientific article published in Nature Communications

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

scientific article

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone

scientific journal article

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

scientific article

Intestinal sensing of nutrients

scientific article published on January 2012

Intolerant of glucose and gasping for oxygen

scientific article published in March 2009

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

scientific article published in January 1999

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

scientific article published on 10 February 2020

LKB1 and AMPK differentially regulate pancreatic β-cell identity.

scientific article

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

scientific article published on 31 January 2015

Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons

scientific article published on 3 June 2010

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

scientific article

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells

scientific article published on 2 July 2015

Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues

scientific article published on 31 August 2017

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA

scientific article

Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion

scientific article

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells

scientific article published on 11 November 2017

Metabolism: a higher power for insulin

scientific article published in April 2005

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

scientific article published on June 1998

Microbial regulation of the L cell transcriptome

scientific article published on 19 January 2018

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

scientific article

Models and Tools for Studying Enteroendocrine Cells

Molecular determinants of KATP channel inhibition by ATP.

scientific article

Molecular mechanisms of incretin hormone secretion

scientific article published on 10 September 2013

Molecular mechanisms underlying nutrient-stimulated incretin secretion

scientific article published on 05 January 2010

Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic

scientific article published on October 2006

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

scientific article published on 28 November 2011

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression

scientific article published on 28 August 2014

Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract

scientific article published on 6 August 2012

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis

scientific article

Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM.

scientific article

Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations

scientific article published on May 2015

Nutrient detection by incretin hormone secreting cells

scientific article published on 13 December 2011

Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells

scientific article

Nutritional regulation of glucagon-like peptide-1 secretion

scientific article

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

scientific article

Open to control--new hope for patients with neonatal diabetes

scientific article published in April 2004

Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release

scientific article

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects

scientific article

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

scientific article published on 8 June 2012

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

scientific article

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans

scientific article published on 11 January 2019

Pain perception is altered by a nucleotide polymorphism in SCN9A

scientific article

Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice

scientific article published on 10 September 2019

Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

scientific article published on 27 January 2016

Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours

scientific article published on 01 August 2018

Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice

scientific article published on 17 March 2021

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

scientific journal article

Placental secretome characterization identifies candidates for pregnancy complications

scientific article published on 08 June 2021

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.

scientific article published on 26 May 2012

Pregnane glycosides from Cynanchum menarandrense

scientific article published on 18 June 2017

Preproglucagon (PPG) neurons innervate neurochemically identified autonomic neurons in the mouse brainstem

scientific article

Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

scientific article published on 02 October 2018

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.

scientific article

Preproglucagon neurons project widely to autonomic control areas in the mouse brain.

scientific article

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

scientific article

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis

article

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights

scientific article published on 7 February 2018

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

scientific article

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

scientific article

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes

scientific article published on December 2013

Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion

scientific article published on April 2016

Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells

scientific article published on May 2011

Roles of the Gut in Glucose Homeostasis

scientific article published on June 2016

Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1.

scientific article published on 26 July 2017

SCFAs strongly stimulate PYY production in human enteroendocrine cells.

scientific article

Scaling it down: new in vitro tools to get the balance right

scientific article published on January 2017

Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine

scientific article published on 03 February 2020

Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse

scientific article

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

scientific journal article

Signalling in the gut endocrine axis

scientific article published on 28 February 2017

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

scientific article published on 24 July 2015

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine

scientific article published on August 2017

Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing

scientific article published on December 2006

Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.

scientific article published on 8 August 2012

Spinally projecting preproglucagon axons preferentially innervate sympathetic preganglionic neurons

scientific article

Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.

scientific article

Stimulation of incretin secreting cells

scientific article

Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids

scientific article published on 15 October 2021

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion

scientific article published on 24 April 2015

Sulfonylurea stimulation of insulin secretion

scientific article

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

scientific article published on 06 April 2007

Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies

scientific article published in February 2018

Targeting development of incretin-producing cells increases insulin secretion

scientific article published on 15 December 2014

The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

scientific article

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

scientific article

The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

scientific article published on 8 June 2017

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

scientific article published on 05 November 2018

The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones

scientific article

The effect of encapsulated glutamine on gut peptide secretion in human volunteers

scientific article published on 2 November 2015

The gut endocrine system as a coordinator of postprandial nutrient homoeostasis

scientific article published on August 21, 2012

The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel

scientific article published on 2 March 2016

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

scientific article published on 20 November 2014

The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.

scientific article published on 13 October 2005

The role of gut endocrine cells in control of metabolism and appetite

scientific article

Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels

scientific article published on September 1, 1998

Towards the harnessing of gut feelings

scientific article published on 16 October 2013

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

scientific article published on 7 July 2016

Trophoblast organoids as a model for maternal-fetal interactions during human placentation

scientific article published on 28 November 2018

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

scientific article (publication date: 8 May 1997)

Use of Ex Vivo Normothermic Perfusion for Quality Assessment of Discarded Human Donor Pancreases.

scientific article published on 18 May 2015

α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin.

scientific article published on 22 December 2015