List of works - Dennis C. Liotta

1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols

scientific article published on 01 July 2005

A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds

scientific article published on 17 July 2018

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

scientific article published on 18 October 2017

A novel class of negative allosteric modulators of NMDA receptor function

scientific article published on 19 October 2015

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

scientific article

A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors

scientific article published on 21 March 2014

A structurally derived model of subunit-dependent NMDA receptor function

scientific article published on 01 August 2018

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

scientific article published on 5 October 2010

A target site for template-based design of measles virus entry inhibitors.

scholarly article

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

article by Verena Dirsch et al published July 1995 in Tetrahedron Letters

Academic Drug Development: The DRIVE Model

scientific article published on 02 April 2018

Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease

scientific article published on 12 March 2020

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus

scientific article published on 10 April 2020

Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy

scientific article published on 06 July 2010

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.

scientific article published on 24 May 2018

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

scientific article

Anti-HIV small-molecule binding in the peptide subpocket of the CXCR4:CVX15 crystal structure

scientific article

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model

scientific article

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

scientific article published on 17 January 2019

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

scientific article published on 30 January 2013

Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog

scientific article

Biased modulators of NMDA receptors control channel opening and ion selectivity

scientific article published on 20 January 2020

Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase

scientific article published on January 2004

Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols

scientific article

C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.

scientific article published on 30 November 2011

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV.

scientific article published on 28 October 2016

Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

scientific article

Cancer and virus leads by HTS, chemical design and SEA data mining

scientific article published in January 2009

Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors.

scientific article published on 18 June 2015

Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP).

scientific article published in January 2010

Confronting Racism in Chemistry Journals

scientific article published on 19 June 2020

Confronting Racism in Chemistry Journals

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects

scientific article

Correction to "Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease"

scientific article published on 24 June 2020

Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

scientific article published on 4 March 2015

Correction to Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

scientific article published on 17 April 2017

Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors

scientific article published on 30 May 2014

Correction: Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model.

scientific article published on 4 May 2011

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

scientific article published on 08 October 2009

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

scientific article published on May 2002

Design and synthesis of C6-C8 bridged epothilone A.

scientific article published on 21 March 2008

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

scientific article published in September 2005

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties

scientific article published on 15 August 2018

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

scientific article

Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury

scientific article

Development of a novel progesterone analog in the treatment of traumatic brain injury

scientific article published on 14 September 2018

Development of a unique small molecule modulator of CXCR4 ⬇️

scientific article published on April 2, 2012

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor

scientific article published on 04 January 2019

Diastereoselective addition of chlorotitanium enolate of N-acyl thiazolidinethione to O-methyl oximes: a novel, stereoselective synthesis of alpha,beta-disubstituted beta-amino carbonyl compounds via chiral auxiliary mediated azetine formation

scientific article published in April 2003

Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity ⬇️

scientific article published on November 24, 2010

Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting

scientific article published on 27 May 2009

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).

scientific article published on 05 October 2016

Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties

scientific article published on 09 April 2018

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

scientific article

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

scientific article published on 21 March 2016

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

scientific article published on 27 May 2008

Discovery of novel N-aryl piperazine CXCR4 antagonists

scientific article published on 17 April 2015

Discovery of small molecule CXCR4 antagonists

scientific article published on 24 October 2007

Discovery of tetrahydroisoquinoline-based CXCR4 antagonists

scientific article published on 5 September 2013

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors

scientific article published on 16 December 2020

Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates

scientific article published on 01 December 2002

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

scientific article published on 09 June 2008

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

scientific article published in March 2005

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

scientific article

Enantioselective synthesis of the carbocyclic nucleoside (−)-abacavir ⬇️

scientific article published on January 25, 2012

Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer

scientific article published on 11 March 2011

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

scientific article published on 4 June 2016

Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells

scientific article

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

scientific article

Group A streptococcus inhibitors by high-throughput virtual screening

scientific article

Highly active anticancer curcumin analogues

scientific article published on January 2007

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex

scientific article

In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats

scientific article published on 30 March 2016

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin

scientific article published on 24 June 2008

Inhibition of breast cancer metastasis to the lungs with UBS109

scientific article published on 16 November 2018

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

scientific article

Innovations in Medicinal Chemistry

scientific article published on 14 July 2016

Introductory Editorial for ACS Medicinal Chemistry Letters

scientific article published on 8 April 2010

Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators

scientific article

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators

scientific article

Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.

scientific article published on 10 January 2015

Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties

scientific article published on 23 April 2013

Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells ⬇️

scientific article published on August 6, 2010

NMDA receptor channel gating control by the pre-M1 helix

scientific article published on 01 April 2020

NMDA receptor modulators: an updated patent review (2013-2014)

scientific article

Negative allosteric modulation of GluN1/GluN3 NMDA receptors

scientific article published on 07 May 2020

Next-Generation Reduction Sensitive Lipid Conjugates of Tenofovir: Antiviral Activity and Mechanism of Release

scientific article

Non-nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase: Synthesis, Structure–Activity Relationships, and Pharmacokinetics ⬇️

scientific article published on April 20, 2012

Nonpeptide inhibitors of measles virus entry

scientific article published on August 2006

Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

scientific article

Novel NMDA receptor modulators: an update ⬇️

scientific article published on September 26, 2012

Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer

scientific article published on 25 March 2011

Opening of tartrate acetals using dialkylboron bromide: evidence for stereoselectivity downstream from ring fission

scientific article

Origins of the enantioselectivity observed in oxazaborolidine-catalyzed reductions of ketones

scientific article (publication date: February 1993)

Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys

scientific article

Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase

scientific article

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase

scientific article published on 6 May 2015

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

scientific article

Recent Reviews. 41.

scientific article

Recent Reviews. 42.

scientific article

Recent Reviews. 43.

scientific article

Recent Reviews. 44.

scientific article

Recent Reviews. 46.

scientific article

Recent Reviews. 47.

scientific article

Recent Reviews. 50.

scientific article

Recent advances in the development of HBV capsid assembly modulators

scientific article published on 02 April 2019

Recent patents regarding the discovery of small molecule CXCR4 antagonists

scientific article published on January 2009

Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

scientific article published on 13 July 2016

Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells.

scientific article

Small molecule and peptide-based CXCR4 modulators as therapeutic agents. A patent review for the period from 2010 to 2018

scientific article published on 07 January 2020

Sphingoid bases and de novo ceramide synthesis: enzymes involved, pharmacology and mechanisms of action

scientific article

Sphingolipid analogues inhibit development of malaria parasites

scientific article

Stereoselective synthesis of quaternary center bearing azetines and their beta-amino acid derivatives

scientific article

Structural analysis of CXCR4 - Antagonist interactions using saturation-transfer double-difference NMR.

scientific article

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

scientific article

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

scientific article published in Nature Communications

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists

scientific article

Synthesis and Antiviral Activity of a Series of 2'-C-Methyl-4'-thionucleoside Monophosphate Prodrugs

scientific article published on 06 November 2020

Synthesis and Biological Evaluation of 5'-C-Methyl Nucleotide Prodrugs for Treating HCV Infections

scientific article published on 09 September 2020

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy

scientific article published on August 2013

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

scientific article published on 8 December 2017

Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents

scientific article published on July 2004

Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents

scientific article published on 03 April 2007

Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors

scientific article published on 20 June 2013

Synthesis of 1-deoxysphingosine derivatives with conformationally restricted pyrrolidinediol head groups.

scientific article

Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system

scientific article published on June 2006

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains.

scientific article published on 20 December 2017

Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent

scientific article

Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.

scientific article

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors

scientific article

Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa

scientific article published on 01 April 2008

Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

scientific article published on 30 November 2018

The Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-D-Aspartate (NMDA) Receptor

scientific article published on 15 June 2020

The Ecstasy and Agony of Assay Interference Compounds

scientific article

The Ecstasy and Agony of Assay Interference Compounds

scientific article published on 28 February 2017

The Ecstasy and Agony of Assay Interference Compounds

scientific article published in 2017

The Ecstasy and Agony of Assay Interference Compounds

The Ecstasy and Agony of Assay Interference Compounds.

scientific article published on 28 February 2017

The GluN2B-Glu413Gly NMDA receptor variant arising from a de novo GRIN2B mutation promotes ligand-unbinding and domain opening

scientific article published on 05 October 2018

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.

scientific article published on 6 June 2017

The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor.

scientific article

The case favoring direct C-alkylation of heteroatom-substituted enolates

article

The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity

scientific article

Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.

scientific article

Two domains that control prefusion stability and transport competence of the measles virus fusion protein

scientific article published on February 2006

Update to Our Reader, Reviewer, and Author Communities-April 2020

scientific article published on 22 April 2020

Update to Our Reader, Reviewer, and Author Communities-April 2020

scientific article published on 23 April 2020

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

scientific article

Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury

scientific article

XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH

scientific article

List of works by Dennis C. Liotta

1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols

A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.

A novel class of negative allosteric modulators of NMDA receptor function

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

A real-time method for measuring cAMP production modulated by Gαi/o-coupled metabotropic glutamate receptors

A structurally derived model of subunit-dependent NMDA receptor function

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

A target site for template-based design of measles virus entry inhibitors.

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

Academic Drug Development: The DRIVE Model

Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus

Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy

An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.

An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model.

Anti-HIV small-molecule binding in the peptide subpocket of the CXCR4:CVX15 crystal structure

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Asymmetric synthesis of host-directed inhibitors of myxoviruses.

Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog

Biased modulators of NMDA receptors control channel opening and ion selectivity

Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase

Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols

C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.

CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV.

Calculated conformer energies for organic molecules with multiple polar functionalities are method dependent: Taxol (case study)

Cancer and virus leads by HTS, chemical design and SEA data mining

Chloride is an Agonist of Group II and III Metabotropic Glutamate Receptors.

Computational studies of transition metal selectivity of octapeptide repeat region of prion protein (PrP).

Confronting Racism in Chemistry Journals

Confronting Racism in Chemistry Journals

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects

Correction to "Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease"

Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Correction to Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity

Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors

Correction: Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model.

Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

Design and synthesis of C6-C8 bridged epothilone A.

Design of a small-molecule entry inhibitor with activity against primary measles virus strains

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury

Development of a novel progesterone analog in the treatment of traumatic brain injury

Development of a unique small molecule modulator of CXCR4 ⬇️

Di-aryl Sulfonamide Motif Adds π-Stacking Bulk in Negative Allosteric Modulators of the NMDA Receptor

Diastereoselective addition of chlorotitanium enolate of N-acyl thiazolidinethione to O-methyl oximes: a novel, stereoselective synthesis of alpha,beta-disubstituted beta-amino carbonyl compounds via chiral auxiliary mediated azetine formation

Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity ⬇️

Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting

Discovery and Development of the Anti-Human Immunodeficiency Virus Drug, Emtricitabine (Emtriva, FTC).

Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties.

Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

Discovery of novel N-aryl piperazine CXCR4 antagonists

Discovery of small molecule CXCR4 antagonists

Discovery of tetrahydroisoquinoline-based CXCR4 antagonists

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors

Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.

EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

Enantioselective synthesis of the carbocyclic nucleoside (−)-abacavir ⬇️

Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells

GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

Group A streptococcus inhibitors by high-throughput virtual screening

Highly active anticancer curcumin analogues

Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex

In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin

Inhibition of breast cancer metastasis to the lungs with UBS109

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

Innovations in Medicinal Chemistry

Introductory Editorial for ACS Medicinal Chemistry Letters

Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators