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List of works by Francesco Dotta

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.

scientific article

A new solid-phase radioimmunoassay to detect anti-GAD65 autoantibodies

scientific article

A novel neuroendocrine cell surface glycoprotein: identification, isolation, and initial characterization.

scientific article published in April 1988

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

scientific article published on 20 September 2018

Activated T cells in normal pregnant women and neonates

scientific article published on 01 November 1986

Acute on chronic limb ischemia: From surgical embolectomy and thrombolysis to endovascular options

scientific article published on 01 June 2018

An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

scientific article published on 29 August 2007

Anti-ganglioside antibodies in new onset type 1 diabetic patients and high risk subjects.

scientific article published on January 1995

Autoantibodies to the GM2-1 islet ganglioside and to GAD-65 at type 1 diabetes onset.

scientific article published in December 1997

Autoantigens in thyroid and islet autoimmunity: similarities and differences

scientific article published on January 1, 1992

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

scientific article

Autoimmunity to the GM2-1 islet ganglioside before and at the onset of type I diabetes

scientific article published on 01 September 1996

Beta-cell markers and autoantigen expression by a human insulinoma cell line: similarities to native beta cells.

scientific article published on July 1996

Beyond Glycemic Control in Diabetes Mellitus: Effects of Incretin-Based Therapies on Bone Metabolism ⬇️

scientific article published on June 18, 2013

Bovine islets are less susceptible than human islets to damage by human cytokines

scientific article published on 01 January 2001

CD4+CD25high regulatory T cells in human autoimmune diabetes

scientific article published on 12 January 2005

Can NK cells be a therapeutic target in human type 1 diabetes?

scientific article

Celiac disease-associated transglutaminase autoantibody target domains at diagnosis are age and sex dependent.

scientific article

Changes in body composition after 9 months of treatment with exenatide twice daily versus glimepiride: comment letter on Jendle et al.

scientific article published on December 2010

Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives.

scientific article published on 12 April 2018

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients.

scientific article published on 10 April 2018

Circulating anti-immunoglobulin antibodies in recent-onset type I diabetic patients

scientific article published on 01 April 1988

Circulating miRNA95 and miRNA190 are sensitive markers for the differential diagnosis of thyroid nodules in a Caucasian population

scientific article published on 24 July 2014

Circulating microRNA (miRNA) Expression Profiling in Plasma of Patients with Gestational Diabetes Mellitus Reveals Upregulation of miRNA miR-330-3p

scientific article published on 12 December 2017

Circulating microRNAs and diabetes mellitus: a novel tool for disease prediction, diagnosis, and staging?

scientific article published on 17 February 2017

Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes

scientific article published on 07 March 2012

Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.

scientific article published on 07 March 2012

Comment on: Meagher et al. Neutralization of interleukin-16 protects nonobese diabetic mice from autoimmune type 1 diabetes by a CCL4-dependent mechanism. Diabetes 2010;59:2862-2871.

scientific article published on February 2011

Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin.

scientific article

Congenital autoimmune diabetes mellitus

scientific article published on 01 May 2000

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

scientific article published on 02 August 2018

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

scholarly article

Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies

scientific article published on 2 November 2009

Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells.

scientific article published on 09 May 2017

Defective lymphocyte caspase-3 expression in type 1 diabetes mellitus.

scientific article

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

scientific article

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

scientific article

Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening

article by C Tiberti et al published December 2011 in Clinical and Experimental Immunology

Diagnosis and approach to posttransplant diabetes.

scientific article published on August 2009

Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.

scientific article published on 18 February 2014

Effects of prolonged exposure to pancreatic glucagon on the function, antigenicity and survival of isolated human islets

scientific article published on 01 July 2000

Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

scientific article published on 12 September 2017

Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial.

scientific article

Endocrine Actions of Osteocalcin ⬇️

scientific article published on April 30, 2013

Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs

scientific article published on February 2014

Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress

scientific article published on 21 October 2015

Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scholarly article published in Diabetologia

Evidence of a selective epitope loss of anti-transglutaminase immunoreactivity in gluten-free diet celiac sera: A new tool to distinguish disease-specific immunoreactivities

article

Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial

scientific article published on 09 June 2012

Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes.

scientific article published in December 1999

Expression of cytoplasmic islet cell antigens by rat pancreas

scientific article published on 01 August 1987

Fighting diabetic foot ulcers-The diabetologist: A king maker of the fight

scientific article published on 01 June 2018

Fostering improved human islet research: a European perspective

scientific article published on 13 June 2019

Function of pancreatic islets isolated from a type 1 diabetic patient

scientific article published on 01 May 2000

G-protein-coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives.

scientific article published on 15 March 2018

GM2-1 pancreatic islet ganglioside: identification and characterization of a novel islet-specific molecule

scientific article published on 01 September 1995

Ganglioside expression in human pancreatic islets.

scientific article published on November 1989

Gangliosides and autoimmune diabetes.

scientific article published on September 1997

Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes

scientific article published on 20 February 2008

Guidelines for the treatment and management of new-onset diabetes after transplantation

scientific article

Hedgehog signaling during expansion of human pancreatic islet-derived precursors

scientific article

High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes.

scientific article published in April 2007

Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report

scientific article published on 01 September 2011

Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo

scientific article published on 4 March 2015

Humoral and cellular immune abnormalities in neonates of diabetic mothers: any pathological role?

scientific article published in August 1987

IA-2 combined epitope assay: a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes.

scientific article published in June 2005

IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets

scientific article published on 19 December 2013

Identification of a novel type 1 diabetes-specific epitope by screening phage libraries with sera from pre-diabetic patients.

scientific article published on May 1997

Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2.

scientific article published on 10 March 2008

Immunology in diabetic pregnancy: activated T cells in diabetic mothers and neonates

scientific article published on 01 February 1987

Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function

scientific article

Impaired caspase-3 expression by peripheral T cells in chronic autoimmune thyroiditis and in autoimmune polyendocrine syndrome-2

scientific article published on 12 September 2006

Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.

scientific article

In type 1 diabetes immunocompetent cells are defective in IL-16 secretion

scientific article published on 01 January 2012

In vitro effects of mycophenolic acid on survival, function, and gene expression of pancreatic beta-cells.

scientific article published on 17 January 2012

Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity

scientific article

Incretin hormones and beta-cell mass expansion: what we know and what is missing?

scientific article published on 23 May 2013

Innate immunity and the pathogenesis of type 1 diabetes.

scientific article published on 10 April 2010

Insulin prophylaxis down-regulates islet antigen expression and islet autoimmunity in the low-dose Stz mouse model of diabetes

scientific article published on 01 January 1999

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

article

Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

scientific article published in February 2018

Long-standing type 1 diabetes: patients with adult-onset develop celiac-specific immunoreactivity more frequently than patients with childhood-onset diabetes, in a disease duration-dependent manner

article

Long-term changes in cardiovascular risk markers during administration of exenatide twice daily or glimepiride: results from the European exenatide study

scientific article

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

article

Mast cells infiltrate pancreatic islets in human type 1 diabetes

scientific article

Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies

scientific article published on 28 April 2011

MicroRNA Expression Analysis of In Vitro Dedifferentiated Human Pancreatic Islet Cells Reveals the Activation of the Pluripotency-Related MicroRNA Cluster miR-302s.

scientific article published on 12 April 2018

MicroRNA expression profiles of human iPSCs differentiation into insulin-producing cells.

scientific article published on 30 December 2016

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

scientific article

MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes

scientific article published in 2018

MicroRNAs as new tools for exploring type 1 diabetes: relevance for immunomodulation and transplantation therapy

scientific article published on 01 January 2011

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.

scientific article

MicroRNAs: Novel Players in the Dialogue between Pancreatic Islets and Immune System in Autoimmune Diabetes

scientific article

MicroRNAs: markers of β-cell stress and autoimmunity

scientific article published on 01 August 2018

Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy

scientific article published on 02 July 2019

New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003.

scientific article

Oral delivery of glutamic acid decarboxylase (GAD)-65 and IL10 by Lactococcus lactis reverses diabetes in recent-onset NOD mice

scientific article published on 27 March 2014

Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse

scientific article published on 29 June 2005

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

scientific article

Pancreatic islet ganglioside expression in nonobese diabetic mice: comparison with C57BL/10 mice and changes after autoimmune beta-cell destruction

scientific article published on 01 January 1992

Photodynamic topical antimicrobial therapy for infected foot ulcers in patients with diabetes: a randomized, double-blind, placebo-controlled study--the D.A.N.T.E (Diabetic ulcer Antimicrobial New Topical treatment Evaluation) study

scientific article published on 19 December 2013

Presence of interleukin 4 or interleukin 10, but not both cytokines, in pancreatic tissue of two patients with recently diagnosed diabetes mellitus type I

scientific article published on 01 October 2000

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

scientific article published in May 2002

Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples

scientific article published on 15 June 2021

Putative endothelial progenitor cells predict long-term mortality in type-2 diabetes

scientific article published on 30 July 2018

Rat pancreatic ganglioside expression: differences between a model of autoimmune islet B cell destruction and a normal strain

scientific article published on 01 February 1993

Reduction of circulating neutrophils precedes and accompanies type 1 diabetes

scientific article published on 24 January 2013

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression

scientific article

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

scientific article

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.

scientific article published on 8 November 2016

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

scientific article published on 9 April 2012

Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death.

scientific article published on August 2004

Selection of phage-displayed peptides mimicking type 1 diabetes-specific epitopes.

scientific article published on June 1996

Serum Levels of miR-148a and miR-21-5p Are Increased in Type 1 Diabetic Patients and Correlated with Markers of Bone Strength and Metabolism

scientific article published on 27 November 2018

Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans

article

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines

scientific article published on March 2005

T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus

scientific article published on 01 September 1999

Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus

scientific article published on 02 January 2019

The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not beta-cell specific.

scientific article published on January 1998

The acquisition of an insulin-secreting phenotype by HGF-treated rat pancreatic ductal cells (ARIP) is associated with the development of susceptibility to cytokine-induced apoptosis.

scientific article

The autonomic innervation of the human greater saphenous vein

scientific article published on 01 January 1983

The case for virus-induced type 1 diabetes ⬇️

scientific article published on August 1, 2013

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets

scientific article

The social burden of hypoglycemia in the elderly

scientific article published on 8 February 2015

Thyrotoxic periodic paralysis in an Italian man: clinical manifestation and genetic analysis

scientific article published on 01 March 2008

Towards an Earlier and Timely Diagnosis of Type 1 Diabetes: Is it Time to Change Criteria to Define Disease Onset?

scientific article published on December 2015

Treatment escalation options for patients with type 2 diabetes after failure of exenatide twice daily or glimepiride added to metformin: results from the prospective European Exenatide (EUREXA) study

scientific article published on 08 May 2015

Type VII collagen in Alport syndrome

scientific article published on 01 August 2007

Tyrosine Phosphatase–Related Islet Antigen 2(256–760)Autoantibodies, the Only Marker of Islet Autoimmunity That Increases by Increasing the Degree of BMI in Obese Subjects With Type 2 Diabetes

scientific article published on 07 January 2015

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

scientific article published on 03 August 2018

Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets

scientific article published in January 2002

Urban diabetes: the case of the metropolitan area of Rome

scientific article published on 23 May 2019

Viral infections and diabetes.

scientific article published on January 2012

Virus Infections: Lessons from Pancreas Histology ⬇️

scientific article published on October 1, 2010

miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

scientific article published on 28 October 2019

β-cell autoimmunity 1998 ⬇️

scientific article published on 01 March 1998

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