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List of works by Mary B Goldring

A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E.

scientific article published on 16 December 2009

A hyaluronic acid-salmon calcitonin conjugate for the local treatment of osteoarthritis: chondro-protective effect in a rabbit model of early OA.

scientific article published on 15 May 2014

A misplaced lncRNA causes brachydactyly in humans

scientific article

A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation

scientific article published on 02 September 2005

ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes

scientific article published on 03 June 2013

Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice

scientific article published on 27 October 2004

Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha

scientific article published on February 2003

Articular Cartilage Degradation in Osteoarthritis ⬇️

scientific article published on January 24, 2012

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

scientific article published on March 2010

Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation

scientific article

Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other? ⬇️

scientific article published on October 19, 2010

C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors--Useful cells in study of cartilage metabolism

scientific article

CCAAT/enhancer binding protein β (C/EBPβ) regulates the transcription of growth arrest and DNA damage-inducible protein 45 β (GADD45β) in articular chondrocytes

scientific article

CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection

scientific article published on 19 March 2019

CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad

scientific article published on 19 March 2019

Cartilage homeostasis in health and rheumatic diseases

scientific article published on 19 May 2009

Cells of the synovium in rheumatoid arthritis. Chondrocytes

scientific article published on January 2007

Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes

scientific article

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk

scientific article published on 22 September 2016

Clinical implications of cartilage metabolism in arthritis

scientific article published on January 1990

Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice

scientific article

Correction to: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model

scholarly article published in Arthritis Research and Therapy

Correction: Cells of the synovium in rheumatoid arthritis. Chondrocytes

scholarly article by Miguel Otero & Mary B Goldring published 16 January 2008 in Arthritis Research and Therapy

Cytokines

scientific article published on January 1988

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

scientific article published on November 2009

DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes

scientific article published on 10 August 2017

Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.

scientific article

Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase

scientific article published on March 2002

Dual proline labeling protocol for individual "baseline" and "response" biosynthesis measurements in human articular cartilage

scientific article published on 8 April 2008

Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible signaling pathway protein 3/CCN6.

scientific article

E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage

scientific article published on 13 March 2018

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress ⬇️

scientific article published on December 9, 2011

E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes

scientific article published on 25 May 2016

ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity

scientific article published on 16 June 2016

ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation

scientific article

ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

scientific article published on May 2008

Early knee osteoarthritis

scientific article

Eating bone or adding it: the Wnt pathway decides

scientific article published on 01 February 2007

Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes

scientific article published on 01 September 2006

Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta

scientific article published on 11 March 2003

Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis

scientific article published on 24 April 2018

Emerging targets in osteoarthritis therapy.

scientific article published on 9 April 2015

Endostatin/collagen XVIII--an inhibitor of angiogenesis--is expressed in cartilage and fibrocartilage

scientific article

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis ⬇️

scientific article published on December 17, 2011

Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis

scientific article published in PLoS ONE

Expression and regulation of human beta-defensin-2 in osteoarthritic cartilage

scientific article published on 01 June 2006

GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes

scientific article

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene

scientific article

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

scientific article

Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis

scientific article

Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation

scientific article published in March 1998

Human beta-defensin 3 mediates tissue remodeling processes in articular cartilage by increasing levels of metalloproteinases and reducing levels of their endogenous inhibitors

scientific article

Human chondrocyte cultures as models of cartilage-specific gene regulation

scientific article published on 01 January 2012

Human chondrocyte cultures as models of cartilage-specific gene regulation.

scientific article

IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.

scientific article

Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes

scientific article published on 01 July 1986

In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae

scientific article published on June 2013

Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis

scientific article published on 01 August 2007

Individual and combined toxicity of T-2 toxin and deoxynivalenol on human C-28/I2 and rat primary chondrocytes

article

Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.

scientific article published on 20 June 2019

Inflammation in osteoarthritis

scientific article published on September 2011

Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study

scientific article published on 19 November 2018

Intact Pericellular Matrix of Articular Cartilage Is Required for Unactivated Discoidin Domain Receptor 2 in the Mouse Model ⬇️

scientific article published on September 1, 2011

Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes

scientific article published on December 1988

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes

scientific article published in December 1994

Is arthroscopic videotape a reliable tool for describing early joint tissue pathology of the knee?

scientific article published on 16 August 2017

Kinematics of meniscal- and ACL-transected mouse knees during controlled tibial compressive loading captured using roentgen stereophotogrammetry

scientific article published on 6 May 2016

Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement

scientific article published on 28 February 2020

Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction

scientific article published on 21 September 2013

Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation

scientific article published on 10 December 2015

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.

scientific article published on March 2013

Mechanical forces induce changes in VEGF and VEGFR-1/sFlt-1 expression in human chondrocytes.

scientific article published on September 2014

Mechanisms of matrix degradation in rheumatoid arthritis

scientific article published on January 1990

Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis

scientific article published on 9 January 2017

Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells

scientific article published on 01 December 1987

Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci

scientific article published on 11 February 2019

Mouse Models of Osteoarthritis: Surgical Model of Post-traumatic Osteoarthritis Induced by Destabilization of the Medial Meniscus

scientific article published on 01 January 2021

Mouse models of osteoarthritis: surgical model of posttraumatic osteoarthritis induced by destabilization of the medial meniscus

scientific article

NF-kappaB signaling: multiple angles to target OA.

scientific article published on May 2010

NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival

scientific article

Osteoarthritis ⬇️

article by Johanne Martel-Pelletier et al published 13 October 2016 in Nature Reviews Disease Primers

Osteoarthritis

scientific article published on 01 December 2007

Osteoarthritis: a disease of the joint as an organ

scientific article

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation

scientific article

Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression

scientific article

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

scientific article published on 15 July 2018

Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis

scientific article

Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha.

scientific article

Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha

scientific article published on January 2006

Potential role for interleukin-1 in fibrosis associated with chronic ambulatory peritoneal dialysis

scientific article published on January 1988

Preparation of Immortalized Human Chondrocyte Cell Lines

scientific article published on January 1, 1999

Production of endogenous antibiotics in articular cartilage.

scientific article published in November 2004

Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading

scientific article published on 20 February 2016

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues ⬇️

scientific article published on April 1, 2013

Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants

scientific article published on January 2006

Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites

scientific article published on 15 February 2013

Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction

scientific article published on 01 July 2007

Response to "Letter to the editor: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement"

scientific article published on 22 July 2020

Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.

scientific article

Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice

scientific article published on 14 September 2017

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis ⬇️

scientific article published on February 24, 2011

Selenium promotes metabolic conversion of T-2 toxin to HT-2 toxin in cultured human chondrocytes

scientific article published on 12 August 2017

Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice ⬇️

scientific article published on February 24, 2011

Skeletal tissue response to cytokines

scientific article published on September 1990

Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester.

scientific article published in April 1987

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes.

scientific article published on 11 December 2015

Suppression of type I collagen gene expression by prostaglandins in fibroblasts is mediated at the transcriptional level

scientific article

Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis.

scientific article published on 23 February 2011

Susceptibility of type I collagen containing mutated alpha 1(1) chains to cleavage by human neutrophil collagenase.

scientific article

T cell-specific expression of the murine CD3delta promoter

scientific article published on 24 September 2002

TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease

scientific article published on November 2006

The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes

scientific article published on 01 April 2005

The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-gamma-mediated inhibition in human chondrocytes: requirement for Stat1 alpha, Jak1 and Jak2.

scientific article published on January 2003

The control of chondrogenesis

scientific article

The effect of paraformaldehyde fixation on the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement

scientific article published on April 2009

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis

scientific article

The integrative analysis of DNA methylation and mRNA expression profiles confirmed the role of selenocompound metabolism pathway in Kashin-Beck disease

scientific article published on 20 August 2020

The role of cytokines in cartilage matrix degeneration in osteoarthritis.

scientific article published in October 2004

Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis

scientific article published on 26 October 2021

Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes.

scientific article

Tribute to Stephen M. Krane

scientific article published in May 2015

Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways

scientific article published on September 2004

VEGF expression in adult permanent thyroid cartilage: implications for lack of cartilage ossification

scientific article published on 01 August 2004

Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes

scientific article published on March 2004

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